C. Canman

发表

P53, cell cycle control and apoptosis: Implications for cancer

Christine E. Canman, M. Kastan, C. Canman, 1995, Cancer and Metastasis Reviews.

Role of p53 in apoptosis.

M. Kastan, C. Canman, 1997, Advances in pharmacology.

Multiple signaling pathways involving ATM.

M. Kastan, C. Canman, S. T. Kim, 2000, Cold Spring Harbor symposia on quantitative biology.

DNA damage induces phosphorylation of the amino terminus of p53.

Y Taya, K. Sakaguchi, E. Appella, 1997, Genes & development.

The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.

A. Fornace, A. Wolff, M. Kastan, 1994, Cancer research.

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

Y Taya, K. Sakaguchi, E. Appella, 1998, Science.

The role of ATM in DNA damage responses and cancer

C. Canman, D. Lim, 1998, Oncogene.

Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.

S. Varambally, A. Chinnaiyan, F. Feng, 2006, Cancer research.

Phosphorylation of Threonine 68 Promotes Oligomerization and Autophosphorylation of the Chk2 Protein Kinase via the Forkhead-associated Domain*

C. Canman, H. Davis, Xianghong Li, 2002, The Journal of Biological Chemistry.

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members*

S. T. Kim, M. Kastan, C. Canman, 1999, The Journal of Biological Chemistry.

ATM binds to β-adaptin in cytoplasmic vesicles

R. Darnell, Y. Shiloh, D. Kirsch, 1998 .

PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer.

Francesca Demichelis, Wei Chen, Arul M Chinnaiyan, 2014, Cancer research.

DNA Polymerase ζ Is a Major Determinant of Resistance to Platinum-Based Chemotherapeutic Agents

C. Canman, Shilpy Sharma, Nicholas A Shah, 2012, Molecular Pharmacology.

Therapeutics , Targets , and Chemical Biology ATDC / TRIM 29 Phosphorylation by ATM / MAPKAP Kinase 2 Mediates Radioresistance in Pancreatic Cancer Cells

T. Lawrence, C. Canman, M. Ljungman, 2014 .

ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells.

Min Zhang, T. Lawrence, C. Canman, 2014, Cancer research.

Loss of atm radiosensitizes multiple p53 null tissues.

P. Leder, C. Westphal, M. Kastan, 1998, Cancer research.

Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity.

C. Canman, D. Shewach, J. Ackroyd, 2013, DNA repair.

Expression and assay of recombinant ATM.

M. Kastan, C. Canman, D. Lim, 2000, Methods in molecular biology.

DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis.

M. Kastan, C. Canman, C. Y. Chen, 1994, Cold Spring Harbor symposia on quantitative biology.

Three paths to stress relief

M. Kastan, C. Canman, 1996, Nature.

Signal transduction. Three paths to stress relief.

M. Kastan, C. Canman, 1996, Nature.

BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade

T. Ludwig, J. Parvin, C. Canman, 2013, Proceedings of the National Academy of Sciences.

A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.

F. Delbos, A. De Smet, J. Weill, 2016, DNA repair.

Psoralen-Induced DNA Interstrand Cross-Links Block Transcription and Induce p53 in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner

C. Canman, M. Ljungman, M. Paulsen, 2009, Molecular Pharmacology.

Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate.

T. Lawrence, C. Canman, Hsin-yi Tang, 1993, Cancer research.

Differential Roles for DNA Polymerases Eta, Zeta, and REV1 in Lesion Bypass of Intrastrand versus Interstrand DNA Cross-Links

T. Glover, C. Canman, M. Paulsen, 2009, Molecular and Cellular Biology.

Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity.

T. Lawrence, C. Canman, Hsin-yi Tang, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Checkpoint Mediators: Relaying Signals from DNA Strand Breaks

C. Canman, 2003, Current Biology.

Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase.

T. Lawrence, C. Canman, J. Maybaum, 1994, Cancer research.

ATM binds to beta-adaptin in cytoplasmic vesicles.

R. Darnell, Y. Shiloh, D. Kirsch, 1998, Proceedings of the National Academy of Sciences of the United States of America.

A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA crosslink, enhances DNA double-strand break, and sensitizes cancer cells to cisplatin

C. Canman, A. Inoue, A. Hishiki, 2014 .

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

Yi-Song Wang, V. Velculescu, P. O'Connor, 1994, Cancer research.

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

M. Kastan, C. Canman, T. Gilmer, 1995, Genes & development.

Reversal of apoptosis by the leukaemia-associated E2A–HLF chimaeric transcription factor

A. Look, M. Kastan, T. Inaba, 1996, Nature.

Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination–Proficient Pancreatic Cancer

Daria M. Tanska, T. Lawrence, C. Canman, 2020, Molecular Cancer Therapeutics.

Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin

E. Domany, Z. Livneh, B. Falini, 2014, Nature Communications.

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

D. Baltimore, C. Barlow, A. Wynshaw-Boris, 1997, Nature.

Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells

M. Kastan, J. Milner, C. Canman, 1997, Oncogene.

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

Jonathan Maybaum, Daria M. Tanska, Theodore S Lawrence, 2009, Molecular Cancer Therapeutics.

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.

H. Piwnica-Worms, C. Canman, J. Schwarz, 2000, Cancer research.

Replication Stress: An Achilles' Heel of Glioma Cancer Stem-like Cells.

C. Canman, M. Morgan, 2018, Cancer research.

The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.

C. Canman, Shilpy Sharma, Corey M. Helchowski, 2013, Mutation research.

Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation.

M. Kastan, C. Canman, Bo Xu, 2004, Molecular cancer research : MCR.

Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.

Bo Xu, M. Kastan, C. Canman, 2003, Molecular cancer research : MCR.

Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis

M. Kastan, C. Canman, 1998, Oncogene.

A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci

C. Canman, Katelyn H Roberts, Corey M. Helchowski, 2013, Cell cycle.

REV1 and polymerase ζ facilitate homologous recombination repair

T. Glover, C. Canman, Shilpy Sharma, 2011, Nucleic acids research.

Dependence of etoposide-induced cytotoxicity and topoisomerase II-mediated DNA strand breakage on the intracellular ionic environment.

T. Lawrence, C. Canman, J. Maybaum, 1989, Cancer research.

Induction of apoptosis by tumor suppressor genes and oncogenes.

M. Kastan, C. Canman, 1995, Seminars in cancer biology.

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

Jonathan Maybaum, Diane M Simeone, Theodore S Lawrence, 2010, Cancer research.

Replication checkpoint: Preventing mitotic catastrophe

C. Canman, 2001, Current Biology.

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensitizes Cancer Cells to Cisplatin*

R. Heath, C. Canman, H. Hashimoto, 2014, The Journal of Biological Chemistry.

Which Holds the Key to BRCAness: Inability to Repair the Break, Protect the Fork, or Prevent the Gap?

C. Canman, 2021, Cancer Research.

The role of p53 in cell-cycle control and apoptosis: implications for cancer.

M. Kastan, C. Canman, C. J. Leonard, 1995, Important advances in oncology.

Lack of dependence of 5-fluorodeoxyuridine-mediated radiosensitization on cytotoxicity.

T. Lawrence, C. Canman, J. Maybaum, 1995, Radiation research.

REV1 and DNA polymerase zeta in DNA interstrand crosslink repair

C. Canman, Shilpy Sharma, Christine E. Canman, 2012, Environmental and molecular mutagenesis.