Heng Zhu

发表

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

Guoping Fan, Heng Zhu, Joo Heon Shin, 2013, Nature Neuroscience.

Systematic characterization of protein-DNA interactions

Heng Zhu, Seth Blackshaw, Shaohui Hu, 2011, Cellular and Molecular Life Sciences.

Global analysis of phosphorylation networks in humans.

W. Hwang, Jiang Qian, Heng Zhu, 2014, Biochimica et biophysica acta.

Activation of diverse signaling pathways by oncogenic PIK3CA mutations

Akhilesh Pandey, Xinyan Wu, Heng Zhu, 2014, Nature Communications.

A Human Proteome Array Approach to Identifying Key Host Proteins Targeted by Toxoplasma Kinase ROP18*

Jun Wan, Jiang Qian, Heng Zhu, 2017, Molecular & Cellular Proteomics.

Toward a systems-level view of dynamic phosphorylation networks

Heng Zhu, R. Newman, Jin Zhang, 2014, Front. Genet..

DNA methylation presents distinct binding sites for human transcription factors

J. Qian, Jun Wan, G. Ming, 2013, eLife.

Transcription factors as readers and effectors of DNA methylation

Jiang Qian, Heng Zhu, Guohua Wang, 2016, Nature Reviews Genetics.

The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity

S. Blackshaw, Heng Zhu, Nicole A. Rapicavoli, 2011, Neural Development.

Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

Ronald J. Moore, Samuel H. Payne, Stefani N. Thomas, 2016, Cell.

Zika-Virus-Encoded NS 2 A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins Graphical

Francisca Rojas Ringeling, Emily M. Lee, G. Ming, 2017 .

Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression.

Heng Zhu, Peng Jin, Jun Wan, 2016, Molecular cell.

A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli

Heng Zhu, Sheng-Ce Tao, Xing Jian, 2008, Nature Methods.

Protein acetylation and aging

J. Boeke, Yu-Yi Lin, Heng Zhu, 2011, Aging.

Proteome-wide Tyrosine Phosphorylation Analysis Reveals Dysregulated Signaling Pathways in Ovarian Tumors*

D. Chan, Hui Zhang, I. Shih, 2018, Molecular & Cellular Proteomics.

Virion Display: A High‐Throughput Method to Express Functional Membrane Proteins

E. Johansen, Heng Zhu, Guan-Da Syu, 2020, Current protocols in molecular biology.

Parkinson-associated SNCA enhancer variants revealed by open chromatin in mouse dopamine neurons

Michael A. Beer, D. Dickel, A. Visel, 2018, bioRxiv.

Parkinson-associated SNCA enhancer variants revealed by open chromatin in mouse dopamine neurons

D. Dickel, A. Visel, A. McCallion, 2018, bioRxiv.

Structural Features of Transcription Factors Associating with Nucleosome Binding.

Melissa M. Harrison, Heng Zhu, K. Zaret, 2019, Molecular cell.

Global analysis of protein function using protein microarrays

Heng Zhu, M. Snyder, Xiaowei Zhu, 2005, Mechanisms of Ageing and Development.

Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex*

W. Hwang, Jiang Qian, S. Blackshaw, 2017, Molecular & Cellular Proteomics.

Applications of Functional Protein Microarrays in Basic and Clinical Research

Jiang Qian, Heng Zhu, Jiang Qian, 2012, Advances in Genetics.

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry

Emily M. Lee, Hongjun Song, Ruili Huang, 2018, Cell Discovery.

Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration

D. Radisky, Heng Zhu, L. Marlow, 2014, Oncotarget.

Developments and Applications of Functional Protein Microarrays*

Heng Zhu, Guan-Da Syu, J. Dunn, 2020, Molecular & Cellular Proteomics.

Functional protein microarray

Jiang Qian, S. Blackshaw, Heng Zhu, 2010 .

Identification of SUMO E3 ligase-specific substrates using the HuProt human proteome microarray.

S. Blackshaw, Heng Zhu, J. Jeong, 2015, Methods in molecular biology.

Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration *

Hui Zhang, Jiang Qian, S. Blackshaw, 2018, Molecular & Cellular Proteomics.

Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes

M. Snyder, Jiang Qian, Heng Zhu, 2009, Molecular systems biology.

Discovery of a potent GLUT inhibitor using rapafucin 3D microarrays.

Jun O. Liu, S. Sukumar, J. Locasale, 2019, Angewandte Chemie.

Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration

Heng Zhu, J. Laterra, S. Xia, 2018, Oncogene.

Analysis of KLF4 regulated genes in cancer cells reveals a role of DNA methylation in promoter- enhancer interactions

Jun Wan, Jiang Qian, Heng Zhu, 2018, Epigenetics.

Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays

Jun O. Liu, S. Sukumar, J. Locasale, 2019, Angewandte Chemie.

Discovery and Validation of a Serologic Autoantibody Panel for Early Diagnosis of Esophageal Squamous Cell Carcinoma

Jiang Qian, Heng Zhu, Xiaojie Pan, 2019, Cancer Epidemiology, Biomarkers & Prevention.

Liver Transplantation for Severe Alcoholic Hepatitis, Updated Lessons from the World's Largest Series.

Sharon R. Weeks, S. Weeks, Heng Zhu, 2018, Journal of the American College of Surgeons.

A protein chip approach for high‐throughput antigen identification and characterization

Huanming Yang, Jian Wang, Shaohui Hu, 2007, Proteomics.

Proteome-wide microarray-based screening of PAR-binding proteins

T. Dawson, V. Dawson, Heng Zhu, 2022, bioRxiv.

An all-to-all approach to the identification of sequence-specific readers for epigenetic DNA modifications on cytosine

Jun Wan, Hongjun Song, P. Jin, 2019, Nature Communications.

Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

J. Qian, Jun Wan, G. Ming, 2017, eLife.

Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications.

S. Gabelli, P. Cole, Heng Zhu, 2021, ACS chemical biology.

A Human Proteome Microarray Identifies that the Heterogeneous Nuclear Ribonucleoprotein K (hnRNP K) Recognizes the 5′ Terminal Sequence of the Hepatitis C Virus RNA*

Heng Zhu, K. Konan, C. Kao, 2013, Molecular & Cellular Proteomics.

Phosphorylation of the Chromatin Binding Domain of KSHV LANA

Jun Wan, Heng Zhu, Jianfei Hu, 2012, PLoS pathogens.

Unbiased discovery of interactions at a control locus driving expression of the cancer-specific therapeutic and diagnostic target, mesothelin.

Jun Wan, S. Kern, A. Pandey, 2012, Journal of proteome research.

Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic

D. Czajkowsky, Heng Zhu, Bingya Liu, 2015, Proceedings of the National Academy of Sciences.

Characterization of the SUMO-Binding Activity of the Myeloproliferative and Mental Retardation (MYM)-Type Zinc Fingers in ZNF261 and ZNF198

S. Blackshaw, Heng Zhu, C. Wolberger, 2014, PloS one.

N ε−Lysine Acetylation of a Bacterial Transcription Factor Inhibits Its DNA-Binding Activity

S. Thao, Heng Zhu, J. Escalante‐Semerena, 2010, PloS one.

Evaluation of autoantibody signatures in pituitary adenoma patients using human proteome arrays

Sanjeeva Srivastava, Heng Zhu, S. Duttagupta, 2022, Proteomics. Clinical applications.

Single-Cell Co-expression Analysis Reveals Distinct Functional Modules, Co-regulation Mechanisms and Clinical Outcomes

Jie Wang, Raghu Machiraju, Jiang Qian, 2016, PLoS Comput. Biol..

Functional protein microarray technology

Heng Zhu, Seth Blackshaw, Shaohui Hu, 2010, Wiley interdisciplinary reviews. Systems biology and medicine.

Protein Microarray Characterization of the S-Nitrosoproteome*

T. Dawson, V. Dawson, S. Blackshaw, 2013, Molecular & Cellular Proteomics.

Lectin microarrays identify cell-specific and functionally significant cell surface glycan markers.

Y. Li, I. Goldstein, Heng Zhu, 2008, Glycobiology.

Protein Array Identification of Substrates of the Epstein-Barr Virus Protein Kinase BGLF4

P. Desai, Heng Zhu, G. Hayward, 2009, Journal of Virology.

Heterozygous IDH1R132H/WT created by “single base editing” inhibits human astroglial cell growth by downregulating YAP

Heng Zhu, S. Xia, Linzhao Cheng, 2018, Oncogene.

CRYβB2 enhances tumorigenesis through upregulation of nucleolin in triple negative breast cancer

Jun O. Liu, L. Cope, E. Gabrielson, 2021, Oncogene.

hPDI: a database of experimental human protein-DNA interactions

Zhi Xie, Jiang Qian, Heng Zhu, 2010, Bioinform..

TiGER: A database for tissue-specific gene expression and regulation

Jiang Qian, Xiong Liu, Heng Zhu, 2008, BMC Bioinformatics.

Prediction of promoters and enhancers using multiple DNA methylation-associated features

W. Hwang, Heng Zhu, S. Merbs, 2015, BMC Genomics.

Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs

J. Qian, D. Zack, Jun Wan, 2013, Nucleic acids research.

Characterization of tissue-specific differential DNA methylation suggests distinct modes of positive and negative gene expression regulation

D. Zack, Jun Wan, Heng Zhu, 2015, BMC Genomics.

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

J. Qian, G. Ming, Hongjun Song, 2016, Science.

Lin 28 A Binds Active Prom oters and Recruits Tet 1 to Regulate Gene Expression Graphical

Jun Wan, G. Ming, Hongjun Song, 2016 .

Insight into novel RNA-binding activities via large-scale analysis of lncRNA-bound proteome and IDH1-bound transcriptome

Xiaohua Shen, Heng Zhu, Yu-Sheng Chen, 2019, Nucleic acids research.

Characterization of tissue-specific differential DNA methylation suggests distinct modes of positive and negative gene expression regulation

D. Zack, Jun Wan, Heng Zhu, 2015, BMC Genomics.

Global tumor protein p53/p63 interactome

Heng Zhu, Yiping Huang, J. Okamura, 2012, Cell cycle.

Integration of IgA and IgG Autoantigens Improves Performance of Biomarker Panels for Early Diagnosis of Lung Cancer*

Shaohui Hu, Heng Zhu, Shuang Liu, 2020, Molecular & Cellular Proteomics.

Identification of Serological Biomarkers for Early Diagnosis of Lung Cancer Using a Protein Array-Based Approach*

Shaohui Hu, Heng Zhu, Shuang Liu, 2017, Molecular & Cellular Proteomics.

Identification of Novel Serological Biomarkers for Inflammatory Bowel Disease Using Escherichia coli Proteome Chip*

Aik Choon Tan, Heng Zhu, Raimond L Winslow, 2009, Molecular & Cellular Proteomics.

Protein Array-based Approaches for Biomarker Discovery in Cancer

Yi Huang, Heng Zhu, Heng Zhu, 2017, Genom. Proteom. Bioinform..

Applications in high-content functional protein microarrays.

Heng Zhu, Heng Zhu, Cedric D Moore, 2016, Current opinion in chemical biology.

Overview of Protein Microarrays

Heng Zhu, Jiang Qian, Heng Zhu, 2013, Current protocols in protein science.

Functional protein microarray as molecular decathlete: A versatile player in clinical proteomics

Heng Zhu, Eric Cox, Jiang Qian, 2012, Proteomics. Clinical applications.

Functional protein microarray: an ideal platform for investigating protein binding property

Heng Zhu, Shu-juan Guo, S. Tao, 2012, Frontiers in Biology.

Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities

Subha Madhavan, Peter B. McGarvey, Li Ding, 2019, Cell.

Binding studies between cytosinpeptidemycin and the superfamily 1 helicase protein of tobacco mosaic virus

Heng Zhu, Maoxi Huang, Di Gao, 2018, RSC advances.

Unrestrictive identification of non‐phosphorylation PTMs in yeast kinases by MS and PTMap

Zhihong Zhang, Yingming Zhao, Heng Zhu, 2010, Proteomics.

Protein chip fabrication by capture of nascent polypeptides

Heng Zhu, S. Tao, Heng Zhu, 2006, Nature Biotechnology.

Microarray-Based Phospho-Proteomic Profiling of Complex Biological Systems12

C. Bettegowda, A. Olivi, Heng Zhu, 2016, Translational oncology.

Profiling the Dynamics of a Human Phosphorylome Reveals New Components in HGF/c-Met Signaling

J. Qian, Jun Wan, Heng Zhu, 2013, PloS one.

Interactome Mapping: Using Protein Microarray Technology to Reconstruct Diverse Protein Networks

Heng Zhu, Ijeoma Uzoma, Heng Zhu, 2013, Genomics, Proteomics & Bioinformatics.

Using functional proteome microarrays to study protein lysine acetylation.

J. Boeke, Yu-Yi Lin, Heng Zhu, 2013, Methods in molecular biology.

Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication.

Sean D. Taverna, P. Desai, Shaohui Hu, 2011, Cell host & microbe.

Acetylation of Yeast AMPK Controls Intrinsic Aging Independently of Caloric Restriction

T. Tai, S. Berger, J. Boeke, 2011, Cell.

MoSfl1 Is Important for Virulence and Heat Tolerance in Magnaporthe oryzae

R. Dean, T. Mitchell, Heng Zhu, 2011, PloS one.

Characterization of protein-DNA interactions using protein microarrays.

J. Qian, S. Blackshaw, Shaohui Hu, 2011, Cold Spring Harbor protocols.

A functional protein microarray approach to characterizing posttranslational modifications on lysine residues.

Heng Zhu, Hee-Sool Rho, J. Jeong, 2011, Methods in molecular biology.

Protein microarrays.

Heng Zhu, Heng Zhu, Chien-Sheng Chen, 2006, BioTechniques.

MeDReaders: a database for transcription factors that bind to methylated DNA

Yadong Wang, Jiang Qian, Guohua Wang, 2017, Nucleic Acids Res..

DNA Binding and Condensation Properties of the Herpes Simplex Virus Type 1 Triplex Protein VP19C

P. Desai, Heng Zhu, A. Bera, 2014, PloS one.

Serine Racemase Regulated by Binding to Stargazin and PSD-95

S. Snyder, S. Blackshaw, Shaohui Hu, 2014, The Journal of Biological Chemistry.

A Protein Array Screen for Kaposi's Sarcoma-Associated Herpesvirus LANA Interactors Links LANA to TIP60, PP2A Activity, and Telomere Shortening

Shaohui Hu, Heng Zhu, Zhi Xie, 2012, Journal of Virology.

Yeast one-hybrid assays for gene-centered human gene regulatory network mapping

David E Hill, Rachel Patton McCord, Heng Zhu, 2011, Nature Methods.

Functional Characterization of Schizophrenia-Associated Variation in CACNA1C

A. McCallion, D. Avramopoulos, Ruihua Wang, 2016, PloS one.

Rapid Identification of Monospecific Monoclonal Antibodies Using a Human Proteome Microarray*

Jef D. Boeke, Heng Zhu, Seth Blackshaw, 2012, Molecular & Cellular Proteomics.

Bcl2-associated Athanogene 3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity*

Li-Jun Bi, Qian Xiong, Heng Zhu, 2013, Molecular & Cellular Proteomics.

Lysine Acetylation Is a Highly Abundant and Evolutionarily Conserved Modification in Escherichia Coli*S

Nick V Grishin, Jimin Pei, Heng Zhu, 2009, Molecular & Cellular Proteomics.

Profiling the Human Protein-DNA Interactome Reveals ERK2 as a Transcriptional Repressor of Interferon Signaling

S. Blackshaw, Xueping Yu, Shaohui Hu, 2009, Cell.

Identification of novel serological autoantibodies in Takayasu arteritis patients using HuProt arrays.

Heng Zhu, Fengchun Zhang, Jianbo Pan, 2020, Molecular & cellular proteomics : MCP.

Novel autoimmune hepatitis-specific autoantigens identified using protein microarray technology.

Yan Zhang, Wei Huang, Peng Chen, 2010, Journal of proteome research.

Systematic Prediction of Scaffold Proteins Reveals New Design Principles in Scaffold-Mediated Signal Transduction

Jin Zhang, Jiang Qian, Jianfei Hu, 2015, PLoS Comput. Biol..

Profiling Lipid–protein Interactions Using Nonquenched Fluorescent Liposomal Nanovesicles and Proteome Microarrays*

Hsuan-Cheng Huang, Chen-Ching Lin, Hsueh-Fen Juan, 2012, Molecular & Cellular Proteomics.

Protein Acetylation Microarray Reveals that NuA4 Controls Key Metabolic Target Regulating Gluconeogenesis

Jun Wan, S. Berger, J. Boeke, 2009, Cell.

Functional Dissection of a HECT Ubiquitin E3 Ligase*S

Yu-Yi Lin, C. Pickart, Heng Zhu, 2008, Molecular & Cellular Proteomics.

Identification of novel serological biomarkers for inflammatory bowel disease using E. coli proteome chip

S. Brant, L. Datta, R. Winslow, 2009 .

Identification of Serum Biomarkers for Gastric Cancer Diagnosis Using a Human Proteome Microarray*

Heng Zhu, Zhenggang Zhu, Zhifeng Shao, 2015, Molecular & Cellular Proteomics.

New Centromere Autoantigens Identified in Systemic Sclerosis Using Centromere Protein Microarrays

Heng Zhu, Lin Wu, Fengchun Zhang, 2013, The Journal of Rheumatology.

Identification of Novel Biomarkers for Behcet Disease Diagnosis Using Human Proteome Microarray Approach*

Heng Zhu, Jiang Qian, Guang Song, 2016, Molecular & Cellular Proteomics.

Evaluation of autoantibody signatures in meningioma patients using human proteome arrays

Aliasgar Moiyadi, Sanjeeva Srivastava, Namrata Singh, 2017, Oncotarget.

A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors

David Fenyö, Richard M Myers, Gaetano T Montelione, 2018, Nature Methods.

Autoantibody Profiling of Glioma Serum Samples to Identify Biomarkers Using Human Proteome Arrays

Santosh B. Noronha, Aliasgar Moiyadi, Sanjeeva Srivastava, 2015, Scientific Reports.

Protein Chips and Chromatin Immunoprecipitation – Emerging Technologies to Study Macromolecule Interactions in M. grisea

R. Dean, T. Mitchell, Heng Zhu, 2009 .

Detection and verification of glycosylation patterns of glycoproteins from clinical specimens using lectin microarrays and lectin-based immunosorbent assays.

Heng Zhu, Yan Li, Sheng-Ce Tao, 2011, Analytical chemistry.

Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates

J. Paulo, S. Gabelli, P. Cole, 2022, The Journal of biological chemistry.

Autoantibody Profiling on Human Proteome Microarray for Biomarker Discovery in Cerebrospinal Fluid and Sera of Neuropsychiatric Lupus

Heng Zhu, Lin Wu, Fengchun Zhang, 2015, PloS one.

Identification of New Autoantigens for Primary Biliary Cirrhosis Using Human Proteome Microarrays*

Li Wang, Heng Zhu, Wei Huang, 2012, Molecular & Cellular Proteomics.

Regulation of CK2 by Phosphorylation and O-GlcNAcylation Revealed by Semisynthesis

G. Hart, S. Blackshaw, P. Cole, 2011, Nature chemical biology.

Notch3 Interactome Analysis Identified WWP2 as a Negative Regulator of Notch3 Signaling in Ovarian Cancer

I. Shih, Tian-Li Wang, S. Blackshaw, 2014, PLoS genetics.

A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP

Heng Zhu, Zhi Xie, Jianfei Hu, 2015, Journal of Virology.

SUMO Binding by the Epstein-Barr Virus Protein Kinase BGLF4 Is Crucial for BGLF4 Function

Heng Zhu, M. Matunis, Catherine M. Guzzo, 2012, Journal of Virology.