H. Mizutani

发表

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Amanda Doucette, Mansoureh Rezaei, Alice McDonald, 2009, Nature.

Modular peptide-based phosphine ligands in asymmetric catalysis: efficient and enantioselective Cu-catalyzed conjugate additions to five-, six-, and seven-membered cyclic enones.

H. Mizutani, A. Hoveyda, S. Degrado, 2001, Journal of the American Chemical Society.

Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route.

Adnan O. Abu-Yousif, M. Mizutani, Courtney A. Cullis, 2021, Journal of medicinal chemistry.

Novel stereoselective synthesis of enantiopure (+)-N-Boc-norpandamarilactonine-A, the intermediate for pandamarilactonines

H. Mizutani, T. Honda, Makoto Ushiwata, 2006 .

First total synthesis of (+)-viroallosecurinine

H. Mizutani, T. Honda, H. Namiki, 2004 .

Enantiospecific synthesis of an indolizidine alkaloid, (+)-ipalbidine

H. Mizutani, T. Honda, H. Nagase, 2003 .

Enantioselective total synthesis of δ-lactonic marine natural products, (+)-tanikolide and (−)-malyngolide, via RCM reaction

H. Mizutani, T. Honda, Masayuki Watanabe, 2002 .

A Formal Total Synthesis of Securinine via an Intramolecular[4+2] Cycloaddition Reaction

H. Mizutani, T. Honda, H. Nagase, 2003 .

Efficient cu-catalyzed asymmetric conjugate additions of alkylzincs to trisubstituted cyclic enones.

H. Mizutani, A. Hoveyda, S. Degrado, 2002, Journal of the American Chemical Society.

Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to acyclic aliphatic enones.

H. Mizutani, A. Hoveyda, S. Degrado, 2002, Journal of the American Chemical Society.

Stereoselective synthesis of Nuphar quinolizidine alkaloid, (−)-deoxynupharidine

H. Mizutani, T. Honda, M. Katoh, 2005 .

Modular Pyridinyl Peptide Ligands in Asymmetric Catalysis: Enantioselective Synthesis of Quaternary Carbon Atoms Through Copper-Catalyzed Allylic Substitutions.

H. Mizutani, A. Hoveyda, K. E. Murphy, 2001, Angewandte Chemie.

Studies on the sharpless asymmetric epoxidation of unsymmetrical divinylmethanols

H. Mizutani, T. Honda, K. Kanai, 1996 .

First diastereoselective chiral synthesis of (-)-securinine.

H. Mizutani, T. Honda, Kyosuke Kaneda, 2004, Organic letters.

Enantiocontrolled Synthesis of (+)-Boronolide.

H. Mizutani, T. Honda, K. Kanai, 1996 .

A novel intramolecular Diels–Alder approach to securinega alkaloids: formal synthesis of securinine

H. Mizutani, T. Honda, H. Nagase, 2000 .

Enantioselective synthesis of the lactone moiety of HMG-CoA reductase inhibitor: stereoselective synthesis of (+)-(4R,6R)-4-hydroxy-6-(2-phenylethyl)-tetrahydro-2H-pyran-2-one

H. Mizutani, T. Honda, K. O. Hallinan, 1997 .

Enantioselective Syntheses of Syributin 1 and Novel C-Glycosidic Elicitors Syringolides 1 and 2

H. Mizutani, T. Honda, K. Kanai, 1996 .

Regioselective Ring-Opening of 2,3-Epoxy Alcohols with Tetramethylammonium Triacetoxyborohydride

H. Mizutani, T. Honda, 1998 .

Enantiocontrolled synthesis of naturally occurring octadecadienoic acid derivatives, self-defensive substances against rice blast disease, by means of the Sharpless asymmetric epoxidation of unsymmetrical divinylmethanol 1

H. Mizutani, T. Honda, Mai Ohta, 1999 .

Regioselective Ring-Opening of 2,3-Epoxy Alcohols with Tetramethylammonium Triacetoxyborohydride.

H. Mizutani, T. Honda, 1998 .

Enantiospecific Total Synthesis of TAN1251C and TAN1251D.

H. Mizutani, T. Honda, Jun Takayama, 2005 .

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor.

Pooja Shah, Hua Liao, John Newcomb, 2017, Nature chemical biology.

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.

Xingyue He, M. Mizutani, T. Soucy, 2021, Journal of medicinal chemistry.

Optimization of tetrahydronaphthalene inhibitors of Raf with selectivity over hERG.

S. Adhikari, H. Mizutani, Mansoureh Rezaei, 2016, Bioorganic & medicinal chemistry letters.

Novel chiral synthetic path to indolizidine and quinolizidine alkaloids by means of a samarium diiodide-promoted reductive carbon-nitrogen cleavage reaction : Synthesis of (+)-(8R, 8aR) -perhydro -8 -indolizidinol and (-)-deoxynupharidine

H. Mizutani, T. Honda, M. Katoh, 2006 .

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

E. Winzeler, L. Tilley, D. Fidock, 2021, Proceedings of the National Academy of Sciences.

Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors.

Yuan Tian, Hongbo Zeng, Mansoureh Rezaei, 2011, Journal of medicinal chemistry.