J. Zempleni

J. Zempleni, J. B. Griffin, J. S. Stanley, 2002, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

Oxidative folding of interleukin-2 is impaired in flavin-deficient jurkat cells, causing intracellular accumulation of interleukin-2 and increased expression of stress response genes.

J. Zempleni, G. Camporeale, 2003, The Journal of nutrition.

Interleukin-2 receptor-γ-dependent endocytosis depends on biotin in Jurkat cells

J. Zempleni, J. B. Griffin, G. Camporeale, 2003 .

14 Ascorbic Acid

J. Gregory, C. Johnston, J. Zempleni, 2013 .

Milk-Derived Exosomes and Metabolic Regulation.

J. Zempleni, Fang Zhou, E. Mutai, 2019, Annual review of animal biosciences.

Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster.

J. Zempleni, F. Döring, S. Onur, 2015, The Journal of nutritional biochemistry.

Novel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism.

J. Zempleni, Dandan Liu, E. Cordonier, 2014, Nutrition reviews.

Cytosine methylation in miR-153 gene promoters increases the expression of holocarboxylase synthetase, thereby increasing the abundance of histone H4 biotinylation marks in HEK-293 human kidney cells.

J. Zempleni, B. Bao, R. Rodriguez‐Melendez, 2012, The Journal of nutritional biochemistry.

A nutrient-sensing hexosamine signaling pathway.

J. Zempleni, K. Dakshinamurti, J. Hanover, 2005 .

Gene regulation by dietary microRNAs1

J. Zempleni, 2016 .

Inhibition of acetyl-CoA carboxylases by soraphen A prevents lipid accumulation and adipocyte differentiation in 3T3-L1 cells.

J. Zempleni, E. Cordonier, Sarah K Jarecke, 2016, European journal of pharmacology.

Anabolic effects of amino acids and insulin in the liver.

J. Zempleni, K. Dakshinamurti, L. Hue, 2005 .

Biotin biochemistry and human requirements.

J. Zempleni, D. Mock, 1999, The Journal of nutritional biochemistry.

Mechanisms for dietary regulation of nitric oxide synthesis in mammals.

J. Zempleni, K. Dakshinamurti, C. Meininger, 2005 .

Nuclear receptors and epigenetic regulation: opportunities for nutritional targeting and disease prevention.

Janos Zempleni, J. Zempleni, D. Romagnolo, 2014, Advances in nutrition.

Biotinylation of histones in human cells

J. Zempleni, J. B. Griffin, J. S. Stanley, 2001 .

Biotinylation of histones in human cells. Effects of cell proliferation.

J. Zempleni, J. B. Griffin, J. S. Stanley, 2001, European journal of biochemistry.

Handbook of Vitamins, Fifth Edition

Jesse, J. Zempleni, P. Stover, 2013 .

The influence of lipids on nuclear protein import, cell growth, and gene expression.

M. Czubryt, J. Zempleni, K. Dakshinamurti, 2005 .

Identification and assessment of markers of biotin status in healthy adults

J. Zempleni, Dong Wang, B. Lee, 2013, British Journal of Nutrition.

Within meal feed back signalling

J. Zempleni, K. Dakshinamurti, J. Halford, 2004 .

The Bioavailability and Distribution of Bovine Milk Exosomes is Distinct from that of their Cargos in Mice

J. Zempleni, D. Giraud, S. Manca, 2017 .

Bioavailability and Biodistribution of Fluorophore‐labeled Exosomes from Cow's Milk after Intravenous and Oral Administration in C57Bl/6J Mice

J. Zempleni, D. Giraud, S. Manca, 2016 .

Vitamin D-regulated pathways: impact on cell proliferation, differentiation, and apoptosis.

J. Welsh, J. Zempleni, K. Dakshinamurti, 2005 .

Advanced nutrition : macronutrients, micronutrients, and metabolism

C. Berdanier, J. Zempleni, 2008 .

Bovine milk-derived extracellular vesicles enhance inflammation and promote M1 polarization following agricultural dust exposure in mice.

D. Romberger, J. Zempleni, B. Swanson, 2019, The Journal of nutritional biochemistry.

Biotin uptake into human peripheral blood mononuclear cells increases early in the cell cycle, increasing carboxylase activities.

J. Zempleni, D. Mock, J. B. Griffin, 2002, The Journal of nutrition.

The utilization of intravenously infused pyridoxine in humans.

J. Zempleni, W. Kübler, Janos Zempleni, 1994, Clinica chimica acta; international journal of clinical chemistry.

NIH workshop on human milk composition: summary and visions.

L. Allen, M. Neville, R. Olson, 2019, The American journal of clinical nutrition.

Review: Milk Small Extracellular Vesicles for Use in the Delivery of Therapeutics

J. Zempleni, Denise M. O. Ramirez, Javaria Munir, 2022, Pharmaceutical Research.

In vivo biotin supplementation at a pharmacologic dose decreases proliferation rates of human peripheral blood mononuclear cells and cytokine release.

R. Helm, J. Zempleni, D. Mock, 2001, The Journal of nutrition.

Milk exosomes in nutrition and drug delivery.

J. Zempleni, Haichuan Wang, Afsana Khanam, 2022, American journal of physiology. Cell physiology.

Preliminary evidence that lectins in infant soy formula apparently bind bovine milk exosomes and prevent their absorption in healthy adults

J. Zempleni, E. Mutai, Alice Ngu, 2021, BMC Nutrition.

Mechanisms of gene transcriptional regulation through biotin and biotin-binding proteins in mammals

J. Zempleni, Dandan Liu, Daniel Câmara Teixeira, 2013 .

Proliferation of peripheral blood mononuclear cells causes increased expression of the sodium-dependent multivitamin transporter gene and increased uptake of pantothenic acidopen star

J. Zempleni, D. Mock, J. Steven Stanley, 2001, The Journal of nutritional biochemistry.

Proliferation of peripheral blood mononuclear cells increases riboflavin influx.

J. Zempleni, D. Mock, 2000 .

Human peripheral blood mononuclear cells: ; Inhibition of biotin transport by reversible competition with pantothenic acid is quantitatively minor.

J. Zempleni, D. Mock, 1999, The Journal of nutritional biochemistry.

The efflux of biotin from human peripheral blood mononuclear cells.

J. Zempleni, D. Mock, D. M. Mock, 1999, The Journal of nutritional biochemistry.

Overview to symposium "Nutrients and epigenetic regulation of gene expression".

J. Zempleni, E. Ho, 2009, The Journal of nutrition.

Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and lifespan and alters gene expression and histone biotinylation patterns.

J. Zempleni, J. C. Eissenberg, J. Shoemaker, 2007, The Journal of nutrition.

Lipoic acid reduces the activities of biotin-dependent carboxylases in rat liver.

J. Zempleni, D. Mock, Timothy A. Trusty, 1997, The Journal of nutrition.

Lipoic acid (thioctic acid) analogs, tryptophan analogs, and urea do not interfere with the assay of biotin and biotin metabolites by high-performance liquid chromatography/avidin-binding assay☆

J. Zempleni, D. Mock, D. B. Mccormick, 1996 .

Glucocorticoid Cell Priming Enhances Transfection Outcomes in Adult Human Mesenchymal Stem Cells.

J. Zempleni, A. Pannier, Sarah A. Plautz, 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

Prokaryotic BirA ligase biotinylates K4, K9, K18 and K23 in histone H3.

J. Zempleni, G. Sarath, Keyna Kobza, 2008, BMB reports.

Prokaryotic BirA ligase biotinylates K 4 , K 9 , K 18 and K 23 in histone H 3 †

J. Zempleni, G. Sarath, Keyna Kobza, 2008 .

Diaminobiotin and desthiobiotin have biotin-like activities in Jurkat cells.

J. Zempleni, B. Lewis, R. Mcmahon, 2003, The Journal of nutrition.

A 96-well plate assay for high-throughput analysis of holocarboxylase synthetase activity.

J. Zempleni, Luisa Rios‐Avila, Sara A Prince, 2011, Clinica chimica acta; international journal of clinical chemistry.

Biotin

J. Zempleni, W. Penberthy, M. Sadri, 2019, Reactions Weekly.

Development of an internet based system for modeling biotin metabolism using Bayesian networks

Dong Wang, Jinglei Zhou, Vicki Schlegel, 2011, Comput. Methods Programs Biomed..

6 Riboflavin (Vitamin B )

J. Gregory, J. Zempleni, R. Rivlin, 2013 .

Nutrition, Histone Epigenetic Marks, and Disease

J. Zempleni, Dandan Liu, J. Xue, 2013 .

Uptake, localization, and noncarboxylase roles of biotin.

J. Zempleni, 2005, Annual review of nutrition.

Biotin and biotinidase deficiency

J. Zempleni, Y. Hassan, Subhashinee S. K. Wijeratne, 2008, Expert review of endocrinology & metabolism.

Effects of single nucleotide polymorphisms in the human holocarboxylase synthetase gene on catalytic activity

J. Zempleni, Shingo Esaki, 2011 .

Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus.

J. Zempleni, G. Camporeale, Michael Gralla, 2008, The Journal of nutritional biochemistry.

K12-biotinylated histone H4 marks heterochromatin in human lymphoblastoma cells.

J. Zempleni, G. Sarath, J. B. Griffin, 2007, The Journal of nutritional biochemistry.

An avidin-based assay for histone debiotinylase activity in human cell nuclei.

J. Zempleni, G. Sarath, Y. Chew, 2007, The Journal of nutritional biochemistry.

K12 biotinylated histone H4 is enriched at human endogenous retrovirus promoter regions and may function in retroviral silencing

J. Zempleni, Y. Chew, J. T. West, 2007 .

Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases.

J. Zempleni, J. C. Eissenberg, G. Camporeale, 2007, The Journal of nutrition.

Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance.

J. Zempleni, E. Giordano, J. C. Eissenberg, 2006, The Journal of nutrition.

Lysine residues in N-terminal and C-terminal regions of human histone H2A are targets for biotinylation by biotinidase.

Janos Zempleni, Gautam Sarath, J. Zempleni, 2006, The Journal of nutritional biochemistry.

Biotinylation of K12 in histone H4 decreases in response to DNA double-strand breaks in human JAr choriocarcinoma cells.

Janos Zempleni, Gautam Sarath, J. Zempleni, 2005, The Journal of nutrition.

K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase

Janos Zempleni, Gautam Sarath, J. Zempleni, 2005, The FEBS journal.

K8 and K12 are biotinylated in human histone H4.

Janos Zempleni, Gautam Sarath, J. Zempleni, 2004, European journal of biochemistry.

Monocarboxylate transporter 1 mediates biotin uptake in human peripheral blood mononuclear cells.

J. Zempleni, J. B. Griffin, R. Cederberg, 2003, The Journal of nutrition.

Biotin dependency due to a defect in biotin transport

M. Jennings, S. Cederbaum, J. Zempleni, 2002 .

Biotinidase catalyzes debiotinylation of histones

J. Zempleni, J. Wolff, J. B. Griffin, 2002, European journal of nutrition.

Biotin dependency due to a defect in biotin transport.

M. Jennings, S. Cederbaum, J. Zempleni, 2002, The Journal of clinical investigation.

Marginal biotin deficiency is teratogenic.

J. Zempleni, D. Mock, Janos Zempleni, 2000, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Identification of biotin sulfone, bisnorbiotin methyl ketone, and tetranorbiotin-l-sulfoxide in human urine.

J. Zempleni, D. Mock, D. B. Mccormick, 1997, The American journal of clinical nutrition.

Regulation of gene expression by biotin (review).

J. Zempleni, R. Rodriguez‐Melendez, 2003, The Journal of nutritional biochemistry.

Biotin

J. Zempleni, Y. Hassan, Subhashinee S. K. Wijeratne, 2021, Reactions Weekly.

Advanced analysis of biotin metabolites in body fluids allows a more accurate measurement of biotin bioavailability and metabolism in humans.

J. Zempleni, D. Mock, 1999, The Journal of nutrition.

Effects of single-nucleotide polymorphisms in the human holocarboxylase synthetase gene on enzyme catalysis

S. Malkaram, J. Zempleni, Shingo Esaki, 2011, European Journal of Human Genetics.

Biotin regulates the expression of holocarboxylase synthetase in the miR-539 pathway in HEK-293 cells.

J. Zempleni, B. Bao, R. Rodriguez‐Melendez, 2010, The Journal of nutrition.

Biotin availability regulates expression of the sodium-dependent multivitamin transporter and the rate of biotin uptake in HepG2 cells.

J. Zempleni, R. S. Solórzano-Vargas, A. González-Noriega, 2005, Molecular genetics and metabolism.

Biotin supply affects rates of cell proliferation, biotinylation of carboxylases and histones, and expression of the gene encoding the sodium-dependent multivitamin transporter in JAr choriocarcinoma cells

J. Zempleni, J. B. Griffin, H. Said, 2004, European journal of nutrition.

Biotin

J. Zempleni, Y. Hassan, Subhashinee S. K. Wijeratne, 2018, Reactions Weekly.

blood mononuclear cells Uptake and metabolism of biotin by human peripheral

J. Zempleni, D. Mock, 2016 .

Epigenetic regulation of chromatin structure and gene function by biotin: are biotin requirements being met?

J. Zempleni, Y. Hassan, Y. Chew, 2008, Nutrition reviews.

Epigenetic regulation of chromatin structure and gene function by biotin.

J. Zempleni, Y. Hassan, 2006, The Journal of nutrition.

Marginal Biotin Deficiency is Teratogenic (44458)

J. Zempleni, D. Mock, 2000 .

Uptake and metabolism of biotin by human peripheral blood mononuclear cells.

J. Zempleni, D. Mock, 1998, The American journal of physiology.

Uptake and metabolism of biotin by human peripheral blood mononuclear cells.

J. Zempleni, D. Mock, 1998, American journal of physiology. Cell physiology.

Use of synthetic peptides for identifying biotinylation sites in human histones.

J. Zempleni, G. Sarath, G. Camporeale, 2008, Methods in molecular biology.

Vitamin-Dependent Modifications of Chromatin: Epigenetic Events and Genomic Stability

J. Zempleni, J. Christman, J. Kirkland, 2007 .

Roles for biotinylation of histones in chromatin structure

J. Zempleni, G. Sarath, G. Camporeale, 2005 .

Biotin supply affects expression of biotin transporters, biotinylation of carboxylases and metabolism of interleukin-2 in Jurkat cells.

J. Zempleni, J. B. Griffin, Karoline C. Manthey, 2002, The Journal of nutrition.

Holocarboxylase synthetase knockout is embryonic lethal in mice

J. Zempleni, Haichuan Wang, T. Kuroishi, 2022, PloS one.

Holocarboxylase synthetase interacts physically with nuclear receptor co-repressor, histone deacetylase 1 and a novel splicing variant of histone deacetylase 1 to repress repeats.

J. Zempleni, Dandan Liu, 2014, The Biochemical journal.

Biotinylation of lysine 16 in histone H4 contributes toward nucleosome condensation.

J. Zempleni, Mahendra P. Singh, Subhashinee S. K. Wijeratne, 2013, Archives of biochemistry and biophysics.

K16-biotinylated histone H4 is overrepresented in repeat regions and participates in the repression of transcriptionally competent genes in human Jurkat lymphoid cells.

J. Zempleni, V. Pestinger, Luisa Rios‐Avila, 2012, Journal of Nutritional Biochemistry.

Novel histone biotinylation marks are enriched in repeat regions and participate in repression of transcriptionally competent genes.

J. Zempleni, V. Pestinger, R. Rodriguez‐Melendez, 2011, The Journal of nutritional biochemistry.

K12-biotinylated histone H4 is enriched in telomeric repeats from human lung IMR-90 fibroblasts.

J. Zempleni, G. Camporeale, Subhashinee S. K. Wijeratne, 2010, The Journal of nutritional biochemistry.

The polypeptide Syn67 interacts physically with human holocarboxylase synthetase, but is not a target for biotinylation.

J. Zempleni, H. Moriyama, Y. Hassan, 2010, Archives of biochemistry and biophysics.

Repression of transposable elements by histone biotinylation.

J. Zempleni, B. Bao, Y. Chew, 2009, The Journal of nutrition.

N- and C-terminal domains in human holocarboxylase synthetase participate in substrate recognition.

J. Zempleni, H. Moriyama, X. Bi, 2009, Molecular genetics and metabolism.

Nitric oxide signaling depends on biotin in Jurkat human lymphoma cells

J. Zempleni, R. Rodriguez‐Melendez, 2009, The Journal of nutrition.

Repression of Transposable Elements by Histone Biotinylation 1 , 2

J. Zempleni, B. Bao, Y. Chew, 2009 .

Biotinyl-methyl 4-(amidomethyl)benzoate is a competitive inhibitor of human biotinidase.

J. Zempleni, G. Sarath, J. M. Takacs, 2008, The Journal of nutritional biochemistry.

A novel, enigmatic histone modification: biotinylation of histones by holocarboxylase synthetase.

J. Zempleni, Y. Hassan, 2008, Nutrition reviews.

Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster.

J. Zempleni, L. Harshman, H. Kabil, 2004, The Journal of nutritional biochemistry.

The nuclear abundance of transcription factors Sp1 and Sp3 depends on biotin in Jurkat cells.

J. Zempleni, J. B. Griffin, R. Rodriguez‐Melendez, 2003, The Journal of nutrition.

Expression of oncogenes depends on biotin in human small cell lung cancer cells NCI-H69.

J. Zempleni, Sarah B. Scheerger, 2003, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

Nutrition and Cancer Biotinylation of K 12 in Histone H 4 Decreases in Response to DNA Double-Strand Breaks in Human JAr Choriocarcinoma Cells 1 , 2

J. Zempleni, G. Sarath, N. Kothapalli, 2005 .

Biotinylation is a natural, albeit rare, modification of human histones.

J. Zempleni, T. Kuroishi, V. Pestinger, 2011, Molecular genetics and metabolism.

Biological functions of biotinylated histones.

J. Zempleni, J. B. Griffin, G. Camporeale, 2005, The Journal of nutritional biochemistry.

Biotin homeostasis during the cell cycle

J. Zempleni, D. Mock, J Zempleni, 2001, Nutrition Research Reviews.

Utilization of biotin in proliferating human lymphocytes.

J. Zempleni, D. Mock, D. M. Mock, 2000, The Journal of nutrition.

Symposium : Mechanistic Aspects of Vitamin and Coenzyme Utilization and Function : A Symposium in Recognition of the Distinguished Career of Donald B . McCormick Utilization of Biotin in Proliferating Human Lymphocytes 1 , 2

J. Zempleni, D. Mock, 2000 .

Chemical synthesis of biotinylated histones and analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis/streptavidin-peroxidase.

J. Zempleni, D. Mock, 1999, Archives of biochemistry and biophysics.

The role of holocarboxylase synthetase in genome stability is mediated partly by epigenomic synergies between methylation and biotinylation events

J. Zempleni, J. Xue, E. Cordonier, 2011, Epigenetics.

Biotin requirements for DNA damage prevention.

J. Zempleni, T. Kuroishi, Scott R. Baier, 2012, Mutation research.

High-throughput immunoblotting identifies biotin-dependent signaling proteins in HepG2 hepatocarcinoma cells.

J. Zempleni, G. Sarath, J. B. Griffin, 2005, The Journal of nutrition.

Biotin deficiency stimulates survival pathways in human lymphoma cells exposed to antineoplastic drugs.

J. Zempleni, J. B. Griffin, 2005, The Journal of nutritional biochemistry.

Clusters of biotin-responsive genes in human peripheral blood mononuclear cells.

S. Wiedmann, J. Zempleni, D. Ortega-Cuellar, 2004, The Journal of nutritional biochemistry.

Nutrient-Gene Interactions The Nuclear Abundance of Transcription Factors Sp 1 and Sp 3 Depends on Biotin in Jurkat Cells 1

J. Zempleni, J. B. Griffin, R. Rodriguez‐Melendez, 2003 .

Holocarboxylase synthetase is a chromatin protein and interacts directly with histone H3 to mediate biotinylation of K9 and K18.

G. Borgstahl, J. Zempleni, Y. Hassan, 2011, The Journal of nutritional biochemistry.

Biotin supplementation increases expression of the cytochrome P450 1B1 gene in Jurkat cells, increasing the occurrence of single-stranded DNA breaks.

J. Zempleni, J. B. Griffin, R. Rodriguez‐Melendez, 2004, The Journal of nutrition.

Sodium-dependent multivitamin transporter gene is regulated at the chromatin level by histone biotinylation in human Jurkat lymphoblastoma cells.

J. Zempleni, Y. Hassan, G. Camporeale, 2009, The Journal of nutrition.

Pantothenic acid and biotin

J. Zempleni, G. Camporeale, R. Rodriguez‐Melendez, 2005 .

Biotin supplementation increases expression of genes encoding interferon-gamma, interleukin-1beta, and 3-methylcrotonyl-CoA carboxylase, and decreases expression of the gene encoding interleukin-4 in human peripheral blood mononuclear cells.

S. Wiedmann, J. Zempleni, J. Eudy, 2003, The Journal of nutrition.

Exposure to UV light causes increased biotinylation of histones in Jurkat cells.

J. Zempleni, J. B. Griffin, M. Beck, 2002, American journal of physiology. Cell physiology.

Biliary excretion of biotin and biotin metabolites is quantitatively minor in rats and pigs.

J. Zempleni, D. Mock, G. Green, 1997, The Journal of nutrition.

Lysine biotinylation and methionine oxidation in the heat shock protein HSP60 synergize in the elimination of reactive oxygen species in human cell cultures.

S. Malkaram, J. Zempleni, Jie Zhou, 2014, The Journal of nutritional biochemistry.

Riboflavin deficiency causes protein and DNA damage in HepG2 cells, triggering arrest in G1 phase of the cell cycle.

J. Zempleni, Karoline C. Manthey, R. Rodriguez‐Melendez, 2006, The Journal of nutritional biochemistry.

The expression of genes encoding ribosomal subunits and eukaryotic translation initiation factor 5A depends on biotin and bisnorbiotin in HepG2 cells.

J. Zempleni, J. B. Griffin, R. Rodriguez‐Melendez, 2006, The Journal of nutritional biochemistry.

Biotinylation of histones represses transposable elements in human and mouse cells and cell lines and in Drosophila melanogaster.

Janos Zempleni, B. Dave, J. Zempleni, 2008, The Journal of nutrition.

Biotinylation of K8 and K12 co‐occurs with acetylation and mono‐methylation in human histone H4

J. Zempleni, G. Sarath, Y. Chew, 2006 .

Roles for nutrients in epigenetic events.

J. Zempleni, G. Sarath, J. B. Griffin, 2005, The Journal of nutritional biochemistry.

Biotin supplementation decreases the expression of the SERCA3 gene (ATP2A3) in Jurkat cells, thus, triggering unfolded protein response.

J. Zempleni, F. Wuytack, J. B. Griffin, 2006, The Journal of nutritional biochemistry.

Jurkat cells respond to biotin deficiency with increased nuclear translocation of NF-kappaB, mediating cell survival.

J. Zempleni, R. Rodriguez‐Melendez, Lyndsay D Schwab, 2004, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

Biokinetic analysis of vitamin absorption and disposition in humans.

J. Zempleni, 1997, Methods in enzymology.

Bioavailability of biotin given orally to humans in pharmacologic doses.

J. Zempleni, D. Mock, 1999, The American journal of clinical nutrition.

Marginal biotin deficiency is teratogenic.

J. Zempleni, D. Mock, 2000, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Regulation of gene expression by biotin, vitamin B6 and vitamin C

J. Zempleni, K. Dakshinamurti, H. Daniel, 2003 .

Epigenetic Synergies Between Biotin and Folate in the Regulation of Pro‐Inflammatory Cytokines and Repeats

J. Zempleni, J. Xue, 2013, Scandinavian journal of immunology.

Holocarboxylase synthetase interacts physically with euchromatic histone-lysine N-methyltransferase, linking histone biotinylation with methylation events.

J. Zempleni, H. Moriyama, Y. Hassan, 2013, The Journal of nutritional biochemistry.

Holocarboxylase synthetase synergizes with methyl CpG binding protein 2 and DNA methyltransferase 1 in the transcriptional repression of long-terminal repeats

Janos Zempleni, J. Zempleni, Jing Xue, 2013, Epigenetics.

Enrichment of meiotic recombination hotspot sequences by avidin capture technology

S. Malkaram, J. Zempleni, Daniel Câmara Teixeira, 2013, Gene.

Human holocarboxylase synthetase with a start site at methionine-58 is the predominant nuclear variant of this protein and has catalytic activity.

J. Zempleni, B. Bao, R. Rodriguez‐Melendez, 2011, Biochemical and biophysical research communications.

8 Pantothenic Acid

J. Gregory, J. Zempleni, P. Stover, 2013 .

Intrauterine elimination of pyridoxal 5'-phosphate in full-term and preterm infants.

J. Zempleni, G. Link, 1996, The American journal of clinical nutrition.

Nuclear receptors and dietary ligands.

J. Zempleni, K. Dakshinamurti, M. Jacobs, 2005 .

Milk exosomes: beyond dietary microRNAs

J. Zempleni, 2017, Genes & Nutrition.

Determination of riboflavin and flavocoenzymes in human blood plasma by high-performance liquid chromatography.

J. Zempleni, 1995, Annals of nutrition & metabolism.

3 Vitamin K

J. Gregory, J. Zempleni, P. Stover, 2013 .

Alterations in glutamate trafficking and signal transduction pathways in hyperammonemia.

R. Butterworth, J. Zempleni, K. Dakshinamurti, 2005 .

Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

J. Zempleni, Bijaya Upadhyaya, E. Mutai, 2018, Scientific Reports.

Depletion of Dietary Bovine Milk Exosomes Impairs Sensorimotor Gating and Spatial Learning in C57BL/6 Mice

J. Zempleni, Fang Zhou, E. Mutai, 2017 .

MicroRNAs and exosomes in human milk

J. Zempleni, 2021 .

Concentrations of Purine Metabolites Are Elevated in Fluids from Adults and Infants and in Livers from Mice Fed Diets Depleted of Bovine Milk Exosomes and their RNA Cargos.

J. Adamec, J. Zempleni, A. Andres, 2018, The Journal of nutrition.

A diet defined by its content of bovine milk exosomes and their RNA cargos has moderate effects on gene expression, amino acid profiles and grip strength in skeletal muscle in C57BL/6 mice.

J. Adamec, J. Zempleni, J. Cui, 2018, The Journal of nutritional biochemistry.

Dietary Bovine Milk Exosomes Elicit Changes in Microbial Communities in C57BL/6 Mice

S. Fernando, J. Zempleni, S. Kachman, 2018, bioRxiv.

Biological Activities of Extracellular Vesicles and Their Cargos from Bovine and Human Milk in Humans and Implications for Infants.

J. Zempleni, Fang Zhou, E. Mutai, 2017, The Journal of nutrition.

Gene regulation by dietary microRNAs.

J. Zempleni, J. Cui, K. Howard, 2015, Canadian journal of physiology and pharmacology.

Ruminant Milk-Derived Extracellular Vesicles: A Nutritional and Therapeutic Opportunity?

C. Blenkiron, J. Zempleni, Alejandra Acevedo-Fani, 2021, Nutrients.

Milk exosomes and microRNAs cross the placenta and promote embryo survival in mice.

J. Zempleni, S. Kachman, J. Cui, 2020, Reproduction.

MicroRNAs in bovine milk exosomes are bioavailable in humans but do not elicit a robust pro-inflammatory cytokine response

J. Zempleni, A. Ramer-Tait, E. Mutai, 2020, ExRNA.

RNase H2-Dependent Polymerase Chain Reaction and Elimination of Confounders in Sample Collection, Storage, and Analysis Strengthen Evidence That microRNAs in Bovine Milk Are Bioavailable in Humans.

J. Zempleni, Lanfang Wang, D. Giraud, 2018, The Journal of nutrition.

MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers.

J. Zempleni, J. Wood, Scott R. Baier, 2014, The Journal of nutrition.

Quantitation of Exosomes and Their MicroRNA Cargos in Frozen Human Milk

A. Delaney, J. Zempleni, Haichuan Wang, 2022, JPGN reports.

Bovine mammary alveolar MAC-T cells afford a tool for studies of bovine milk exosomes in drug delivery.

J. Zempleni, Haichuan Wang, M. Ogunnaike, 2021, International journal of pharmaceutics.

Comment on "The Role of Human Breast-Milk Extracellular Vesicles in Child Health and Disease".

J. Zempleni, 2021, Advances in nutrition.

Metabolism of vitamin B6 by human kidney

J. Zempleni, W. Kübler, 1995 .

Amino acid-sensing mTOR signaling.

J. Zempleni, K. Dakshinamurti, Jie Chen, 2005 .

Milk Exosomes Cross the Blood-Brain Barrier in Murine Cerebral Cortex Endothelial Cells and Promote Dendritic Complexity in the Hippocampus and Brain Function in C57BL/6J Mice

Haluk Dogan, J. Zempleni, Pengyun Ji, 2021, bioRxiv.

2 Vitamin D

J. Gregory, J. Zempleni, Wei Zheng, 2013 .

Nutrient signaling to muscle and adipose tissue by leucine.

J. Zempleni, K. Dakshinamurti, C. Lynch, 2005 .

Three promoters regulate the transcriptional activity of the human holocarboxylase synthetase gene.

S. Malkaram, J. Zempleni, Mengna Xia, 2013, The Journal of nutritional biochemistry.

1 Vitamin A: Nutritional Aspects of Retinoids and Carotenoids

J. Gregory, J. Zempleni, P. Stover, 2013 .

Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice

J. Zempleni, Jiujiu Yu, S. Kachman, 2020, Nutrients.

Genomic Implications of H2O2 for Cell Proliferation and Growth of Caco-2 Cells

J. Zempleni, S. Cuppett, Theresa A. Herring, 2007, Digestive Diseases and Sciences.

Off-target effects of sulforaphane include the derepression of long terminal repeats through histone acetylation events.

J. Zempleni, V. Schlegel, Scott R. Baier, 2014, The Journal of nutritional biochemistry.

Extracellular Vesicles and Circulating Nucleic Acids

Akers, D. Steindler, H. Sultana, 2021 .

Low activity of LSD1 elicits a pro-inflammatory gene expression profile in riboflavin-deficient human T Lymphoma Jurkat cells

J. Zempleni, Dandan Liu, 2014, Genes & Nutrition.

Diet, DNA methylation and cancer.

J. Zempleni, J. Christman, H. Daniel, 2003 .

16 Vitamin–Genome Interactions

J. Gregory, J. Zempleni, P. Stover, 2013 .

Storage of Extracellular Vesicles in Human Milk, and MicroRNA Profiles in Human Milk Exosomes and Infant Formulas.

J. Zempleni, J. Cui, Jiang Shu, 2019, Journal of pediatric gastroenterology and nutrition.

Dietary MicroRNA Database (DMD): An Archive Database and Analytic Tool for Food-Borne microRNAs

Jiang Shu, Juan Cui, Janos Zempleni, 2015, PloS one.

Human vascular endothelial cells transport foreign exosomes from cow's milk by endocytosis.

J. Zempleni, Sonal Sukreet, R. Kusuma, 2016, American journal of physiology. Cell physiology.

The Intestinal Transport of Bovine Milk Exosomes Is Mediated by Endocytosis in Human Colon Carcinoma Caco-2 Cells and Rat Small Intestinal IEC-6 Cells.

J. Zempleni, Scott R. Baier, T. Wolf, 2015, The Journal of nutrition.

Diet-responsive MicroRNAs Are Likely Exogenous

K. Hirschi, J. Zempleni, Scott R. Baier, 2015, The Journal of Biological Chemistry.

Loss of miRNAs during processing and storage of cow's (Bos taurus) milk.

J. Zempleni, J. Vanamala, Laura Markham, 2015, Journal of agricultural and food chemistry.

Holocarboxylase synthetase catalyzes biotinylation of heat shock protein 72, thereby inducing RANTES expression in HEK-293 cells.

J. Zempleni, Jie Zhou, J. Xue, 2013, American journal of physiology. Cell physiology.

Pharmacokinetics of vitamin B6 supplements in humans.

J. Zempleni, 1995, Journal of the American College of Nutrition.

Utilization of intravenously infused thiamin hydrochloride in healthy adult males

J. Zempleni, S. Vogel, M. Hagen, 1996 .

The transport of thiamine, riboflavin and pyridoxal 5'-phosphate by human placenta.

J. Zempleni, G. Link, W. Kübler, 1992, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

Fatty acids and gene expression.

J. Zempleni, J. Heeren, U. Beisiegel, 2003 .

The Role of Histone H4 Biotinylation in the Structure of Nucleosomes

G. Borgstahl, Y. Lyubchenko, J. Zempleni, 2011, PloS one.

Transcriptional regulation of the albumin gene depends on the removal of histone methylation marks by the FAD-dependent monoamine oxidase lysine-specific demethylase 1 in HepG2 human hepatocarcinoma cells.

J. Zempleni, Dandan Liu, 2014, The Journal of nutrition.

Transcriptional Regulation of the Albumin Gene Depends on the Removal of Histone Methylation Marks by the Flavin-Adenine Dinucleotide- Dependent Monoamine Oxidase Lysine-Specific Demethylase 1 in HepG2 Human

J. Zempleni, Dandan Liu, 2014 .

Class A scavenger receptor-1/2 facilitates the uptake of bovine milk exosomes in murine bone marrow-derived macrophages and C57BL/6J mice.

J. Zempleni, Jiujiu Yu, Afsana Khanam, 2021, American journal of physiology. Cell physiology.

The arcuate nucleus: its special place in the brain networks that control feeding behavior.

J. Zempleni, K. Dakshinamurti, B. Beck, 2005 .