P. Wilder

发表

Inhibiting S100B Restores p53 Levels in Primary Malignant Melanoma Cancer Cells*

David J Weber, Jing Lin, Qingyuan Yang, 2004, Journal of Biological Chemistry.

Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B.

David J Weber, Jing Lin, P. Wilder, 2006, Biochimica et biophysica acta.

The Calcium-binding Protein S100B Down-regulates p53 and Apoptosis in Malignant Melanoma*

David J Weber, Jing Lin, Qingyuan Yang, 2010, The Journal of Biological Chemistry.

Inhibiting S100B in Malignant Melanoma

Alexander D. MacKerell, David J Weber, P. Wilder, 2013 .

In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction.

Edwin Pozharski, David J Weber, Andrew Coop, 2010, International journal of high throughput screening.

Unprecedented anticancer activities of organorhenium sulfonato and carboxylato complexes against hormone-dependent MCF-7 and hormone-independent triple-negative MDA-MB-231 breast cancer cells

David J Weber, P. Zavalij, H. Banerjee, 2018, Molecular and Cellular Biochemistry.

Solution structure of S100A1 bound to the CapZ peptide (TRTK12).

David J Weber, P. Wilder, Kristen M Varney, 2009, Journal of molecular biology.

Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a di-heptamer macromolecular assembly

A. Grishaev, D. Beckett, A. MacKerell, 2020, Proceedings of the National Academy of Sciences.

Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a novel macromolecular assembly

Alexander D. MacKerell, David J Weber, A. Grishaev, 2019, bioRxiv.

Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein.

Alexander D. MacKerell, P. Wilder, J. Yap, 2016, European journal of medicinal chemistry.

The structural and biochemical impacts of monomerizing human acetylcholinesterase

K. Adipietro, P. Wilder, Z. A. Wood, 2019, Protein science : a publication of the Protein Society.

Covalent Small Molecule Inhibitors of Ca2+-Bound S100B

Timothy L. Foley, David J Weber, A. Jadhav, 2014, Biochemistry.

Calcium-binding properties of wild-type and EF-hand mutants of S100B in the presence and absence of a peptide derived from the C-terminal negative regulatory domain of p53.

Ryan S. Udan, David J Weber, J. Markowitz, 2005, Biochemistry.

Location of the Zn2+-Binding Site on S100B As Determined by NMR Spectroscopy and Site-Directed Mutagenesis

Ryan S. Udan, David J Weber, P. Wilder, 2003 .

The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling

N. Hay, M. Cavalier, K. Adipietro, 2021, PloS one.

The Activation of Protein Kinase A by the Calcium-Binding Protein S100A1 Is Independent of Cyclic AMP

David J Weber, K. Adipietro, P. Wilder, 2017, Biochemistry.

Targeting S100 Calcium-Binding Proteins with Small Molecule Inhibitors.

David J Weber, P. Wilder, Kristen M Varney, 2019, Methods in molecular biology.

Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.

Alexander D. MacKerell, M. I. Ansari, David J Weber, 2016, Journal of medicinal chemistry.

Discovery of Mcl-1 inhibitors based on a thiazolidine-2,4-dione scaffold.

P. Wilder, S. Fletcher, Jay Chauhan, 2017, Bioorganic & medicinal chemistry letters.

The effect of processing and cryopreservation on nucleated umbilical cord blood cells

P. Wilder, L. Adams, M. Reece, 2004, Journal of perinatal medicine.

Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade.

Alexander D. MacKerell, P. Wilder, Michael D. Johnson, 2011, Journal of medicinal chemistry.

Hydrocarbon‐Stapled Helices: A Novel Approach for Blocking Protein‐Protein Interactions

David J Weber, P. Wilder, T. Charpentier, 2007, ChemMedChem.

Kröhnke pyridines: Rapid and facile access to Mcl-1 inhibitors.

R. Godoy-Ruiz, P. Wilder, S. Fletcher, 2018, Bioorganic & medicinal chemistry letters.

Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder

David J Weber, P. Alexander, F. McCormick, 2019, Proceedings of the National Academy of Sciences.

S100B(ββ) inhibits the protein kinase C‐dependent phosphorylation of a peptide derived from p53 in a Ca2+‐dependent manner

David J Weber, P. Wilder, R. Rustandi, 1998 .

Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B.

Alexander D. MacKerell, David J Weber, R. Godoy-Ruiz, 2012, ACS medicinal chemistry letters.

Complex Formation between S100B Protein and the p90 Ribosomal S6 Kinase (RSK) in Malignant Melanoma Is Calcium-dependent and Inhibits Extracellular Signal-regulated Kinase (ERK)-mediated Phosphorylation of RSK*

David J Weber, P. Wilder, P. Shapiro, 2014, The Journal of Biological Chemistry.

Small molecules bound to unique sites in the target protein binding cleft of calcium-bound S100B as characterized by nuclear magnetic resonance and X-ray crystallography.

Alexander D. MacKerell, David J Weber, P. Wilder, 2009, Biochemistry.

Divalent metal ion complexes of S100B in the absence and presence of pentamidine.

Alexander D. MacKerell, David J Weber, P. Wilder, 2008, Journal of molecular biology.

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors.

Alexander D. MacKerell, P. Wilder, J. Yap, 2012, Organic & biomolecular chemistry.

A Novel Organometallic Rhenium Salt: DNA-Binding and Cytotoxicity Studies on Pancreatic, Breast and Lymphoma Cancers

F. Sarkar, H. Banerjee, P. Wilder, 2021 .

Solution structure of zinc- and calcium-bound rat S100B as determined by nuclear magnetic resonance spectroscopy.

David J Weber, P. Wilder, R. Gitti, 2005, Biochemistry.

Physiologically relevant free Ca2+ ion concentrations regulate STRA6-calmodulin complex formation via the BP2 region of STRA6.

F. Mancia, O. Clarke, R. Godoy-Ruiz, 2021, Journal of molecular biology.

The Calcium-Dependent Interaction between S100B and the Mitochondrial AAA ATPase ATAD3A and the Role of This Complex in the Cytoplasmic Processing of ATAD3A

David J Weber, D. Rousseau, P. Wilder, 2010, Molecular and Cellular Biology.

Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA.

David J Weber, V. Malashkevich, S. Almo, 2008, Biochemistry.

Structure of the S100A4/myosin-IIA complex

David J Weber, S. Almo, A. Bresnick, 2013, BMC Structural Biology.

The Ca2+-Dependent Interaction of S100B(ββ) with a Peptide Derived from p53†

David J Weber, P. Wilder, D. Baldisseri, 1998 .

The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak

Alexander D. MacKerell, Xiaobo Cao, Kenno Vanommeslaeghe, 2013, Molecular Cancer.

S100B(betabeta) inhibits the protein kinase C-dependent phosphorylation of a peptide derived from p53 in a Ca2+-dependent manner.

David J Weber, P. Wilder, R. Rustandi, 1998, Protein science : a publication of the Protein Society.

Loss of S100A1 expression leads to Ca2+ release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1

David J Weber, P. Wilder, W. Melzer, 2018, Physiological reports.

Structure-based design of 3-carboxy-substituted 1,2,3,4-tetrahydroquinolines as inhibitors of myeloid cell leukemia-1 (Mcl-1).

P. Wilder, S. Fletcher, P. Shapiro, 2016, Organic & biomolecular chemistry.

Structural Re‐engineering of the α‐Helix Mimetic JY‐1‐106 into Small Molecules: Disruption of the Mcl‐1–Bak‐BH3 Protein–Protein Interaction with 2,6‐Di‐Substituted Nicotinates

P. Wilder, J. Yap, S. Fletcher, 2016, ChemMedChem.

Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold.

P. Wilder, J. Yap, S. Fletcher, 2015, Organic & biomolecular chemistry.

Amphipathic α-helix mimetics based on a 1,2-diphenylacetylene scaffold.

Alexander D. MacKerell, P. Wilder, J. Yap, 2013, Organic letters.

Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1.

J. Eu, P. Wilder, R. Lovering, 2011, American journal of physiology. Cell physiology.

The Ca(2+)-dependent interaction of S100B(beta beta) with a peptide derived from p53.

David J Weber, P. Wilder, D. Baldisseri, 1998, Biochemistry.

Location of the Zn(2+)-binding site on S100B as determined by NMR spectroscopy and site-directed mutagenesis.

Ryan S. Udan, David J Weber, P. Wilder, 2003, Biochemistry.

Alexander D. MacKerell, P. Wilder, J. Yap, 2013, Molecular Cancer.

Novel protein-inhibitor interactions in site 3 of Ca(2+)-bound S100B as discovered by X-ray crystallography.

Alexander D. MacKerell, David J Weber, M. Cavalier, 2016, Acta crystallographica. Section D, Structural biology.

1‐Sulfonylated 1,2,3,4‐tetrahydroquinoline‐6‐carboxylic acids as simple, readily‐accessible MCL‐1 inhibitors

P. Wilder, S. Fletcher, Lijia Chen, 2022, Drug development research.

Simultaneous inhibition of key growth pathways in melanoma cells and tumor regression by a designed bidentate constrained helical peptide

S. Chattopadhyay, Siddhartha Roy, Piya Ghosh, 2014, Biopolymers.

Rationally Designed Polypharmacology: α‐Helix Mimetics as Dual Inhibitors of the Oncoproteins Mcl‐1 and HDM2

A. MacKerell, P. Wilder, S. Fletcher, 2020, ChemMedChem.

The effects of CapZ peptide (TRTK-12) binding to S100B-Ca2+ as examined by NMR and X-ray crystallography.

Laura E. Thompson, David J Weber, P. Wilder, 2010, Journal of molecular biology.

The calcium-binding protein S 100 B down-regulates p 53 and apoptosis in malignant melanoma 1

David J Weber, Jing Lin, Qingyuan Yang, 2010 .

David J Weber, P. Wilder, P. Shapiro, 2014, The Journal of Biological Chemistry.

Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade.

Alexander D. MacKerell, P. Wilder, Michael D. Johnson, 2011, Journal of medicinal chemistry.

Correction to: 1HN, 13C, and 15N resonance assignments of human calmodulin bound to a peptide derived from the STRA6 vitamin A transporter (CaMBP2)

David J Weber, F. Mancia, P. Wilder, 2019, Biomolecular NMR assignments.

1HN, 13C, and15N resonance assignments of human calmodulin bound to a peptide derived from the STRA6 vitamin A transporter (CaMBP2)

David J Weber, F. Mancia, P. Wilder, 2019, Biomolecular NMR assignments.

In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction.

David J Weber, A. MacKerell, P. Wilder, 2010, International journal of high throughput screening.

Small molecules bound to unique sites in the target protein binding cleft of calcium-bound S100B as characterized by nuclear magnetic resonance and X-ray crystallography.

Alexander D. MacKerell, David J Weber, P. Wilder, 2009, Biochemistry.

Targeting S100 Calcium-Binding Proteins with Small Molecule Inhibitors.

David J Weber, P. Wilder, Kristen M. Varney, 2019, Methods in molecular biology.