S. Gianni

发表

Seeking allosteric networks in PDZ domains

Candice Gautier, Louise Laursen, P. Jemth, 2018, Protein engineering, design & selection : PEDS.

Distinguishing induced fit from conformational selection.

P. Jemth, S. Gianni, Jakob Dogan, 2014, Biophysical chemistry.

Demonstration of long-range interactions in a PDZ domain by NMR, kinetics, and protein engineering.

Geerten W Vuister, Alessandro Arcovito, Andrea Bellelli, 2006, Structure.

Demonstration of a folding after binding mechanism in the recognition between the measles virus NTAIL and X domains.

S. Gianni, Marion Dosnon, Daniela Bonetti, 2015, ACS chemical biology.

A folding-after-binding mechanism describes the recognition between the transactivation domain of c-Myb and the KIX domain of the CREB-binding protein.

M. Brunori, S. Gianni, Angela Morrone, 2012, Biochemical and biophysical research communications.

How order and disorder within paramyxoviral nucleoproteins and phosphoproteins orchestrate the molecular interplay of transcription and replication

S. Gianni, S. Longhi, Louis-Marie Bloyet, 2017, Cellular and Molecular Life Sciences.

Anticancer Activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a New Dishevelled 1 Inhibitor

A. Coluccia, R. Silvestri, G. La Regina, 2022, Cancers.

A complex equilibrium among partially unfolded conformations in monomeric transthyretin.

F. Chiti, S. Gianni, F. Bemporad, 2014, Biochemistry.

The binding mechanisms of intrinsically disordered proteins.

P. Jemth, S. Gianni, Jakob Dogan, 2014, Physical chemistry chemical physics : PCCP.

Structural Characterization of the Early Events in the Nucleation-Condensation Mechanism in a Protein Folding Process.

M. Vendruscolo, D. Korzhnev, S. Gianni, 2017, Journal of the American Chemical Society.

A Strategic Protein in Cytochrome c Maturation

M. Brunori, S. Gianni, Nicoletta Calosci, 2007, Journal of Biological Chemistry.

Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain

M. Selmer, P. Jemth, S. Gianni, 2012, PloS one.

Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity

F. Chiti, S. Gianni, F. Bemporad, 2018, The Journal of Biological Chemistry.

A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins

P. Jemth, S. Gianni, Jakob Dogan, 2018, The Journal of Biological Chemistry.

Fuzzy regions in an intrinsically disordered protein impair protein–protein interactions

Denis Gerlier, Sonia Longhi, Monika Fuxreiter, 2016, The FEBS journal.

Modulation of Measles Virus NTAIL Interactions through Fuzziness and Sequence Features of Disordered Binding Sites

S. Gianni, S. Longhi, C. Bignon, 2018, Biomolecules.

Partner-Mediated Polymorphism of an Intrinsically Disordered Protein.

S. Gianni, S. Longhi, C. Bignon, 2017, Journal of molecular biology.

Experimental Characterization of Fuzzy Protein Assemblies: Interactions of Paramyxoviral NTAIL Domains With Their Functional Partners.

M. Fuxreiter, S. Gianni, S. Longhi, 2018, Methods in enzymology.

Towards a structural biology of the hydrophobic effect in protein folding

C. Dobson, M. Brunori, M. Vendruscolo, 2016, Scientific Reports.

Determining folding and binding properties of the C‐terminal SH2 domain of SHP2

S. Gianni, C. Nardella, A. Toto, 2021, Protein science : a publication of the Protein Society.

Unveiling the Molecular Basis of the Noonan Syndrome-Causing Mutation T42A of SHP2

S. Gianni, A. Toto, Francesca Troilo, 2020, International journal of molecular sciences.

Energetic pathway sampling in a protein interaction domain.

M. Selmer, P. Jemth, S. Gianni, 2013, Structure.

Role of Ser11 in the stabilization of the structure of Ochrobactrum anthropi glutathione transferase.

L. Federici, S. Gianni, C. di Ilio, 2007, The Biochemical journal.

An Outlook on the Complexity of Protein Morphogenesis in Health and Disease

M. Brunori, S. Gianni, 2022, Frontiers in Molecular Biosciences.

Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents

A. Coluccia, R. Silvestri, G. La Regina, 2019, ACS medicinal chemistry letters.

Coupled binding and folding of intrinsically disordered proteins: what can we learn from kinetics?

P. Jemth, S. Gianni, Jakob Dogan, 2016, Current opinion in structural biology.

Comparing the binding properties of peptides mimicking the Envelope protein of SARS‐CoV and SARS‐CoV‐2 to the PDZ domain of the tight junction‐associated PALS1 protein

S. Gianni, K. Strømgaard, A. Toto, 2020, Protein science : a publication of the Protein Society.

A conserved hydrogen-bond network stabilizes the structure of Beta class glutathione S-transferases.

L. Federici, S. Gianni, C. di Ilio, 2009, Biochemical and biophysical research communications.

Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat

S. Gianni, C. Nardella, A. De Simone, 2022, Protein science : a publication of the Protein Society.

Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State

S. Gianni, C. D. De Luca, A. Toto, 2019, International journal of molecular sciences.

Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains

R. Guérois, S. Gianni, Eva di Silvio, 2017, Scientific Reports.

Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain*

M. Brunori, M. Vendruscolo, S. Gianni, 2016, The Journal of Biological Chemistry.

Folding and Binding Mechanisms of the SH2 Domain from Crkl

S. Gianni, C. Nardella, A. Toto, 2022, Biomolecules.

Fast Coordination Changes in Cytochrome c Do Not Necessarily Imply Folding*

M. Brunori, S. Gianni, A. Bellelli, 2001, The Journal of Biological Chemistry.

Understanding Binding-Induced Folding by Temperature Jump.

S. Gianni, A. Toto, Francesca Troilo, 2020, Methods in molecular biology.

SH2 Domains: Folding, Binding and Therapeutical Approaches

S. Gianni, C. Nardella, A. Toto, 2022, International journal of molecular sciences.

Exploring the Cytochrome c Folding Mechanism

M. Brunori, A. Tramontano, S. Gianni, 2003, Journal of Biological Chemistry.

Snapshots of protein folding. A study on the multiple transition state pathway of cytochrome c(551) from Pseudomonas aeruginosa.

M. Brunori, S. Gianni, F. Cutruzzolà, 2001, Journal of molecular biology.

Characterization of early and late transition states of the folding pathway of a SH2 domain

S. Gianni, C. Nardella, A. Toto, 2022, Protein Science : A Publication of the Protein Society.

Allostery frustrates the experimentalist.

P. Jemth, S. Gianni, 2022, Journal of molecular biology.

Exploring the effect of tethered domains on the folding of Grb2 protein.

S. Gianni, C. Nardella, A. Toto, 2022, Archives of biochemistry and biophysics.

The Denatured State Dictates the Topology of Two Proteins with Almost Identical Sequence but Different Native Structure and Function*

Valerie Daggett, Michelle E McCully, M. Brunori, 2010, The Journal of Biological Chemistry.

Activation Barrier-Limited Folding and Conformational Sampling of a Dynamic Protein Domain.

P. Jemth, S. Gianni, Jakob Dogan, 2016, Biochemistry.

An Obligatory Intermediate in the Folding Pathway of Cytochrome c552 from Hydrogenobacter thermophilus*

M. Brunori, Alessandro Borgia, S. Gianni, 2005, Journal of Biological Chemistry.

GB1 is not a two-state folder: identification and characterization of an on-pathway intermediate.

Valerie Daggett, Rudesh D Toofanny, Rudesh D. Toofanny, 2011, Biophysical journal.

Understanding the effect of alternative splicing in the folding and function of the second PDZ from Protein Tyrosine Phosphatase-BL

S. Gianni, Daniela Bonetti, Angela Morrone, 2015, Scientific Reports.

Molecular medicine - To be or not to be.

M. Brunori, S. Gianni, 2016, Biophysical chemistry.

Demonstration of Binding Induced Structural Plasticity in a SH2 Domain

S. Gianni, A. De Simone, A. Toto, 2020, Frontiers in Molecular Biosciences.

Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer

A. Coluccia, R. Silvestri, G. La Regina, 2021, Biology direct.

Engineering a switchable toxin: the potential use of PDZ domains in the expression, targeting and activation of modified saporin variants.

S. Gianni, R. Ippoliti, M. Fabbrini, 2010, Protein engineering, design & selection : PEDS.

Mechanism of Folding and Binding of the N-Terminal SH2 Domain from SHP2.

M. Brunori, S. Gianni, Daniela Bonetti, 2018, The journal of physical chemistry. B.

Targeting the Interaction between the SH3 Domain of Grb2 and Gab2

A. Coluccia, R. Silvestri, S. Gianni, 2020, Cells.

Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2.

S. Gianni, Daniela Bonetti, A. De Simone, 2017, Oncotarget.

Emerging Therapeutic Agents for Colorectal Cancer

R. Silvestri, G. La Regina, S. Gianni, 2021, Molecules.

Experimental Characterization of the Interaction between the N-Terminal SH3 Domain of Crkl and C3G

S. Gianni, C. Nardella, A. Toto, 2021, International journal of molecular sciences.

Azole drugs trap cytochrome P450 EryK in alternative conformational states.

B. Vallone, S. Gianni, L. C. Montemiglio, 2010, Biochemistry.

Agitation and high ionic strength induce amyloidogenesis of a folded PDZ domain in native conditions.

F. Chiti, N. Taddei, S. Gianni, 2009, Biophysical journal.

Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases

Alessandro Paiardini, S. Gianni, A. Paiardini, 2011, Proceedings of the National Academy of Sciences.

Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00166a

S. Gianni, M. Coletta, D. Milardi, 2018, Chemical science.

Plasticity of the protein folding landscape: switching between on- and off-pathway intermediates.

M. Brunori, S. Gianni, C. Travaglini-Allocatelli, 2007, Archives of biochemistry and biophysics.

Deciphering the mechanisms of binding induced folding at nearly atomic resolution: The Φ value analysis applied to IDPs

P. Jemth, S. Gianni, Jakob Dogan, 2014, Intrinsically disordered proteins.

Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain

M. Brunori, M. Vendruscolo, S. Gianni, 2010, Nature Structural &Molecular Biology.

The kinetics of folding of the NSH2 domain from p85

S. Gianni, A. Toto, F. Malagrinò, 2019, Scientific Reports.

Folding mechanism of the C‐terminal domain of nucleophosmin: residual structure in the denatured state and its pathophysiological significance

L. Federici, M. Brunori, B. Falini, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

InSiDDe: A Server for Designing Artificial Disordered Proteins

S. Gianni, S. Longhi, P. Lieutaud, 2017, International journal of molecular sciences.

Ligand binding to the PDZ domains of postsynaptic density protein 95.

P. Jemth, S. Gianni, Celestine N. Chi, 2016, Protein engineering, design & selection : PEDS.

A conserved folding mechanism for PDZ domains

P. Jemth, S. Gianni, Celestine N. Chi, 2007, FEBS letters.

Two Conserved Residues Govern the Salt and pH Dependencies of the Binding Reaction of a PDZ Domain*

P. Jemth, S. Gianni, Celestine N. Chi, 2006, Journal of Biological Chemistry.

How Fast Is Protein-Ligand Association?

P. Jemth, S. Gianni, 2017, Trends in biochemical sciences.

Functional role of transient conformations: Rediscovering “chronosteric effects” thirty years later

S. Gianni, P. Ascenzi, 2013, IUBMB life.

1 Ligand binding by PDZ domains

P. Jemth, S. Gianni, Celestine N. Chi, 2014 .

Ligand binding by PDZ domains

P. Jemth, S. Gianni, Celestine N. Chi, 2012, BioFactors.

Sequence-specific Long Range Networks in PSD-95/Discs Large/ZO-1 (PDZ) Domains Tune Their Binding Selectivity*

M. Brunori, P. Jemth, S. Gianni, 2011, The Journal of Biological Chemistry.

Interactions outside the boundaries of the canonical binding groove of a PDZ domain influence ligand binding.

Patrik Lundström, P. Jemth, S. Gianni, 2012, Biochemistry.

Characterization of human frataxin missense variants in cancer tissues

E. Capriotti, A. Pastore, S. Gianni, 2019, Human mutation.

Functional interplay between protein domains in a supramodular structure involving the postsynaptic density protein PSD-95

Louise Laursen, P. Jemth, S. Gianni, 2019, The Journal of Biological Chemistry.

Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein

M. Brunori, M. Vendruscolo, S. Gianni, 2016, Scientific Reports.

GA/GB Fold switching may modulate fatty acid transfer from human serum albumin to bacteria

S. Gianni, P. Ascenzi, F. Polticelli, 2012, IUBMB life.

Investigating the Structural Plasticity of a Cytochrome P450

A. Miele, G. Sciara, B. Vallone, 2009, The Journal of Biological Chemistry.

Folding Mechanism of the SH3 Domain from Grb2.

M. Brunori, S. Gianni, Daniela Bonetti, 2018, The journal of physical chemistry. B.

On the Effects of Disordered Tails, Supertertiary Structure and Quinary Interactions on the Folding and Function of Protein Domains

S. Gianni, C. Nardella, A. Toto, 2022, Biomolecules.

Protein folding: Vexing debates on a fundamental problem.

P. Jemth, S. Gianni, 2016, Biophysical chemistry.

PDZ domains: folding and binding.

Per Jemth, P. Jemth, S. Gianni, 2007, Biochemistry.

Mapping the allosteric network within a SH3 domain

S. Gianni, Daniela Bonetti, A. Toto, 2019, Scientific Reports.

The Effect of Proline cis-trans Isomerization on the Folding of the C-Terminal SH2 Domain from p85

S. Gianni, A. Toto, Francesca Troilo, 2019, International journal of molecular sciences.

The kinetic pathway of folding of barnase.

A. Fersht, S. Gianni, Jessica I. Chuang, 2003, Journal of molecular biology.

Double Mutant Cycles as a Tool to Address Folding, Binding, and Allostery

P. Jemth, S. Gianni, A. Toto, 2021, International journal of molecular sciences.

Identification and characterization of protein folding intermediates.

M. Brunori, P. Jemth, S. Gianni, 2007, Biophysical chemistry.

β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy

I. Fournier, A. Coluccia, R. Silvestri, 2018, Oncogene.

Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations.

P. Jemth, S. Gianni, K. Strømgaard, 2013, Journal of the American Chemical Society.

How order and disorder within paramyxoviral nucleoproteins and phosphoproteins orchestrate the molecular interplay of transcription and replication

S. Gianni, S. Longhi, Louis-Marie Bloyet, 2017, Cellular and Molecular Life Sciences.

Folding and Misfolding in a Naturally Occurring Circularly Permuted PDZ Domain*

M. Brunori, S. Gianni, Y. Ivarsson, 2008, Journal of Biological Chemistry.

Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly

P. Wolynes, M. Fuxreiter, P. Jemth, 2021, Accounts of chemical research.

Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics.

E. Di Cera, S. Gianni, A. Bah, 2007, Biophysical chemistry.

Understanding the Binding Induced Folding of Intrinsically Disordered Proteins by Protein Engineering: Caveats and Pitfalls

S. Gianni, A. Toto, Francesca Troilo, 2020, International journal of molecular sciences.

Templated folding of intrinsically disordered proteins

M. Brunori, P. Jemth, S. Gianni, 2020, The Journal of Biological Chemistry.

Deciphering the folding transition state structure and denatured state properties of Nucleophosmin C-terminal domain

L. Federici, M. Brunori, S. Gianni, 2010, Proceedings of the National Academy of Sciences.

Supertertiary protein structure affects an allosteric network

Louise Laursen, P. Jemth, S. Gianni, 2020, Proceedings of the National Academy of Sciences.

Conserved nucleation sites reinforce the significance of Phi value analysis in protein‐folding studies

P. Jemth, S. Gianni, 2014, IUBMB life.

An expanded view of the protein folding landscape of PDZ domains.

P. Jemth, S. Gianni, Celestine N. Chi, 2012, Biochemical and biophysical research communications.

Unifying features in protein-folding mechanisms

Valerie Daggett, A. Fersht, V. Daggett, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The folding process of acylphosphatase from Escherichia coli is remarkably accelerated by the presence of a disulfide bond.

F. Chiti, N. Taddei, S. Gianni, 2008, Journal of molecular biology.

Structural characterization of an on‐pathway intermediate and transition state in the folding of the N‐terminal SH2 domain from SHP2

S. Gianni, A. Toto, F. Malagrinò, 2019, The FEBS journal.

The Folding Mechanism of c-Type Cytochromes

M. Brunori, S. Gianni, C. Travaglini-Allocatelli, 2010 .

A PDZ domain recapitulates a unifying mechanism for protein folding

Michele Vendruscolo, Geerten W Vuister, Per Jemth, 2007, Proceedings of the National Academy of Sciences.

Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains

R. Guérois, S. Gianni, Eva di Silvio, 2017, Scientific Reports.

Direct quantification of protein dimerization preference shed light on SOD1-associated ALS.

P. Jemth, S. Gianni, 2020, Journal of molecular biology.

The Folding Pathway of the KIX Domain.

M. Brunori, S. Gianni, Daniela Bonetti, 2017, ACS chemical biology.

The kinetics of folding of frataxin.

M. Brunori, A. Pastore, S. Gianni, 2014, Physical chemistry chemical physics : PCCP.

The folding pathway of a functionally competent C-terminal domain of nucleophosmin: protein stability and denatured state residual structure.

L. Federici, M. Brunori, S. Gianni, 2013, Biochemical and biophysical research communications.

Folding and stability of globular proteins and implications for function.

P. Jemth, S. Gianni, Y. Ivarsson, 2009, Current opinion in structural biology.

Mechanisms of protein folding

M. Brunori, S. Gianni, Y. Ivarsson, 2008, European Biophysics Journal.

The structure of the major transition state for folding of an FF domain from experiment and simulation.

A. Fersht, V. Daggett, P. Jemth, 2005, Journal of molecular biology.

Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains

S. Gianni, C. Nardella, A. Toto, 2023, The Journal of biological chemistry.

Probing the effects of local frustration in the folding of a multidomain protein.

S. Gianni, C. Nardella, A. Toto, 2021, Journal of molecular biology.

Folding and misfolding of a PDZ tandem repeat.

S. Gianni, A. Toto, Francesca Troilo, 2021, Journal of molecular biology.

Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate

M. Brunori, Candice Gautier, S. Gianni, 2020, Proceedings of the National Academy of Sciences.

Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins

M. Vendruscolo, B. Richter, P. Jemth, 2008, Proceedings of the National Academy of Sciences.

Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein

Carlo Camilloni, Michele Vendruscolo, Pietro Sormanni, 2014, Proceedings of the National Academy of Sciences.

The mechanism of binding of the KIX domain to the mixed lineage leukemia protein and its allosteric role in the recognition of c‐Myb

M. Brunori, S. Gianni, Rajanish Giri, 2014, Protein science : a publication of the Protein Society.

Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system

M. Brunori, S. Gianni, Angela Morrone, 2013, Proceedings of the National Academy of Sciences.

Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators.

A. Coluccia, R. Silvestri, G. La Regina, 2023, Bioorganic chemistry.

Parallel pathways in cytochrome c(551) folding.

M. Brunori, H. Roder, S. Gianni, 2003, Journal of molecular biology.

A common folding mechanism in the cytochrome c family.

M. Brunori, S. Gianni, C. Travaglini-Allocatelli, 2004, Trends in biochemical sciences.

Fast folding kinetics and stabilization of apo‐cytochrome c

M. Brunori, Alessandro Borgia, S. Gianni, 2008, FEBS letters.

Cytochrome c(551) as a model system for protein folding.

M. Brunori, S. Gianni, F. Cutruzzolà, 2002, Biophysical chemistry.

Refolding kinetics of cytochrome c551 reveals a mechanistic difference between urea and guanidine

S. Gianni, Maurizio Brunori, Carlo Travaglini‐Allocatelli, 2001, Protein science : a publication of the Protein Society.

Understanding the role of phosphorylation in the binding mechanism of a PDZ domain

P. Jemth, S. Gianni, A. Toto, 2016, Protein engineering, design & selection : PEDS.

The mechanism of binding of the second PDZ domain from the Protein Tyrosine Phosphatase-BL to the Adenomatous Polyposis Coli tumor suppressor.

S. Gianni, Daniela Bonetti, Angela Morrone, 2014, Protein engineering, design & selection : PEDS.

The Kinetics of PDZ Domain-Ligand Interactions and Implications for the Binding Mechanism*

P. Jemth, S. Gianni, A. Engström, 2005, Journal of Biological Chemistry.

Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands.

S. Gianni, A. Toto, P. Pietrangeli, 2023, Archives of biochemistry and biophysics.

Binding induced folding: Lessons from the kinetics of interaction between NTAIL and XD.

S. Gianni, S. Longhi, A. Toto, 2019, Archives of biochemistry and biophysics.

The Plastic Energy Landscape of Protein Folding

M. Selmer, P. Jemth, S. Gianni, 2010, The Journal of Biological Chemistry.

An On-pathway Intermediate in the Folding of a PDZ Domain*

M. Brunori, P. Jemth, S. Gianni, 2007, Journal of Biological Chemistry.

Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains.

Greta Hultqvist, Per Jemth, Patrik Lundström, 2012, Journal of the American Chemical Society.

A sequential binding mechanism in a PDZ domain.

P. Jemth, S. Gianni, Celestine N. Chi, 2009, Biochemistry.

Protein folds and protein folding.

R Dustin Schaeffer, Valerie Daggett, V. Daggett, 2011, Protein engineering, design & selection : PEDS.

Morphogenesis of a protein: folding pathways and the energy landscape.

M. Brunori, S. Gianni, Angela Morrone, 2012, Biochemical Society transactions.

The folding pathway of an engineered circularly permuted PDZ domain.

M. Brunori, S. Gianni, Y. Ivarsson, 2008, Protein engineering, design & selection : PEDS.

Kinetic folding mechanism of PDZ2 from PTP-BL.

M. Brunori, G. W. Vuister, S. Gianni, 2005, Protein engineering, design & selection : PEDS.

Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation.

A. Fersht, V. Daggett, P. Jemth, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Affinity versus specificity in coupled binding and folding reactions.

P. Jemth, S. Gianni, 2019, Protein engineering, design & selection : PEDS.

Understanding Intramolecular Crosstalk in an Intrinsically Disordered Protein.

S. Gianni, Daniela Bonetti, S. Longhi, 2019, ACS chemical biology.

How Robust Is the Mechanism of Folding-Upon-Binding for an Intrinsically Disordered Protein?

M. Brunori, S. Gianni, Daniela Bonetti, 2018, Biophysical journal.

Analyzing the Folding and Binding Steps of an Intrinsically Disordered Protein by Protein Engineering.

M. Brunori, S. Gianni, Daniela Bonetti, 2017, Biochemistry.

Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95

Candice Gautier, P. Jemth, S. Gianni, 2017, Scientific Reports.

Fast folding kinetics and stabilization of apo‐cytochrome c

M. Brunori, Alessandro Borgia, S. Gianni, 2008, FEBS letters.

A complex equilibrium among partially unfolded conformations in monomeric transthyretin.

F. Chiti, S. Gianni, Xinyi Li, 2014, Biochemistry.

Functional role of transient conformations: Rediscovering “chronosteric effects” thirty years later

S. Gianni, P. Ascenzi, 2013, IUBMB life.

Engineered symmetric connectivity of secondary structure elements highlights malleability of protein folding pathways.

M. Brunori, S. Gianni, Y. Ivarsson, 2009, Journal of the American Chemical Society.

Folding and Misfolding in a Naturally Occurring Circularly Permuted PDZ Domain*

M. Brunori, S. Gianni, Y. Ivarsson, 2008, Journal of Biological Chemistry.

Deciphering the folding transition state structure and denatured state properties of Nucleophosmin C-terminal domain

L. Federici, M. Brunori, S. Gianni, 2010, Proceedings of the National Academy of Sciences.

Simulation and experiment conspire to reveal cryptic intermediates and a slide from the nucleation-condensation to framework mechanism of folding.

Valerie Daggett, Per Jemth, A. Fersht, 2005, Journal of molecular biology.

Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases

S. Gianni, A. Paiardini, F. Cutruzzolà, 2011, Proceedings of the National Academy of Sciences of the United States of America.

Human Mutation

E. Capriotti, A. Pastore, S. Gianni, 2019 .

A short structural extension dictates the early stages of folding of a PDZ domain.

Candice Gautier, S. Gianni, 2022, Biochimica et biophysica acta. Proteins and proteomics.

Demonstration of a folding after binding mechanism in the recognition between the measles virus NTAIL and X domains.

S. Gianni, Marion Dosnon, Daniela Bonetti, 2015, ACS chemical biology.

Unveiling induced folding of intrinsically disordered proteins - Protein engineering, frustration and emerging themes.

S. Gianni, C. Nardella, A. Toto, 2021, Current opinion in structural biology.

Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain*

M. Brunori, M. Vendruscolo, S. Gianni, 2016, The Journal of Biological Chemistry.

Folding pathways of proteins with increasing degree of sequence identities but different structure and function

Per Jemth, M. Brunori, P. Jemth, 2012, Proceedings of the National Academy of Sciences.

Frustration Sculpts the Early Stages of Protein Folding.

M. Brunori, S. Gianni, Eva di Silvio, 2015, Angewandte Chemie.

Mutational Analysis of the Binding-Induced Folding Reaction of the Mixed-Lineage Leukemia Protein to the KIX Domain.

S. Gianni, A. Toto, 2016, Biochemistry.

Reassessing the folding of the KIX domain: Evidence for a two‐state mechanism

M. Brunori, S. Gianni, Angela Morrone, 2012, Protein science : a publication of the Protein Society.

GA/GB Fold switching may modulate fatty acid transfer from human serum albumin to bacteria

S. Gianni, P. Ascenzi, F. Polticelli, 2012, IUBMB life.

Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains.

Patrik Lundström, P. Jemth, S. Gianni, 2012, Journal of the American Chemical Society.

The cooperative folding of annexin A2 relies on a transient nonnative intermediate

S. Gianni, Y. Nominé, G. Travé, 2022, Biophysical journal.

The Denatured State Dictates the Topology of Two Proteins with Almost Identical Sequence but Different Native Structure and Function*

M. Brunori, V. Daggett, P. Bryan, 2010, The Journal of Biological Chemistry.