S. Nikas

发表

Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats

B. Cravatt, D. Piomelli, L. Panlilio, 2016, Psychopharmacology.

Chain Substituted Cannabilactones with Selectivity for the CB2 Cannabinoid Receptor

S. Nikas, S. O. Alapafuja, A. Makriyannis, 2019, Molecules.

Brain Penetrant, but not Peripherally Restricted, Synthetic Cannabinoid 1 Receptor Agonists Promote Morphine-Mediated Respiratory Depression.

I. Spigelman, S. Nikas, A. Makriyannis, 2021, Cannabis and cannabinoid research.

Structural requirements for cannabinoid receptor probes.

S. Nikas, A. Makriyannis, G. Thakur, 2005, Handbook of experimental pharmacology.

Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon

B. Bahr, S. Nikas, A. Makriyannis, 2017, Journal of Molecular Neuroscience.

Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist

S. Nikas, A. Makriyannis, K. Vemuri, 2015, Psychopharmacology.

Novel 1',1'-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist.

Anna L. Bowman, S. Nikas, S. O. Alapafuja, 2010, Journal of medicinal chemistry.

A concise methodology for the synthesis of (-)-Δ9-tetrahydrocannabinol and (-)-Δ9-tetrahydrocannabivarin metabolites and their regiospecifically deuterated analogs

M. Huestis, S. Nikas, S. O. Alapafuja, 2007 .

Design and synthesis of novel prostaglandin E2 ethanolamide and glycerol ester probes for the putative prostamide receptor(s).

S. Nikas, C. Serhan, N. Chiang, 2015, Tetrahedron letters.

Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal

K. Mackie, A. Hohmann, S. Nikas, 2018, Molecular Pharmacology.

( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.

K. Mackie, L. Marnett, A. Hohmann, 2018, Journal of medicinal chemistry.

Novel C-Ring-Hydroxy-Substituted Controlled Deactivation Cannabinergic Analogues.

S. Nikas, A. Makriyannis, J. Bergman, 2016, Journal of medicinal chemistry.

Enantioselective synthesis of (10S)- and (10R)-methyl-anandamides.

S. Nikas, A. Makriyannis, Marsha D'Souza, 2012, Tetrahedron.

Design and synthesis of (13S)-methyl-substituted arachidonic acid analogues: templates for novel endocannabinoids.

S. Nikas, A. Makriyannis, D. Papahatjis, 2010, Chemistry.

Aspirin-triggered metabolites of EFAs.

S. Nikas, A. Makriyannis, 2011, Chemistry & biology.

Cannabinoid CB1 Discrimination: Effects of Endocannabinoids and Catabolic Enzyme Inhibitors

S. Nikas, S. O. Alapafuja, A. Makriyannis, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Modulation of cannabinoid receptor signaling by endocannabinoids

R. Dror, M. J. Robertson, G. Skiniotis, 2022, bioRxiv.

Synthesis of Functionalized Cannabilactones

S. Nikas, A. Makriyannis, Yingpeng Liu, 2020, Molecules.

3'-functionalized adamantyl cannabinoid receptor probes.

M. Tius, S. Nikas, Han Zhou, 2015, Journal of medicinal chemistry.

Sulfonyl fluoride inhibitors of fatty acid amide hydrolase.

Anna L. Bowman, S. Nikas, S. O. Alapafuja, 2012, Journal of medicinal chemistry.

Antiemetic Effects of Cannabinoid Agonists in Nonhuman Primates

S. Nikas, A. Makriyannis, J. Bergman, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Maternal Dietary Fatty Acids and Their Relationship to Derived Endocannabinoids in Human Milk

S. Nikas, A. Makriyannis, J. Wood, 2021, Journal of human lactation : official journal of International Lactation Consultant Association.

Differential Enantiomer-Specific Signaling of Cannabidiol at CB1 Receptors

S. Nikas, K. Mackie, J. Wager-Miller, 2022, Molecular Pharmacology.

The role of halogen substitution in classical cannabinoids: A CB1 pharmacophore model

S. Nikas, Sonyuan Lin, J. Grzybowska, 2004, The AAPS Journal.

Cannabinoid-2 Agonism with AM2301 Mitigates Morphine-Induced Respiratory Depression.

S. Nikas, A. Makriyannis, T. Vanderah, 2020, Cannabis and cannabinoid research.

Evidence for spontaneous cannabinoid withdrawal in mice

S. Nikas, J. Bergman, Ioannis Papanastasiou, 2021, Behavioural pharmacology.

Diuretic Effects of Cannabinoids

S. Nikas, A. Makriyannis, G. Thakur, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Crystal structures of agonist-bound human cannabinoid receptor CB1

Shan Jiang, Tian Hua, Suwen Zhao, 2017, Nature.

Cannabinoid-induced lower lip retraction in rats

Rishi Sharma, S. Nikas, A. Makriyannis, 2018, Psychopharmacology.

C-ring cannabinoid lactones: a novel cannabinergic chemotype.

S. Nikas, A. Makriyannis, J. Wood, 2014, ACS medicinal chemistry letters.

Targeting the Endocannabinoid System for Neuroprotection: A 19F-NMR Study of a Selective FAAH Inhibitor Binding with an Anandamide Carrier Protein, HSA

Rishi Sharma, S. Nikas, A. Makriyannis, 2013, Journal of pharmaceutics & pharmacology.

The Interaction of Fatty Acid Amide Hydrolase (FAAH) Inhibitors with an Anandamide Carrier Protein Using 19F-NMR

S. Nikas, A. Makriyannis, Jianhong Zhao, 2013, The AAPS Journal.

A New Generation Fatty Acid Amide Hydrolase Inhibitor Protects Against Kainate-Induced Excitotoxicity

B. Bahr, S. Nikas, S. O. Alapafuja, 2011, Journal of Molecular Neuroscience.

C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols.

S. Nikas, S. O. Alapafuja, A. Tsotinis, 2007, Journal of medicinal chemistry.

Novel 1′,1′-chain substituted Δ8-tetrahydrocannabinols

S. Nikas, A. Makriyannis, D. Papahatjis, 2002 .

CB1 cannabinoid receptor ligands.

S. Nikas, G. Thakur, A. Makriyannis, 2005, Mini reviews in medicinal chemistry.

C1'-Azacycloalkyl Hexahydrocannabinols.

M. Tius, S. Nikas, N. Shimada, 2017, The Journal of organic chemistry.

Effects of cannabinoid exposure on short-term memory and medial orbitofrontal cortex function and chemistry in adolescent female rhesus macaques

S. Nikas, J. Jensen, J. Bergman, 2022, Frontiers in Neuroscience.

AM2389, a high-affinity, in vivo potent CB1-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice

S. Nikas, A. Makriyannis, T. Järbe, 2012, Psychopharmacology.

Substrate-selective activation of COX-2 by AM-8138

L. Marnett, C. Rouzer, S. Nikas, 2015 .

Inhibiting fatty acid amide hydrolase normalizes endotoxin‐induced enhanced gastrointestinal motility in mice

K. Mackie, B. Cravatt, S. Nikas, 2012, British journal of pharmacology.

Cannabinoid-induced lower lip retraction in rats

Rishi Sharma, S. Nikas, A. Makriyannis, 2018, Psychopharmacology.

Regiospecifically deuterated (−)-Δ9-tetrahydrocannabivarins

S. Nikas, G. Thakur, A. Makriyannis, 2002 .

Synthesis of side chain specifically deuterated (-)-Δ9-tetrahydrocannabinols

S. Nikas, G. Thakur, A. Makriyannis, 2002 .

Microwave Assisted Synthesis of Sodium Sulfonates Precursors of Sulfonyl Chlorides and Fluorides.

S. Nikas, A. Makriyannis, Ioannis Papanastasiou, 2009, Tetrahedron letters.

Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-methoxy-1-methyltryptamines.

S. Nikas, A. Tsotinis, K. Davidson, 2006, Journal of medicinal chemistry.

New aminoadamantane derivatives with antiproliferative activity

S. Nikas, A. Tsotinis, Ioannis Papanastasiou, 2013, Medicinal Chemistry Research.

Oxa-Adamantyl Cannabinoids.

M. Tius, S. Nikas, A. Makriyannis, 2021, Bioorganic & medicinal chemistry letters.

Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist

S. Nikas, A. Makriyannis, K. Vemuri, 2015, Psychopharmacology.

Formation and crystal structure of an exocyclic enol δ-lactone obtained from dimedone and trimethylsilylethynyl phenyliodonium triflate†

S. Nikas, A. Terzis, N. Rodios, 1996 .

Novel tail and head group prostamide probes.

S. Nikas, C. Serhan, N. Chiang, 2015, Bioorganic & medicinal chemistry letters.

Altered sleep during spontaneous cannabinoid withdrawal in male mice

S. Nikas, W. Carlezon, J. Bergman, 2022, Behavioural pharmacology.

Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures

Suwen Zhao, S. Nikas, A. Makriyannis, 2020, Cell.

Conformational study of lipophilic ligands in phospholipid model membrane systems by solution NMR.

S. Nikas, A. Makriyannis, Jianxin Guo, 2003, Journal of medicinal chemistry.

Fluorescent probes for G-protein-coupled receptor drug discovery

R. Kulkarni, S. Nikas, A. Makriyannis, 2018, Expert opinion on drug discovery.

Controlled-deactivation cannabinergic ligands.

S. Nikas, A. Makriyannis, J. Wood, 2013, Journal of medicinal chemistry.

Synthon-based ligand discovery in virtual libraries of over 11 billion compounds

Yurii S. Moroz, Xi-Ping Huang, B. Roth, 2021, Nature.

Synthon-based ligand discovery in virtual libraries of over 11 billion compounds

Yurii S. Moroz, Xi-Ping Huang, B. Roth, 2021, Nature.

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

A. Caspi, K. Sugden, B. Williams, 2013, Molecular Psychiatry.

Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.

Joseph Tam, Grzegorz Godlewski, Alexandros Makriyannis, 2010, Chemistry & biology.

The application of 3D-QSAR studies for novel cannabinoid ligands substituted at the C1' position of the alkyl side chain on the structural requirements for binding to cannabinoid receptors CB1 and CB2.

Serdar Durdagi, Agnes Kapou, Thomas Mavromoustakos, 2007, Journal of medicinal chemistry.

Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'.

S. Nikas, Wei Xu, A. Makriyannis, 2003, Journal of medicinal chemistry.

Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure

K. Mackie, S. Nikas, A. Makriyannis, 2018, Pharmaceuticals.

13-Methylarachidonic Acid Is a Positive Allosteric Modulator of Endocannabinoid Oxygenation by Cyclooxygenase*

Shu Xu, Lawrence J. Marnett, Alexandros Makriyannis, 2015, The Journal of Biological Chemistry.

Synthesis and characterization of a compact tricyclic resorcinol from (+)- and (-)-3-pinanol.

S. Nikas, A. Makriyannis, Xiuwen Han, 2012, Tetrahedron letters.

Cannabinoid receptors as therapeutic targets.

S. Nikas, G. Thakur, A. Makriyannis, 2006, Current pharmaceutical design.

The Interaction of Fatty Acid Amide Hydrolase (FAAH) Inhibitors with an Anandamide Carrier Protein Using 19F-NMR

S. Nikas, A. Makriyannis, Jianhong Zhao, 2013, The AAPS Journal.

Cannabinoid Antagonist Drug Discrimination in Nonhuman Primates

S. Nikas, A. Makriyannis, J. Bergman, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates

S. Nikas, A. Makriyannis, J. Bergman, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Acute and chronic effects of cannabidiol on Δ⁹-tetrahydrocannabinol (Δ⁹-THC)-induced disruption in stop signal task performance.

S. Nikas, A. Makriyannis, J. Bergman, 2016, Experimental and clinical psychopharmacology.

New aminoadamantane derivatives with antiproliferative activity

S. Nikas, A. Tsotinis, Ioannis Papanastasiou, 2014, Medicinal Chemistry Research.

&Dgr;9-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice

S. Nikas, A. Makriyannis, C. Paronis, 2012, Behavioural pharmacology.

Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists.

S. Nikas, A. Makriyannis, J. Wood, 2021, European journal of medicinal chemistry.

Probing the Carboxyester Side Chain in Controlled Deactivation (−)-Δ8-Tetrahydrocannabinols

Rishi Sharma, S. Nikas, A. Makriyannis, 2014, Journal of medicinal chemistry.

Blockade of CB1 or Activation of CB2 Cannabinoid Receptors Is Differentially Efficacious in the Treatment of the Early Pathological Events in Streptozotocin-Induced Diabetic Rats

S. Nikas, A. Makriyannis, K. Vemuri, 2022, International journal of molecular sciences.

Accurate Redetermination of Diiodobis(phenylsulfonyl)methane, (PhSO2)2CI2

C. Glidewell, S. Nikas, G. Ferguson, 1996 .

Endocannabinoid Metabolome Characterization of Milk from Guatemalan Women Living in the Western Highlands

L. Allen, S. Nikas, A. Makriyannis, 2019, Current developments in nutrition.

The Reaction of Trimethylsilylethynyl(phenyl)iodonium Triflate with Some Phenolates: Formation of Substitution and sp2 C-H Insertion Products

S. Nikas, N. Rodios, A. Varvoglis, 2000 .

Structural basis for activation of CB1 by an endocannabinoid analog

M. J. Robertson, G. Skiniotis, B. Kobilka, 2023, Nature communications.

Relationship Between Endocannabinoids During Pregnancy and Infant Heart Rate and Heart Rate Variability

S. Nikas, A. Makriyannis, L. Ji, 2021 .

Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.

B. Cravatt, S. Nikas, A. Makriyannis, 2010, Chemistry & biology.

Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon

B. Bahr, S. Nikas, A. Makriyannis, 2017, Journal of Molecular Neuroscience.

A New Ring-Forming Methodology for the Synthesis of Conformationally Constrained Bioactive Molecules

S. Nikas, A. Tsotinis, A. Makriyannis, 2001 .

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

A. Caspi, K. Sugden, R. Poulton, 2013, Molecular Psychiatry.

Probing the Carboxyester Side Chain in Controlled Deactivation (−)-Δ8-Tetrahydrocannabinols

Rishi Sharma, S. Nikas, A. Makriyannis, 2014, Journal of medicinal chemistry.

Effects of cannabinoid agonists and antagonists in male rats discriminating the synthetic cannabinoid AM2201.

S. Nikas, A. Makriyannis, M. Georgiadis, 2023, European journal of pharmacology.

Chiral Me-2-arachidonoyl Glycerols: The First Potent Endocannabinoid Glyceride Templates with Stability to COX-2.

V. Katritch, S. Nikas, Shalley N. Kudalkar, 2024, ACS medicinal chemistry letters.