J. Matthews

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Dimers, oligomers, everywhere.

J. Matthews, M. Sunde, 2012, Advances in experimental medicine and biology.

The power of two: protein dimerization in biology.

J. Matthews, M. Sunde, Neelan J Marianayagam, 2004, Trends in biochemical sciences.

The hydrophobin EAS is largely unstructured in solution and functions by forming amyloid-like structures.

J. Mackay, J. Matthews, M. Templeton, 2001, Structure.

Mechanism of allosteric regulation of transglutaminase 2 by GTP

L. Lorand, M. A. Wouters, R. Graham, 2006, Proceedings of the National Academy of Sciences.

Protein-protein interactions in human disease.

J. Matthews, Daniel P Ryan, Jacqueline M Matthews, 2005, Current opinion in structural biology.

14α-Hydroxylation of Androst-4-en-3, 17-dione by the Whole Cells of Cyanobacterium Nostoc piscinale

J. Mackay, J. Matthews, Daniel P Ryan, 2009 .

Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA.

S. Helder, J. Mackay, M. Vandevenne, 2014, Angewandte Chemie.

Solution Structure of the LIM-Homeodomain Transcription Factor Complex Lhx3/Ldb1 and the Effects of a Pituitary Mutation on Key Lhx3 Interactions

J. Trewhella, J. Mackay, J. Matthews, 2012, PloS one.

The tandem β‐zipper: Modular binding of tandem domains and linear motifs

J. Matthews, J. Potts, 2013, FEBS letters.

Designed metal-binding sites in biomolecular and bioinorganic interactions.

Joel P Mackay, J. Mackay, J. Matthews, 2008, Current opinion in structural biology.

New Insights into DNA Recognition by Zinc Fingers Revealed by Structural Analysis of the Oncoprotein ZNF217*

J. Mackay, M. Vandevenne, J. Matthews, 2013, The Journal of Biological Chemistry.

The LIM Protein FHL3 Binds Basic Krüppel-like Factor/Krüppel-like Factor 3 and Its Co-repressor C-terminal-binding Protein 2*

J. Matthews, M. Crossley, J. Turner, 2003, The Journal of Biological Chemistry.

Analysis of disease-causing GATA1 mutations in murine gene complementation systems.

J. Mackay, G. Blobel, J. Matthews, 2013, Blood.

LIM-domain Proteins

J. Matthews, 2013 .

Crystallization of FLINC4, an intramolecular LMO4-ldb1 complex.

J. Visvader, M. Maher, J. Matthews, 2003, Acta crystallographica. Section D, Biological crystallography.

1D Self-Assembly and Ice Recrystallization Inhibition Activity of Antifreeze Glycopeptide-Functionalized Perylene Bisimides.

Brendan L Wilkinson, J. Matthews, I. Manners, 2018, Chemistry.

IP7-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery

A. Saiardi, B. Crossett, T. Sorrell, 2020, mBio.

The characterization of protein interactions - what, how and how much?

J. Mackay, J. Matthews, Jason K. K. Low, 2021, Chemical Society reviews.

The Structure of an LIM-Only Protein 4 (LMO4) and Deformed Epidermal Autoregulatory Factor-1 (DEAF1) Complex Reveals a Common Mode of Binding to LMO4

J. Mackay, J. Matthews, A. Kwan, 2014, PloS one.

Genetic and structural basis of the human anti-α-galactosyl antibody response

Katherine Jackson, J. Matthews, C. Goodnow, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants.

Brendan L Wilkinson, J. Mackay, J. Matthews, 2012, Organic letters.

Contribution of DEAF1 Structural Domains to the Interaction with the Breast Cancer Oncogene LMO4

J. Matthews, D. Richard, L. Cubeddu, 2012, PloS one.

Structural and Biophysical Analysis of the DNA Binding Properties of Myelin Transcription Factor 1*

Jason A. Lowry, J. Mackay, J. Matthews, 2008, Journal of Biological Chemistry.

Disruption of the disulfide bonds of recombinant murine interleukin-6 induces formation of a partially unfolded state.

J. G. Zhang, L. D. Ward, R. Simpson, 1997, Biochemistry.

Crystallization and diffraction of an Lhx4-Isl2 complex.

J. Matthews, J. Guss, D. Langley, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization of an Lhx3-Isl1 complex.

J. Matthews, J. Guss, M. Bhati, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

A Quantitative Fluorescence-Based Assay for Assessing LIM Domain-Peptide Interactions.

J. Matthews, Neil O Robertson, Manan Shah, 2016, Angewandte Chemie.

A Structural Analysis of DNA Binding by Myelin Transcription Factor 1 Double Zinc Fingers*

Jason A. Lowry, J. Mackay, M. Vandevenne, 2013, The Journal of Biological Chemistry.

Transcription Factor 1 Double A Structural Analysis of DNA Binding by Protein Structure and Folding :

Jason A. Lowry, J. Mackay, M. Vandevenne, 2013 .

No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations

G. Kay, J. Matthews, T. Cox, 2013, Mammalian Genome.

Mutation of a Critical Arginine in the GTP-binding Site of Transglutaminase 2 Disinhibits Intracellular Cross-linking Activity*

R. Graham, J. Matthews, S. Iismaa, 2006, Journal of Biological Chemistry.

Total synthesis of homogeneous antifreeze glycopeptides and glycoproteins.

Brendan L Wilkinson, N. Packer, J. Matthews, 2012, Angewandte Chemie.

Synthesis of peptides and glycopeptides with polyproline II helical topology as potential antifreeze molecules.

J. Matthews, R. Payne, Chantelle J. Capicciotti, 2013, Bioorganic & medicinal chemistry.

Recombinant CLIC1 (NCC27) Assembles in Lipid Bilayers via a pH-dependent Two-state Process to Form Chloride Ion Channels with Identical Characteristics to Those Observed in Chinese Hamster Ovary Cells Expressing CLIC1*

W. D. Fairlie, P. Curmi, J. Matthews, 2002, The Journal of Biological Chemistry.

The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease

J. Dalton, J. Matthews, M. Robinson, 2009, PLoS neglected tropical diseases.

Protein Dimerization and Oligomerization in Biology

Jacqueline M. Matthews, J. Matthews, 2012, Advances in Experimental Medicine and Biology.

The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers

J. Matthews, S. Harten, Luke Isbel, 2015, BMC Biology.

Mutations in MITF and PAX3 Cause “Splashed White” and Other White Spotting Phenotypes in Horses

J. Matthews, C. Drögemüller, T. Leeb, 2012, PLoS Genetics.

Implementing the LIM code: the structural basis for cell type‐specific assembly of LIM‐homeodomain complexes

J Mitchell Guss, Joel P Mackay, Mihwa Lee, 2008, The EMBO journal.

Mechanisms of DNA-binding specificity and functional gene regulation by transcription factors.

J. Matthews, Jacqueline M Matthews, Ngaio C Smith, 2016, Current opinion in structural biology.

Solution structure of a tethered Lmo2LIM2/Ldb1LID complex

J. Mackay, J. Matthews, A. Kwan, 2012, Protein science : a publication of the Protein Society.

Identification of the key LMO2-binding determinants on Ldb1.

Joel P Mackay, J. Visvader, J. Mackay, 2006, Journal of molecular biology.

Protein Complex Hierarchy and Translocation Gene Products

J. Matthews, 2015 .

LIM-domain-only proteins in cancer

Soumya Joseph, Jacqueline M. Matthews, David J. Curtis, 2013, Nature Reviews Cancer.

Dimerization of CtIP may stabilize in vivo interactions with the Retinoblastoma-pocket domain.

J. Matthews, P. H. Stokes, L. Thompson, 2007, Biochemical and biophysical research communications.

Dimerization of CtIP, a BRCA1- and CtBP-interacting Protein, Is Mediated by an N-terminal Coiled-coil Motif*

J. Visvader, J. Glover, M. Dubin, 2004, Journal of Biological Chemistry.

A Structural Basis for the Regulation of the LIM-Homeodomain Protein Islet 1 (Isl1) by Intra- and Intermolecular Interactions*

J. Matthews, A. Kwan, D. Jacques, 2013, The Journal of Biological Chemistry.

Intermolecular Interactions byLIM-Homeodomain Protein Islet 1 ( Isl 1 ) A Structural Basis for the Regulation of the Protein Structure and Folding :

J. Matthews, A. Kwan, D. Jacques, 2013 .

Crystallization and diffraction of an Isl1-Ldb1 complex.

J. Matthews, D. Jacques, J. Guss, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Assembly of the oncogenic DNA‐binding complex LMO2‐Ldb1‐TAL1‐E12

P. Kuchel, J. Matthews, Christopher Lee, 2007, Proteins.

Zinc Fingers‐‐Folds for Many Occasions

J. Matthews, M. Sunde, Margaret Sunde, 2002, IUBMB life.

A Classic Zinc Finger from Friend of GATA Mediates an Interaction with the Coiled-coil of Transforming Acidic Coiled-coil 3*

J. Visvader, J. Mackay, J. Matthews, 2004, Journal of Biological Chemistry.

Alpha-helix stability in proteins. II. Factors that influence stability at an internal position.

A. Fersht, A. Horovitz, J. Matthews, 1992, Journal of molecular biology.

Contrasting DNA-binding behaviour by ISL1 and LHX3 underpins differential gene targeting in neuronal cell specification

J. Trewhella, J. Matthews, A. Kwan, 2020, Journal of structural biology: X.

Interleukin‐6: Structure‐function relationships

L. D. Ward, J. Matthews, A. Hammacher, 1997, Protein science : a publication of the Protein Society.

Characterization of the Conserved Interaction between GATA and FOG Family Proteins* 210

D. Gell, J. Mackay, J. Matthews, 2002, The Journal of Biological Chemistry.

Engineering a protein scaffold from a PHD finger.

D. Gell, J. Mackay, J. Matthews, 2003, Structure.

It takes two to tango: the structure and function of LIM, RING, PHD and MYND domains.

J. Mackay, J. Matthews, R. E. Mansfield, 2009, Current pharmaceutical design.

Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa

Olwyn Byron, Jacqueline M. Matthews, Nicholas P. Tucker, 2016, The Biochemical journal.

A class of zinc fingers involved in protein-protein interactions biophysical characterization of CCHC fingers from fog and U-shaped.

J. Mackay, A. Fox, J. Matthews, 2000, European journal of biochemistry.

Interactions between LHX3- and ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans

E. Llamosas, J. Matthews, C. Jeffries, 2017, Scientific Reports.

LIM domain binding proteins 1 and 2 have different oligomeric states.

J. Trewhella, J. Matthews, C. Jeffries, 2010, Journal of molecular biology.

Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes

Anna L. Brown, J. Matthews, H. Scott, 2017, Leukemia.

GATA2 is required for lymphatic vessel valve development and maintenance.

G. Secker, David M. Lawrence, J. Matthews, 2015, The Journal of clinical investigation.

Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex

J. Visvader, M. Maher, J. Matthews, 2004, The EMBO journal.

LIM‐domain‐binding protein 1: a multifunctional cofactor that interacts with diverse proteins

J. Visvader, J. Matthews, 2003, EMBO reports.

CCHX Zinc Finger Derivatives Retain the Ability to Bind Zn(II) and Mediate Protein-DNA Interactions*

J. Mackay, J. Matthews, M. Crossley, 2003, Journal of Biological Chemistry.

GATA2 is required for lymphatic vessel valve development and maintenance.

G. Secker, David M. Lawrence, J. Matthews, 2015, The Journal of clinical investigation.

Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification*

Jill Trewhella, J Mitchell Guss, Cy M Jeffries, 2011, The Journal of Biological Chemistry.

Competition between LIM-binding domains.

J. Matthews, M. Sunde, C. Jeffries, 2008, Biochemical Society transactions.

Structural basis for the recognition of ldb1 by the N‐terminal LIM domains of LMO2 and LMO4

J. Visvader, J. Mackay, J. Matthews, 2003, The EMBO journal.

Letter to the Editor: 1H, 15N and 13C assignments of FLIN2, an intramolecular LMO2:ldb1 complex

J. Visvader, J. Mackay, J. Matthews, 2001, Journal of biomolecular NMR.

Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes.

J. Visvader, J. Mackay, J. Matthews, 2001, Protein engineering.

GATA1 directly mediates interactions with closely spaced pseudopalindromic but not distantly spaced double GATA sites on DNA

J. Matthews, D. Jacques, Lorna Wilkinson-White, 2015, Protein science : a publication of the Protein Society.

Stabilization of a binary protein complex by intein‐mediated cyclization

J. Matthews, C. Jeffries, J. Guss, 2006, Protein science : a publication of the Protein Society.

Stabilization of native protein fold by intein-mediated covalent cyclization.

Phil Attard, Gottfried Otting, N. K. Williams, 2005, Journal of molecular biology.

Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction.

James McCluskey, Anthony W Purcell, Jamie Rossjohn, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Equilibrium denaturation of recombinant murine interleukin-6: effect of pH, denaturants, and salt on formation of folding intermediates.

J. G. Zhang, L. D. Ward, R. Simpson, 1995, Biochemistry.

Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1

Siavoush Dastmalchi, Merlin Crossley, Joel P Mackay, 2011, Proceedings of the National Academy of Sciences.

Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin

Laura J. Norton, J. Vadolas, K. Quinlan, 2015, Nature Communications.

Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction.

J. Mackay, J. Matthews, A. Kwan, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA.

J. Mackay, M. Vandevenne, J. Matthews, 2012, Angewandte Chemie.

Backbone and side-chain assignments of a tethered complex between LMO4 and DEAF-1

J. Mackay, J. Matthews, A. Kwan, 2014, Biomolecular NMR assignments.

Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8.

J E Visvader, C. W. Liew, J. Visvader, 2013, Journal of molecular biology.

1H, 15N and 13C assignments of an intramolecular LMO4-LIM1/CtIP complex

C. W. Liew, J. Mackay, J. Matthews, 2011, Biomolecular NMR Assignments.

Letter to the Editor: 1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex

J. Visvader, J. Mackay, J. Matthews, 2002, Journal of biomolecular NMR.

A Complex Mechanism Determines Polarity of DNA Replication Fork Arrest by the Replication Terminator Complex of Bacillus subtilis*

N. Dixon, J. Mackay, J. Matthews, 2005, Journal of Biological Chemistry.

Protein–protein interactions: Analysis of a false positive GST pulldown result

C. W. Liew, J. Mackay, J. Matthews, 2011, Proteins.

A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution.

D. Gell, J. Mackay, J. Matthews, 2002, Structure.

Influence of Interleukin-6 (IL-6) Dimerization on Formation of the High Affinity Hexameric IL-6·Receptor Complex*

L. D. Ward, R. Moritz, L. Fabri, 1996, The Journal of Biological Chemistry.

The Core of the Respiratory Syncytial Virus Fusion Protein Is a Trimeric Coiled Coil

Joel P. Mackay, Jacqueline M. Matthews, J. Mackay, 2000, Journal of Virology.

Fusion Protein Is a Trimeric Coiled Coil The Core of the Respiratory Syncytial Virus

J. Mackay, J. Matthews, S. Tucker, 2000 .

ATP binding equilibria of the Na(+),K(+)-ATPase.

J. Matthews, H. Apell, P. Sebban, 2008, Biochemistry.

Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting.

J. Mackay, J. Wilce, J. Matthews, 2005, Structure.

Bmc Structural Biology Grb7 Sh2 Domain Structure and Interactions with a Cyclic Peptide Inhibitor of Cancer Cell Migration and Proliferation

Joel P Mackay, Corrine J Porter, Edu, 2022 .

Tropoelastin bridge region positions the cell-interactive C terminus and contributes to elastic fiber assembly

Manfred Roessle, Giselle C Yeo, Clair Baldock, 2012, Proceedings of the National Academy of Sciences.

Roles of histidine 31 and tryptophan 34 in the structure, self-association, and folding of murine interleukin-6.

L. D. Ward, R. Norton, R. Simpson, 1997, Biochemistry.

Protein interactions: is seeing believing?

Merlin Crossley, Joel P Mackay, Jason A. Lowry, 2007, Trends in biochemical sciences.

The association of unfolding intermediates during the equilibrium unfolding of recombinant murine interleukin-6

L. D. Ward, R. Simpson, J. Matthews, 1996 .

Structural Analysis of MED-1 Reveals Unexpected Diversity in the Mechanism of DNA Recognition by GATA-type Zinc Finger Domains*

J. Mackay, J. Matthews, A. Kwan, 2009, Journal of Biological Chemistry.

Cyclic peptides can engage a single binding pocket through highly divergent modes

J. Mackay, J. Matthews, R. Payne, 2020, Proceedings of the National Academy of Sciences.

Cyclic peptides can engage a single binding pocket through multiple, entirely divergent modes

J. Mackay, J. Matthews, R. Payne, 2019, bioRxiv.

Extrapolation to water of kinetic and equilibrium data for the unfolding of barnase in urea solutions.

A. Fersht, J. Matthews, A. Matouschek, 1994, Protein engineering.

TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer.

L. Young, J. Mackay, J. Matthews, 2004, Cancer research.

Structural basis for rodlet assembly in fungal hydrophobins.

J. Mackay, J. Matthews, M. Sunde, 2006, Proceedings of the National Academy of Sciences of the United States of America.

New Insights into DNA Recognition by Zinc Fingers Revealed by Structural Analysis of the Oncoprotein ZNF217*

J. Mackay, M. Vandevenne, J. Matthews, 2013, The Journal of Biological Chemistry.

Exploring the energy surface of protein folding by structure-reactivity relationships and engineered proteins: observation of Hammond behavior for the gross structure of the transition state and anti-Hammond behavior for structural elements for unfolding/folding of barnase.

A. Fersht, J. Matthews, A R Fersht, 1995, Biochemistry.

Single versus parallel pathways of protein folding and fractional formation of structure in the transition state.

A. Fersht, L. Itzhaki, D. Otzen, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Disparate binding kinetics by an intrinsically disordered domain enables temporal regulation of transcriptional complex formation

J. Matthews, A. Kwan, Neil O Robertson, 2018, Proceedings of the National Academy of Sciences.

Binding and folding in transcriptional complexes.

S. Shammas, J. Matthews, M. Kuravsky, 2020, Current opinion in structural biology.

The single mutation Phe173 --> Ala induces a molten globule-like state in murine interleukin-6.

R. Norton, R. Simpson, J. Matthews, 2000, Biochemistry.

1H, 15N and 13C assignments of an intramolecular LMO4-LIM1/CtIP complex

C. W. Liew, J. Mackay, J. Matthews, 2012, Biomolecular NMR assignments.

The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers

J. Matthews, S. Harten, Luke Isbel, 2015, BMC Biology.

Mutations in MITF and PAX3 Cause “Splashed White” and Other White Spotting Phenotypes in Horses

J. Matthews, C. Drögemüller, T. Leeb, 2012, PLoS genetics.

Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes

J. Matthews, J. Guss, S. Cheung, 2015, Molecular microbiology.

Correction: Mutations in MITF and PAX3 Cause “Splashed White” and Other White Spotting Phenotypes in Horses

J. Matthews, C. Drögemüller, T. Leeb, 2019, PLoS Genetics.

TNP Analogues Inhibit the Virulence Promoting IP3-4 Kinase Arg1 in the Fungal Pathogen Cryptococcus neoformans

T. Sorrell, J. Mackay, J. Matthews, 2022, Biomolecules.

Competition between LIM-binding domains.

J. Matthews, M. Sunde, C. Jeffries, 2008, Biochemical Society transactions.

1H, 15N and 13C assignments of an intramolecular Lmo2-LIM2/Ldb1-LID complex

J. Mackay, J. Matthews, A. Kwan, 2010, Biomolecular NMR assignments.

Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation

D. Krag, J. Mackay, J. Wilce, 2007, BMC Structural Biology.

Disparate binding kinetics by an intrinsically disordered domain enables temporal regulation of transcriptional complex formation

J. Matthews, A. Kwan, Neil O Robertson, 2018, Proceedings of the National Academy of Sciences.

Structural Analysis of MED-1 Reveals Unexpected Diversity in the Mechanism of DNA Recognition by GATA-type Zinc Finger Domains*

Jason A. Lowry, Morris F. Maduro, J. Mackay, 2009, Journal of Biological Chemistry.