Yongheng Chen

发表

Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion

Remo Rohs, Peter Z. Qin, Yongheng Chen, 2013, Nucleic acids research.

Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.

Yongheng Chen, Yongheng Chen, R. Dey, 2010, Structure.

Conformations of p53 response elements in solution deduced using site-directed spin labeling and Monte Carlo sampling

Remo Rohs, Peter Z. Qin, Yongheng Chen, 2013, Nucleic acids research.

Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements

Yongheng Chen, Zhuchu Chen, Lin Chen, 2019, The Journal of Biological Chemistry.

Genetic association between eNOS gene polymorphisms and risk of carotid atherosclerosis

Yongheng Chen, Lin Chen, Qiliang Zhou, 2020, Herz.

Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4.

Yongheng Chen, Zhuchu Chen, Lin Chen, 2019, Chemical communications.

Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors

Yongheng Chen, Zhuchu Chen, S. Dai, 2019, Cells.

LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.

Yongheng Chen, Zhuchu Chen, Lin Chen, 2018, Chemical communications.

Suberoylanilide Hydroxamic Acid (SAHA) Treatment Reveals Crosstalk Among Proteome, Phosphoproteome, and Acetylome in Nasopharyngeal Carcinoma Cells

Yongheng Chen, Zhuchu Chen, Yankun Duan, 2022, Frontiers in Genetics.

Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors

Yongheng Chen, Zhuchu Chen, S. Dai, 2022, Communications Chemistry.

Development of a Potent and Specific FGFR4 Inhibitor for the Treatment of Hepatocellular Carcinoma.

J. Carpten, Yongheng Chen, P. Cao, 2020, Journal of medicinal chemistry.

Quantitative proteomic analysis of differential proteins in the stroma of nasopharyngeal carcinoma and normal nasopharyngeal epithelial tissue

Yongheng Chen, Zhuchu Chen, Fang Peng, 2009, Journal of cellular biochemistry.

Identification of metastasis associated proteins in human lung squamous carcinoma using two-dimensional difference gel electrophoresis and laser capture microdissection.

Yongheng Chen, Zhuchu Chen, Cui Li, 2009, Lung cancer.

Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter.

Yongheng Chen, Zhuchu Chen, S. Dai, 2019, Biochemical and biophysical research communications.

Targeting MCL-1 in cancer: current status and perspectives

Yongheng Chen, M. Guo, Hudie Wei, 2021, Journal of Hematology & Oncology.

Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site.

Jared M. Sagendorf, A. C. Dantas Machado, R. Rohs, 2017, Biochemistry.

Recent advances in therapeutic strategies for triple-negative breast cancer

Yongheng Chen, Lin Chen, S. Leonov, 2022, Journal of Hematology & Oncology.

Identification of a pyroptosis-related lncRNA risk model for predicting prognosis and immune response in colon adenocarcinoma

Yongheng Chen, Y. Tan, Xujun Liang, 2022, World Journal of Surgical Oncology.

Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455

Yongheng Chen, Zhuchu Chen, Lin Chen, 2016, PloS one.

Structural study of ponatinib in inhibiting SRC kinase.

Yongheng Chen, Zhuchu Chen, Yankun Duan, 2022, Biochemical and biophysical research communications.

Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor.

Yongheng Chen, S. Dai, L. Qu, 2022, Biochemical and biophysical research communications.

Structural basis of tropifexor as a potent and selective agonist of farnesoid X receptor.

Yongheng Chen, D. Xiao, S. Dai, 2020, Biochemical and biophysical research communications.

Simultaneous Inhibition of EGFR and HER2 via Afatinib Augments the Radiosensitivity of Nasopharyngeal Carcinoma Cells

Yongheng Chen, Lin Chen, Fang Peng, 2019, Journal of Cancer.

Characterization of ibrutinib as a non-covalent inhibitor of SRC-family kinases.

Yongheng Chen, Zhuchu Chen, Yankun Duan, 2020, Bioorganic & medicinal chemistry letters.

Quantitative proteomic profiling of tumor-associated vascular endothelial cells in colorectal cancer

Yongheng Chen, Zhuchu Chen, Fang Peng, 2019, Biology Open.

m6A Methyltransferase KIAA1429 Regulates the Cisplatin Sensitivity of Gastric Cancer Cells via Stabilizing FOXM1 mRNA

Yongheng Chen, Wenxue Liu, Yuanquan Zhou, 2022, Cancers.

Cytoskeletal and Cytoskeleton-Associated Proteins: Key Regulators of Cancer Stem Cell Properties

Heming Ge, Yongheng Chen, C. Güngör, 2022, Pharmaceuticals.

Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors.

J. Smaill, Yongheng Chen, Xiaoyun Lu, 2021, ACS medicinal chemistry letters.

Identification of prognostic genes in the pancreatic adenocarcinoma immune microenvironment by integrated bioinformatics analysis

Yongheng Chen, Xujun Liang, Liqing Lu, 2021, Cancer Immunology, Immunotherapy.

CapG promoted nasopharyngeal carcinoma cell motility involving Rho motility pathway independent of ROCK

Yongheng Chen, Zhuchu Chen, Xujun Liang, 2022, World Journal of Surgical Oncology.

p53 amyloid aggregation in cancer: function, mechanism, and therapy

Yongheng Chen, Zhuchu Chen, Lin Chen, 2022, Experimental Hematology & Oncology.

Proteomic Characterization Reveals a Molecular Portrait of Nasopharyngeal Carcinoma Differentiation

Yongheng Chen, Zhuchu Chen, Fang Peng, 2017, Journal of Cancer.

Learning important features from multi-view data to predict drug side effects

Ying Fu, Jun Li, Pengfei Zhang, 2019, Journal of Cheminformatics.

A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma

Yongheng Chen, Miaolong Lu, M. Guo, 2020, Cell Death & Disease.

Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases.

Lin Chen, F. Ni, Yongheng Chen, 2017, Journal of the American Chemical Society.

FGFR-TKI resistance in cancer: current status and perspectives

Yongheng Chen, Xiaojuan Chen, Yu-kun Li, 2021, Journal of Hematology & Oncology.

DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions

Lee E. Edsall, Celso A. Espinoza, S. Grant, 2015, Nucleic acids research.

The role and regulation of Maf proteins in cancer

Yongheng Chen, Ting Liu, Yalan Deng, 2023, Biomarker Research.

Recent advances in systemic therapy for hepatocellular carcinoma

Yongheng Chen, Longying Jiang, Huajun Zhang, 2022, Biomarker research.

Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations

Yongheng Chen, S. Dai, Jun Li, 2021, Nucleic acids research.

DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation.

Remo Rohs, Ana Carolina Dantas Machado, Yongheng Chen, 2012, Cell reports.

Proteomic analysis of stromal proteins in different stages of colorectal cancer establishes Tenascin-C as a stromal biomarker for colorectal cancer metastasis

Yongheng Chen, Zhuchu Chen, Yang Fu, 2016, Oncotarget.

Dissecting characteristics and dynamics of differentially expressed proteins during multistage carcinogenesis of human colorectal cancer.

Yongheng Chen, Zhuchu Chen, Fang Peng, 2016, World journal of gastroenterology.

Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates.

Yongheng Chen, Zhuchu Chen, S. Dai, 2022, Biochemical and biophysical research communications.

Nanomaterials for cancer therapy: current progress and perspectives

Yongheng Chen, R. Dey, Zhe Cheng, 2021, Journal of Hematology & Oncology.

Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

Yongheng Chen, Zhuchu Chen, Lin Chen, 2021, Nature communications.

Nanotechnology in cancer diagnosis: progress, challenges and opportunities

Yongheng Chen, Maoyu Li, Ting Liu, 2019, Journal of Hematology & Oncology.

Detection and Analysis of RNAs Expression Profile for Methylated Candidate Tumor Suppressor Genes in Nasopharyngeal Carcinoma.

Yongheng Chen, Zhuchu Chen, Fang Peng, 2019, Anti-cancer agents in medicinal chemistry.

Identificating 14-3-3 sigma as a lymph node metastasis-related protein in human lung squamous carcinoma.

Peng-Fei Zhang, Yongheng Chen, Zhuchu Chen, 2009, Cancer letters.

The Significance of Serum S100A9 and TNC Levels as Biomarkers in Colorectal Cancer

Yongheng Chen, Zhuchu Chen, Maoyu Li, 2019, Journal of Cancer.

Identification of stromal differentially expressed proteins in the colon carcinoma by quantitative proteomics

Yongheng Chen, Zhuchu Chen, X. Zhan, 2013, Electrophoresis.

Mechanism of forkhead transcription factors binding to a novel palindromic DNA site

Yongheng Chen, Zhuchu Chen, Lin Chen, 2021, Nucleic acids research.

Dissection of Anti-tumor Activity of Histone Deacetylase Inhibitor SAHA in Nasopharyngeal Carcinoma Cells via Quantitative Phosphoproteomics

Yongheng Chen, Zhuchu Chen, Lin Chen, 2020, Frontiers in Cell and Developmental Biology.

Coupling of Cell Surface Biotinylation and SILAC-Based Quantitative Proteomics Identified Myoferlin as a Potential Therapeutic Target for Nasopharyngeal Carcinoma Metastasis

Yongheng Chen, Zhuchu Chen, Fang Peng, 2021, Frontiers in Cell and Developmental Biology.

c-Src Binds to the Cancer Drug Ruxolitinib with an Active Conformation

Yongheng Chen, Lin Chen, Yankun Duan, 2014, PloS one.

The Radiosensitization of Sodium Glycididazole on Nasopharyngeal Carcinoma Cells via Enhancing DNA Damage and Promoting Apoptosis

Yongheng Chen, Zhuchu Chen, Maoyu Li, 2019, Journal of Cancer.

Structure-based design of a dual-warhead covalent inhibitor of FGFR4

Yongheng Chen, S. Dai, Jun Li, 2022, Communications Chemistry.

Structural basis for DNA recognition by FOXG1 and the characterization of disease-causing FOXG1 mutations.

Yongheng Chen, Zhuchu Chen, S. Dai, 2020, Journal of molecular biology.

Species-Specific Deamidation of RIG-I Reveals Collaborative Action between Viral and Cellular Deamidases in HSV-1 Lytic Replication

Yongheng Chen, Jun Zhao, Zanxian Xia, 2021, mBio.

Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells.

J. Stroud, C. Benoist, D. Mathis, 2011, Immunity.

Structural basis for DNA recognition by FOXC2.

Yongheng Chen, Zhuchu Chen, Lin Chen, 2019 .

Structural basis for DNA recognition by FOXC2

Yongheng Chen, Zhuchu Chen, Lin Chen, 2019, Nucleic acids research.

DNA-binding properties of FOXP3 transcription factor

Yongheng Chen, Zhuchu Chen, Lin Chen, 2017, Acta biochimica et biophysica Sinica.

Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA.

D. Bates, Yongheng Chen, Lin Chen, 2008, Journal of molecular biology.

Acetylation-mediated degradation of HSD17B4 regulates the progression of prostate cancer

Yongheng Chen, Zhuchu Chen, Lin Chen, 2020, Aging.

A small molecular compound CC1007 induces cross-lineage differentiation by inhibiting HDAC7 expression and HDAC7/MEF2C interaction in BCR-ABL1− pre-B-ALL

Yongheng Chen, Lin Chen, Guoyu Hu, 2020, Cell Death & Disease.

DNA methylation-mediated silencing of Neuronatin promotes hepatocellular carcinoma proliferation through the PI3K-Akt signaling pathway.

Yongheng Chen, Xujun Liang, Dandan Zhu, 2022, Life sciences.

Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor

Yongheng Chen, Jun Li, S. Dai, 2022, Nature Communications.

A novel &mgr;‐conotoxin from worm‐hunting Conus tessulatus that selectively inhibit rat TTX‐resistant sodium currents

Yongheng Chen, Zhuchu Chen, Maojun Zhou, 2017, Toxicon : official journal of the International Society on Toxinology.

Mechanistic insights into the preference for tandem binding sites in DNA recognition by FOXM1.

Yongheng Chen, S. Dai, Jun Li, 2021, Journal of molecular biology.

Design, synthesis, and biological evaluation of indazole derivatives as selective and potent FGFR4 inhibitors for the treatment of FGF19-driven hepatocellular cancer.

Yongheng Chen, Chengguang Zhao, Yuepiao Cai, 2021, European journal of medicinal chemistry.

Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design.

Yongheng Chen, Zheng-chao Tu, Ke Ding, 2021, Bioorganic & medicinal chemistry.

Reciprocal Regulation Between Forkhead Box M1/NF‐κB and Methionine Adenosyltransferase 1A Drives Liver Cancer

Shelly C. Lu, Meng Li, Hui Peng, 2020, Hepatology.

A novel Ala275Val mutation in factor X gene influences its structural compatibility and impairs intracellular trafficking and coagulant activity.

Yongheng Chen, Guangsen Zhang, Hongling Peng, 2016, Thrombosis research.

Quantitative Proteomic Analysis of Formalin-fixed and Paraffin-embedded Nasopharyngeal Carcinoma Using iTRAQ Labeling, Two-dimensional Liquid Chromatography, and Tandem Mass Spectrometry

Yongheng Chen, Zhuchu Chen, Fang Peng, 2010, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Yongheng Chen, Zhe Cheng, Xujun Liang, 2023, Pharmaceuticals.

A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma

Yongheng Chen, Miaolong Lu, M. Guo, 2020, Cell Death & Disease.

Farnesoid X receptor (FXR): Structures and ligands

Yongheng Chen, D. Xiao, Hudie Wei, 2021, Computational and structural biotechnology journal.

Afatinib Reverses EMT via Inhibiting CD44-Stat3 Axis to Promote Radiosensitivity in Nasopharyngeal Carcinoma

Yongheng Chen, Zhuchu Chen, Yankun Duan, 2022, Pharmaceuticals.

Identifying DCN and HSPD1 as Potential Biomarkers in Colon Cancer Using 2D-LC-MS/MS Combined with iTRAQ Technology

Yongheng Chen, Zhuchu Chen, Fang Peng, 2017, Journal of Cancer.

KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2

Yongheng Chen, Lin Chen, Yun Li, 2023, iScience.

Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.

J. Smaill, Yongheng Chen, Xiaoyun Lu, 2022, Journal of medicinal chemistry.

Quantitative proteomic analysis identifying three annexins as lymph node metastasis-related proteins in lung adenocarcinoma

Yongheng Chen, Zhuchu Chen, Fang Peng, 2012, Medical Oncology.

Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA

Yongheng Chen, Zhuchu Chen, D. Xiao, 2023, Computational and structural biotechnology journal.

Discovery of a novel AR/HDAC6 dual inhibitor for prostate cancer treatment

Yongheng Chen, Zhuchu Chen, Maojun Zhou, 2021, Aging.

Expression and purification of the kinase domain of PINK1 in Pichia pastoris.

Yongheng Chen, Zhuchu Chen, Lin Chen, 2016, Protein expression and purification.

Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

Yongheng Chen, Zhuchu Chen, Lin Chen, 2021, Nature Communications.

Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins

Yongheng Chen, M. Guo, Hudie Wei, 2023, Computational and structural biotechnology journal.

S-Adenosylmethionine Affects Cell Cycle Pathways and Suppresses Proliferation in Liver Cells

Yongheng Chen, Zhuchu Chen, Zhuohua Zhang, 2019, Journal of Cancer.

Crystal Structural of FOXC2 DNA binding domain bound to PC promoter

Yongheng Chen, Zhuchu Chen, Lin Chen, 2019 .

Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter

Yongheng Chen, Zhuchu Chen, L. Jiang, 2019 .

Expression and purification of the kinase domain of PINK1 in Pichia pastoris.

Yongheng Chen, Zhuchu Chen, Lin Chen, 2016, Protein expression and purification.

Quantitative proteome analysis reveals annexin A3 as a novel biomarker in lung adenocarcinoma

Yongheng Chen, Zhuchu Chen, C. Li, 2009, The Journal of pathology.

Predicting miRNA-Disease Associations by Combining Graph and Hypergraph Convolutional Network.

Yongheng Chen, Xujun Liang, M. Guo, 2024, Interdisciplinary sciences, computational life sciences.

LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.

Yongheng Chen, Zhuchu Chen, Lin Chen, 2018, Chemical communications.

Prediction of drug side effects with transductive matrix co-completion

Yongheng Chen, Xujun Liang, L. Qu, 2023, Bioinform..

Structural characterization of the DNA binding mechanism of retinoic acid-related orphan receptor gamma.

Yongheng Chen, S. Dai, Xujun Liang, 2024, Structure.

Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma

Yongheng Chen, M. Guo, Ying Fu, 2024, Cell death & disease.

Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases.

Lin Chen, F. Ni, Yongheng Chen, 2017, Journal of the American Chemical Society.