C. Goodnow

发表

Comparison of predicted and actual consequences of missense mutations

T. Andrews, M. Field, B. Beutler, 2015, Proceedings of the National Academy of Sciences.

Autoimmune tolerance and Type 1 (insulin-dependent) diabetes mellitus

G. Nossal, K. Herold, C. Goodnow, 1992, Diabetologia.

Induction of self-tolerance in mature peripheral B lymphocytes

Jeffrey Crosbie, Christopher C. Goodnow, C. Goodnow, 1989, Nature.

IgD attenuates the IgM-induced anergy response in transitional and mature B cells

M. Field, T. Andrews, P. Humburg, 2016, Nature Communications.

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

Christopher C. Goodnow, R. Dolmetsch, C. Goodnow, 1997, Nature.

HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse

D. Adelson, David M. Lawrence, C. Goodnow, 2015, PLoS genetics.

T cells and follicular dendritic cells in germinal center B‐cell formation and selection

C. Goodnow, M. Linterman, C. Vinuesa, 2010, Immunological reviews.

Immunology: DNA drives autoimmunity

C. Goodnow, C. Vinuesa, 2002, Nature.

Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models

T. Andrews, M. Field, B. Beutler, 2012, Open Biology.

Cellular and genetic mechanisms of self tolerance and autoimmunity

C. Goodnow, C. Vinuesa, J. Sprent, 2005, Nature.

Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

T. Mak, J. Cyster, C. Goodnow, 1996, Nature.

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

S. Smith‐Gill, C. Goodnow, J. Crosbie, 2009, Journal of immunology.

CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.

S. Watson, A. Weiss, C. Goodnow, 2010, Immunity.

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination

Benjamin T. Porebski, K. Patterson, C. Goodnow, 2018, Science.

Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.

M. Fleming, C. Goodnow, R. Simpson, 2009, Blood.

Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL.

S. Dunwoodie, Y. Sontani, C. Goodnow, 2011, Leukemia research.

DNA repair is limiting for haematopoietic stem cells during ageing

Anastasia Nijnik, Predrag Slijepcevic, Tariq Enver, 2007, Nature.

Phospho-tuning immunity through Denisovan, modern human and mouse TNFAIP3 gene variants

Benjamin T. Porebski, G. Nolan, M. Cox, 2019, bioRxiv.

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

Jinfeng Liu, Saritha Kusam, Jeffrey Tom, 2015, Nature.

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody

Timothy J. Peters, F. Luciani, T. Mercer, 2020, Cell.

Discriminating Microbe from Self Suffers a Double Toll

C. Goodnow, 2006, Science.

Functional Annotation of Mouse Genome Sequences

Hans Lehrach, William C. Skarnes, Wolfgang Wurst, 2001, Science.

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

Susan M. Schlenner, D. Lambrechts, N. Petrovsky, 2016, Nature Genetics.

Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.

Diego G. Silva, Souvik Das, C. Goodnow, 2013, Immunity.

Defective T‐cell function leading to reduced antibody production in a kleisin‐β mutant mouse

C. Goodnow, N. Verma, Katharine M Gosling, 2008, Immunology.

A mutation in a chromosome condensin II subunit, kleisin β, specifically disrupts T cell development

L. Makaroff, B. Whittle, C. Goodnow, 2007, Proceedings of the National Academy of Sciences.

High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes

F. Luciani, T. Phan, J. Blackburn, 2018, bioRxiv.

Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway.

J. Cyster, C. Goodnow, R. Cornall, 1999, Current topics in microbiology and immunology.

Reliably Detecting Clinically Important Variants Requires Both Combined Variant Calls and Optimized Filtering Strategies

T. Andrews, M. Field, V. Cho, 2015, PloS one.

Pathways for self-tolerance and the treatment of autoimmune diseases

C. Goodnow, 2001, The Lancet.

Differential Requirement for the CD45 Splicing Regulator hnRNPLL for Accumulation of NKT and Conventional T Cells

C. Goodnow, G. Hoyne, M. Yabas, 2011, PloS one.

Signaling through murine CD38 is impaired in antigen receptor‐unresponsive B cells

M. Cooke, C. Goodnow, N. Solvason, 1995, European journal of immunology.

Control systems and decision making for antibody production

C. Goodnow, F. Mackay, C. Vinuesa, 2010, Nature Immunology.

Self-tolerance in B lymphocytes.

C. Goodnow, A. Basten, 1989, Seminars in immunology.

Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate.

J. Cyster, C. Goodnow, Christopher C. Goodnow, 1995, Immunity.

Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells

J. Allison, C. Goodnow, J. Rathmell, 1998, The Journal of experimental medicine.

Resistance to CpG DNA–induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

C. Goodnow, L. Rui, C. Vinuesa, 2003, Nature Immunology.

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

S. Tangye, J. Cyster, B. Whittle, 2009, Nature Immunology.

The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs

N. Dixon, C. Goodnow, A. Barker, 2010, The FEBS journal.

Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment.

J. Cyster, C. Goodnow, Christopher C. Goodnow, 1997, Immunity.

A Missense Mutation in the Transcription Factor ETV5 Leads to Sterility, Increased Embryonic and Perinatal Death, Postnatal Growth Restriction, Renal Asymmetry and Polydactyly in the Mouse

B. Whittle, C. Goodnow, M. O’Bryan, 2013, PloS one.

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.

D. Irvine, Hao Wu, F. Luscinskas, 2016, The Journal of clinical investigation.

Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells

C. Goodnow, S. Daley, A. Chan, 2019, Cell Death & Differentiation.

The Ubiquitin Ligase Adap tor NDFIP 1 Selectively Enforces a CD 8 + T Cell Tolerance Checkpoint to High-Dose Antigen Graphical

C. Goodnow, Seong-Seng Tan, M. Wagle, 2018 .

University of Dundee The Ubiquitin Ligase Adaptor NDFIP 1 Selectively Enforces a CD 8 + T Cell Tolerance Checkpoint to High-Dose Antigen

C. Goodnow, Seong-Seng Tan, M. Wagle, 2018 .

The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen.

C. Goodnow, Seong-Seng Tan, M. Wagle, 2018, Cell reports.

Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice.

N. Petrovsky, M. Yeh, C. Goodnow, 2006, Biochemical and biophysical research communications.

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

S. Kummerfeld, G. Salvesen, S. Warming, 2015, Nature.

Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment

Chuan-Sheng Foo, R. Horton, S. Watson, 2014, eLife.

Integration of single-cell RNA and protein data identifies novel clinically-relevant lymphocyte phenotypes in breast cancers

Bertrand Z. Yeung, J. Lundeberg, T. Phan, 2022, bioRxiv.

Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.

Diego G. Silva, C. Goodnow, M. Linterman, 2009, Immunity.

Genetic and structural basis of the human anti-α-galactosyl antibody response

Katherine Jackson, J. Matthews, C. Goodnow, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Gene Dose–Dependent Maturation and Receptor Editing of B Cells Expressing Immunoglobulin (Ig)g1 or Igm/Igg1 Tail Antigen Receptors

C. Goodnow, S. Pogue, 2000, The Journal of experimental medicine.

Danger - pathogen on the premises! Immunological tolerance.

C. Janeway, R. Medzhitov, C. Goodnow, 1996, Current biology : CB.

A genomic view of immunology

Christopher C. Goodnow, C. Goodnow, J. Bazan, 2001, Nature.

Mechanisms of self-tolerance and autoimmunity: from whole-animal phenotypes to molecular pathways.

L. Miosge, C. Goodnow, D. Mack, 1999, Cold Spring Harbor symposia on quantitative biology.

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells

P. Linsley, K. Shokat, M. Cooke, 1994, The Journal of experimental medicine.

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

Susan R. Wilson, G. Crabtree, A. Strasser, 2004, Immunity.

F31 Organ-speciﬁc Autoimmune Disease: A Deﬁciency of Tolerogenic

C. Goodnow, S. Lesage, 2001 .

The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ‐specific and systemic autoimmunity

C. Goodnow, G. Hoyne, Gerard F. Hoyne, 2006, Immunological reviews.

Spontaneous B cell hyperactivity in autoimmune-prone MRL mice.

C. Goodnow, H. Ferry, R. Cornall, 2006, International immunology.

Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.

C. Goodnow, J. Rathmell, 1994, Journal of immunology.

Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity.

A. Liston, C. Goodnow, 2005, Novartis Foundation symposium.

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

A. Kelleher, C. Goodnow, M. Sobti, 2020, bioRxiv.

Murine T-cell receptor genes.

Y. Chien, M. Davis, C. Goodnow, 1987, Advances in experimental medicine and biology.

T-cell receptor gene structure and function.

Y. Chien, M. Davis, C. Goodnow, 1986, Cellular immunology.

Murine T-Cell Receptor Genes and the Problems of Cellular Recognition and Repertoire Selection

Mark M. Davis, Y. Chien, C. Goodnow, 1986 .

Immunodeficiency Signaling: Implications for Human Virus Control in Mice with Attenuated Tcr T Cell Expansion Is the Limiting Factor Of

H. Pircher, S. Ehl, A. Enders, 2022 .

T Cell Expansion Is the Limiting Factor of Virus Control in Mice with Attenuated TCR Signaling: Implications for Human Immunodeficiency

H. Pircher, S. Ehl, A. Enders, 2015, The Journal of Immunology.

Spontaneous Follicular Exclusion of SHP1-deficient B Cells Is Conditional on the Presence of Competitor Wild-type B Cells

J. Cyster, C. Goodnow, K. Schmidt, 1998, The Journal of experimental medicine.

Single cell multi-modal analysis with VDJPuzzle identifies clonality and gene expression profiles of T and B cells

F. Luciani, C. Goodnow, J. Reed, 2019 .

RAB-Like 2 Has an Essential Role in Male Fertility, Sperm Intra-Flagellar Transport, and Tail Assembly

Mark C. Field, J. Whisstock, B. Whittle, 2012, PLoS genetics.

Cancer immunotherapy: new leads on an elusive goal

C. Goodnow, 1998, The Medical journal of Australia.

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.

Scott N. Mueller, G. Smyth, B. Phipson, 2011, Blood.

Autoimmunity, self-tolerance and immune homeostasis: from whole animal phenotypes to molecular pathways.

L. Miosge, C. Goodnow, D. Mack, 2001, Advances in experimental medicine and biology.

Glimpses into the balance between immunity and self-tolerance.

C. Goodnow, 2007, Ciba Foundation symposium.

Autoimmunity: The Fas track

C. Goodnow, J. Rathmell, 1995, Current Biology.

Censoring of self-reactive B cells with a range of receptor affinities in transgenic mice expressing heavy chains for a lysozyme-specific antibody.

C. Goodnow, S. Hartley, Christopher C. Goodnow, 1994, International immunology.

Nossal and Pike 1975: A Turning Point in the Effort to Define Self-Tolerance Mechanisms

C. Goodnow, 2007, The Journal of Immunology.

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

I. Konstantinov, Y. D'udekem, L. Loh, 2016, Nature Immunology.

Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice.

D. Mason, C. Goodnow, Margaret Jones, 1992, International immunology.

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

J. McCluskey, J. Rossjohn, D. Pellicci, 2015, The Journal of experimental medicine.

TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints

A. Liston, C. Goodnow, S. Lesage, 2016, Immunology and cell biology.

B cell antigen receptor signalling in the balance of tolerance and immunity.

C. Goodnow, R. Cornall, 1998, Novartis Foundation symposium.

Organ-Specific Autoimmune Disease

C. Goodnow, S. Lesage, 2001, The Journal of experimental medicine.

Analysis of Lyn/CD22 double‐deficient B cells in vivo demonstrates Lyn‐ and CD22‐independent pathways affecting BCR regulation and B cell survival

C. Goodnow, H. Ferry, R. Cornall, 2005, European journal of immunology.

Lyn/CD22/SHP-1 and their importance in autoimmunity.

C. Goodnow, J. Blasioli, 2002, Current directions in autoimmunity.

Abortive Proliferation of Rare T Cells Induced by Direct or Indirect Antigen Presentation by Rare B Cells In Vivo

C. Goodnow, S. E. Townsend, 1998, The Journal of experimental medicine.

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

M. Cooke, D. Lenschow, C. Goodnow, 1994, Journal of immunology.

Intrinsic in vitro abnormalities in dendritic cell generation caused by non‐MHC non‐obese diabetic genes

C. Goodnow, Simon J. Prasad, 2002, Immunology and cell biology.

Expression of T-cell receptor alpha-chain genes in transgenic mice

M. Davis, C. Goodnow, H. Garchon, 1988, Molecular and cellular biology.

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

K. Shokat, R. Tisch, H. Mcdevitt, 1996, Proceedings of the National Academy of Sciences of the United States of America.

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

J. Casanova, Joanne M. Smart, C. Picard, 2011, The Journal of experimental medicine.

DOCK 8 de ! ciency impairs CD 8 T cell survival and function in humans and mice

J. Casanova, Joanne M. Smart, C. Picard, 2011 .

DOCK 8 deficiency impairs CD 8 T cell survival and function in humans and mice

J. Casanova, Joanne M. Smart, C. Picard, 2011 .

Immune responses: Costimulatory receptors have their say

C. Goodnow, B. Weintraub, 1998, Current Biology.

SATB1 ensures appropriate transcriptional programs within naïve CD8+ T cells

K. Kedzierska, S. Turner, L. Miosge, 2022, Immunology and cell biology.

Quantitative Reduction of the TCR Adapter Protein SLP-76 Unbalances Immunity and Immune Regulation

A. Liston, L. Miosge, C. Goodnow, 2015, The Journal of Immunology.

Quantitative reduction of the T cell receptor adapter protein SLP-76 unbalances immunity and immune regulation

A. Liston, L. Miosge, C. Goodnow, 2015 .

Tracing the action of IL‐2 in tolerance to islet‐specific antigen

A. Liston, C. Goodnow, O. Siggs, 2007, Immunology and cell biology.

Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords

J. Cyster, C. Goodnow, 1995, The Journal of experimental medicine.

An Essential Role for Katanin p80 and Microtubule Severing in Male Gamete Production

Lee B. Smith, B. Whittle, C. Goodnow, 2012, PLoS genetics.

epithelial cells Developmental kinetics, turnover and stimulatory capacity of thymic

D. Gray, A. Liston, C. Goodnow, 2010 .

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.

D. Gray, A. Liston, C. Goodnow, 2006, Blood.

1 Developmental kinetics, turnover and stimulatory capacity of thymic epithelial cells.

D. Gray, A. Liston, C. Goodnow, 2006 .

LRGUK-1 Is Required for Basal Body and Manchette Function during Spermatogenesis and Male Fertility

B. Whittle, C. Goodnow, D. J. Merriner, 2015, PLoS genetics.

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10–driven MARCH1-mediated ubiquitination and degradation

C. Goodnow, M. Degli-Esposti, K. Horikawa, 2011, The Journal of experimental medicine.

Lymphoma and the control of B cell growth and differentiation.

C. Goodnow, L. Rui, 2006, Current molecular medicine.

Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren’s syndrome

M. Field, G. Huttley, P. Milburn, 2015, Journal of Translational Medicine.

Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo.

B. Beutler, C. Goodnow, K. Horikawa, 2016, Blood.

A ZAP‐70 kinase domain variant prevents thymocyte‐positive selection despite signalling CD69 induction

Susan M. Schlenner, A. Liston, C. Goodnow, 2014, Immunology.

A Novel Mechanism for Complement Activation at the Surface of B Cells Following Antigen Binding1

M. Walport, C. Goodnow, C. Parish, 2006, The Journal of Immunology.

Preponderance of CTLA4 Variation Associated With Autosomal Dominant Immune Dysregulation in the MYPPPY Motif

C. Goodnow, M. Craig, D. Singh-Grewal, 2019, Front. Immunol..

to Type 1 Diabetes Islet-Reactive CD4 T Cells and Susceptibility Visualizing the Role of Cbl-b in Control of

C. Goodnow, W. Langdon, G. Hoyne, 2011 .

Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells

J. Casanova, A. Bousfiha, S. Tangye, 2022, Science Immunology.

Manipulation of Transgene-Encoded Self-Antigens to Explore Mechanisms of B Cell Tolerance

C. Goodnow, S. Hartley, 1994 .

Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen

D. Mason, C. Goodnow, J. Crosbie, 1992, The Journal of experimental medicine.

A timeline demarcating two waves of clonal deletion and Foxp3 upregulation during thymocyte development

C. Goodnow, S. Daley, Rushika C. Wirasinha, 2016, Immunology and cell biology.

Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-κB in B cell clonal anergy

L. Miosge, C. Goodnow, M. Bléry, 2006, The Journal of experimental medicine.

ZBTB7B (Th-POK) Regulates the Development of IL-17–Producing CD1d-Restricted Mouse NKT Cells

A. Enders, C. Goodnow, M. Yabas, 2012, The Journal of Immunology.

Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production

L. Notarangelo, S. Choo, Joanne M. Smart, 2019, The Journal of experimental medicine.

Dependence of germinal center B cells on expression of CD21/CD35 for survival.

G. Kelsoe, C. Goodnow, M. Carroll, 1998, Science.

DOCK8 is critical for the survival and function of NKT cells.

Joanne M. Smart, S. Tangye, H. Lockstone, 2013, Blood.

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

Matthew E. Ritchie, Timothy Baldwin, I. Konstantinov, 2019, Science Immunology.

Redundant expression but selective utilization of nuclear factor of activated T cells family members.

G. Crabtree, S. Ho, C. Goodnow, 1997, Journal of immunology.

Thymic precursors to the mucosal-associated invariant T cell lineage

I. Konstantinov, Y. D'udekem, L. Loh, 2016 .

The in vivo balance between B cell clonal expansion and elimination is regulated by CD95 both on B cells and in their micro‐environment

C. Goodnow, J. Rathmell, 1998, Immunology and cell biology.

Consequences of Increased CD45RA and RC Isoforms for TCR Signaling and Peripheral T Cell Deficiency Resulting from Heterogeneous Nuclear Ribonucleoprotein L-Like Mutation

C. Goodnow, G. Hoyne, Zuopeng Wu, 2010, The Journal of Immunology.

Isoforms for TCR Signaling and Peripheral Consequences of Increased CD45RA and RC

C. Goodnow, G. Hoyne, Zuopeng Wu, 2010 .

L-Like Mutation Heterogeneous Nuclear Ribonucleoprotein Cell Deficiency Resulting from TIsoforms for TCR Signaling and Peripheral Consequences of Increased CD 45 RA and RC

C. Goodnow, G. Hoyne, Zuopeng Wu, 2010 .

Augmented neutralization of SARS‐CoV‐2 Omicron variant by boost vaccination and monoclonal antibodies

H. Jäck, C. Goodnow, M. Hoffmann, 2022, European journal of immunology.

NINJ1 mediates plasma membrane rupture during lytic cell death

T. Andrews, Rohit Reja, Z. Modrušan, 2020, Nature.

Repression of B 7 . 2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD 4 1 T Cells

J. Allison, C. Goodnow, J. Rathmell, 1998 .

T cell-mediated elimination of B7.2 transgenic B cells.

J. Allison, C. Goodnow, J. Rathmell, 1997, Immunity.

Antigen-specific B cells preferentially induce CD4+ T cells to produce IL-4.

D. Umetsu, C. Goodnow, R. DeKruyff, 1997, Journal of immunology.

Dedicator of cytokinesis 8–deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells

J. Casanova, J. Orange, J. Ziegler, 2017, The Journal of allergy and clinical immunology.

DOCK 8-Deficient CD 4 + T Cells are Biased to a Th 2 Effector Fate at the Expense of Th 1 and Th 17 Cells

J. Ziegler, Joanne M. Smart, S. Tangye, 2016 .

Safe havens for self-reactive cells

C. Goodnow, 1992, Current Biology.

Tuning Antigen Receptor Signaling Review by CD 22 : Integrating Cues from Antigens and the Microenvironment

J. Cyster, C. Goodnow, 1997 .

Corrigendum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

S. Tangye, J. Cyster, B. Whittle, 2010, Nature Immunology.

A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes.

C. Goodnow, S. E. Bell, Sarah Bell, 1994, The EMBO journal.

Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes.

R. Dolmetsch, C. Goodnow, J. I. Healy, 1998, Novartis Foundation symposium.

A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation

Adelaide I J Young, B. Whittle, E. Bertram, 2017, PLoS genetics.

7 th European Workshop on Immune-Mediated Inflammatory Diseases Noordwijk

T. Andrews, L. Miosge, Y. Sontani, 2012 .

The Essential Role of DOCK8 in Humoral Immunity

C. Goodnow, Katrina L. Randall, R. Cornall, 2010, Disease markers.

IgD expression on B cells is more efficient than IgM but both receptors are functionally equivalent in up‐regulation CD80/CD86 co‐stimulatory molecules

C. Goodnow, R. Brink, A. Basten, 1995, European journal of immunology.

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation.

Timothy J. Peters, S. Mustjoki, S. Tangye, 2022, Immunity.

A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred

M. Field, Yafei Zhang, B. Whittle, 2015, Human Genome Variation.

Balancing Immunity, Autoimmunity, and Self‐tolerance a

C. Goodnow, 1997, Annals of the New York Academy of Sciences.

Consequences of the recurrent MYD88L265P somatic mutation for B cell tolerance

B. Beutler, C. Goodnow, K. Horikawa, 2014, The Journal of experimental medicine.

A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy.

H. Young, L. Miosge, Y. Sontani, 2016, The American journal of pathology.

A novel mutation in the nucleoporin NUP35 causes murine degenerative colonic smooth muscle myopathy

H. Young, L. Miosge, Y. Sontani, 2016, bioRxiv.

Multistep Pathogenesis of Autoimmune Disease

C. Goodnow, 2007, Cell.

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.

S. Tangye, G. Huttley, T. Vyse, 2010, Arthritis and rheumatism.

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis

Christopher C. Goodnow, C. Goodnow, D. Mack, 2000, Nature.

IRF2 transcriptionally induces GSDMD expression for pyroptosis

T. Andrews, S. Kummerfeld, C. Watanabe, 2019, Science Signaling.

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells

M P Cooke, M. Cooke, M. Davis, 1994, The Journal of experimental medicine.

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

C. Goodnow, J. Crosbie, R. Brink, 1991, Nature.

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

R. Copley, J. Bell, B. Whittle, 2005, Nature.

Themis is a member of a new metazoan gene family and is required for completion of thymocyte positive selection

L. Aravind, R. Schwartz, C. Goodnow, 2009, Nature Immunology.

Secretion of a chimeric T-cell receptor-immunoglobulin protein.

M. Davis, C. Goodnow, N. Gascoigne, 1987, Proceedings of the National Academy of Sciences of the United States of America.

RBM5 Is a Male Germ Cell Splicing Factor and Is Required for Spermatid Differentiation and Male Fertility

J. Wilce, B. Whittle, C. Goodnow, 2013, PLoS genetics.

Delayed control of herpes simplex virus infection and impaired CD4+ T cell migration to the skin in mouse models of DOCK8 deficiency

D. Tscharke, I. Flesch, L. Miosge, 2015, Immunology and cell biology.

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

C. Goodnow, M. Cook, D. Taupin, 2008, PLoS medicine.

SAMD9L autoinflammatory or ataxia pancytopenia disease mutations activate cell-autonomous translational repression

J. Ziegler, W. Sewell, C. Goodnow, 2021, Proceedings of the National Academy of Sciences.

The actin regulator coronin-1A is mutated in a thymic egress deficient mouse strain and in a T−B+NK+ SCID patient

J. Puck, S. Watson, J. Cyster, 2008, Nature Immunology.

Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability

H. Jäck, A. Kelleher, K. J. Jackson, 2021, Immunity.

Molecular Profiling and Clonal Tracking of Secreted Rheumatoid Factors in Primary Sjögren's Syndrome

C. Goodnow, J. Reed, T. Gordon, 2018, Arthritis & rheumatology.

Positive versus negative signaling by lymphocyte antigen receptors.

C. Goodnow, J. I. Healy, Christopher C. Goodnow, 1998, Annual review of immunology.

erratum: How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis

C. Goodnow, D. Mack, J. I. Healy, 2000, Nature.

A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration

Brian V. Jenkins, S. Kay, E. Masliah, 2009, Proceedings of the National Academy of Sciences.

Role of Syk in B-cell development and antigen-receptor signaling.

T Pawson, T. Pawson, C. Goodnow, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

G. Crabtree, R. Dolmetsch, J. Cyster, 1997, Immunity.

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

Benjamin T. Porebski, G. Nolan, M. Cox, 2019, Nature Immunology.

T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency

A. Enders, C. Goodnow, S. Daley, 2010, Proceedings of the National Academy of Sciences.

Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

Timothy J. Peters, J. Trapani, F. Luciani, 2021, Nature Communications.

Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system.

C. Goodnow, P. Papathanasiou, 2005, Annual review of genetics.

Genetic lesions in T‐cell tolerance and thresholds for autoimmunity

D. Gray, A. Liston, C. Goodnow, 2005, Immunological reviews.

Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes

C. Goodnow, S. Lesage, S. Hartley, 2002, The Journal of experimental medicine.

Cell-intrinsic effects of non-MHC NOD genes on dendritic cell generation in vivo.

C. Goodnow, Simon J. Prasad, 2002, International immunology.

Novel approaches for identifying genes regulating lymphocyte development and function.

C. Goodnow, A. Loy, 2002, Current opinion in immunology.

Understanding the immunological impact of the human mutation explosion.

T. Andrews, C. Goodnow, G. Sjollema, 2013, Trends in immunology.

Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice

C. Goodnow, L. Rui, R. Brink, 2020, bioRxiv.

Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity

C. Goodnow, J. Reed, D. Christ, 2019, Immunological reviews.

Two levels of protection for the B cell genome during somatic hypermutation

D. Schatz, D. Richter, S. Kleinstein, 2008, Nature.

DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns.

Cathryn M. Gould, Timothy J. Peters, M. Rubin, 2019, Cancer cell.

Foxp 3 regulatory T cells exert asymmetric control over murine helper responses by inducing Th 2 cell apoptosis

L. Makaroff, A. Liston, C. Goodnow, 2011 .

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

S. Smith‐Gill, C. Goodnow, J. Crosbie, 1988, Nature.

Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB

C. Goodnow, S. Daley, Daniel Y. Hu, 2013, The Journal of experimental medicine.

Aire regulates negative selection of organ-specific T cells

L. Peltonen, A. Liston, C. Goodnow, 2003, Nature Immunology.

Genome-wide ENU mutagenesis to reveal immune regulators.

C. Goodnow, K. Nelms, Christopher C. Goodnow, 2001, Immunity.

Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing.

T. Behrens, C. Goodnow, M. Jenkins, 1998, Immunity.

B‐lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays

G. Ghandour, C. Goodnow, D. Mack, 2000, Immunological reviews.

Genes, pathways and checkpoints in lymphocyte development and homeostasis

L. Miosge, C. Goodnow, 2005, Immunology and cell biology.

Antigen-induced B-cell death and elimination during germinal-centre immune responses

K. Shokat, C. Goodnow, 1995, Nature.

Synergistic cooperation and crosstalk between MYD88L265P and mutations that dysregulate CD79B and surface IgM

P. Humburg, C. Goodnow, K. Horikawa, 2017, The Journal of experimental medicine.

Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren’s syndrome

M. Field, G. Huttley, P. Milburn, 2015, Journal of Translational Medicine.

Self-tolerance checkpoints in B lymphocyte development.

M. Cooke, J. Cyster, C. Goodnow, 1995, Advances in immunology.

B-cell tolerance.

C. Goodnow, 1992, Current opinion in immunology.

Expression of T cell receptor genes in an antigen-specific hybridoma and radiation-induced variants

M. Davis, C. Goodnow, C. Bona, 1986, The Journal of experimental medicine.

Variability and repertoire size of T-cell receptor Vα gene segments

Mark M. Davis, K. Arai, Y. Chien, 1985, Nature.

Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate

Timothy J. Peters, G. Smyth, S. Clark, 2021, Nucleic acids research.

Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson’s syndrome

A. Rimmer, C. Goodnow, T. Hough, 2013, The Journal of pathology.

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

Mark M. Davis, M. Cooke, C. Goodnow, 1995, Nature.

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

M. Cooke, C. Goodnow, A. W. Harris, 1993, Cell.

The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA

Yan Mei, T. Andrews, V. Cho, 2014, Genome Biology.

Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility

L. Notarangelo, K. Dobbs, Karin Chen, 2020, The Journal of experimental medicine.

Omenn syndrome associated with a functional reversion due to a somatic second-site mutation in CARD11 deficiency.

U. Pannicke, K. Schwarz, S. Ehl, 2015, Blood.

Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100.

M. Field, B. Whittle, C. Goodnow, 2014, Blood.

Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.

L. Makaroff, A. Liston, C. Goodnow, 2011, Blood.

Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy.

A. Liston, E. Bertram, C. Goodnow, 2011, The Journal of allergy and clinical immunology.

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

J. Penninger, L. Miosge, C. Goodnow, 2003, Immunity.

A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice

T. Andrews, S. Rosenzweig, L. Miosge, 2021, The Journal of Immunology.

Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor.

A. Perkins, S. Smale, C. Goodnow, 2003, Immunity.

A mechanism for Ikaros regulation of human globin gene switching

Michael R. Tallack, J. Dekker, A. Perkins, 2008, British Journal of Haematology.

Structural analysis of the myeloma-associated membrane antigen KMA.

C. Goodnow, R. Raison, 1985, Journal of immunology.

A repository of ENU mutant mouse lines and their potential for male fertility research

C. Goodnow, M. O’Bryan, M. Holland, 2005 .

Correction: HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse

D. Adelson, David M. Lawrence, C. Goodnow, 2015, PLoS genetics.

T-bet–dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow

J. Chun, L. Lanier, S. Watson, 2009, The Journal of experimental medicine.

Differential activationof transcription factors inducedbyCa 2 þ response amplitudeandduration

R. Dolmetsch, C. Goodnow, Richard S Lewis, 2022 .

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire

J. Cyster, C. Goodnow, S. Hartley, 1994, Nature.

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice

T. Andrews, E. Eyras, S. Nutt, 2021, bioRxiv.

Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases

A. Mawson, C. Goodnow, M. O’Bryan, 2021, Breast cancer research : BCR.

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

T. Andrews, M. Field, J. Cyster, 2013, eLife.

Regulation of mouse CD72 gene expression during B lymphocyte development.

C. Goodnow, J. I. Healy, J. Parnes, 1998, Journal of immunology.

ERK Signaling Is a Molecular Switch Integrating Opposing Inputs from B Cell Receptor and T Cell Cytokines to Control TLR4-Driven Plasma Cell Differentiation1

Christopher C. Goodnow, C. Goodnow, L. Rui, 2006, The Journal of Immunology.

TLR 4-Driven Plasma Cell Differentiation Receptor and T Cell Cytokines to Control Integrating Opposing Inputs from B Cell ERK Signaling Is a Molecular Switch

C. Goodnow, L. Rui, J. I. Healy, 2006 .

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

R. Flavell, C. Goodnow, J. Rathmell, 1996, Cell.

Loss of hnRNPLL‐dependent splicing of Ptprc has no impact on B‐cell development, activation and terminal differentiation into antibody‐secreting cells

A. Enders, C. Goodnow, G. Hoyne, 2020, Immunology and cell biology.

Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes

T. Andrews, M. Field, L. Miosge, 2014, Proceedings of the National Academy of Sciences.

Self Tolerance in the B‐Cell Repertoire

C. Goodnow, J. Crosbie, R. Brink, 1991, Immunological reviews.

The need for central and peripheral tolerance in the B cell repertoire.

C. Goodnow, A. Basten, S. Adelstein, 1990, Science.

CD19-Regulated Signaling Thresholds Control Peripheral Tolerance and Autoantibody Production in B Lymphocytes

C. Goodnow, M. Inaoki, T. Tedder, 1997, The Journal of experimental medicine.

Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.

P. Jeggo, C. Goodnow, R. Cornall, 2009, The Journal of clinical investigation.

C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

Christopher C. Goodnow, D. Fearon, C. Goodnow, 1996, Science.

Self-reactive B Cells Are Not Eliminated or Inactivated by Autoantigen Expressed on Thyroid Epithelial Cells

C. Goodnow, S. Akkaraju, K. Canaan, 1997, The Journal of experimental medicine.

A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.

M. Davis, C. Goodnow, W. Ho, 1997, Immunity.

Transgenic mice and analysis of B-cell tolerance.

C. Goodnow, 1992, Annual review of immunology.

Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling

C. Goodnow, Jesse E Jun, 2003, Nature Immunology.

Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen.

C. Goodnow, J. Crosbie, A. Basten, 1991, Science.

Bulk Segregation Mapping of Mutations in Closely Related Strains of Mice

B. Beutler, B. Whittle, C. Goodnow, 2010, Genetics.

Gene Dosage–limiting Role of Aire in Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

L. Peltonen, D. Gray, A. Liston, 2004, The Journal of experimental medicine.

Indirect presentation in the thymus limits naive and regulatory T‐cell differentiation by promoting deletion of self‐reactive thymocytes

C. Goodnow, S. Daley, A. Chan, 2018, Immunology.

Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint.

Timothy J. Peters, L. Miosge, C. Goodnow, 2022, Cell reports.

Overactive STAT3 drives accumulation of disease-associated CD21low B cells

Timothy J. Peters, S. Mustjoki, S. Tangye, 2021, bioRxiv.

Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint

Timothy J. Peters, L. Miosge, C. Goodnow, 2021, bioRxiv.

Breakdown of self-tolerance in anergic B lymphocytes

C. Goodnow, R. Brink, E. Adams, 1991, Nature.

Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion

T. Andrews, A. Sinclair, M. Field, 2016, PLoS genetics.

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3+ regulatory T cells

A. Strasser, P. Bouillet, C. Goodnow, 2019, Immunology and cell biology.

Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

Arthur Weiss, Adrian Liston, A. Liston, 2007, Immunity.

Analysis of an Ethylnitrosourea-generated Mouse Mutation Defines a Cell Intrinsic Role of Nuclear Factor κB2 in Regulating Circulating B Cell Numbers

L. Miosge, C. Goodnow, M. Bléry, 2002, The Journal of experimental medicine.

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.

J. Cyster, C. Goodnow, M. Hibbs, 1998, Immunity.

IL-2 prevents deletion of developing T-regulatory cells in the thymus

C. Goodnow, S. Daley, Rushika C. Wirasinha, 2017, Cell Death and Differentiation.

Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells

Diego G. Silva, C. Goodnow, K. Lam, 2011, Diabetes.

Visualizing the Role of Cbl-b in Control of Islet-Reactive CD4 T Cells and Susceptibility to Type 1 Diabetes

C. Goodnow, W. Langdon, G. Hoyne, 2011, The Journal of Immunology.

IL-10+CTLA-4+ Th2 Inhibitory Cells Form in a Foxp3-Independent, IL-2–Dependent Manner from Th2 Effectors during Chronic Inflammation

C. Goodnow, M. Cook, J. Altin, 2012, The Journal of Immunology.

B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects.

L. Notarangelo, S. Tangye, T. Phan, 2019, The Journal of allergy and clinical immunology.

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

C. Goodnow, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Immunological tolerance: Danger – pathogen on the premises!

C. Janeway, R. Medzhitov, C. Goodnow, 1996, Current Biology.

Candidate gene discovery in autoimmunity by using extreme phenotypes, next generation sequencing and whole exome capture.

M. Field, J. Anaya, C. Goodnow, 2015, Autoimmunity reviews.

Mouse strains with point mutations in TAP1 and TAP2

D. Tscharke, B. Whittle, A. Enders, 2010, Immunology and cell biology.

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

Diego G. Silva, C. Goodnow, P. Leedman, 2007, Nature.

CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells

C. Goodnow, E. Deenick, K. Horikawa, 2023, Frontiers in Immunology.

Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization

C. Goodnow, J. Reed, D. Christ, 2016, The Journal of experimental medicine.

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity

C. Goodnow, D. Kipling, R. Brink, 2014, Proceedings of the National Academy of Sciences.

A Role for Alström Syndrome Protein, Alms1, in Kidney Ciliogenesis and Cellular Quiescence

P. McNamara, R. Vega, C. Goodnow, 2006, PLoS genetics.

Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL.

Daniel E. Zak, D. Zak, A. Aderem, 2008, Immunity.

A critical role for complement in maintenance of self-tolerance.

C. Goodnow, M. Carroll, S. Goerg, 1998, Immunity.

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

Russell G. Jones, M. Febbraio, C. Goodnow, 2015, eLife.

Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene

W. Alexander, D. Hilton, M. Kauppi, 2006, Proceedings of the National Academy of Sciences.

COVID‐19, varying genetic resistance to viral disease and immune tolerance checkpoints

C. Goodnow, 2020, Immunology and cell biology.

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8− dendritic cells require the intramembrane endopeptidase SPPL2A

T. Andrews, M. Field, A. Rimmer, 2013, The Journal of experimental medicine.

Human transitional and IgMlow mature naïve B cells preserve permissive B‐cell receptors

Huji Xu, C. Goodnow, J. Reed, 2021, Immunology and cell biology.

B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle

Mandeep Singh, Fabio Luciani, Simone Rizzetto, 2017, bioRxiv.

Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells

Lawren C. Wu, C. Goodnow, M. Cook, 2014, Proceedings of the National Academy of Sciences.

SnapShot: Interactions between B Cells and T Cells

S. Tangye, T. Phan, C. Goodnow, 2015, Cell.

Tolerance mechanisms in the late phase of the antibody response.

C. Goodnow, L. Rui, C. Vinuesa, 2007, Advances in experimental medicine and biology.

Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice.

C. Goodnow, A. Basten, E. Adams, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Enhancement and suppression of signaling by the conserved tail of IgG memory–type B cell antigen receptors

Stephen W. Martin, C. Goodnow, K. Takatsu, 2007, The Journal of experimental medicine.

Manner from Th 2 Effectors during Chronic Dependent − in a Foxp 3-Independent , IL-2 Th 2 Inhibitory Cells Form + CTLA-4 + IL-10

C. Goodnow, M. Cook, J. Altin, 2012 .

Human lymphoma mutations reveal CARD11 as the switch between self-antigen–induced B cell death or proliferation and autoantibody production

Herman K. H. Fung, S. Nutt, C. Goodnow, 2012, The Journal of experimental medicine.

Analysis of B Cell Memory Formation Using DNA Microarrays

M. Cooke, I. Maclennan, C. Goodnow, 2002, Annals of the New York Academy of Sciences.

Axon growth and guidance genes identify T‐dependent germinal centre B cells

Di Yu, Pico Caroni, P. Caroni, 2008, Immunology and cell biology.

Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens

Benjamin T. Porebski, A. Buckle, C. Goodnow, 2020, Proceedings of the National Academy of Sciences.

Genomic-scale gene expression analysis of lymphocyte growth, tolerance and malignancy.

G. Ghandour, C. Goodnow, R. Glynne, 2000, Current opinion in immunology.

αβ T‐cell receptors with a central CDR3 cysteine are enriched in CD8αα intraepithelial lymphocytes and their thymic precursors

C. Goodnow, Mandeep Singh, S. Archer, 2018, Immunology and cell biology.

Decreased TCR signaling through Card11 differentially compromises Foxp3+ regulatory versus Th2 effector cells to cause allergy

A. Liston, E. Bertram, C. Goodnow, 2011 .

Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

J. DeVoss, D. Seshasayee, W. Sandoval, 2016, Nature.

ENU-mutagenesis: insight into immune function and pathology.

C. Goodnow, M. Cook, C. Vinuesa, 2006, Current opinion in immunology.

How host defense is encoded in the mammalian genome

B. Beutler, C. Goodnow, 2011, Mammalian Genome.

Class II-restricted presentation of an endogenously derived immunodominant T-cell determinant of hen egg lysozyme.

J. McCluskey, L. Kjer-Nielsen, C. Goodnow, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The essential role of DOCK 8 in humoral immunity

C. Goodnow, Katrina L. Randall, R. Cornall, 2014 .

Corrigendum: Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

L. Aravind, R. Schwartz, C. Goodnow, 2010, Nature Immunology.

Illuminating autoimmune regulators through controlled variation of the mouse genome sequence.

C. Goodnow, C. Vinuesa, 2004, Immunity.

Fat aussie--a new Alström syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis.

Diego G. Silva, N. Petrovsky, C. Goodnow, 2006, Molecular endocrinology.

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells

Timothy J. Peters, S. Mustjoki, S. Tangye, 2022, bioRxiv.

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

J. Sprent, S. Bröer, Yafei Zhang, 2011, Nature Immunology.

Clonal silencing of self-reactive B lymphocytes in a transgenic mouse model.

D. Mason, S. Smith‐Gill, C. Goodnow, 1989, Cold Spring Harbor symposia on quantitative biology.

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.

J. Cyster, C. Goodnow, Christopher C. Goodnow, 1995, Immunity.

Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations

Steve D. M. Brown, Ann-Marie Mallon, Gerton Lunter, 2013, PLoS genetics.

Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory

Stephen W. Martin, C. Goodnow, 2002, Nature Immunology.

The regulation of self-reactive B cells.

J. Cyster, C. Goodnow, R. Cornall, 1995, Current opinion in immunology.

Identification of a pathogenic variant in TREX1 in early-onset cerebral systemic lupus erythematosus by Whole-exome sequencing.

T. Andrews, V. Pascual, C. Goodnow, 2014, Arthritis & rheumatology.

DOCK8 deficiency diminishes thymic T‐regulatory cell development but not thymic deletion

C. Goodnow, Katrina L. Randall, S. Daley, 2021, Clinical & translational immunology.

Cellular mechanisms of self-tolerance.

C. Goodnow, 1989, Current opinion in immunology.

Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion

D. Tscharke, L. Miosge, Y. Sontani, 2017, Proceedings of the National Academy of Sciences.

CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells

J. Sprent, N. Bottini, C. Goodnow, 2016, Nature Communications.

Atp11c Is Critical for Phosphatidylserine Internalization and B Lymphocyte Differentiation Hhs Public Access Sequencing and Mutation Identification Generation of Bone Marrow Chimeras Annexin-v Staining Supplementary Material

J. Sprent, S. Bröer, Yafei Zhang, 2022 .

Entry of B Cell Receptor into Signaling Domains Is Inhibited in Tolerant B Cells

Anthony C. Bishop, K. Shokat, A. Bishop, 2000, The Journal of experimental medicine.

Immunology: Memory needs no reminders

Stephen W. Martin, C. Goodnow, 2000, Nature.

Lymphocyte homing: The scent of a follicle

J. Cyster, C. Goodnow, 1997, Current Biology.

Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation

C. Goodnow, I. Parish, R. Brink, 2017, Immunology and cell biology.

Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling

Susan R. Wilson, Y. Pittelkow, L. Makaroff, 2007, Genome Biology.

Growing up on the streets: why B-cell development differs from T-cell development.

C. Goodnow, S. E. Townsend, B. Weintraub, 1999, Immunology today.

STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis.

Timothy J. Peters, W. Al-Herz, S. Tangye, 2022, Journal of Allergy and Clinical Immunology.

Identification of a pathogenic variant in TREX1 in early-onset cerebral SLE by whole-exome sequencing.

T. Andrews, V. Pascual, M. Field, 2016, Pathology.

A monoclonal antibody with selectivity for human kappa myeloma and lymphoma cells which has potential as a therapeutic agent.

C. Goodnow, H. Boux, R. Raison, 1985, Advances in experimental medicine and biology.

STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles

Susan M. Corley, M. Wilkins, S. Tangye, 2018, Scientific Reports.

A repository of ENU mutant mouse lines and their potential for male fertility research.

C. Goodnow, M. O’Bryan, M. Holland, 2004, Molecular human reproduction.

DOCK8-Deficient CD4(+) T Cells are Biased to a Th2 Effector Fate at the Expense of Th1 and Th17 Cells.

J. Casanova, J. Orange, J. Ziegler, 2016 .

Self-Tolerance in B-Cells from Different Lines of Lysozyme Double-Transgenic Mice

D. Mason, C. Goodnow, J. Crosbie, 1989 .

Reducing the search space for causal genetic variants with VASP

T. Daniel Andrews, Carola G. Vinuesa, Matthew C. Cook, 2015, Bioinform..

High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes

F. Luciani, J. Blackburn, Martin A. Smith, 2018, Nature Communications.

Single epitope multiple staining to detect ultralow frequency B cells.

C. Goodnow, R. Cornall, S. E. Townsend, 2001, Journal of immunological methods.

Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment

Chuan-Sheng Foo, R. Horton, S. Watson, 2014 .

Tolerant Autoreactive B Lymphocytes in the Follicular Mantle Zone Compartment: Substrates for Receptor Editing and Reform

D. Mason, C. Goodnow, E. Adams, 1993 .

Understanding Immune Tolerance of Cancer: Re‐Purposing Insights from Fetal Allografts and Microbes

W. Cooper, C. Goodnow, S. Kao, 2018, BioEssays : news and reviews in molecular, cellular and developmental biology.

DOCK2-deficiency causes defects in anti-viral T cell responses and poor control of herpes simplex virus infection

D. Tscharke, I. Flesch, L. Miosge, 2023, bioRxiv.

Finding new immune regulatory genes by ENU mutagenesis

T. Andrews, L. Miosge, Y. Sontani, 2012, Journal of Translational Medicine.