J. Kašpárková

K. Kuča, V. Brabec, J. Kašpárková, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Synthesis, characterization and biological evaluation of Co(III) complexes with quinolone drugs.

V. Brabec, J. Kašpárková, P. Buglyó, 2019, Journal of inorganic biochemistry.

Lichen secondary metabolites as DNA-interacting agents.

J. Kašpárková, M. Bačkor, M. Kožurková, 2014, Toxicology in vitro : an international journal published in association with BIBRA.

DNA binding of properties of trinuclear platinum complex

V. Brabec, N. Farrell, J. Kašpárková, 1997 .

Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates

V. Brabec, J. Kašpárková, I. Zanellato, 2017, Scientific Reports.

Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes.

P. Sadler, V. Brabec, J. Kašpárková, 2008, Journal of medicinal chemistry.

Effect of geometric isomerism in dinuclear platinum antitumor complexes on DNA interstrand cross-linking.

V. Brabec, N. Farrell, J. Kašpárková, 1999, Biochemistry.

DNA interactions of bifunctional dinuclear platinum(II) antitumor agents.

V. Brabec, N. Farrell, J. Kašpárková, 1997, European journal of biochemistry.

The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes.

P. Sadler, V. Brabec, J. Kašpárková, 2008, Inorganic chemistry.

Activation of Trans Geometry in Bifunctional Mononuclear Platinum Complexes by a Piperidine Ligand

V. Brabec, J. Kašpárková, O. Novakova, 2003, Journal of Biological Chemistry.

Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo

V. Brabec, J. Kašpárková, R. Phillips, 2020, Angewandte Chemie.

Novel Antitumor Platinum(II) Conjugates Containing the Nonsteroidal Anti-inflammatory Agent Diclofenac: Synthesis and Dual Mechanisms of Antiproliferative Effects.

V. Brabec, G. Natile, J. Kašpárková, 2017, Inorganic chemistry.

Antiproliferative Activity and Associated DNA Interactions of [Co2L3]6+ Cylinders Derived from Bis(bidentate) 2-Pyridyl-1,2,3-triazole Ligands

V. Brabec, J. Kašpárková, H. Kostrhunova, 2020 .

A Subset of New Platinum Antitumor Agents Kills Cells by a Multimodal Mechanism of Action Also Involving Changes in the Organization of the Microtubule Cytoskeleton.

V. Brabec, J. Kašpárková, J. Aldrich-Wright, 2019, Journal of medicinal chemistry.

An Anticancer PtIV Prodrug That Acts by Mechanisms Involving DNA Damage and Different Epigenetic Effects.

V. Brabec, J. Kašpárková, D. Gibson, 2019, Chemistry.

Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells

V. Brabec, J. Kašpárková, J. Zajac, 2018, Oncotarget.

DNA binding by antitumor trans-[PtCl2(NH3)(thiazole)]. Protein recognition and nucleotide excision repair of monofunctional adducts.

V. Brabec, N. Farrell, J. Kašpárková, 2003, Biochemistry.

A potent cytotoxic photoactivated platinum complex

P. Sadler, V. Brabec, J. Kašpárková, 2007, Proceedings of the National Academy of Sciences.

A Cyclometalated IrIII Complex Conjugated to a Coumarin Derivative Is a Potent Photodynamic Agent against Prostate Differentiated and Tumorigenic Cancer Stem Cells.

V. Brabec, J. Kašpárková, H. Kostrhunova, 2021, Chemistry.

Dipyridophenazine iridium(III) complex as a phototoxic cancer stem cell selective, mitochondria targeting agent.

V. Brabec, J. Kašpárková, J. Ruiz, 2022, Chemico-biological interactions.

Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands.

V. Brabec, G. Natile, J. Kašpárková, 2008, Journal of medicinal chemistry.

Unexpected solution behaviour of ester-functionalized half-sandwich Ru(II) and Ir(III) complexes.

V. Brabec, J. Kašpárková, I. Němec, 2021, Dalton transactions.

Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates

V. Brabec, J. Kašpárková, I. Zanellato, 2017, Scientific Reports.

Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose-Coated Magnetic Nanoparticles.

V. Brabec, J. Kašpárková, M. Petr, 2016, Chemistry.

Different affinity of nuclear factor‐kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer

V. Brabec, J. Kašpárková, P. Midoux, 2014, The FEBS journal.

Diazido Mixed-Amine Platinum(IV) Anticancer Complexes Activatable by Visible-Light Form Novel DNA Adducts

P. Sadler, V. Brabec, J. Kašpárková, 2013, Chemistry.

Insight into the toxic effects of cis-dichloridoplatinum(II) complexes containing 7-azaindole halogeno derivatives in tumor cells

V. Brabec, J. Kašpárková, Z. Trávníček, 2013, JBIC Journal of Biological Inorganic Chemistry.

Energetics, conformation, and recognition of DNA duplexes containing a major adduct of an anticancer azolato-bridged dinuclear Pt(II) complex.

V. Brabec, J. Kašpárková, J. Malina, 2012, Biochimica et biophysica acta.

Antitumor bifunctional dinuclear PtII complex BBR3535 forms interduplex DNA cross-links under molecular crowding conditions

V. Brabec, S. Quintal, N. Farrell, 2012, JBIC Journal of Biological Inorganic Chemistry.

A new 4-(pyridinyl)-4H-benzo[g]chromene-5,10-dione ruthenium(II) complex inducing senescence in 518A2 melanoma cells

V. Brabec, J. Kašpárková, R. Schobert, 2019, JBIC Journal of Biological Inorganic Chemistry.

Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity.

V. Brabec, N. Farrell, J. Kašpárková, 2008, Journal of medicinal chemistry.

Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: a comparison with the 5'-5' directional isomer.

V. Brabec, N. Farrell, J. Kašpárková, 2009, Chemistry.

1,2-GG intrastrand cross-link of antitumor dinuclear bifunctional platinum compound with spermidine linker inhibits DNA polymerization more effectively than the cross-link of conventional cisplatin.

V. Brabec, N. Farrell, J. Kašpárková, 2007, Archives of biochemistry and biophysics.

Synthesis, antiproliferative activity in cancer cells and DNA interaction studies of [Pt(cis-1,3-diaminocycloalkane)Cl2] analogs

V. Brabec, J. Kašpárková, O. Novakova, 2020, JBIC Journal of Biological Inorganic Chemistry.

Mechanistic insights into toxic effects of a benzotriazolate-bridged dinuclear platinum(II) compound in tumor cells

V. Brabec, J. Kašpárková, O. Novakova, 2012 .

Platinum-DNA interstrand crosslinks: molecular determinants of bending and unwinding of the double helix.

V. Brabec, J. Kašpárková, K. Kubícek, 2012, Journal of inorganic biochemistry.

Antitumor bifunctional dinuclear PtII complex BBR3535 forms interduplex DNA cross-links under molecular crowding conditions

V. Brabec, S. Quintal, N. Farrell, 2011, JBIC Journal of Biological Inorganic Chemistry.

Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione.

V. Brabec, J. Kašpárková, D. Gibson, 2010, Molecular pharmaceutics.

Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand.

P. Sadler, V. Brabec, J. Kašpárková, 2011, Molecular pharmaceutics.

Role of DNA Repair in Antitumour Effects of Platinum Drugs

V. Brabec, J. Kašpárková, 2009 .

An anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell-selective, mammosphere potent agent that kills cells by necroptosis

V. Brabec, J. Kašpárková, Z. Trávníček, 2019, Scientific Reports.

High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells.

S. Kern, V. Brabec, K. Bachman, 2007, Cancer research.

Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic.

V. Brabec, J. Kašpárková, Zdenka Medříková, 2016, Chemistry.

Molecular superoxide radical photogeneration in cancer cells by dipyridophenazine iridium(iii) complexes

V. Brabec, J. Kašpárková, C. Janiak, 2019, Inorganic Chemistry Frontiers.

Effects of monofunctional adducts of platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes.

V. Brabec, J. Kašpárková, Vendula Bursová, 2005, Biophysical journal.

Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru(II) complexes containing terphenyl arenes.

P. Sadler, V. Brabec, J. Kašpárková, 2010, Chemistry.

Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of Antitumor trans-[PtCl2(NH3)(thiazole)]

V. Brabec, N. Farrell, J. Kašpárková, 2005, Nucleic acids research.

DNA bending and unwinding due to the major 1, 2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent

Jana Kasparkova, Viktor Brabec, Kristyna Stehlikova, 2002, Nucleic Acids Res..

3-[(E)-(acridin-9'-ylmethylidene)amino]-1-substituted thioureas and their biological activity.

V. Brabec, J. Kašpárková, M. Becka, 2017, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

Unique DNA binding mode of antitumor trinuclear tridentate platinum(II) compound.

V. Brabec, J. Kašpárková, O. Novakova, 2011, Molecular pharmaceutics.

DNA Interstrand Crosslinks of the Novel Antitumor Trinuclear Platinum Complex BBR3464. Conformation, Recognition by HMG-Domain Proteins and Nucleotide Excision Repair*

V. Brabec, N. Farrell, J. Kašpárková, 2002 .

Effects of cytotoxic cis- and trans-diammine monochlorido platinum(II) complexes on selenium-dependent redox enzymes and DNA.

V. Brabec, J. Kašpárková, C. Lillig, 2018, Journal of inorganic biochemistry.

The induction of lysis in lysogenic strains of Escherichia coli by a new antitumor transplatin derivative and its DNA interactions.

V. Brabec, J. Kašpárková, O. Novakova, 2015, Dalton transactions.

Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand

V. Brabec, J. Kašpárková, D. Gibson, 2005, JBIC Journal of Biological Inorganic Chemistry.

Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis

V. Brabec, J. Kašpárková, H. Kostrhunova, 2023, Inorganic chemistry.

A [Pt(cis-1,3-diaminocycloalkane)Cl2] analog exhibits hallmarks typical of immunogenic cell death inducers in model cancer cells.

V. Brabec, J. Kašpárková, J. Hoeschele, 2021, Journal of inorganic biochemistry.

Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes

P. Sadler, V. Brabec, J. Kašpárková, 2008, JBIC Journal of Biological Inorganic Chemistry.

Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes

V. Brabec, N. Farrell, J. Kašpárková, 2006, The FEBS journal.

DNA interactions of platinum anticancer drugs. Recent advances and mechanisms of action

V. Brabec, J. Kašpárková, 2005 .

Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A.

V. Brabec, J. Kašpárková, K. Stehlikova, 2006, Archives of biochemistry and biophysics.

Potentiation of cytotoxic action of cis-[PtCl2(NH3)(1M7AI)] by UVA irradiation. Mechanistic insights

V. Brabec, G. Natile, J. Kašpárková, 2017 .

Chiral discrimination in platinum anticancer drugs.

V. Brabec, G. Natile, J. Kašpárková, 2002, Environmental health perspectives.

Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin.

V. Brabec, J. Kašpárková, D. Gibson, 2016, Journal of inorganic biochemistry.

Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-Sandwich Organoruthenium Catalysts

P. Sadler, V. Brabec, J. Kašpárková, 2018, Organometallics.

Antiproliferative, DNA binding, and cleavage properties of dinuclear Co(III) complexes containing the bioactive quinizarin ligand

V. Brabec, J. Kašpárková, H. Kostrhunova, 2020, JBIC Journal of Biological Inorganic Chemistry.

Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding.

V. Brabec, N. Farrell, J. Kašpárková, 2004, Journal of inorganic biochemistry.

Walking of antitumor bifunctional trinuclear PtII complex on double-helical DNA

Jaroslav Malina, Jana Kasparkova, Nicholas P. Farrell, 2010, Nucleic Acids Res..

Preparation of bis(5-phenyltetrazolato) Pt(II) and Pt(IV) analogues of transplatin and in vitro evaluation for antitumor activity

V. Brabec, J. Kašpárková, P. Bednarski, 2017 .

Formation of platinated GG cross-links on DNA by photoactivation of a platinum(IV) azide complex

P. Sadler, V. Brabec, J. Kašpárková, 2003, JBIC Journal of Biological Inorganic Chemistry.

Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies.

Y. Barenholz, V. Brabec, J. Kašpárková, 2006, Journal of medicinal chemistry.

Explorer A potent cytotoxic photoactivated platinum complex

P. Sadler, V. Brabec, J. Kašpárková, 2017 .

Palladium and Platinum Complexes of the Antimetabolite Fludarabine with Vastly Enhanced Selectivity for Tumour over Non-Malignant Cells

V. Brabec, J. Kašpárková, T. Mueller, 2023, Molecules.

Recognition of DNA interstrand cross-link of antitumor cisplatin by HMGB1 protein.

V. Brabec, J. Kašpárková, O. Delalande, 2003, Biochemistry.

Effects of histidin-2-ylidene vs. imidazol-2-ylidene ligands on the anticancer and antivascular activity of complexes of ruthenium, iridium, platinum, and gold.

M. Albrecht, V. Brabec, Florian Schmitt, 2016, Journal of inorganic biochemistry.

Novel Antitumor Platinum(II) Conjugates Containing the Non-steroidal Anti-inflammatory Agent Diclofenac: Synthesis and Mechanisms of Antiproliferative Effects

J. Kašpárková, F. Intini, C. Pacifico, 2021 .

Platinum(IV) Derivatives of [Pt(1S,2S-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells

V. Brabec, J. Kašpárková, O. Novakova, 2023, Journal of medicinal chemistry.

Half-sandwich Os(ii) and Ru(ii) bathophenanthroline complexes: anticancer drug candidates with unusual potency and a cellular activity profile in highly invasive triple-negative breast cancer cells.

V. Brabec, J. Kašpárková, Z. Trávníček, 2018, Dalton Transactions.

Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine.

V. Brabec, G. Natile, J. Kašpárková, 2008, Journal of inorganic biochemistry.

Toxicity in tumor cells, DNA binding mode, and resistance to decomposition by sulfur nucleophiles of new dinuclear bifunctional trans-PtII complexes containing long alkane linkers

V. Brabec, J. Kašpárková, O. Novakova, 2012 .

Effects of a piperidine ligand on DNA modification by antitumor cisplatin analogues.

V. Brabec, J. Kašpárková, O. Novakova, 2003, Chemical research in toxicology.

Factors Affecting DNA–DNA Interstrand Cross-Links in the Antiparallel 3 ′ –3 ′ Sense: A Comparison with the 5 ′ –5 ′ Directional Isomer

V. Brabec, J. Kašpárková, Xiaohong Yang, 2010 .

Organoruthenium Complexes with C^N Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action.

V. Brabec, J. Kašpárková, J. Ruiz, 2017, Chemistry.

N-Indolyl diiron vinyliminium complexes exhibit antiproliferative effects in cancer cells associated with disruption of mitochondrial homeostasis, ROS scavenging, and antioxidant activity.

J. Kašpárková, G. Pampaloni, L. Biancalana, 2023, Chemico-biological interactions.

A metal-free DNA nuclease based on a cyclic peptide scaffold.

V. Brabec, J. Kašpárková, E. Yavin, 2010, Bioconjugate chemistry.

Antiproliferative, DNA binding, and cleavage properties of dinuclear Co(III) complexes containing the bioactive quinizarin ligand

V. Brabec, J. Kašpárková, P. Buglyó, 2020, JBIC Journal of Biological Inorganic Chemistry.

Biophysical studies on the stability of DNA intrastrand cross-links of transplatin.

J. Kašpárková, Victoria Marini, Viktor Brabec, 2008, Biophysical journal.

Effect of sulfonamidoethylenediamine substituents in RuII arene anticancer catalysts on transfer hydrogenation of coenzyme NAD+ by formate.

P. Sadler, V. Brabec, J. Kašpárková, 2018, Dalton transactions.