E. Schönbrunn

发表

Structural Basis of Glyphosate Tolerance Resulting from Mutations of Pro101 in Escherichia coli 5-Enolpyruvylshikimate-3-phosphate Synthase*

Ernst Schönbrunn, M. Healy-Fried, T. Funke, 2007, Journal of Biological Chemistry.

Cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains.

S. Olesen, E. Schönbrunn, Mathew P. Martin, 2013, ACS chemical biology.

Discovery of a potential allosteric ligand binding site in CDK2.

Huijong Han, E. Schönbrunn, Mathew P. Martin, 2011, ACS chemical biology.

Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations

Bryce K. Allen, E. Schönbrunn, S. Schürer, 2017, ACS omega.

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

S. Olesen, A. Becker, E. Schönbrunn, 2014, ACS chemical biology.

A Novel Approach to the Discovery of Small‐Molecule Ligands of CDK2

E. Schönbrunn, Mathew P. Martin, S. Betzi, 2012, Chembiochem : a European journal of chemical biology.

Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)*

S. Olesen, Huijong Han, E. Schönbrunn, 2012, The Journal of Biological Chemistry.

Differential antibacterial properties of the MurA inhibitors terreic acid and fosfomycin

S. Olesen, E. Schönbrunn, D. Ingles, 2014, Journal of basic microbiology.

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX*

Ernst Schönbrunn, Baozong Li, W. Guida, 2009, The Journal of Biological Chemistry.

Stability of the Human Hsp90-p50Cdc37 Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2

S. Olesen, E. Schönbrunn, Mathew P. Martin, 2015, Molecules.

Structural basis of inhibitor selectivity in the BRD7/9 subfamily of bromodomains.

E. Schönbrunn, Jin-Yi Zhu, R. Karim, 2020, Journal of medicinal chemistry.

An Advanced Tool To Interrogate BRD9.

E. Schönbrunn, R. Karim, 2016, Journal of medicinal chemistry.

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).

W. Guida, E. Schönbrunn, S. Sebti, 2012, MedChemComm.

Advances of small molecule targeting of kinases.

E. Schönbrunn, N. Berndt, R. Karim, 2017, Current opinion in chemical biology.

Crystallization and preliminary X-ray analysis of the single-headed and double-headed motor protein kinesin.

E. Mandelkow, E. Schönbrunn, S. Brady, 1997, Journal of structural biology.

X-ray crystallographic and Solution State NMR Spectroscopic Investigations of NADP + Binding to Ferredoxin-NADP Reductase (FPR) from Pseudomonas aeruginosa , †,‡

Huijong Han, E. Schönbrunn, M. Rivera, 2009 .

1,4‐Dihydropyridinebutyrolactone‐derived ring‐opened ester and amide analogs targeting BET bromodomains

J. Qi, E. Schönbrunn, G. Georg, 2022, Archiv der Pharmazie.

Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.

A. Becker, E. Schönbrunn, N. Berndt, 2021, Journal of medicinal chemistry.

Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.

J. Qi, E. Schönbrunn, G. Georg, 2022, Journal of medicinal chemistry.

Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis†

E. Schönbrunn, G. Georg, J. Hawkinson, 2020, Biology of Reproduction.

Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof.

E. Schönbrunn, G. Reuther, H. Lawrence, 2021, Journal of medicinal chemistry.

Crystallization of a macromolecular ring assembly of tubulin liganded with the anti-mitotic drug podophyllotoxin.

E. Mandelkow, E. Schönbrunn, B. Trinczek, 1999, Journal of structural biology.

Crystallization and Preliminary X-Ray Diffraction Analysis of UDP-N-acetylglucosamine Enolpyruvyltransferase ofEnterobacter cloacae

Z. Dauter, E. Mandelkow, E. Schönbrunn, 1996 .

Crystallization and preliminary X-ray diffraction analysis of UDP-N-acetylglucosamine enolpyruvyltransferase of Enterobacter cloacae.

Z. Dauter, E. Mandelkow, E. Schönbrunn, 1996, Journal of structural biology.

Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target.

U. Rix, E. Schönbrunn, E. Haura, 2023, ACS chemical biology.

RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.

Ying Sun, E. Schönbrunn, S. Sebti, 2012, Cancer research.

Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors.

Rommie E. Amaro, Shuai Liu, J. Qi, 2021, Journal of medicinal chemistry.

Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases.

E. Schönbrunn, G. Georg, J. Tash, 2012, The Journal of organic chemistry.

A Novel Inhibitor That Suspends the Induced Fit Mechanism of UDP-N-acetylglucosamine Enolpyruvyl Transferase (MurA)*

Ernst Schönbrunn, Melanie A. Priestman, E. Schönbrunn, 2005, Journal of Biological Chemistry.

A New View of the Mechanisms of UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) and 5-Enolpyruvylshikimate-3-phosphate Synthase (AroA) Derived from X-ray Structures of Their Tetrahedral Reaction Intermediate States*

W. Kabsch, E. Schönbrunn, S. Eschenburg, 2003, Journal of Biological Chemistry.

Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analogues.

M. Healy-Fried, T. Funke, Huijong Han, 2007, Biochemistry.

Evidence That the Fosfomycin Target Cys115 in UDP-N-acetylglucosamine Enolpyruvyl Transferase (MurA) Is Essential for Product Release*

Melanie A. Priestman, E. Schönbrunn, S. Eschenburg, 2005, Journal of Biological Chemistry.

Comparative X‐ray analysis of the un‐liganded fosfomycin‐target MurA

E. Schönbrunn, S. Eschenburg, 2000, Proteins.

X-ray crystallographic and solution state nuclear magnetic resonance spectroscopic investigations of NADP+ binding to ferredoxin NADP reductase from Pseudomonas aeruginosa.

Huijong Han, E. Schönbrunn, M. Rivera, 2008, Biochemistry.

Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail.

W. Kabsch, E. Schönbrunn, J. N. Evans, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Biochemical and structural characterization of Pseudomonas aeruginosa Bfd and FPR: ferredoxin NADP+ reductase and not ferredoxin is the redox partner of heme oxygenase under iron-starvation conditions.

Huijong Han, E. Schönbrunn, M. Rivera, 2007, Biochemistry.

Molecular basis for the herbicide resistance of Roundup Ready crops

M. Healy-Fried, T. Funke, Huijong Han, 2006, Proceedings of the National Academy of Sciences.

The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) .

S. Olesen, A. Becker, Huijong Han, 2010, Biochemistry.

Fluorinated Aromatic Amino Acids Are Sensitive 19F NMR Probes for Bromodomain-Ligand Interactions

N. Mishra, E. Schönbrunn, W. Pomerantz, 2014, ACS chemical biology.

Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.

S. Olesen, E. Schönbrunn, G. Georg, 2017, Journal of medicinal chemistry.

Structure–Activity Studies of N‐Butyl‐1‐deoxynojirimycin (NB‐DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2

Erick J Carlson, E. Schönbrunn, G. Georg, 2017, ChemMedChem.

Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors.

E. Schönbrunn, David C. Mikles, G. Georg, 2018, ACS chemical biology.

A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A.

E. Schönbrunn, S. Sebti, Riazul Alam, 2012, ACS chemical biology.

Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon

W. Guida, A. Becker, K. Daniel, 2018, The Journal of Biological Chemistry.

How the mutation glycine96 to alanine confers glyphosate insensitivity to 5-enolpyruvyl shikimate-3-phosphate synthase from Escherichia coli

Melanie A. Priestman, E. Schönbrunn, G. Lushington, 2002, Planta.

Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation

Bin Fang, Weiwei Zhu, Charlene Rivera, 2010, PloS one.

Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics

Patricia Greninger, C. Benes, E. Schönbrunn, 2017, Molecular Cancer Therapeutics.

New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition.

K. Shi, E. Schönbrunn, M. Fischer, 2021, Journal of medicinal chemistry.

BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.

Gunda I Georg, William C K Pomerantz, Ernst Schönbrunn, 2017, Journal of medicinal chemistry.

Back Cover: Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET‐BRET (ChemMedChem 23/2016)

Luke W. Koblan, Shuai Liu, Dennis L. Buckley, 2016 .

NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex.

Peter D Ycas, E. Schönbrunn, Jorden A. Johnson, 2020, Biochemistry.

Tetrahydroindazole inhibitors of CDK2/cyclin complexes.

A. Becker, E. Schönbrunn, G. Georg, 2021, European journal of medicinal chemistry.

The Crystal Structure of Dimeric Kinesin and Implications for Microtubule-Dependent Motility

E. Mandelkow, E. Mandelkow, V. Biou, 1997, Cell.

Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurA.

K. Luger, E. Schönbrunn, N. Amrhein, 2000, Biochemistry.

Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.

Jiandong Chen, E. Schönbrunn, Lihong Chen, 2022, Journal of medicinal chemistry.

Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents

N. Levinson, E. Schönbrunn, V. Chennathukuzhi, 2022, bioRxiv.

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

Huan Yang, J. Cheng, E. Schönbrunn, 2010, Cell Death and Differentiation.

Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core.

R. F. Weaver, E. Schönbrunn, R. Hanzlik, 2006, Biochemistry.

Molecular basis for the glyphosate‐insensitivity of the reaction of 5‐enolpyruvylshikimate 3‐phosphate synthase with shikimate

A. Becker, T. Funke, Melanie A. Priestman, 2005, FEBS letters.

Evidence for a major structural change in Escherichia coli chorismate synthase induced by flavin and substrate binding.

D. Svergun, S. Bornemann, E. Schönbrunn, 1998, The Biochemical journal.

Dihydropyridine Lactam Analogs Targeting BET Bromodomains

J. Qi, E. Schönbrunn, G. Georg, 2021, ChemMedChem.

MurA as a Primary Target of Tulipalin B and 6-Tuliposide B

S. Olesen, M. Ubukata, E. Schönbrunn, 2013, Bioscience, biotechnology, and biochemistry.

Structural characterization of the hemophore HasAp from Pseudomonas aeruginosa: NMR spectroscopy reveals protein-protein interactions between Holo-HasAp and hemoglobin.

A. Becker, T. Funke, E. Schönbrunn, 2009, Biochemistry.

Discovery of Diverse Small‐Molecule Inhibitors of Mammalian Sterile20‐like Kinase 3 (MST3)

S. Olesen, E. Schönbrunn, Jin-Yi Zhu, 2016, ChemMedChem.

Identification and Screening of Selective WEE2 Inhibitors to Develop Non-Hormonal Contraceptives that Specifically Target Meiosis.

E. Schönbrunn, Mat Martin, G. Georg, 2019, ChemistrySelect.

Correction

E. Schönbrunn, W. Pomerantz, Andrew K. Urick, 2011, Journal of NeuroInterventional Surgery.

Design, Synthesis, and Characterization of a Fluorescence Polarization Pan-BET Bromodomain Probe.

E. Schönbrunn, G. Georg, J. Hawkinson, 2018, ACS medicinal chemistry letters.

5‐Enolpyruvylshikimate‐3‐phosphate synthase from Staphylococcus aureus is insensitive to glyphosate

T. Funke, Melanie A. Priestman, E. Schönbrunn, 2005, FEBS letters.

Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycin.

E. Mandelkow, E. Schönbrunn, A. Perrakis, 1996, Structure.

Studies on the conformational changes in the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine enolpyruvyltransferase (MurA).

D. Svergun, E. Schönbrunn, M. Koch, 1998, European journal of biochemistry.

Structural basis for the interaction of the fluorescence probe 8-anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA.

W. Kabsch, K. Luger, E. Schönbrunn, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Interaction of phosphonate analogues of the tetrahedral reaction intermediate with 5-enolpyruvylshikimate-3-phosphate synthase in atomic detail.

Gerald H Lushington, Ernst Schönbrunn, A. Becker, 2005, Biochemistry.

Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr97 → Ile and Pro101 → Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coli*

S. Olesen, A. Becker, M. Healy-Fried, 2009, Journal of Biological Chemistry.

Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.

Nan Wang, N. Levinson, E. Schönbrunn, 2023, Journal of medicinal chemistry.