P. Jemth

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Seeking allosteric networks in PDZ domains

Candice Gautier, Louise Laursen, P. Jemth, 2018, Protein engineering, design & selection : PEDS.

Distinguishing induced fit from conformational selection.

P. Jemth, S. Gianni, Jakob Dogan, 2014, Biophysical chemistry.

Reassessing a sparse energetic network within a single protein domain

Tord Snäll, Per Jemth, Celestine N Chi, 2008, Proceedings of the National Academy of Sciences.

Demonstration of long-range interactions in a PDZ domain by NMR, kinetics, and protein engineering.

Geerten W Vuister, Alessandro Arcovito, Andrea Bellelli, 2006, Structure.

Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation

A. Menzel, A. Fersht, D. van der Spoel, 2015, PloS one.

Fast Association and Slow Transitions in the Interaction between Two Intrinsically Disordered Protein Domains*

Per Jemth, P. Jemth, Jakob Dogan, 2012, The Journal of Biological Chemistry.

The binding mechanisms of intrinsically disordered proteins.

P. Jemth, S. Gianni, Jakob Dogan, 2014, Physical chemistry chemical physics : PCCP.

Coupled Binding and Helix Formation Monitored by Synchrotron-Radiation Circular Dichroism.

S. Hoffmann, P. Jemth, M. Kjaergaard, 2019, Biophysical journal.

Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1alpha interactions.

P. Jemth, C. Bex, A. Buchberger, 2006, Oncogene.

Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain

M. Selmer, P. Jemth, S. Gianni, 2012, PloS one.

A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins

P. Jemth, S. Gianni, Jakob Dogan, 2018, The Journal of Biological Chemistry.

Characterization of the endopeptidase activity of tripeptidyl-peptidase II.

P. Jemth, Jakob Dogan, H. Kalbacher, 2012, Biochemical and biophysical research communications.

Divergent Evolution of a Protein–Protein Interaction Revealed through Ancestral Sequence Reconstruction and Resurrection

T. Gibson, Louise Laursen, P. Jemth, 2020, Molecular biology and evolution.

Energetic pathway sampling in a protein interaction domain.

M. Selmer, P. Jemth, S. Gianni, 2013, Structure.

Emergence and evolution of an interaction between intrinsically disordered proteins

M. Vendruscolo, P. Jemth, Jakob Dogan, 2017, eLife.

The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A

S. Kerje, L. Andersson, P. Jemth, 2017, PLoS genetics.

Evolution of the p53-MDM2 pathway

M. Grabherr, P. Jemth, Greta Hultqvist, 2017, BMC Evolutionary Biology.

Measurement of Glutathione Transferases

P. Jemth, B. Mannervik, 2002, Current protocols in toxicology.

Disordered regions flanking the binding interface modulate affinity between CBP and NCOA.

C. Herrmann, P. Jemth, C. Camilloni, 2022, Journal of molecular biology.

Coupled binding and folding of intrinsically disordered proteins: what can we learn from kinetics?

P. Jemth, S. Gianni, Jakob Dogan, 2016, Current opinion in structural biology.

A semisynthetic glutathione peroxidase with high catalytic efficiency. Selenoglutathione transferase.

P. Jemth, B. Mannervik, Junqiu Liu, 2002, Chemistry & biology.

A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses

Louise Laursen, P. Jemth, Y. Ivarsson, 2022, bioRxiv.

Mapping the transition state for a binding reaction between ancient intrinsically disordered proteins.

Frieda A. Sorgenfrei, P. Jemth, C. Camilloni, 2020, The Journal of biological chemistry.

Single-molecule studies of intrinsically disordered proteins using solid-state nanopores.

M. J. Kim, J. Edel, P. Jemth, 2013, Analytical chemistry.

Nitrocellulose filter binding to assess binding of glycosaminoglycans to proteins.

P. Jemth, J. Kreuger, U. Lindahl, 2003, Methods in enzymology.

Binding Rate Constants Reveal Distinct Features of Disordered Protein Domains.

P. Jemth, Jakob Dogan, Eva Andersson, 2015, Biochemistry.

CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 and E7 induces senescence in cervical cancer cells

P. Jemth, Raviteja Inturi, 2020, bioRxiv.

Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases

P. Jemth, B. Mannervik, G. Williamson, 1997, FEBS letters.

Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions

P. Jemth, Y. Ivarsson, Eszter Kassa, 2022, bioRxiv.

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Norman E. Davey, N. Davey, E. Petsalaki, 2022, bioRxiv.

Processing of Macromolecular Heparin by Heparanase*

P. Jemth, I. Vlodavsky, U. Lindahl, 2003, Journal of Biological Chemistry.

Fibroblast growth factors share binding sites in heparan sulphate.

P. Jemth, D. Ron, M. Salmivirta, 2005, The Biochemical journal.

Allostery frustrates the experimentalist.

P. Jemth, S. Gianni, 2022, Journal of molecular biology.

Determinants of affinity, specificity, and phase separation in a supramodule from Post-synaptic density protein 95

Louise Laursen, P. Jemth, S. Østergaard, 2022, iScience.

Activation Barrier-Limited Folding and Conformational Sampling of a Dynamic Protein Domain.

P. Jemth, S. Gianni, Jakob Dogan, 2016, Biochemistry.

Probing Backbone Hydrogen Bonds in Proteins by Amide‐to‐Ester Mutations

P. Jemth, K. Strømgaard, S. Pless, 2018, Chembiochem : a European journal of chemical biology.

Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases.

P. Jemth, B. Mannervik, G. Williamson, 1998, The Biochemical journal.

Rigidified Clicked Dimeric Ligands for Studying the Dynamics of the PDZ1‐2 Supramodule of PSD‐95

P. Jemth, Jakob Dogan, Mingjie Zhang, 2015, Chembiochem : a European journal of chemical biology.

Single molecule unfolding and stretching of protein domains inside a solid-state nanopore by electric field

M. J. Kim, J. Edel, P. Jemth, 2013, Scientific Reports.

Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring—An Inactive Enzyme with Intact Substrate Binding

Mats E. Pettersson, L. Andersson, M. Selmer, 2020, Biomolecules.

An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes.

P. Jemth, B. Mannervik, A. Larsson, 2002, Journal of molecular biology.

Oligosaccharide Library-based Assessment of Heparan Sulfate 6-O-Sulfotransferase Substrate Specificity*

P. Jemth, K. Kimata, H. Habuchi, 2003, Journal of Biological Chemistry.

Rescue of Escherichia coli auxotrophy by de novo small proteins

P. Jemth, M. Larsson, Erik Holmqvist, 2022, bioRxiv.

Chemical, Thermal, and Electric Field Induced Unfolding of Single Protein Molecules Studied Using Nanopores

M. J. Kim, J. Edel, P. Jemth, 2022 .

The evolution of binding affinities between p53 and MDM2 across the animal kingdom demonstrates high plasticity of motif-mediated interactions

P. Jemth, Emma Åberg, Eva Andersson, 2023, bioRxiv.

Divergent evolution of a protein-protein interaction revealed through ancestral sequence reconstruction and resurrection

T. Gibson, Louise Laursen, P. Jemth, 2020, bioRxiv.

Biosynthetic Oligosaccharide Libraries for Identification of Protein-binding Heparan Sulfate Motifs

P. Jemth, G. Giménez-Gallego, L. Sturiale, 2002, The Journal of Biological Chemistry.

CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells.

P. Jemth, Raviteja Inturi, 2021, Virology.

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets

Norman E. Davey, N. Davey, P. Jemth, 2022, bioRxiv.

Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins

R. Riek, P. Güntert, Beat Vögeli, 2018, Science Advances.

Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme.

P. Jemth, B. Mannervik, 1997, Archives of biochemistry and biophysics.

Binding Kinetics of the Intrinsically Disordered p53 Family Transactivation Domains and MDM2.

P. Jemth, Emma Åberg, Eva Andersson, 2018, The journal of physical chemistry. B.

The dynamic properties of a nuclear coactivator binding domain are evolutionarily conserved

Frieda A. Sorgenfrei, P. Jemth, Jakob Dogan, 2021, Communications Biology.

Evolution of an interaction between disordered proteins resulted in increased heterogeneity of the binding transition state

P. Jemth, C. Camilloni, Frieda A Sorgenfrei, 2020, bioRxiv.

A Frustrated Binding Interface for Intrinsically Disordered Proteins*

Per Jemth, P. Jemth, Jakob Dogan, 2014, The Journal of Biological Chemistry.

Deciphering the mechanisms of binding induced folding at nearly atomic resolution: The Φ value analysis applied to IDPs

P. Jemth, S. Gianni, Jakob Dogan, 2014, Intrinsically disordered proteins.

The transition state structure for coupled binding and folding of disordered protein domains

Per Jemth, P. Jemth, Jakob Dogan, 2013, Scientific Reports.

Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions

P. Jemth, Y. Ivarsson, G. Sundell, 2016, Scientific Reports.

Ligand binding to the PDZ domains of postsynaptic density protein 95.

P. Jemth, S. Gianni, Celestine N. Chi, 2016, Protein engineering, design & selection : PEDS.

Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

P. Jemth, A. Kristensen, K. Strømgaard, 2014, Nature Communications.

The transition state of coupled folding and binding for a flexible β-finger.

Per Jemth, Celestine N Chi, P. Jemth, 2012, Journal of molecular biology.

A conserved folding mechanism for PDZ domains

P. Jemth, S. Gianni, Celestine N. Chi, 2007, FEBS letters.

Two Conserved Residues Govern the Salt and pH Dependencies of the Binding Reaction of a PDZ Domain*

P. Jemth, S. Gianni, Celestine N. Chi, 2006, Journal of Biological Chemistry.

Nonequilibrium capture rates induce protein accumulation and enhanced adsorption to solid-state nanopores.

M. J. Kim, J. Edel, P. Jemth, 2014, ACS nano.

Affinity and specificity of motif-based protein-protein interactions.

Ylva Ivarsson, Per Jemth, P. Jemth, 2019, Current opinion in structural biology.

How Fast Is Protein-Ligand Association?

P. Jemth, S. Gianni, 2017, Trends in biochemical sciences.

1 Ligand binding by PDZ domains

P. Jemth, S. Gianni, Celestine N. Chi, 2014 .

Ligand binding by PDZ domains

P. Jemth, S. Gianni, Celestine N. Chi, 2012, BioFactors.

Sequence-specific Long Range Networks in PSD-95/Discs Large/ZO-1 (PDZ) Domains Tune Their Binding Selectivity*

M. Brunori, P. Jemth, S. Gianni, 2011, The Journal of Biological Chemistry.

Interactions outside the boundaries of the canonical binding groove of a PDZ domain influence ligand binding.

Patrik Lundström, P. Jemth, S. Gianni, 2012, Biochemistry.

Heterologous expression, purification and characterization of rat class theta glutathione transferase T2-2.

P. Jemth, B. Mannervik, G. Stenberg, 1996, The Biochemical journal.

An evolutionary approach to the design of glutathione-linked enzymes.

P. Jemth, L. Hansson, B. Mannervik, 1998, Chemico-biological interactions.

Functional interplay between protein domains in a supramodular structure involving the postsynaptic density protein PSD-95

Louise Laursen, P. Jemth, S. Gianni, 2019, The Journal of Biological Chemistry.

Renal cell carcinoma risk in type 2 von Hippel–Lindau disease correlates with defects in pVHL stability and HIF-1α interactions

P. Jemth, C. Bex, A. Buchberger, 2006, Oncogene.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Norman E. Davey, N. Davey, P. Jemth, 2022, Molecular systems biology.

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

Norman E. Davey, M. Mann, N. Davey, 2021, Nature Communications.

Investigating the Structural Plasticity of a Cytochrome P450

A. Miele, G. Sciara, B. Vallone, 2009, The Journal of Biological Chemistry.

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

Patrik Lundström, B. Vestergaard, P. Jemth, 2012, Proceedings of the National Academy of Sciences.

Protein folding: Vexing debates on a fundamental problem.

P. Jemth, S. Gianni, 2016, Biophysical chemistry.

Only kinetics can prove conformational selection.

P. Jemth, Jakob Dogan, 2014, Biophysical journal.

Biophysical Characterization of the Complex between Human Papillomavirus E6 Protein and Synapse-associated Protein 97*♦

Patrik Lundström, N. Ferguson, P. Jemth, 2010, The Journal of Biological Chemistry.

PDZ domains: folding and binding.

Per Jemth, P. Jemth, S. Gianni, 2007, Biochemistry.

Thermodynamic Aspects of cAMP Dependent Protein Kinase Catalytic Subunit Allostery

J. Järv, P. Jemth, R. Kivi, 2014, The Protein Journal.

Development of Monoclonal Antibodies to Detect for SARS-CoV-2 Proteins

R. Davey, J. Teyra, S. Sidhu, 2022, Journal of Molecular Biology.

Evolution of the p53-MDM2 pathway

M. Grabherr, P. Jemth, F. Saccoccia, 2017, BMC Evolutionary Biology.

Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction.

L. Olsen, P. Jemth, Celestine N. Chi, 2009, Angewandte Chemie.

Double Mutant Cycles as a Tool to Address Folding, Binding, and Allostery

P. Jemth, S. Gianni, A. Toto, 2021, International journal of molecular sciences.

An early association between the α-helix of the TEAD binding domain of YAP and TEAD drives the formation of the YAP:TEAD complex.

D. Erdmann, P. Jemth, P. Chène, 2020, Biochemistry.

Identification and characterization of protein folding intermediates.

M. Brunori, P. Jemth, S. Gianni, 2007, Biophysical chemistry.

Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

P. Jemth, Celestine N. Chi, K. Strømgaard, 2008, Journal of medicinal chemistry.

Targeting Protein-Protein Interactions with Trimeric Ligands: High Affinity Inhibitors of the MAGUK Protein Family

P. Jemth, A. Kristensen, K. Strømgaard, 2015, PloS one.

Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations.

P. Jemth, S. Gianni, K. Strømgaard, 2013, Journal of the American Chemical Society.

Phospholipid hydroperoxide glutathione peroxidase activity of rat class theta glutathione transferase T2-2.

P. Jemth, B. Mannervik, G. Williamson, 1997, Biochemical Society Transactions.

Evolution of affinity between p53 transactivation domain and MDM2 across the animal kingdom demonstrates high plasticity of motif‐mediated interactions

P. Jemth, Emma Åberg, Eva Andersson, 2023, Protein science : a publication of the Protein Society.

Evolution of affinity between p53 and MDM2 across the animal kingdom demonstrates high plasticity of motif-mediated interactions

P. Jemth, Emma Åberg, Eva Andersson, 2023, bioRxiv.

Deciphering the Kinetic Binding Mechanism of Dimeric Ligands Using a Potent Plasma-stable Dimeric Inhibitor of Postsynaptic Density Protein-95 as an Example*

P. Jemth, Celestine N. Chi, A. Kristensen, 2010, The Journal of Biological Chemistry.

Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly

P. Wolynes, M. Fuxreiter, P. Jemth, 2021, Accounts of chemical research.

The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain

P. Jemth, K. Strømgaard, Søren W. Pedersen, 2014, PloS one.

Yeast Glyoxalase I Is a Monomeric Enzyme with Two Active Sites*

P. Jemth, B. Mannervik, M. Widersten, 2001, The Journal of Biological Chemistry.

Templated folding of intrinsically disordered proteins

M. Brunori, P. Jemth, S. Gianni, 2020, The Journal of Biological Chemistry.

Supertertiary protein structure affects an allosteric network

Louise Laursen, P. Jemth, S. Gianni, 2020, Proceedings of the National Academy of Sciences.

Conserved nucleation sites reinforce the significance of Phi value analysis in protein‐folding studies

P. Jemth, S. Gianni, 2014, IUBMB life.

An expanded view of the protein folding landscape of PDZ domains.

P. Jemth, S. Gianni, Celestine N. Chi, 2012, Biochemical and biophysical research communications.

A PDZ domain recapitulates a unifying mechanism for protein folding

Michele Vendruscolo, Geerten W Vuister, Per Jemth, 2007, Proceedings of the National Academy of Sciences.

Kinetics of Acrylodan-Labelled cAMP-Dependent Protein Kinase Catalytic Subunit Denaturation

J. Järv, P. Jemth, M. Loog, 2013, The Protein Journal.

Direct quantification of protein dimerization preference shed light on SOD1-associated ALS.

P. Jemth, S. Gianni, 2020, Journal of molecular biology.

Folding and stability of globular proteins and implications for function.

P. Jemth, S. Gianni, Y. Ivarsson, 2009, Current opinion in structural biology.

The structure of the major transition state for folding of an FF domain from experiment and simulation.

A. Fersht, V. Daggett, P. Jemth, 2005, Journal of molecular biology.

Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins

M. Vendruscolo, B. Richter, P. Jemth, 2008, Proceedings of the National Academy of Sciences.

Active Site Serine Promotes Stabilization of the Reactive Glutathione Thiolate in Rat Glutathione Transferase T2-2

P. Jemth, B. Mannervik, 2000, The Journal of Biological Chemistry.

Role of the glutamyl alpha-carboxylate of the substrate glutathione in the catalytic mechanism of human glutathione transferase A1-1.

P. Jemth, B. Mannervik, L. Grehn, 2001, Biochemistry.

Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus

P. Jemth, G. Travé, Celestine N. Chi, 2015, Scientific Reports.

Understanding the role of phosphorylation in the binding mechanism of a PDZ domain

P. Jemth, S. Gianni, A. Toto, 2016, Protein engineering, design & selection : PEDS.

The Kinetics of PDZ Domain-Ligand Interactions and Implications for the Binding Mechanism*

P. Jemth, S. Gianni, A. Engström, 2005, Journal of Biological Chemistry.

The C-terminal region of human glutathione transferase A1-1 affects the rate of glutathione binding and the ionization of the active-site Tyr9.

P. Jemth, B. Mannervik, A. Gustafsson, 1999, Biochemistry.

Folded alpha helical putative new proteins from Apilactobacillus kunkeei

S. Andersson, P. Jemth, Celestine N. Chi, 2023, bioRxiv.

Helical propensity in an intrinsically disordered protein accelerates ligand binding.

P. Jemth, Jakob Dogan, K. Teilum, 2014, Angewandte Chemie.

The Plastic Energy Landscape of Protein Folding

M. Selmer, P. Jemth, S. Gianni, 2010, The Journal of Biological Chemistry.

An On-pathway Intermediate in the Folding of a PDZ Domain*

M. Brunori, P. Jemth, S. Gianni, 2007, Journal of Biological Chemistry.

Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains.

Greta Hultqvist, Per Jemth, Patrik Lundström, 2012, Journal of the American Chemical Society.

A sequential binding mechanism in a PDZ domain.

P. Jemth, S. Gianni, Celestine N. Chi, 2009, Biochemistry.

Gustavson syndrome is caused by an in-frame deletion in RBMX associated with potentially disturbed SH3 domain interactions.

A. Ameur, M. Vihinen, A. Nordgren, 2023, European journal of human genetics : EJHG.

Fast product formation and slow product release are important features in a hysteretic reaction mechanism of glutathione transferase T2-2.

P. Jemth, B. Mannervik, 1999, Biochemistry.

Helix formation during the coupled binding and folding of intrinsically disordered proteins monitored by synchrotron-radiation circular dichroism spectroscopy

S. Hoffmann, P. Jemth, N. Jones, 2019, bioRxiv.

Proteome-scale amino-acid resolution footprinting of protein-binding sites in the intrinsically disordered regions of the human proteome

Norman E. Davey, P. Jemth, Y. Ivarsson, 2021, bioRxiv.

Evolution of the p53-MDM2 pathway

M. Grabherr, P. Jemth, F. Saccoccia, 2017, BMC Evolutionary Biology.

Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation.

A. Fersht, V. Daggett, P. Jemth, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Affinity versus specificity in coupled binding and folding reactions.

P. Jemth, S. Gianni, 2019, Protein engineering, design & selection : PEDS.

Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95

Candice Gautier, P. Jemth, S. Gianni, 2017, Scientific Reports.

The transition state of coupled folding and binding for a flexible β-finger.

P. Jemth, Celestine N. Chi, A. Engström, 2012, Journal of molecular biology.

Intrinsically Disordered Flanking Regions Increase the Affinity of a Transcriptional Coactivator Interaction across Vertebrates

P. Jemth, Weihua Ye, Elin Karlsson, 2023, Biochemistry.

Conservation of affinity rather than sequence underlies a dynamic evolution of the motif-mediated p53/MDM2 interaction in teleosts

Mats E. Pettersson, R. Betancur-R, P. Jemth, 2023, bioRxiv.

Simulation and experiment conspire to reveal cryptic intermediates and a slide from the nucleation-condensation to framework mechanism of folding.

Valerie Daggett, Per Jemth, A. Fersht, 2005, Journal of molecular biology.

Kinetic Methods of Deducing Binding Mechanisms Involving Intrinsically Disordered Proteins.

P. Jemth, Elin Karlsson, 2021, Methods in molecular biology.

Folding pathways of proteins with increasing degree of sequence identities but different structure and function

Per Jemth, M. Brunori, P. Jemth, 2012, Proceedings of the National Academy of Sciences.