K. Muegge

发表

The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences

Jianke Ren, Victorino R Briones, Samantha Barbour, 2015, Nucleic acids research.

Bax deficiency partially corrects interleukin-7 receptor α deficiency

K. Muegge, H. Young, A. Khaled, 2002 .

The chromatin remodeling protein Lsh alters nucleosome occupancy at putative enhancers and modulates binding of lineage specific transcription factors

Jianke Ren, K. Muegge, R. Finney, 2019, Epigenetics.

Advanced Applications of RNA Sequencing and Challenges

Yixing Han, K. Muegge, Shouguo Gao, 2015, Bioinformatics and biology insights.

Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences

K. Zhao, R. Leighty, Victorino R Briones, 2011, Proceedings of the National Academy of Sciences.

Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene.

K. Muegge, S. Durum, M. Vila, 1993, Science.

New cytokines and receptors make their debut in San Antonio.

K. Muegge, S. Durum, D. Quinn, 1991, Immunology today.

Interleukin-3 Withdrawal Induces an Early Increase in Mitochondrial Membrane Potential Unrelated to the Bcl-2 Family

C. Thompson, K. Muegge, H. Young, 2001, The Journal of Biological Chemistry.

IL-7 withdrawal induces a stress pathway activating p38 and Jun N-terminal kinases.

K. Muegge, H. Young, S. Durum, 2002, Cellular signalling.

LSH catalyzes ATP-driven exchange of histone variants macroH2A1 and macroH2A2.

K. Muegge, Kai Ni, 2021, Nucleic acids research.

Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia

K. Muegge, C. Baumann, R. De La Fuente, 2008, BMC Molecular Biology.

Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance

Na Liu, Weishi Yu, K. Muegge, 2018, Cell Death & Disease.

Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability

Scott E. Martin, Eugen C. Buehler, Xia Ding, 2020, Science Signaling.

Direct evidence for an intracellular role for IFN-gamma. Microinjection of human IFN-gamma induces Ia expression on murine macrophages.

K. Muegge, H. Kung, H. Young, 1990, Journal of immunology.

Thymic emigrants isolated by a new method possess unique phenotypic and functional properties.

K. Muegge, S. Durum, W. Murphy, 2001, Blood.

The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-T1, -T2, and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways.

K. Muegge, T. Sayers, S. Durum, 1998, Journal of immunology.

Independent of Fas and p 53 Pathways Cells Correlates with Bcl-2 and Bax Levels and Is Inhibition of Apoptosis of ProT 1 ,-T 2 , and-T 3 The Trophic Action of IL-7 on ProT Cells :

K. Muegge, T. Sayers, S. Durum, 1998 .

p53-dependent apoptosis and transcription of p21waf/cip1/sdi1 in SCID mice following gamma-irradiation.

K. Muegge, S. Durum, S. Candéias, 1997, Biochimie.

Association of Lsh, a Regulator of DNA Methylation, with Pericentromeric Heterochromatin Is Dependent on Intact Heterochromatin

S. Lockett, K. Muegge, Edward H. Cho, 2003, Molecular and Cellular Biology.

Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh).

K. Muegge, S. Durum, T. Geiman, 1998, Genomics.

Specific inhibition of lymphokine biosynthesis and autocrine growth using antisense oligonucleotides in Th1 and Th2 helper T cell clones

A. Harel-Bellan, A. Abbas, K. Muegge, 1988, The Journal of experimental medicine.

and Kathrin Heterochromatin Heterochromatin Is Dependent on Intact Methylation , with Pericentromeric Association of Lsh , a Regulator of DNA

S. Lockett, K. Muegge, Edward H. Cho, 2003 .

CD16 Cross-Linking Blocks Rearrangement of the TCRβ Locus and Development of αβ T Cells and Induces Development of NK Cells from Thymic Progenitors

K. Muegge, S. Durum, W. Murphy, 1998, The Journal of Immunology.

The Interleukin 7 Receptor Is Required for T Cell Receptor γ Locus Accessibility to the V(D)j Recombinase

K. Muegge, M. Schlissel, S. Durum, 2000, The Journal of experimental medicine.

Interleukin (IL)-7 Induces Rapid Activation of Pyk2, Which Is Bound to Janus Kinase 1 and IL-7Rα*

K. Muegge, S. Durum, N. Benbernou, 2000, The Journal of Biological Chemistry.

Interleukin 7 Receptor Control of T Cell Receptor γ Gene Rearrangement: Role of Receptor-associated Chains and Locus Accessibility

W. Leonard, K. Muegge, S. Durum, 1998, The Journal of experimental medicine.

Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways

D. Landsman, R. Lister, J. Ecker, 2014, Genome research.

Cytokine Knockouts

K. Rajewsky, K. Muegge, S. Durum, 1998, Nature Medicine.

Lsh, a SNF2 family member, is required for normal murine development.

K. Muegge, L. Tessarollo, M. Anver, 2001, Biochimica et biophysica acta.

Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes.

K. Muegge, T. Geiman, 2000, Proceedings of the National Academy of Sciences of the United States of America.

From cell code to gene code: cytokines and transcription factors.

K. Muegge, S. Durum, Durum Sk, 1989, The New biologist.

Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS

Victorino R Briones, K. Muegge, Y. Tao, 2011, Nucleic acids research.

IL-7 receptor and VDJ recombination: trophic versus mechanistic actions.

K. Muegge, S. Durum, S. Candéias, 1997, Immunity.

Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.

K. Muegge, H. Young, W. Li, 2002, Immunity.

The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation

M. Aladjem, Xia Ding, Jianke Ren, 2021, Nature Communications.

Interleukin 1 induces beta-endorphin secretion via Fos and Jun in AtT-20 pituitary cells.

J. Axelrod, K. Muegge, F. Aiello, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Measurement of Soluble and Membrane‐Bound Interleukin 1 Using a Fibroblast Bioassay

K. Muegge, S. Durum, C. Dinarello, 2000, Current protocols in immunology.

The Relationship Between T Cells and Interleukin 1

K. Muegge, F. Aiello, S. Durum, 1989 .

Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination

A. Nussenzweig, Jianke Ren, K. Muegge, 2020, Proceedings of the National Academy of Sciences.

Cloning Thymic Precursor Cells: Demonstration That Individual Pro-T1 Cells Have Dual T–NK Potential and Individual Pro-T2 Cells Have Dual αβ–γδ T Cell Potential

K. Muegge, S. Durum, W. Murphy, 1999 .

The see-saw of differentiation: tipping the chromatin balance.

K. Muegge, S. Xi, T. Geiman, 2008, Molecular interventions.

HELLS (Helicase, Lymphoid-Specific)

K. Muegge, T. Geiman, 2014 .

Malignant Transformation and Epigenetics

Jianke Ren, Weishi Yu, Yixing Han, 2015 .

Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells

K. Muegge, I. Dobrinski, C. Baumann, 2006, Nature Cell Biology.

Lsh is involved in de novo methylation of DNA

E. Li, K. Muegge, S. Xi, 2006, The EMBO journal.

Lsh, a member of the SNF2 family, is required for genome-wide methylation.

K. Muegge, T. Geiman, Q. Yan, 2001, Genes & development.

Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes

G. Crabtree, Jianke Ren, K. Muegge, 2018, Epigenetics.

Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells

Jianke Ren, Weishi Yu, Yixing Han, 2017, Scientific Reports.

CG hypomethylation in Lsh−/− mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity

R. Lister, J. Ecker, R. Leighty, 2014, Proceedings of the National Academy of Sciences.

silencing pathways de-repression of repeat elements and redundant epigenetic Genome-wide DNA methylation patterns in LSH mutant reveals Material Supplemental

D. Landsman, R. Lister, J. Ecker, 2014 .

Interleukin-7: physiological roles and mechanisms of action.

K. Muegge, A. Khaled, S. Durum, 1999, Cytokine & growth factor reviews.

Survey Interleukin-7: physiological roles and mechanisms of action

K. Muegge, S. Durum, E. Rajnavölgyi, 1999 .

Duo-Plasmaline — a linearly extended homogeneous low pressure plasma source

K. Muegge, E. Räuchle, W. Petasch, 1997 .

Lsh controls silencing of the imprinted Cdkn1c gene

C. Stewart, K. Muegge, J. Hagan, 2005, Development.

Induction of oxidative DNA damage in u937 cells by TNF or anti-Fas stimulation.

K. Muegge, S. Durum, M. Dizdaroglu, 2000, Cytokine.

Lsh controls Hox gene silencing during development

K. Muegge, S. Xi, Hong Xu, 2007, Proceedings of the National Academy of Sciences.

Lsh Mediated RNA Polymerase II Stalling at HoxC6 and HoxC8 Involves DNA Methylation

Victorino R Briones, K. Muegge, S. Xi, 2010, PloS one.

DNA methylation in early development

K. Muegge, T. Geiman, Theresa M Geiman, 2010, Molecular reproduction and development.

Lsh, a guardian of heterochromatin at repeat elements.

K. Muegge, 2005, Biochemistry and cell biology = Biochimie et biologie cellulaire.

The SNF2‐like helicase HELLS mediates E2F3‐dependent transcription and cellular transformation

N. Rajewsky, J. Maaskola, C. Loddenkemper, 2012, The EMBO journal.

DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development

Jean A. Roayaei, Victorino R Briones, K. Muegge, 2008, Epigenetics.

Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

K. Muegge, A. Khaled, S. Durum, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Trophic Factor Withdrawal: p38 Mitogen-Activated Protein Kinase Activates NHE1, Which Induces Intracellular Alkalinization

K. Muegge, R. Fisher, D. Ferris, 2001, Molecular and Cellular Biology.

Lymphoid-Specific Helicase (HELLS) Is Essential for Meiotic Progression in Mouse Spermatocytes1

K. Muegge, S. Xi, D. D. de Rooij, 2011, Biology of reproduction.

Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1.

M. Karin, K. Muegge, H. Young, 1989, Science.

A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53.

Herbert Yu, Weishi Yu, K. Muegge, 2018, Cancer research.

Control of chromatin accessibility for V(D)J recombination by interleukin‐7

K. Muegge, Jiaqiang Huang, Jiaqiang Huang, 2001, Journal of leukocyte biology.

Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase.

K. Muegge, Y. Tao, B. Yan, 2016, Cancer research.

An ATPase-deficient variant of the SNF2 family member HELLS shows altered dynamics at pericentromeric heterochromatin.

A. Jeltsch, K. Muegge, R. Jurkowska, 2015, Journal of molecular biology.

A novel putative helicase produced in early murine lymphocytes.

K. Muegge, S. Durum, S. Candéias, 1996, Gene.

The ghosts in the machine: DNA methylation and the mystery of differentiation.

Victorino R Briones, K. Muegge, 2012, Biochimica et biophysica acta.

Defective T-cell receptor γ gene rearrangement in interleukin-7 receptor knockout mice

K. Muegge, S. Durum, J. Peschon, 1997 .

Seminars in cell and development biology on histone variants remodelers of H2A variants associated with heterochromatin.

F. Berger, K. Muegge, E. Richards, 2022, Seminars in cell & developmental biology.

Lsh, an epigenetic guardian of repetitive elements.

Stephen P. Fox, H. Issaq, K. Muegge, 2004, Nucleic acids research.

Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression

Jianke Ren, Samantha Barbour, Weishi Yu, 2015, Epigenetics.

Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8

K. Muegge, Y. Tao, B. Yan, 2015, Oncogene.

LSH mediates gene repression through macroH2A deposition

G. Crabtree, Jianke Ren, K. Muegge, 2020, Nature Communications.

Lsh Participates in DNA Methylation and Silencing of Stem Cell Genes

Victorino R Briones, K. Muegge, S. Xi, 2009, Stem cells.

Defining functional domains of Ku80: DNA end binding and survival after radiation.

K. Muegge, P. Hasty, S. Durum, 1999, Biochemical and biophysical research communications.

Junctional diversity in signal joints from T cell receptor beta and delta loci via terminal deoxynucleotidyl transferase and exonucleolytic activity

K. Muegge, S. Durum, S. Candéias, 1996, The Journal of experimental medicine.

Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance

Na Liu, Weishi Yu, K. Muegge, 2018, Cell Death & Disease.

Cytokines and transcription factors.

K. Muegge, S. Durum, 1990, Cytokine.

Epigenetic Control during Lymphoid Development and Immune Responses

K. Muegge, H. Young, J. Mikovits, 2003, Annals of the New York Academy of Sciences.

Lsh, a modulator of CpG methylation, is crucial for normal histone methylation

K. Muegge, Jiaqiang Huang, Q. Yan, 2003, The EMBO journal.

Lsh-deficient murine embryonal fibroblasts show reduced proliferation with signs of abnormal mitosis.

K. Muegge, D. Ferris, Jiaqiang Huang, 2003, Cancer research.

Defining the Minimal Domain of Ku80 for Interaction with Ku70*

K. Muegge, S. Durum, O. Osipovich, 1997, The Journal of Biological Chemistry.

Preparing the target for the bullet

K. Muegge, 2002, Nature Immunology.

Interleukin 1 induction of the c-jun promoter.

P. Herrlich, K. Muegge, G. Gusella, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Cutting edge: histone acetylation and recombination at the TCR gamma locus follows IL-7 induction.

K. Muegge, S. Durum, J. Huang, 2001, Journal of immunology.

Production of T-T hybrids from T cell clones. Direct comparison between cloned T cells and T hybridoma cells derived from them.

J. Berzofsky, K. Muegge, S. Durum, 1988, Journal of immunology.

Cutting Edge: Histone Acetylation and Recombination at the TCRγ Locus Follows IL-7 Induction

K. Muegge, S. Durum, Jiaqiang Huang, 2001, The Journal of Immunology.

IL-7 Induction Locus Follows γ Recombination at the TCR Cutting Edge : Histone Acetylation and

K. Muegge, S. Durum, Jiaqiang Huang, 2001 .

Thymocytes Expressing Both αβ and γδ TCRs: Implications for Models of Lineage Commitment

K. Muegge, S. Durum, C. Lee, 1997 .

Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells

Jianke Ren, Weishi Yu, Yixing Han, 2017, Scientific Reports.

Modifications of histone cores and tails in V(D)J recombination

K. Muegge, 2003, Genome Biology.