R. Tjhen

发表

Structure of a Construct of a Human Poly(C)-binding Protein Containing the First and Second KH Domains Reveals Insights into Its Regulatory Mechanisms*

Z. Du, S. Fenn, R. Tjhen, 2008, Journal of Biological Chemistry.

Crystal Structure of the First KH Domain of Human Poly(C)-binding Protein-2 in Complex with a C-rich Strand of Human Telomeric DNA at 1.7 Å*

Zhihua Du, Robert M. Stroud, Thomas L. James, 2005, Journal of Biological Chemistry.

X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2.

Zhihua Du, Robert M Stroud, R. Stroud, 2007, RNA.

Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage

Zhihua Du, Robert M Stroud, R. Stroud, 2008, Proceedings of the National Academy of Sciences.

Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability

Xingyue He, M. Klein, R. Tjhen, 2018, EMBO molecular medicine.

Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.

M. Klein, R. Tjhen, T. Kawamoto, 2017, Journal of medicinal chemistry.

Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 Å resolution

R. Stroud, Z. Du, S. Fenn, 2007, Nucleic acids research.

Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes

M. Klein, R. Tjhen, M. Hixon, 2017, Journal of medicinal chemistry.

Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode.

M. Klein, R. Tjhen, Biching Sang, 2019, ACS medicinal chemistry letters.

197 Modeling the maturation pathway of the HIV-1 5’-UTR RNA dimer

R. Tjhen, T. James, C. Guilbert, 2013 .

Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization.

M. Fushimi, R. Tjhen, S. Endo, 2021, Journal of medicinal chemistry.