R. Puca

发表

HIPK2--A therapeutical target to be (re)activated for tumor suppression: Role in p53 activation and HIF-1α inhibition

D. Givol, G. D’Orazi, L. Nardinocchi, 2010, Cell cycle.

HIPK2 modulates p53 activity towards pro-apoptotic transcription

Gideon Rechavi, David Givol, D. Givol, 2009, Molecular Cancer.

Targeting Hypoxia in Cancer Cells by Restoring Homeodomain Interacting Protein-Kinase 2 and p53 Activity and Suppressing HIF-1α

D. Givol, G. D’Orazi, L. Nardinocchi, 2009, PLoS ONE.

“Axitinib Affects Cell Viability and Migration of a Primary Foetal Lung Adenocarcinoma Culture”

E. Rendina, R. Puca, V. Petrozza, 2014, Cancer investigation.

A standardized laboratory and surgical method for in vitro culture isolation and expansion of primary human Tenon’s fibroblasts

R. Puca, E. Vingolo, G. Frati, 2012, Cell and Tissue Banking.

The Transcription Factor EGR1 Localizes to the Nucleolus and Is Linked to Suppression of Ribosomal Precursor Synthesis

D. Mercola, P. Roussel, M. Thiry, 2014, PloS one.

Peribiliary Glands as a Niche of Extrapancreatic Precursors Yielding Insulin‐Producing Cells in Experimental and Human Diabetes

R. Puca, G. Carpino, E. Gaudio, 2016, Stem cells.

HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation

G. D’Orazi, L. Nardinocchi, R. Puca, 2011, Aging.

Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth.

D. Guidolin, G. D’Orazi, G. Bossi, 2009, Biochimica et biophysica acta.

The Inhibition of KCa3.1 Channels Activity Reduces Cell Motility in Glioblastoma Derived Cancer Stem Cells

R. Puca, F. Franciolini, B. Fioretti, 2012, PloS one.

Influence of Egr-1 in Cardiac Tissue-Derived Mesenchymal Stem Cells in Response to Glucose Variations

R. Puca, G. Pompilio, Daniela Bastianelli, 2014, BioMed research international.

Homeodomain Interacting Protein Kinase 2: A Target for Alzheimer's Beta Amyloid Leading to Misfolded p53 and Inappropriate Cell Survival

M. Memo, G. D’Orazi, L. Nardinocchi, 2010, PloS one.

Extra-virgin olive oil phenols block cell cycle progression and modulate chemotherapeutic toxicity in bladder cancer cells

R. Puca, L. Mosca, E. Lendaro, 2016, Oncology reports.

Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc.

D. Givol, G. D’Orazi, G. Bossi, 2009, Experimental cell research.

Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.

D. Givol, G. D’Orazi, L. Nardinocchi, 2010, Free radical biology & medicine.

Morbid Obesity is Associated to Altered Fatty Acid Profile of Erythrocyte Membranes

R. Marfella, R. Puca, D. Pournaras, 2015 .

Mass spectrometry profiling of oxysterols in human sperm identifies 25-hydroxycholesterol as a marker of sperm function

R. Puca, L. Iuliano, R. Rago, 2016, Redox biology.

Adult Human Biliary Tree Stem Cells Differentiate to β-Pancreatic Islet Cells by Treatment with a Recombinant Human Pdx1 Peptide

Lola M. Reid, Vincenzo Cardinale, Guido Carpino, 2015, PloS one.

Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo

C. Leonetti, M. Porru, D. Givol, 2010, PloS one.

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells

D. Givol, G. D’Orazi, L. Nardinocchi, 2010, Oncogene.

Interaction of p53 with Mdm2 and azurin as studied by atomic force spectroscopy

S. Cannistraro, A. Bizzarri, G. D’Orazi, 2009, Journal of molecular recognition : JMR.

HIPK2 knock-down compromises tumor cell efficiency to repair damaged DNA.

G. D’Orazi, L. Nardinocchi, R. Puca, 2007, Biochemical and biophysical research communications.

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs

C. Leonetti, M. Porru, D. Givol, 2011, Cell cycle.

HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway

G. D’Orazi, L. Nardinocchi, R. Puca, 2007, Cell Death and Differentiation.

Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells.

G. D’Orazi, L. Nardinocchi, R. Puca, 2008, Gynecologic oncology.

Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown.

D. Notterman, E. Domany, C. Leonetti, 2008, Cancer research.

Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2

G. D’Orazi, L. Nardinocchi, R. Puca, 2008, Journal of experimental & clinical cancer research : CR.

A standardized laboratory and surgical method for in vitro culture isolation and expansion of primary human Tenon’s fibroblasts

R. Puca, E. Vingolo, G. Frati, 2013, Cell and Tissue Banking.

Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function

O. Margalit, A. Yosepovich, I. Barshack, 2012, International journal of cancer.

Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis

G. D’Orazi, L. Nardinocchi, R. Puca, 2009, Molecular Cancer.

Suitability of Human Tenon’s Fibroblasts as Feeder Cells for Culturing Human Limbal Epithelial Stem Cells

R. Puca, E. Vingolo, A. Polistena, 2013, Stem Cell Reviews and Reports.

Counteracting MDM2‐induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells

D. Givol, G. D’Orazi, L. Nardinocchi, 2010, FEBS letters.

Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells.

G. D’Orazi, L. Nardinocchi, R. Puca, 2008, Gynecologic oncology.

Influence of Egr-1 in Cardiac Tissue-Derived Mesenchymal Stem Cells in Response to Glucose Variations

R. Puca, G. Pompilio, Daniela Bastianelli, 2014, BioMed research international.