B. Pagano

发表

Mutants of the tumour suppressor p53 L1 loop as second-site suppressors for restoring DNA binding to oncogenic p53 mutations: structural and biochemical insights.

Franca Fraternali, F. Fraternali, P. Nikolova, 2010, The Biochemical journal.

Noncanonical DNA Secondary Structures as Drug Targets: the Prospect of the i‐Motif

E. Novellino, B. Pagano, Jussara Amato, 2014, ChemMedChem.

In silico phosphorylation of the autoinhibited form of p47(phox): insights into the mechanism of activation.

A. Fornili, F. Fraternali, K. Rittinger, 2010, Biophysical journal.

Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics

E. Novellino, B. Pagano, Ferruccio Palazzesi, 2020, Scientific Reports.

Targeting multiple G-quadruplex-forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives.

E. Novellino, B. Pagano, Federica Moraca, 2019, European journal of medicinal chemistry.

Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations

Stefano Alcaro, Federica Moraca, Anna Artese, 2017, Proceedings of the National Academy of Sciences.

G-quadruplex on oligo affinity support (G4-OAS): an easy affinity chromatography-based assay for the screening of G-quadruplex ligands.

E. Novellino, B. Pagano, Jussara Amato, 2014, Analytical chemistry.

Looking for Efficient G‐Quadruplex Ligands: Evidence for Selective Stabilizing Properties and Telomere Damage by Drug‐Like Molecules

E. Novellino, B. Pagano, Jussara Amato, 2015, ChemMedChem.

Bio-Inspired Dual Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives.

E. Novellino, B. Pagano, Jussara Amato, 2020, Journal of medicinal chemistry.

Controlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands.

B. Pagano, A. Arciello, Jussara Amato, 2018, Analytica chimica acta.

Targeting G-quadruplex structure in the human c-Kit promoter with short PNA sequences.

G. Piccialli, E. Pauw, B. Pagano, 2011, Bioconjugate chemistry.

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

E. Novellino, B. Pagano, Jussara Amato, 2017, Biochimica et biophysica acta. General subjects.

Probing the interaction of distamycin A with S100β: the “unexpected” ability of S100β to bind to DNA‐binding ligands

B. Pagano, L. Cerofolini, M. Fragai, 2015, Journal of molecular recognition : JMR.

Shooting for selective druglike G-quadruplex binders: evidence for telomeric DNA damage and tumor cell death.

E. Novellino, B. Pagano, L. Marinelli, 2012, Journal of medicinal chemistry.

The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: biophysical and molecular modeling studies.

E. Novellino, B. Pagano, S. Neidle, 2011, Biochimie.

Selective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)]4

E. Novellino, B. Pagano, C. Mattia, 2010, Journal of nucleic acids.

Targeting DNA quadruplexes with distamycin A and its derivatives: an ITC and NMR study.

B. Pagano, C. Mattia, C. Giancola, 2008, Biochimie.

Differential scanning calorimetry to investigate G-quadruplexes structural stability.

E. Novellino, B. Pagano, C. Giancola, 2013, Methods.

Native Ion Mobility Mass Spectrometry: When Gas-Phase Ion Structures Depend on the Electrospray Charging Process

B. Pagano, Jussara Amato, A. Randazzo, 2018, Journal of The American Society for Mass Spectrometry.

Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle.

Ettore Novellino, Vittorio Limongelli, Luciana Marinelli, 2010, Journal of the American Chemical Society.

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex

E. Novellino, B. Pagano, Jussara Amato, 2014, Front. Chem..

The G-triplex DNA.

Michele Parrinello, Ivano Bertini, Ettore Novellino, 2013, Angewandte Chemie.

Thermodynamics and kinetics of PNA-DNA quadruplex-forming chimeras.

G. Piccialli, B. Pagano, C. Mattia, 2005, Journal of the American Chemical Society.

Characterization of monovarietal extra virgin olive oils from the province of Béjaïa (Algeria)

E. Novellino, B. Pagano, G. Tenore, 2016 .

Thermodynamic properties of hydroxypropyl-β-cyclodextrin/guest interaction: a survey of recent studies

B. Pagano, F. D'Aria, C. Giancola, 2021, Journal of Thermal Analysis and Calorimetry.

Common G-Quadruplex Binding Agents Found to Interact With i-Motif-Forming DNA: Unexpected Multi-Target-Directed Compounds

E. Novellino, Zoë A. E. Waller, B. Pagano, 2018, Front. Chem..

Targeting of Telomeric Repeat-Containing RNA G-Quadruplexes: From Screening to Biophysical and Biological Characterization of a New Hit Compound

B. Pagano, Jussara Amato, S. De Tito, 2021, International journal of molecular sciences.

Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives

B. Pagano, Jussara Amato, A. Randazzo, 2020, International journal of molecular sciences.

Human inhalable antibody fragments neutralizing SARS-CoV-2 variants for COVID-19 therapy

B. Pagano, E. Pich, A. Anastasi, 2021, bioRxiv.

dl922-947 Adenovirus and G-Quadruplex Binder Combination Against Breast Cancer and Modulation of Monocyte Activity

B. Pagano, A. Randazzo, A. Malfitano, 2021 .

Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry.

B. Pagano, Jussara Amato, A. Randazzo, 2019, The Analyst.

HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

E. Novellino, B. Pagano, L. Hurley, 2018, Chemical communications.

Printed Electrochemical Strip for the Detection of miRNA-29a: A Possible Biomarker Related to Alzheimer’s Disease

B. Pagano, A. Fuso, M. Lucarelli, 2022, Analytical chemistry.

Targeting the BCL2 Gene Promoter G‐Quadruplex with a New Class of Furopyridazinone‐Based Molecules

E. Novellino, B. Pagano, Jussara Amato, 2018, ChemMedChem.

Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

E. Novellino, B. Pagano, G. Capranico, 2020, Journal of medicinal chemistry.

Shading the TRF2 recruiting function: a new horizon in drug development.

E. Gilson, E. Novellino, B. Pagano, 2014, Journal of the American Chemical Society.

KRAS Promoter G-Quadruplexes from Sequences of Different Length: A Physicochemical Study

B. Pagano, F. D'Aria, C. Giancola, 2021, International journal of molecular sciences.

Combination of dl922-947 Oncolytic Adenovirus and G-Quadruplex Binders Uncovers Improved Antitumor Activity in Breast Cancer

Giuliano G. Castellano, B. Pagano, A. Randazzo, 2022, Cells.

Relative stereochemistry of a diterpene from Salvia cinnabarina.

B. Pagano, C. Mattia, A. Bisio, 2007, Molecules.

A fast route for the synthesis of tetrazolyl oximes by a novel multicomponent reaction between Z-chlorooximes, isocyanides and trimethylsilyl azide

E. Novellino, Michele Pavone, B. Pagano, 2017 .

Identification of an acetal derivative of the piperonyl methyl ketone in tablets seized for suspected drug trafficking

E. Novellino, B. Pagano, A. Randazzo, 2014, Forensic Toxicology.

Structure of onchidione, a bis-γ-pyrone polypropionate from a marine pulmonate mollusk

B. Pagano, C. Mattia, M. Carbone, 2009 .

Structure of Onchidione, a Bis‐γ‐pyrone Polypropionate from a Marine Pulmonate Mollusk.

B. Pagano, C. Mattia, M. Carbone, 2009 .

State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders.

E. Novellino, B. Pagano, Valeria La Pietra, 2012, Current pharmaceutical design.

Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes

B. Pagano, C. Mattia, C. Giancola, 2009, International journal of molecular sciences.

Thermodynamic Analysis Of Quadruplex Dna-Drug Interaction

B. Pagano, C. Mattia, C. Giancola, 2007, Nucleosides, nucleotides & nucleic acids.

Cyclodextrin-assisted assembly of PEGylated polyester nanoparticles decorated with folate.

F. Ungaro, E. Reddi, B. Pagano, 2016, Colloids and surfaces. B, Biointerfaces.

Tailoring a lead-like compound targeting multiple G-quadruplex structures.

E. Novellino, B. Pagano, Jussara Amato, 2019, European journal of medicinal chemistry.

Physico-chemical characterization of DNA G-quadruplexes and their interaction with proteins and potential anticancer agents

B. Pagano, 2011 .

Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes.

B. Pagano, S. Neidle, C. Giancola, 2009, The journal of physical chemistry. B.

On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model.

G. Colombo, B. Pagano, Jussara Amato, 2020, International journal of biological macromolecules.

Use of NMR in profiling of cocaine seizures.

Ettore Novellino, Maria Giovanna Chini, Ilaria Lauri, 2013, Forensic science international.

Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands.

Salvatore Florio, Francesco Paduano, Francesco Trapasso, 2011, Bioorganic & medicinal chemistry.

Structural revision of clusianone and 7-epi-clusianone and anti-HIV activity of polyisoprenylated benzophenones

V. Barone, Michele Pavone, B. Pagano, 2005 .

Characterisation of the Dynamic Interactions between Complex N‐Glycans and Human CD22

B. Pagano, Y. Manabe, K. Fukase, 2020, Chembiochem : a European journal of chemical biology.

Human single-chain antibodies neutralize SARS-CoV-2 variants by engaging an essential epitope of the spike: a new weapon against COVID-19

B. Pagano, A. Anastasi, R. De Santis, 2021 .

Structure and Stability Insights into Tumour Suppressor p53 Evolutionary Related Proteins

P. Martinez, F. Fraternali, P. Nikolova, 2013, PloS one.

Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein

E. Novellino, A. Rosato, C. Luchinat, 2019, Nucleic acids research.

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

E. Gilson, G. Stassi, E. Novellino, 2015, Nucleic acids research.

How are thermodynamically stable G-quadruplex–duplex hybrids?

E. Novellino, B. Pagano, C. Giancola, 2015, Journal of Thermal Analysis and Calorimetry.

Energetics of quadruplex-drug recognition in anticancer therapy.

B. Pagano, C. Giancola, Bruno Pagano, 2007, Current cancer drug targets.

Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.

E. Novellino, B. Pagano, L. Botta, 2017, Journal of medicinal chemistry.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

G. Rastelli, P. Fossa, A. Mangoni, 2020, Molecules.

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

E. Novellino, B. Pagano, G. Capranico, 2017, Biochimica et biophysica acta. General subjects.

Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders.

B. Pagano, Federica Moraca, B. Catalanotti, 2022, Chemical communications.

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.

Stephan A. Ohnmacht, E. Novellino, B. Pagano, 2016, Journal of medicinal chemistry.

Ligand binding to G-quadruplex DNA: new insights from ultraviolet resonance Raman spectroscopy.

J. Brady, B. Pagano, F. D'Aria, 2020, Physical chemistry chemical physics : PCCP.

Studying the effect of crowding and dehydration on DNA G-quadruplexes.

B. Pagano, C. Giancola, L. Petraccone, 2012, Methods.

Energetics of ligand binding to G-quadruplexes.

B. Pagano, C. Giancola, Bruno Pagano, 2013, Topics in current chemistry.

Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors.

E. Novellino, P. Seneci, B. Pagano, 2021, Journal of medicinal chemistry.

Identification of novel interactors of human telomeric G-quadruplex DNA.

E. Novellino, B. Pagano, Jussara Amato, 2015, Chemical communications.

Cross-talk between prion protein and quadruplex-forming nucleic acids: a dynamic complex formation

A. Zagari, B. Pagano, C. Giancola, 2012, Nucleic acids research.

Conformational stability and DNA binding energetics of the rat thyroid transcription factor 1 homeodomain

A. Leonardi, S. Formisano, B. Pagano, 2008, Proteins.

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

E. Gilson, E. Novellino, M. Pisanu, 2013, Nucleic acids research.

Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study

E. Novellino, R. Budriesi, B. Pagano, 2019, Journal of enzyme inhibition and medicinal chemistry.

NMR Assignment of N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide Seized as Herbal Incense for the First Time in Italy

E. Novellino, B. Pagano, A. Randazzo, 2014 .

Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4.

Giuseppe Bifulco, Luigi Martino, Simone Di Micco, 2007, Journal of the American Chemical Society.

Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation

B. Pagano, M. Caterino, C. Giancola, 2017, Molecules.

Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics

E. Novellino, B. Pagano, Ferruccio Palazzesi, 2020, Scientific Reports.

Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence.

A. Cavalli, E. Novellino, B. Pagano, 2013, Journal of medicinal chemistry.

Stability and binding properties of a modified thrombin binding aptamer.

Luigi Martino, B. Pagano, C. Giancola, 2008, Biophysical journal.

Application of "magnetic tongue" to the sensory evaluation of extra virgin olive oil.

Ettore Novellino, Raffaele Sacchi, Ilaria Lauri, 2013, Food chemistry.

Effects of Sequence and Base Composition on the CD and TDS Profiles of i‐DNA

B. Pagano, J. Mergny, A. Randazzo, 2021, Angewandte Chemie.

Synthesis and Characterization of Bis-Triazolyl-Pyridine Derivatives as Noncanonical DNA-Interacting Compounds

B. Pagano, D. Brancaccio, A. Carotenuto, 2021, International journal of molecular sciences.

Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds

B. Pagano, M. Mori, L. Pompili, 2021, Pharmaceutics.

G-Quadruplex Binders Induce Immunogenic Cell Death Markers in Aggressive Breast Cancer Cells

B. Pagano, Jussara Amato, A. Randazzo, 2019, Cancers.

A novel β-hairpin peptide derived from the ARC repressor selectively interacts with the major groove of B-DNA.

E. Novellino, A. Mollica, B. Pagano, 2021, Bioorganic chemistry.

Improved Anti-Prion Nucleic Acid Aptamers by Incorporation of Chemical Modifications.

E. Novellino, B. Pagano, C. Giancola, 2020, Nucleic acid therapeutics.

Fluorescence enhancement upon G-quadruplex folding: synthesis, structure, and biophysical characterization of a dansyl/cyclodextrin-tagged thrombin binding aptamer.

E. Novellino, B. Pagano, A. Cummaro, 2013, Bioconjugate chemistry.

Cytosine epigenetic modifications and conformational changes in G-quadruplex DNA: An ultraviolet resonance Raman spectroscopy study.

B. Pagano, F. D'Aria, Jussara Amato, 2023, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

Conformational plasticity of DNA secondary structures: probing the conversion between i-motif and hairpin species by circular dichroism and ultraviolet resonance Raman spectroscopies.

B. Pagano, F. D'Aria, C. Giancola, 2022, Physical chemistry chemical physics : PCCP.

Assessing the influence of pH and cationic strength on i-motif DNA structure

E. Novellino, R. Leardi, B. Pagano, 2019, Analytical and Bioanalytical Chemistry.

Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells

B. Pagano, G. Capranico, Jussara Amato, 2022, Journal of medicinal chemistry.

Stability and cations coordination of DNA and RNA 14-mer G-quadruplexes: a multiscale computational approach.

F. Fraternali, B. Pagano, L. Cavallo, 2008, The journal of physical chemistry. B.

Targeting G-quadruplex motifs interferes with differentiation of adipose-derived mesenchymal stem cells

B. Pagano, P. Formisano, A. Randazzo, 2023, Stem Cell Research & Therapy.

Structural and conformational investigation of nemorosone : A combined X-ray and quantum mechanical study

V. Barone, Michele Pavone, B. Pagano, 2008 .

Molecular dynamics study of the conformational stability of esterase 2 from Alicyclobacillus acidocaldarius.

B. Pagano, C. Mattia, P. Del Vecchio, 2011, International journal of biological macromolecules.

Hit identification of novel small molecules interfering with MALAT1 triplex by a structure‐based virtual screening

P. Tassone, B. Pagano, Jussara Amato, 2023, Archiv der Pharmazie.

HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

E. Novellino, B. Pagano, L. Hurley, 2018, Chemical Communications.

Unveiling the interaction between DNA G-quadruplexes and RG-rich peptides.

B. Pagano, F. Merlino, F. D'Aria, 2023, International journal of biological macromolecules.

G-quadruplexes in cancer-related gene promoters: from identification to therapeutic targeting

B. Pagano, Jussara Amato, A. Randazzo, 2023, Expert opinion on therapeutic patents.