Tina Talreja

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Amanda Doucette, Mansoureh Rezaei, Alice McDonald, 2009, Nature.

Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.

Tina Talreja, Yibin Zeng, S. Queener, 2007, Journal of medicinal chemistry.

Acceleration of Petasis reactions of salicylaldehyde derivatives with molecular sieves.

Tina Talreja, Xiangli Shi, Zhili Xin, 2012, The Journal of organic chemistry.

Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.

K. Rhodes, Lin Xu, D. Kocisko, 2011, Bioorganic & medicinal chemistry letters.

Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists.

I. Enyedy, Tina Talreja, T. Bohnert, 2015, Bioorganic & medicinal chemistry letters.

Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator.

K. Rhodes, Lin Xu, Tina Talreja, 2011, ACS medicinal chemistry letters.

BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease

K. Rhodes, Lin Xu, Tina Talreja, 2016, Neuropharmacology.