D. Xirodimas

H. C. Beck, D. Xirodimas, Manuel S Rodríguez, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

N. Little, A. Jochemsen, M. Saville, 2001, EMBO reports.

Influence of the Nuclear Membrane, Active Transport, and Cell Shape on the Hes1 and p53–Mdm2 Pathways: Insights from Spatio-temporal Modelling

Alan J. Terry, M. Chaplain, D. Xirodimas, 2012, Bulletin of Mathematical Biology.

Quantitative FLIM-FRET Microscopy to Monitor Nanoscale Chromatin Compaction In Vivo Reveals Structural Roles of Condensin Complexes.

D. Norman, D. Xirodimas, D. Llères, 2017, Cell reports.

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

M. Saville, D. Xirodimas, A. Sparks, 2007, The EMBO journal.

Mixed in chains: NEDD8 polymers in the Protein Quality Control system.

D. Xirodimas, J. Polanowska, Dimitris P. Xirodimas, 2022, Seminars in cell & developmental biology.

Accumulating active p53 in the nucleus by inhibition of nuclear export: a novel strategy to promote the p53 tumor suppressor function.

D. Lane, D. Xirodimas, S. Laín, 1999, Experimental cell research.

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

Shelly C. Lu, J. Bruix, D. Xirodimas, 2014, Oncotarget.

Detection of protein SUMOylation in vivo

M. Tatham, D. Xirodimas, R. Hay, 2009, Nature Protocols.

Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo*

D. Lane, M. Saville, J. Bourdon, 2004, Journal of Biological Chemistry.

The deubiquitinating enzyme USP 2 a regulates the p 53 pathway by targeting Mdm 2

D. Lane, M. Saville, D. Xirodimas, 2013 .

The p53 isoforms are differentially modified by Mdm2

D. Lane, J. Bourdon, K. Fernandes, 2012, Cell cycle.

Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53.

M. Scheffner, D. Xirodimas, 2010, Sub-cellular biochemistry.

Regulation of the p53 Tumor‐Suppressor Protein by Ubiquitin and Ubiquitin‐Like Molecules

D. Xirodimas, Dimitris P. Xirodimas, 2007 .

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo

D. Lane, M. Saville, D. Xirodimas, 2001, Oncogene.

Mechanism of Hypoxia-Induced NF-κB

D. Xirodimas, S. Rocha, Sharon Mudie, 2010, Molecular and Cellular Biology.

Perturbation of 60 S Ribosomal Biogenesis Results in Ribosomal Protein L5- and L11-dependent p53 Activation*

M. Dai, D. Xirodimas, Dimitris P. Xirodimas, 2010, The Journal of Biological Chemistry.

Regulation of nucleolar signalling to p53 through NEDDylation of L11

Geng-Hung Liu, D. Xirodimas, Dimitris P. Xirodimas, 2009, EMBO reports.

PKA-Dependent Phosphorylation of Ribosomal Protein S6 Does Not Correlate with Translation Efficiency in Striatonigral and Striatopallidal Medium-Sized Spiny Neurons

A. Nishi, J. Girault, E. Valjent, 2015, The Journal of Neuroscience.

Targeting a nucleolar SUMO protease for degradation: A mechanism by which ARF induces SUMO conjugation

D. Lane, D. Xirodimas, 2008 .

Targeting a nucleolar SUMO protease for dégradation

D. Lane, D. Xirodimas, 2008 .

Novel substrates and functions for the ubiquitin-like molecule NEDD8.

D. Xirodimas, Dimitris P. Xirodimas, 2008, Biochemical Society transactions.

Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1

James H Naismith, J. Naismith, D. Xirodimas, 2005, The EMBO journal.

Characterization of MRFAP1 Turnover and Interactions Downstream of the NEDD8 Pathway

E. Lundberg, M. Uhlén, A. Lamond, 2011, Molecular & Cellular Proteomics.

Antibody RING-Mediated Destruction of Endogenous Proteins

M. Tatham, A. Prescott, D. Xirodimas, 2020, Molecular cell.

The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity

A. Gartner, D. Xirodimas, Orsolya Leidecker, 2019, Cell reports.

The NEDD8 cycle controlled by NEDP1 upon DNA damage is a regulatory module of the HSP70 ATPase activity

A. Gartner, D. Xirodimas, Orsolya Leidecker, 2019, bioRxiv.

The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage.

D. Xirodimas, Dimitris P. Xirodimas, A. Bailly, 2021, Biochemical Society transactions.

In the family with ubiquitin

D. Xirodimas, N. Pariente, Gabriela Alexandru, 2011, EMBO reports.

DNA-binding regulates site-specific ubiquitination of IRF-1.

V. Landré, D. Xirodimas, K. Ball, 2013, The Biochemical journal.

Targeting the NEDP1 enzyme to ameliorate ALS phenotypes through stress granule disassembly

D. Xirodimas, J. Polanowska, J. Mandrioli, 2023, Science advances.

Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.

D. Xirodimas, S. Lobato-Gil, Petra Beli, 2021, Cell reports.

Molecular Evolution of the Thermosensitive PAb1620 Epitope of Human p53 by DNA Shuffling*

D. Xirodimas, D. Lane, Dimitris P. Xirodimas, 1999, The Journal of Biological Chemistry.

Targeting the deNEDDylating enzyme NEDP1 to ameliorate ALS phenotypes through Stress Granules dissolution

D. Xirodimas, J. Polanowska, J. Mandrioli, 2023, bioRxiv.

NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress

P. Marin, D. Xirodimas, S. Lobato-Gil, 2018, Nature Communications.

Stable Isotope Labeling with Amino acids in Nematodes

Angus I. Lamond, Grant Buchanan, Sarah Coulthurst, 2011, Nature Methods.

Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses.

Tao Yu, J. Sivak, D. Xirodimas, 2023, Cell reports.