C. Verma

发表

Roles of computational modelling in understanding p53 structure, biology, and its therapeutic targeting

Y. S. Tan, Yasmina Mhoumadi, C. Verma, 2019, Journal of molecular cell biology.

Reactivation of mutant p 53 : constraints on mechanism highlighted by principal component analysis of the DNA binding domain

J. Essex, D. Lane, C. Verma, 2016 .

Reactivation of mutant p53: Constraints on mechanism highlighted by principal component analysis of the DNA binding domain

J. Essex, D. Lane, C. Verma, 2016, Proteins.

Dimerization of the core domain of the p53 family: A computational study

D. Lane, C. Verma, A. Madhumalar, 2009, Cell cycle.

Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket

Mohan R. Pradhan, C. Kwoh, D. Lane, 2019, Nucleic acids research.

R248Q mutation—Beyond p53‐DNA binding

Adelene Y. L. Sim, D. Lane, C. Verma, 2015, Proteins.

Mapping the Structural and Dynamical Features of Multiple p53 DNA Binding Domains: Insights into Loop 1 Intrinsic Dynamics

Suryani Lukman, David P. Lane, Chandra S. Verma, 2013, PloS one.

A Novel p53 Phosphorylation Site within the MDM2 Ubiquitination Signal

M. Walkinshaw, C. Verma, A. Madhumalar, 2010, The Journal of Biological Chemistry.

The Mdm2 and p53 genes are conserved in the Arachnids

D. Lane, C. Verma, A. Madhumalar, 2010, Cell cycle.

Conformational dynamics of capping protein and interaction partners: Simulation studies

Suryani Lukman, Chandra S Verma, Robert C Robinson, 2012, Proteins.

The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans

S. Brenner, B. Venkatesh, B. Tay, 2016, Genes & development.

Inhibition of Nutlin-Resistant HDM2 Mutants by Stapled Peptides

D. Lane, C. Verma, F. Ghadessy, 2013, PloS one.

Wetting of nonconserved residue‐backbones: A feature indicative of aggregation associated regions of proteins

Mohan R. Pradhan, D. Lane, C. Verma, 2016, Proteins.

Differences in the transactivation domains of p53 family members: a computational study

Chandra Verma, David P Lane, Arumugam Madhumalar, 2010, BMC Genomics.

Awakening guardian angels: drugging the p53 pathway

Alan R. Fersht, Christopher J. Brown, Sonia Lain, 2009, Nature Reviews Cancer.

Long range recognition and selection in IDPs: the interactions of the C-terminus of p53

Srinivasaraghavan Kannan, David P. Lane, Chandra S. Verma, 2016, Scientific Reports.

Designing dual inhibitors of Mdm2/MdmX: Unexpected coupling of water with gatekeeper Y100/99

Adelene Y. L. Sim, C. Verma, X. Lee, 2017, Proteins.

Differential binding of p53 and nutlin to MDM2 and MDMX: Computational studies

Chandra S Verma, Christopher J Brown, David P Lane, 2010, Cell cycle.

Stapled peptides in the p53 pathway: Computer simulations reveal novel interactions of the staples with the target protein

D. Lane, C. Verma, T. Joseph, 2010, Cell cycle.

AKT signaling in ERBB2-amplified breast cancer.

Maurizio Scaltriti, Chandra Verma, Valentina Rossi, 2016, Pharmacology & therapeutics.

Correction to Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations.

Shi Hua Ang, C. Verma, S. Kannan, 2017, Biochemistry.

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.

Shi Hua Ang, Eldwin Sum Wai Tan, C. Chuah, 2018, Journal of medicinal chemistry.

Preclinical Characteristics of the Irreversible Pan-HER Kinase Inhibitor Neratinib Compared with Lapatinib: Implications for the Treatment of HER2-Positive and HER2-Mutated Breast Cancer

J. Crown, C. Verma, S. Kannan, 2019, Cancers.

Characterizing the Conformational Landscape of Flavivirus Fusion Peptides via Simulation and Experiment

C. Verma, R. Huber, J. K. Marzinek, 2016, Scientific Reports.

Extending the Martini coarse-grained forcefield to N-glycans

Richard H. Henchman, P. Matsudaira, C. Verma, 2020, bioRxiv.

DIVISIONS P 11 HUMAN INFECTIOUS DISEASES P 12 GENOME AND GENE EXPRESSION DATA ANALYSIS DIVISION P 14

V. Kuznetsov, F. Eisenhaber, I. Mihalek, 2012 .

Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1

Barry Merriman, Chandra Verma, Hane Lee, 2011, Nature Genetics.

Translating p53 into the clinic

David P. Lane, Chandra S. Verma, J. Baselga, 2010, Nature Reviews Clinical Oncology.

A comparison of the dynamics of pantothenate synthetase from M. tuberculosis and E. coli: Computational studies

Yaw Sing Tan, Chandra Verma, Gloria Fuentes, 2011, Proteins.

Molecular dynamics simulations of a new branched antimicrobial peptide: a comparison of force fields.

C. Verma, R. Beuerman, R. Lakshminarayanan, 2012, The Journal of chemical physics.

The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions.

D. Spring, Y. S. Tan, C. Verma, 2015, Journal of chemical theory and computation.

Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer

J. Brenton, D. Spring, L. Itzhaki, 2016, Angewandte Chemie.

Prion and water: tight and dynamical hydration sites have a key role in structural stability.

Chandra S Verma, Franca Fraternali, A. Zagari, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Conformational flexibility of Mycobacterium tuberculosis thioredoxin reductase: crystal structure and normal-mode analysis.

K. Suhre, C. Verma, S. Mande, 2005, Acta crystallographica. Section D, Biological crystallography.

Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches

Adelene Y. L. Sim, C. Verma, Haiwei Song, 2017, PloS one.

Gating by tryptophan 73 exposes a cryptic pocket at the protein-binding interface of the oncogenic eIF4E protein.

D. Lane, C. Verma, Dilraj Lama, 2015, Biochemistry.

Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc06383h

D. Lane, L. Rénia, Y. S. Tan, 2020, Chemical science.

Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled α-helical peptide modality

D. Lane, Y. S. Tan, C. Verma, 2019, bioRxiv.

Recognition Dynamics of p53 and MDM2: Implications for Peptide Design.

D. Lane, L. Caves, C. Verma, 2016, The journal of physical chemistry. B.

Toward Understanding the Molecular Recognition of Albumin by p53-Activating Stapled Peptide ATSP-7041.

C. Verma, Garima Tiwari, 2017, The journal of physical chemistry. B.

Rational design of thermally stable proteins: relevance to bionanotechnology.

G. Narasimhan, R. Garduño-Juárez, Pingzuo Li, 2005, Journal of nanoscience and nanotechnology.

Comparison of Charge Derivation Methods Applied to Amino Acid Parameterization

C. Verma, P. Aronica, S. Fox, 2018, ACS omega.

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00798a

D. Spring, Y. S. Tan, C. Verma, 2019, Chemical science.

Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc01262h

C. Verma, U. Surana, S. Kannan, 2018, Chemical science.

A novel fragment based strategy for membrane active antimicrobials against MRSA.

C. Verma, R. Beuerman, R. Lakshminarayanan, 2015, Biochimica et biophysica acta.

Role of N‐glycosylation in EGFR ectodomain ligand binding

C. Verma, S. Kannan, Maryam Azimzadeh Irani, 2017, Proteins.

Three-dimensional structure of Megabalanus rosa Cement Protein 20 revealed by multi-dimensional NMR and molecular dynamics simulations

C. Verma, A. Miserez, K. Pervushin, 2019, Philosophical Transactions of the Royal Society B.

Enthalpie and Entropie Contributions in the Transesterification of Sucrose: Computational Study of Lipases and Subtilisin

A. Ballesteros, C. Verma, G. Fuentes, 2007, Journal of biomolecular structure & dynamics.

Topology independent comparison of RNA 3D structures using the CLICK algorithm

Adelene Y. L. Sim, M. Madhusudhan, Y. Wan, 2016, Nucleic acids research.

Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE)

C. Verma, Dilraj Lama, Yen-Chu Lin, 2022, bioRxiv.

Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an Atypical and versatile PDZ-domain motif interaction and identification of putative functional modules

C. Verma, Indrajit Sahu, P. Venkatraman, 2014, FEBS open bio.

Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it

F. Eisenhaber, B. Eisenhaber, C. Verma, 2017, Cell cycle.

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide

D. Tenen, Y. S. Tan, C. Verma, 2018, Proceedings of the National Academy of Sciences.

Dynamics of Rnase Sa: A simulation perspective complementary to NMR/X-ray

V. Hornak, L. Caves, C. Verma, 2002 .

Palmitoylation of caspase-6 by HIP14 regulates its activation

Shaun S. Sanders, D. Ehrnhoefer, M. Hayden, 2016, Cell Death and Differentiation.

Protein hydration water: Structure and thermodynamics

Jeremy C. Smith, Stefan Fischer, C. Verma, 2002 .

De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits.

Nils A. Berglund, D. Lane, C. Verma, 2020, ACS medicinal chemistry letters.

Altered ionization of the B13 Glu in insulin B9 and B10 mutants: a computational analysis.

R. Greaves, C. Verma, G. Dodson, 2004, Protein engineering, design & selection : PEDS.

Modeling the Structure of Keratin 1 and 10 Terminal Domains and their Misassembly in Keratoderma.

Adelene Y. L. Sim, E. Lane, C. Verma, 2017, The Journal of investigative dermatology.

Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways

P. Nordlund, C. Verma, Dilraj Lama, 2021 .

Conformational ordering of intrinsically disordered peptides for targeting translation initiation

D. Lane, C. Verma, Dilraj Lama, 2020, bioRxiv.

Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design

M. Noble, D. Lane, Y. S. Tan, 2016, The journal of physical chemistry letters.

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.

D. Spring, G. McKenzie, Peterson de Andrade, 2015, Angewandte Chemie.

Mdm 2 in Evolution

D. Lane, C. Verma, 2012 .

Systematic mutational analysis of an ubiquitin ligase (MDM2)-binding peptide: computational studies

D. Lane, C. Verma, Yun Liu, 2011 .

A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma

T. Tan, B. Goh, N. Syn, 2020, Nature Communications.

Structural origins of the interfacial activation in Thermomyces (Humicola) lanuginosa lipase.

D. Lawson, C. Verma, A. Brzozowski, 2000, Biochemistry.

Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex

P. Nordlund, C. Verma, Dilraj Lama, 2022, Nature Communications.

High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer

C. Caldas, A. Gonzalez-Perez, N. López-Bigas, 2021, Nature Communications.

Computational Design of Macrocyclic Binders of S100B(ββ): Novel Peptide Theranostics

C. Verma, S. Kannan, T. Nguyen, 2021, Molecules.

Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties

Mohan R. Pradhan, D. Lane, J. Hochman, 2019, Molecules.

Dynamics of Bcl-xL in Water and Membrane: Molecular Simulations

C. Verma, A. Maity, Shubhra Ghosh Dastidar, 2013, PloS one.

Large scale ab initio modeling of structurally uncharacterized antimicrobial peptides reveals known and novel folds

D. Rigden, C. Verma, Jens M. H. Thomas, 2018, Proteins.

Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1

C. Verma, T. Hupp, J. Alfaro, 2019, International journal of molecular sciences.

Activation of p53: How phosphorylated Ser15 triggers sequential phosphorylation of p53 at Thr18 by CK1δ

J. Warwicker, C. Verma, S. Kannan, 2022, Proteins.

Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations.

Shi Hua Ang, C. Verma, S. Kannan, 2015, Biochemistry.

The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling.

Seng-Lai Tan, Shufeng Zhou, E. Chan, 2006, Cellular signalling.

Quantum scale biomimicry of low dimensional growth: An unusual complex amorphous precursor route to TiO2 band confinement by shape adaptive biopolymer-like flexibility for energy applications

Caroline Sunyong Lee, Sung-hoon Ahn, Sung-yong Kim, 2019, Scientific Reports.

Enrichment of charge-absent regions in phase separated proteins

J. Warwicker, C. Verma, Sonia T. Nicolaou, 2022, bioRxiv.

Activating the p53 anti-cancer pathway by targeting the MDM2/MDMX dimer interface with short peptide segments: a computational peptide design experiment

L. Caves, C. Verma, K. M. ElSawy, 2022, Molecular Systems Design & Engineering.

Deciphering the mechanistic effects of eIF4E phosphorylation on mRNA‐cap recognition

C. Verma, Dilraj Lama, 2019, Protein science : a publication of the Protein Society.

Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish

S. Brenner, B. Venkatesh, B. Tay, 2011, Cell cycle.

N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases

A. Slawin, C. Verma, T. Joseph, 2011 .

Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting human insulins.

A. Wilkinson, E. Dodson, C. Verma, 2004, Biochemistry.

A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53

D. Lane, C. Verma, J. H. Wong, 2017, BMC Biology.

Designer co-beta-peptide copolymer selectively targets resistant and biofilm Gram-negative bacteria.

G. Bazan, M. Chan-Park, P. Hammond, 2023, Biomaterials.

Identification of interactions involved in the generation of nucleophilic reactivity and of catalytic competence in the catalytic site Cys/His ion pair of papain.

C. Verma, S. Gul, S. Hussain, 2011, Biochemistry.

Probing the nature of substrate binding in Humicola lanuginosa lipase through X-ray crystallography and intuitive modelling.

D. Lawson, C. Verma, A. Brzozowski, 1994, Protein engineering.

A comparison and optimization of methods and factors affecting the transformation of Escherichia coli

D. Lane, C. Verma, W. Chan, 2013, Bioscience reports.

Mussel adhesion is dictated by time-regulated secretion and molecular conformation of mussel adhesive proteins

C. Verma, S. Kannan, N. J. Patil, 2015, Nature Communications.

Symmetrically Substituted Xanthone Amphiphiles Combat Gram-Positive Bacterial Resistance with Enhanced Membrane Selectivity.

D. Tan, C. Verma, R. Beuerman, 2017, Journal of medicinal chemistry.

Design and synthesis of amphiphilic xanthone-based, membrane-targeting antimicrobials with improved membrane selectivity.

Lei Zhou, Rajamani Lakshminarayanan, Ai Ling Tan, 2013, Journal of medicinal chemistry.

Specificity in lipases: A computational study of transesterification of sucrose

C. Verma, G. Fuentes, A. Ballesteros, 2004, Protein science : a publication of the Protein Society.

Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections.

D. Tan, C. Verma, R. Beuerman, 2015, Journal of medicinal chemistry.

Stabilization of peptides against proteolysis through disulfide-bridged conjugation with synthetic aromatics.

C. Verma, Jinghui Wang, Chuanliu Wu, 2017, Organic & biomolecular chemistry.

An intramolecular tryptophan-condensation approach for peptide stapling.

Y. S. Tan, C. Verma, B. Rout, 2018, Organic & biomolecular chemistry.

Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.

A. Peier, D. Lane, J. Hochman, 2018, Bioorganic & medicinal chemistry.

Crystal structure of GerE, the ultimate transcriptional regulator of spore formation in Bacillus subtilis.

G N Murshudov, E J Dodson, G. Leonard, 2001, Journal of molecular biology.

Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting.

D. Tan, C. Verma, R. Beuerman, 2013, Biochimica et biophysica acta.

Molecular dynamics and simulations study on the vibrational and electronic solvatochromism of benzophenone.

C. Verma, S. Umapathy, V. Ravi Kumar, 2016, The Journal of chemical physics.

Branched Peptide, B2088, Disrupts the Supramolecular Organization of Lipopolysaccharides and Sensitizes the Gram-negative Bacteria

B. Sukumaran, C. Verma, R. Beuerman, 2016, Scientific Reports.

Molecular modeling and interaction between Arabidopsis sulfite oxidase and the GW motif of Turnip crinkle virus coat protein.

C. Verma, S. Kannan, K. Swaminathan, 2020, Virology.

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles

Y. S. Tan, C. Verma, C. Brown, 2019, Chemical science.

Stapled peptides with improved potency and specificity that activate p53.

D. Lane, C. Verma, C. Brown, 2013, ACS chemical biology.

A chemical biology approach reveals a dependency of glioblastoma on biotin distribution

Jhin Jieh Lim, D. Ong, T. Benoukraf, 2021, Science advances.

Synthetic Multivalent Antifungal Peptides Effective against Fungi

H. Riezman, C. Verma, R. Beuerman, 2014, PloS one.

Structural origins of the functional divergence of human insulin-like growth factor-I and insulin.

Z. Dauter, G. Murshudov, E. Dodson, 2002, Biochemistry.

Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies

H. Dua, C. Verma, R. Beuerman, 2021, bioRxiv.

Molecular simulations suggest how a branched antimicrobial peptide perturbs a bacterial membrane and enhances permeability.

C. Verma, R. Beuerman, R. Lakshminarayanan, 2013, Biochimica et biophysica acta.

Structure of a slow processing precursor penicillin acylase from Escherichia coli reveals the linker peptide blocking the active-site cleft.

K. Wilson, G. Murshudov, C. Verma, 2000, Journal of molecular biology.

MODES OF ACTION OF AMPS Structure of the Bacterial Membrane : The Target of AMPs

C. Verma, R. Beuerman, R. Lakshminarayanan, 2018 .

Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design

C. Verma, R. Beuerman, R. Lakshminarayanan, 2017, Front. Neurosci..

The 1.8 A resolution structure of hydroxycinnamoyl-coenzyme A hydratase-lyase (HCHL) from Pseudomonas fluorescens, an enzyme that catalyses the transformation of feruloyl-coenzyme A to vanillin.

C. Verma, A. Lebedev, A. Brzozowski, 2006, Acta crystallographica. Section D, Biological crystallography.

Functional relevance of dynamic properties of Dimeric NADP-dependent Isocitrate Dehydrogenases

Chandra Verma, Indira Ghosh, Rithvik Vinekar, 2012, BMC Bioinformatics.

Understanding the mechanism of ice binding by type III antifreeze proteins.

P. Lillford, A. Antson, R. Hubbard, 2001, Journal of molecular biology.

Extending the Martini Coarse-Grained Force Field to N-Glycans

Chandra S Verma, Richard H. Henchman, Roland G Huber, 2020, J. Chem. Inf. Model..

Dissecting the Molecular Mechanism of Colistin Resistance in mcr-1 Bacteria

Jianguo Li, Roger Beuerman, Chandra S Verma, 2020, J. Chem. Inf. Model..

FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer.

J. Reis-Filho, J. Baselga, R. Koche, 2020, Cancer cell.

Domain motions in dihydrofolate reductase: a molecular dynamics study.

G C Roberts, R E Hubbard, R. Hubbard, 1997, Journal of molecular biology.

Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513

C. Verma, J. Lescar, R. Sasisekharan, 2018, Scientific Reports.

Structural dynamics and allostery of Rab proteins: strategies for drug discovery and design

Suryani Lukman, Ammu Prasanna Kumar, Chandra S. Verma, 2020, Briefings Bioinform..

Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity

J. Baselga, J. Arribas, C. Verma, 2009, Oncogene.

USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination

J. Seoane, C. Verma, Dilraj Lama, 2015, Scientific Reports.

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

S. Chandarlapaty, J. Baselga, E. Brogi, 2016, Cancer cell.

Defensins knowledgebase: a manually curated database and information source focused on the defensins family of antimicrobial peptides

Roger Beuerman, Chandra Verma, Danny Chuon, 2006, Nucleic Acids Res..

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase

D. Spring, L. Itzhaki, Y. S. Tan, 2017, Journal of the American Chemical Society.

Design of a novel MDM2 binding peptide based on the p53 family

D. Lane, C. Verma, A. Madhumalar, 2009, Cell cycle.

Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation

T. Tan, B. Goh, C. Verma, 2020, Nature Communications.

Can Glycosylation Mask the Detection of MHC Expressing p53 Peptides by T Cell Receptors?

C. Verma, T. Nguyen, D. Lane, 2021, Biomolecules.

Rational design and biophysical characterization of thioredoxin-based aptamers: insights into peptide grafting.

Shubhra Ghosh Dastidar, Chandra Verma, Christopher J Brown, 2010, Journal of molecular biology.

Update on the Development of MNK Inhibitors as Therapeutic Agents.

C. Verma, S. Kannan, K. Nacro, 2021, Journal of medicinal chemistry.

Title In vitro selection of mutant HDM 2 resistant to nutlininhibition

Adelene Y. L. Sim, D. Lane, C. Verma, 2017 .

Title Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm 2

D. Lane, C. Verma, F. Ghadessy, 2017 .

Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens

D. Lane, Y. S. Tan, C. Verma, 2016, Scientific Reports.

Structure of a Stapled Peptide Antagonist Bound to Nutlin-Resistant Mdm2

D. Lane, C. Verma, F. Ghadessy, 2014, PloS one.

In Vitro Selection of Mutant HDM2 Resistant to Nutlin Inhibition

Adelene Y. L. Sim, D. Lane, C. Verma, 2013, PloS one.

Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silico based mechanism

J. Baselga, C. Verma, M. Scaltriti, 2011, Breast Cancer Research.

Molecular rotors as conditionally fluorescent labels for rapid detection of biomolecular interactions.

Min Yen Lee, Sydney Brenner, C. Verma, 2014, Journal of the American Chemical Society.

Stapled peptide design: principles and roles of computation.

Chandra S Verma, Yaw Sing Tan, David P Lane, 2016, Drug Discovery Today.

Functionalised staple linkages for modulating the cellular activity of stapled peptides

D. Spring, L. Itzhaki, D. Lane, 2014 .

Stapled BH3 Peptides against MCL-1: Mechanism and Design Using Atomistic Simulations

D. Lane, C. Verma, T. Joseph, 2012, PloS one.

Reactivation of p53: from peptides to small molecules.

D. Lane, C. Verma, C. F. Cheok, 2011, Trends in pharmacological sciences.

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.

Stephen J. Walsh, D. Spring, L. Itzhaki, 2019, Chemical communications.

How does a hydrocarbon staple affect peptide hydrophobicity?

Adelene Y. L. Sim, Chandra Verma, C. Verma, 2015, J. Comput. Chem..

Investigating peptide sequence variations for 'double-click' stapled p53 peptides.

D. Spring, D. Lane, G. McKenzie, 2014, Organic & biomolecular chemistry.

Mechanism of Stapled Peptide Binding to MDM2: Possible Consequences for Peptide Design.

Adelene Y. L. Sim, D. Lane, C. Verma, 2014, Journal of chemical theory and computation.

Exploiting protein intrinsic flexibility in drug design.

Suryani Lukman, Chandra S Verma, Gloria Fuentes, 2014, Advances in experimental medicine and biology.

Modulating the p53 pathway.

D. Lane, C. Verma, A. Dey, 2010, Seminars in cancer biology.

Role of protein flexibility in the discovery of new drugs

Chandra Verma, Shubhra Ghosh Dastidar, Gloria Fuentes, 2011 .

Author Correction: c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

E. Domany, T. Tan, J. Thiery, 2019, Nature Communications.

TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors

Amanda R. Kulick, M. Berger, A. Drilon, 2019, SSRN Electronic Journal.

De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits

Nils A. Berglund, D. Lane, C. Verma, 2019, bioRxiv.

Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib

Chandra Verma, Srinivasaraghavan Kannan, Daniel Shao-Weng Tan, 2017, Scientific Reports.

Why an A-loop phospho-mimetic fails to activate PAK1: understanding an inaccessible kinase state by molecular dynamics simulations.

C. Verma, E. Manser, P. M. Chan, 2010, Structure.

Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore

C. K. Lim, P. Ng, A. Wilm, 2018, Cell.

Peptide Inhibitors of Viral Assembly: A Novel Route to Broad-Spectrum Antivirals

Leo S. D. Caves, Karim M. ElSawy, Reidun Twarock, 2012, J. Chem. Inf. Model..

Mdm2 and p53 are highly conserved from placozoans to man

D. Lane, C. Verma, A. Madhumalar, 2010, Cell cycle.

N-Lipidated Peptide Dimers: Effective Antibacterial Agents against Gram-Negative Pathogens through Lipopolysaccharide Permeabilization.

D. Tan, C. Verma, R. Beuerman, 2015, Journal of medicinal chemistry.

Development and application of a transcriptional sensor for detection of heterologous acrylic acid production in E. coli

N. Nagarajan, C. Verma, F. Ghadessy, 2019, Microbial Cell Factories.

Reactive Metabolite-induced Protein Glutathionylation: A Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity*

C. Verma, R. Beuerman, E. Chan, 2018, Molecular & Cellular Proteomics.

Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody.

Chandra S Verma, James E Crowe, Adelene Y. L. Sim, 2019, Structure.

The Use of Chlorobenzene as a Probe Molecule in Molecular Dynamics Simulations

David R. Spring, Chris Abell, Chandra Verma, 2014, J. Chem. Inf. Model..

Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members

C. G. Suresh, Z. Dauter, E. Dodson, 1999, Nature Structural Biology.

Regulation of transcriptional activators by DNA-binding domain ubiquitination

V. Landré, N. Gilbert, C. Verma, 2017, Cell Death and Differentiation.

Molecular simulations of protein dynamics: new windows on mechanisms in biology

David P Lane, C. Verma, G. Dodson, 2008, EMBO reports.

Structure of a consensus chitin-binding domain revealed by solution NMR.

C. Verma, J. Lescar, A. Miserez, 2021, Journal of structural biology.

Structure of a consensus chitin-binding domain revealed by solution NMR

Ali Miserez, Chandra S. Verma, C. Verma, 2020, bioRxiv.

Palmitoylation of caspase-6 by HIP14 regulates its activation

Shaun S. Sanders, D. Ehrnhoefer, M. Hayden, 2016, Cell Death & Differentiation.

A New Generation of Arachidonic Acid Analogues as Potential Neurological Agent Targeting Cytosolic Phospholipase A2

C. Verma, S. Kannan, C. Low, 2017, Scientific Reports.

Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides

D. Lane, C. Verma, Arumay Pal, 2019, Scientific Reports.

The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors

D. Lane, C. Verma, S. Kannan, 2019, International journal of molecular sciences.

c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

E. Domany, T. Tan, J. Thiery, 2019, Nature Communications.

Identification of a second Nutlin‐3 responsive interaction site in the N‐terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry

Jin Yuan Teo, C. Verma, E. Růčková, 2013, Proteomics.

Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100

Chandra S. Verma, Shubhra Ghosh Dastidar, David P. Lane, 2009, BMC Bioinformatics.

Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations

S. Gosavi, C. Verma, Shilpa Yadahalli, 2017, Scientific Reports.

Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding

D. Lane, C. Verma, S. G. Dastidar, 2012, Cell cycle.

Chemical states of the N-terminal “lid” of MDM2 regulate p53 binding: Simulations reveal complexities of modulation

Chandra S Verma, Shubhra Ghosh Dastidar, David P Lane, 2011, Cell cycle.

Multiple peptide conformations give rise to similar binding affinities: molecular simulations of p53-MDM2.

Shubhra Ghosh Dastidar, David P. Lane, Chandra S. Verma, 2008, Journal of the American Chemical Society.

Liquid-Liquid Phase Separation of Short Histidine- and Tyrosine-Rich Peptides: Sequence Specificity and Molecular Topology.

C. Verma, K. Low, A. Miserez, 2021, The journal of physical chemistry. B.

The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution.

Chandra Verma, S. Krzywda, A. Wilkinson, 2002, Structure.

The crystal structure of the globular domain of sheep prion protein.

P. Bayley, E. Dodson, C. Verma, 2004, Journal of molecular biology.

Hydration of a hydrophobic cavity and its functional role: A simulation study of human interleukin‐1β

C. Verma, Sandeep Somani, Choon-Peng Chng, 2007, Proteins.

TRAF4 Inhibits Bladder Cancer Progression by Promoting BMP/SMAD Signaling

T. Tan, H. Mei, C. Verma, 2020, bioRxiv.

Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells

Chang Siang Lim, E. Tai, V. G. Krishnan, 2021, Nature Communications.

Effects of Single Nucleotide Polymorphisms on the Binding of Afatinib to EGFR: A Potential Patient Stratification Factor Revealed by Modeling Studies

Srinivasaraghavan Kannan, Daniel Shao-Weng Tan, Chandra Shekhar Verma, 2018, J. Chem. Inf. Model..

University of Dundee PDK 1-SGK 1 signaling sustains AKT-independent mTORC 1 activation and confers resistance to PI 3 K inhibition

S. Chandarlapaty, J. Baselga, E. Brogi, 2016 .

Molecular Environment Modulates Conformational Differences between Crystal and Solution States of Human β-Defensin 2.

C. Verma, Zhongqiao Hu, R. Beuerman, 2017, The journal of physical chemistry. B.

Substrate Specificity of Cyclins Determined by Electrostatics

Gek Huey Chua, A. Krishnan, D. Lane, 2007, Cell cycle.

Characterization of Hydration Properties in Structural Ensembles of Biomolecules

Chee-Keong Kwoh, Chandra S Verma, Mohan Pradhan, 2019, J. Chem. Inf. Model..

mAb806 binding to epidermal growth factor receptor: a computational study

C. Verma, S. Kannan, G. Fuentes, 2015, Proteins.

The Singapore National Precision Medicine Strategy

Chee Yong Chua, P. Gluckman, T. Tan, 2023, Nature Genetics.

On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: A Brownian dynamics study

Chandra S Verma, Reidun Twarock, Leo S D Caves, 2013, Cell cycle.

Characterization of the Ligand Receptor Encounter Complex and Its Potential for in Silico Kinetics-Based Drug Development.

Chandra S Verma, Reidun Twarock, Leo S D Caves, 2012, Journal of chemical theory and computation.

Probing the mechanism of ATP hydrolysis and substrate translocation in the AAA protease FtsH by modelling and mutagenesis

A. Wilkinson, C. Verma, T. Ogura, 2001, Molecular microbiology.

Structome: Exploring the structural neighbourhood of proteins

C. Verma, A. Poole, J. R. Allison, 2023, bioRxiv.

Progressive endoplasmic reticulum stress over time due to human insulin gene mutation contributes to pancreatic beta cell dysfunction

Y. S. Tan, C. Verma, D. Gardner, 2021, Diabetologia.

Title Binding of translationally controlled tumour protein to theN-terminal domain of HDM 2 is inhibited by Nutlin-3

D. Lane, C. Verma, F. Ghadessy, 2017 .

Binding of Translationally Controlled Tumour Protein to the N-Terminal Domain of HDM2 Is Inhibited by Nutlin-3

D. Lane, C. Verma, F. Ghadessy, 2012, PLoS ONE.

Dissecting the Vibrational Entropy Change on Protein/Ligand Binding: Burial of a Water Molecule in Bovine Pancreatic Trypsin Inhibitor

Chandra Verma, Jeremy C. Smith, C. Verma, 2001 .

Binding of buried structural water increases the flexibility of proteins.

S. Fischer, C. Verma, C S Verma, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Mdm2 in evolution.

D. Lane, C. Verma, 2012, Genes & cancer.

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

A. Peier, P. Orth, C. Verma, 2021, bioRxiv.

The crystal structure of the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia at 1.7 A resolution.

I. Taylor, S. Gamblin, C. Verma, 1998, Journal of molecular biology.

Structural and functional analysis of phosphothreonine-dependent FHA domain interactions.

Sarah L. Westcott, M. Yaffe, S. Smerdon, 2010, Structure.

Protein–Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of Carboxy-Terminus of Hsc70- Interacting Protein (CHIP)*□S

V. Landré, M. Walkinshaw, C. Verma, 2019 .

Protein–Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of Carboxy-Terminus of Hsc70-Interacting Protein (CHIP)*

V. Landré, M. Walkinshaw, C. Verma, 2015, Molecular & Cellular Proteomics.

An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin.

C. Verma, S. Kannan, T. Hupp, 2019, Journal of proteomics.

p53: updates on mechanisms, biology and therapy (II)

D. Lane, C. Verma, 2019, Journal of molecular cell biology.

Stability of the core domain of p53: insights from computer simulations

Chandra Verma, Arumugam Madhumalar, Derek John Smith, 2008, BMC Bioinformatics.

Nonpeptidic Amphiphilic Xanthone Derivatives: Structure-Activity Relationship and Membrane-Targeting Properties.

D. Tan, C. Verma, R. Beuerman, 2016, Journal of medicinal chemistry.

Cation-Mediated Interplay of Loops in Chaperonin-10

C. Verma, S. Mande, R. Sen, 2006, Journal of biomolecular structure & dynamics.

Insight into the Assembly Properties and Functional Organisation of the Magnetotactic Bacterial Actin-like Homolog, MamK

D. Faivre, C. Verma, G. Fuentes, 2012, PloS one.

On quantum computing and geometry optimization

C. Verma, Ashar J. Malik, 2023, bioRxiv.

Proteins as data storage devices: insights from computer models

Chandra Verma, Mifuel Oriz-Lombardia, C. Verma, 2006 .

Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites

Suryani Lukman, Chandra Verma, Ammu Prasanna Kumar, 2018, Proteins.

Elucidating the bactericidal mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH2.

C. Verma, Qiu Ying Lau, F. Ng, 2018, Biochimica et biophysica acta. Biomembranes.

Water-Bridge Mediates Recognition of mRNA Cap in eIF4E.

Mohan R. Pradhan, C. Kwoh, D. Lane, 2016, Structure.

Water-Bridge Mediates Re cognition of mRNA Cap in eIF 4 E Graphical

Mohan R. Pradhan, C. Kwoh, D. Lane, 2016 .

Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces

Rajamani Lakshminarayanan, Dilraj Lama, Roger W. Beuerman, 2013, Scientific Reports.

The 2-Å Crystal Structure of 6-Oxo Camphor Hydrolase

C. Verma, J. Turkenburg, J. Whittingham, 2003, The Journal of Biological Chemistry.

hydroxycinnamoyl-coenzyme A hydratase-lyase (HCHL) from Pseudomonas fluorescens ,a n enzyme that catalyses the transformation of feruloyl-coenzyme A to vanillin

C. Verma, N. Walton, P. Leonard, 2006 .

A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2

Adelene Y. L. Sim, D. Lane, L. Caves, 2015, Cell cycle.

On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein

D. Lane, L. Caves, C. Verma, 2013, Cell cycle.

Crystallographic investigation of the role of aspartate 95 in the modulation of the redox potentials of Desulfovibrio vulgaris flavodoxin.

Chandra S Verma, Andrew A McCarthy, Gerrit Voordouw, 2002, Biochemistry.

Phosphorylation regulates auto-inhibition of kinesin KIF3A

C. Verma, Dilraj Lama, W. Saw, 2018 .

Dephosphorylation of YB-1 is Required for Nuclear Localisation During G2 Phase of the Cell Cycle

H. Cunliffe, P. Bhatia, C. Verma, 2020, Cancers.

On the Resolution of Chiral Substrates by a retro-Claisenase Enzyme: Biotransformations of Heteroannular Bicyclic β-Diketones by 6-Oxocamphor Hydrolase

C. Verma, G. Grogan, D. Smith, 2007 .

Desymmetrisations of 1‐Alkylbicyclo[3.3.0]octane‐2,8‐diones by Enzymatic Retro‐Claisen Reaction Yield Optically Enriched 2,3‐Substituted Cyclopentanones

C. Verma, G. Grogan, C. Hill, 2007 .

Improved eIF4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects

D. Lane, C. Verma, C. Brown, 2012, PloS one.

The very C-terminus of protein kinase Cepsilon is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1.

Seng-Lai Tan, Shufeng Zhou, E. Chan, 2006, Cellular signalling.

Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor.

Chandra S Verma, Hendrikus J Dubbink, Jan Trapman, 2004, Molecular endocrinology.

Linear Analogues of Human β‐Defensin 3: Concepts for Design of Antimicrobial Peptides with Reduced Cytotoxicity to Mammalian Cells

C. Verma, R. Beuerman, Lei Zhou, 2008, Chembiochem : a European journal of chemical biology.

Disorder–Order Interplay of a Barnacle Cement Protein Triggered by Interactions with Calcium and Carbonate Ions: A Molecular Dynamics Study

C. Verma, H. Le Ferrand, A. Miserez, 2020 .

Small Molecules Targeting the Inactive Form of the Mnk1/2 Kinases

Mohan R. Pradhan, C. Verma, S. Kannan, 2017, ACS omega.

Increased Protein S-Glutathionylation in Leber’s Hereditary Optic Neuropathy (LHON)

D. Milea, C. Verma, R. Beuerman, 2020, International journal of molecular sciences.

Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities

May Yin Lee, Hui Chin Goh, W. Tam, 2023, Nature Communications.

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

Chandra S Verma, Chao Shan, Hongping Dong, 2019, PLoS pathogens.

PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions

J. Warwicker, C. Verma, M. Hebditch, 2021, Scientific Reports.

A high‐throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell‐based assays

A. Therien, C. Verma, S. Kannan, 2023, Bioengineering & Translational Medicine.

Computational Methods and Tools in Antimicrobial Peptide Research

Jonathan W. Essex, Stephen J. Fox, Pietro G. A. Aronica, 2021, J. Chem. Inf. Model..

DNAApp: a mobile application for sequencing data analysis

Samuel Ken-En Gan, Phi-Vu Nguyen, Chandra Shekhar Verma, 2014, Bioinform..

Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology

Gergana Popova, D. Lane, C. Verma, 2020, The Journal of Biological Chemistry.

A novel determinant of PSMD9 PDZ binding guides the evolution of first generation of super binding peptides.

Mohan R. Pradhan, C. Verma, S. Kannan, 2019, Biochemistry.

Subunit F modulates ATP binding and migration in the nucleotide-binding subunit B of the A1AO ATP synthase of Methanosarcina mazei Gö1

C. Verma, G. Grüber, S. Gayen, 2012, Journal of Bioenergetics and Biomembranes.

Mechanism of polyamine induced colistin resistance through electrostatic networks on bacterial outer membranes.

C. Verma, R. Beuerman, Jianguo Li, 2020, Biochimica et biophysica acta. Biomembranes.

Density functional study of the heme moiety of cytochrome c

V. Renugopalakrishnan, C. Verma, Anilesh Kumar, 2005 .

Effect of Ser392 phosphorylation on the structure and dynamics of the polybasic domain of ADP ribosylation factor nucleotide site opener protein: a molecular simulation study.

Chandra S Verma, Gerhard Grüber, C. Verma, 2013, Biochemistry.

Modelling of the disulphide-swapped isomer of human insulin-like growth factor-1: implications for receptor binding.

B. Ursø, J. Pitts, C. Verma, 1999, Protein engineering.

Critical Role for Cold Shock Protein YB-1 in Cytokinesis

P. Bhatia, C. Verma, S. Kannan, 2020, bioRxiv.

Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2

L. Itzhaki, Y. S. Tan, C. Verma, 2019, Scientific Reports.

Avoiding drug resistance through extended drug target interfaces: a case for stapled peptides

D. Lane, C. Verma, F. Ghadessy, 2016, Oncotarget.

C-Terminal Substitution of MDM2 Interacting Peptides Modulates Binding Affinity by Distinctive Mechanisms

C. Verma, C. Brown, B. Chia, 2011, PloS one.

Structure-dependent charge density as a determinant of antimicrobial activity of peptide analogues of defensin.

C. Verma, R. Beuerman, Y. Mu, 2009, Biochemistry.

The structural parameters for antimicrobial activity, human epithelial cell cytotoxicity and killing mechanism of synthetic monomer and dimer analogues derived from hBD3 C-terminal region

L. Guo, C. Verma, J. Mavinahalli, 2010, Amino Acids.

Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site

D. Lane, M. Walkinshaw, C. Verma, 2009, Cell cycle.

Progressive Structuring of a Branched Antimicrobial Peptide on the Path to the Inner Membrane Target*

C. Verma, R. Beuerman, R. Lakshminarayanan, 2012, The Journal of Biological Chemistry.

Bioinformatics and systems biology research update from the 15th International Conference on Bioinformatics (InCoB2016)

S. Ranganathan, C. Schönbach, C. Verma, 2016, BMC Bioinformatics.

Generation of nucleophilic character in the Cys25/His159 ion pair of papain involves Trp177 but not Asp158.

C. Verma, Mark P Thomas, S. Gul, 2008, Biochemistry.

Conformational change in the activation of lipase: An analysis in terms of low‐frequency normal modes

R. Hubbard, L. Caves, C. Verma, 1998, Protein science : a publication of the Protein Society.

Pushing the Envelope: Dengue Viral Membrane Coaxed into Shape by Molecular Simulations.

Chandra Verma, Roland G Huber, Daniel A Holdbrook, 2016, Structure.

Modelling study of dimerization in mammalian defensins

Chandra Verma, Anita Suresh, C. Verma, 2006, BMC Bioinformatics.

Temperature Effects on Protein Motions: A Molecular Dynamics Study of RNase-Sa

L. Caves, C. Verma, J. Ševčík, 2000 .

The role of molecular simulations in understanding the mechanisms of cell-penetrating peptides.

Lauren M. Reid, J. Essex, C. Verma, 2019, Drug discovery today.

SAW sensor for Influenza A virus detection enabled with efficient surface functionalization

K. Yao, C. Verma, Lei Zhang, 2015 .

Hierarchical Assembly of Tough Bioelastomeric Egg Capsules is Mediated by a Bundling Protein.

Shawn Hoon, C. Verma, A. Miserez, 2017, Biomacromolecules.

Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation

T. Tan, B. Goh, D. Lane, 2020, Nature Communications.

Homologous Lympho-Epithelial Kazal-type Inhibitor Domains Delay Blood Coagulation by Inhibiting Factor X and XI with Differential Specificity.

F. Chew, C. Verma, Dilraj Lama, 2018, Structure.

The p53 inducing drug dosage may determine quiescence or senescence

D. Lane, C. Verma, Cheok Chit Fang, 2010, Aging.

Disrupting the Dok3–Card9 Interaction with Synthetic Peptides Enhances Antifungal Effector Functions of Human Neutrophils

C. Verma, S. Kannan, K. Lam, 2023, Pharmaceutics.

The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.

Shufeng Zhou, W. Duan, C. Verma, 2008, Archives of biochemistry and biophysics.

Cytochrome c: the effect of temperature and pressure from molecular dynamics simulations

M. Prabhakaran, R. Garduño-Juárez, V. Renugopalakrishnan, 2004 .

Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein

A. Phan, C. Verma, S. Kannan, 2022, bioRxiv.

Application of Recurrence Quantification Analysis (RQA) in Biosequence Pattern Recognition

Alessandro Giuliani, Achuthsankar S. Nair, Chandra Verma, 2011, ACC.

Sequence signatures of allosteric proteins towards rational design

A. Giuliani, P. Dhar, C. Verma, 2010, Systems and Synthetic Biology.

CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma

D. Ong, C. Verma, S. Kannan, 2023, Cell Death & Differentiation.

Inherent flexibility of calmodulin domains: a normal mode analysis study

L. Caves, C. Verma, N. Barton, 2002 .

Insight into membrane selectivity of linear and branched polyethylenimines and their potential as biocides for advanced wound dressings.

S. Ramakrishna, C. Verma, R. Beuerman, 2016, Acta biomaterialia.

Straightforward incorporation of multiple ligand types into molecular dynamics simulations for efficient binding site detection and characterization.

Y. S. Tan, C. Verma, 2020, Journal of chemical theory and computation.

Synthesis of graphene oxide coated Nafion membrane for actuator application

Pramod K. Singh, C. Verma, B. Bhattacharya, 2015 .

A Funneled Conformational Landscape Governs Flavivirus Fusion Peptide Interaction with Lipid Membranes.

Chandra S Verma, Thorsten Wohland, Roland G Huber, 2018, Journal of chemical theory and computation.

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists

J. Hochman, C. Verma, S. Kannan, 2023, bioRxiv.

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

D. Spring, L. Itzhaki, Y. S. Tan, 2016, Scientific Reports.

The polybasic insert, the RBD of the SARS-CoV-2 spike protein, and the feline coronavirus – evolved or yet to evolve

C. Verma, S. Kannan, P. Venkatraman, 2021, Biochemistry and Biophysics Reports.

Aspergillus fumigatus harbouring the sole Y121F mutation shows decreased susceptibility to voriconazole but maintained susceptibility to itraconazole and posaconazole.

C. Verma, J. Lescar, A. Datry, 2014, The Journal of antimicrobial chemotherapy.

Discovering Putative Protein Targets of Small Molecules: A Study of the p53 Activator Nutlin

Chandra S Verma, Vivek Tanavde, Neeladri Sen, 2019, J. Chem. Inf. Model..

Stabilizing the eIF4G1 α-helix increases its binding affinity with eIF4E: implications for peptidomimetic design strategies.

C. Brown, D. Lane, C. Verma, 2011, Journal of molecular biology.

Protein stability and ligand binding: new paradigms from in-silico experiments.

Chandra S Verma, Stefan Fischer, Stefan Fischer, 2005, Biophysical chemistry.

Engineering the C-region of human insulin-like growth factor-1: implications for receptor binding.

B. Ursø, J. Pitts, J. Murray-Rust, 1996, Protein engineering.

Modeling the full length HIV-1 Gag polyprotein reveals the role of its p6 subunit in viral maturation and the effect of non-cleavage site mutations in protease drug resistance

C. Kwoh, C. Verma, S. Gan, 2018, Journal of biomolecular structure & dynamics.

Stapled peptides as a new technology to investigate protein–protein interactions in human platelets† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00284c

D. Spring, Y. S. Tan, C. Verma, 2018, Chemical science.

Enhancement of protein thermal stability: toward the design of robust proteins for bionanotechnological applications

G. Narasimhan, Pingzuo Li, V. Renugopalakrishnan, 2006 .

The Parasol Protocol for computational mutagenesis.

P G A Aronica, C Verma, B Popovic, 2016, Protein engineering, design & selection : PEDS.

Predicting Cell-Penetrating Peptides: Building and Interpreting Random Forest based prediction Models

Shilpa Yadahalli, Chandra S. Verma, C. Verma, 2020, bioRxiv.

Molecular Insights into the Membrane Affinities of Model Hydrophobes

C. Verma, R. Beuerman, Jianguo Li, 2018, ACS omega.

Molecular Insights into the Membrane A ffi nities of Model Hydrophobes

C. Verma, R. Beuerman, Jianguo Li, 2018 .

Conformational ordering of intrinsically disordered peptides for targeting translation initiation.

D. Lane, C. Verma, Dilraj Lama, 2020, Biochimica et biophysica acta. General subjects.

TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors.

B. Taylor, M. Berger, A. Drilon, 2020, Cancer discovery.

D. Spring, Y. S. Tan, C. Verma, 2019, Chemical science.

A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma

T. Tan, B. Goh, N. Syn, 2020, Nature Communications.

DStabilize: A Web Resource to Generate Mirror Images of Biomolecules.

Chandra S Verma, Ashar J Malik, Pietro G A Aronica, 2020, Structure.

Inhibiting S100B(ββ) for Activating Wild-Type p53: Design of Stapled Peptides

Y. S. Tan, C. Verma, S. Kannan, 2019, ACS Omega.

Structural basis of the sulphate starvation response in E. coli: crystal structure and mutational analysis of the cofactor-binding domain of the Cbl transcriptional regulator.

A. Wilkinson, J. Zaim, C. Verma, 2006, Journal of molecular biology.

Rclick: a web server for comparison of RNA 3D structures

Chandra Verma, Minh N. Nguyen, C. Verma, 2015, Bioinform..

Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53

D. Lane, Y. S. Tan, C. Verma, 2017, Oncotarget.

Modulation of the p53-MDM2 Interaction by Phosphorylation of Thr18: A Computational Study

Deepak Srinivasan, D. Lane, C. Verma, 2007, Cell cycle.

Forces mediating protein–protein interactions: a computational study of p53 “approaching” MDM2

Shubhra Ghosh Dastidar, Chandra Verma, David P. Lane, 2010 .

Exploring Gatekeeper Mutations in EGFR through Computer Simulations

Chandra S Verma, Srinivasaraghavan Kannan, Stephen J Fox, 2019, J. Chem. Inf. Model..

Branched Peptide, B2088, Disrupts the Supramolecular Organization of Lipopolysaccharides and Sensitizes the Gram-negative Bacteria

Jianguo, Balamuralidhar, B. Sukumaran, 2016, Scientific Reports.

Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.

A. Peier, D. Lane, J. Hochman, 2018, Bioorganic & medicinal chemistry.

Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding

D. Lane, C. Verma, S. G. Dastidar, 2012, Cell cycle.

New approaches to bridging the timescale gap in the computer simulation of biomolecular processes

L. Caves, C. Verma, 2005 .

Stapled peptides with improved potency and specificity that activate p53.

D. Lane, C. Verma, C. Brown, 2013, ACS chemical biology.

Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03759k

D. Lane, C. Verma, Dilraj Lama, 2019, Chemical science.

Water-Bridge Mediates Recognition of mRNA Cap in eIF4E.

Mohan R. Pradhan, C. Kwoh, D. Lane, 2016, Structure.

Stapled peptide design: principles and roles of computation.

D. Lane, Y. S. Tan, C. Verma, 2016, Drug discovery today.

Macrostate Identification from Biomolecular Simulations through Time Series Analysis

Chandra S. Verma, Efthimios Motakis, Weizhuang Zhou, 2012, J. Chem. Inf. Model..

On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein

D. Lane, L. Caves, C. Verma, 2013, Cell cycle.

Multiple peptide conformations give rise to similar binding affinities: molecular simulations of p53-MDM2.

D. Lane, C. Verma, S. G. Dastidar, 2008, Journal of the American Chemical Society.

Investigating peptide sequence variations for 'double-click' stapled p53 peptides.

D. Spring, D. Lane, G. McKenzie, 2014, Organic and biomolecular chemistry.

Calculation of the reaction pathway for the aromatic ring flip in methotrexate complexed to dihydrofolate reductase

Stefan Fischer, R. Hubbard, L. Caves, 1996 .