S. Neidle

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Protein and drug interactions in the minor groove of DNA.

Stephen Neidle, Zdenek Morávek, B. Schneider, 2002, Nucleic acids research.

The high resolution crystal structure of the DNA decamer d(AGGCATGCCT).

S Neidle, S. Neidle, C. M. Nunn, 1996, Journal of molecular biology.

Small-molecule quadruplex-targeted drug discovery.

Stephen Neidle, Stephan A. Ohnmacht, S. Neidle, 2014, Bioorganic & medicinal chemistry letters.

Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands.

Stephan A. Ohnmacht, G. Vignaroli, S. Neidle, 2013, Bioorganic & medicinal chemistry letters.

G‐Quadruplexes as Therapeutic Targets in Cancer

S. Neidle, 2013 .

A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines.

S. Neidle, Rupesh K. Nanjunda, W. Wilson, 2012, Bioorganic & medicinal chemistry letters.

DNA and RNA Quadruplex Structures

S. Neidle, 2012 .

Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives.

Stephan A. Ohnmacht, M. Micco, M. Zloh, 2012, Bioorganic & medicinal chemistry letters.

Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes.

Stephen Neidle, Shozeb Haider, S. Neidle, 2010, Methods in molecular biology.

Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor.

S. Neidle, L. Kèlland, Christopher M Incles, 2003, Molecular pharmacology.

Oxford handbook of nucleic acid structure

S. Neidle, 1998 .

Inhibition of human telomerase by a G-quadruplex-interactive compound.

S. Neidle, J. Trent, L. Hurley, 1997, Journal of medicinal chemistry.

On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis.

C. Fierke, S. Neidle, S. Haider, 2011, Bioorganic & medicinal chemistry letters.

G‐quadruplexes: Emerging roles in neurodegenerative diseases and the non‐coding transcriptome

G. Parkinson, S. Neidle, A. Isaacs, 2015, FEBS letters.

A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus.

D. Livermore, S. Neidle, M. Gunaratnam, 2013, International journal of antimicrobial agents.

Highly prevalent putative quadruplex sequence motifs in human DNA

S. Neidle, A. K. Todd, Matthew Johnston, 2005, Nucleic acids research.

Quadruplex DNA: sequence, topology and structure

Sarah W. Burge, G. Parkinson, S. Neidle, 2006, Nucleic acids research.

Quadruplex Nucleic Acids as Novel Therapeutic Targets.

S. Neidle, 2016, Journal of medicinal chemistry.

Crystal structure of parallel quadruplexes from human telomeric DNA

Stephen Neidle, G. Parkinson, S. Neidle, 2002, Nature.

Structure of a G-quadruplex-ligand complex.

Stephen Neidle, Gary N Parkinson, G. Parkinson, 2003, Journal of molecular biology.

The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

Stephen Neidle, S. Neidle, J. Double, 2005, Cancer research.

Structural basis of DNA quadruplex recognition by an acridine drug.

Stephen Neidle, Gary N Parkinson, G. Parkinson, 2008, Journal of the American Chemical Society.

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

Stephen Neidle, Laurence H. Hurley, Shankar Balasubramanian, 2011, Nature Reviews Drug Discovery.

DNA structure and recognition.

S. Neidle, 1994 .

Interaction of berenil with the EcoRI dodecamer d(CGCGAATTCGCG)2 in solution studied by NMR.

S Neidle, A. Lane, S. Neidle, 1991, Biochemistry.

Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes.

Julie E Reed, S. Neidle, R. Vilar, 2006, Journal of the American Chemical Society.

Effects of metal coordination geometry on stabilization of human telomeric quadruplex DNA by square-planar and square-pyramidal metal complexes.

S. Neidle, A. Arola-Arnal, R. Vilar, 2008, Inorganic chemistry.

Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes.

G. Parkinson, N. Campbell, S. Neidle, 2012, Journal of medicinal chemistry.

Principles in the Design of DNA-Interactive Molecules

S. Neidle, 1994 .

Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex.

G. Parkinson, M. Zloh, S. Neidle, 2013, Journal of the American Chemical Society.

Thiophene-based diamidine forms a "super" at binding minor groove agent.

Stephen Neidle, Christian Bailly, C. Bailly, 2004, Journal of the American Chemical Society.

Molecular modeling to study DNA intercalation by anti-tumor drugs.

S. Neidle, T. C. Jenkins, 1991, Methods in enzymology.

Molecular foundations of drug—receptor interaction

Stephen Neidle, S. Neidle, 1988 .

Folding of guanine quadruplex molecules-funnel-like mechanism or kinetic partitioning? An overview from MD simulation studies.

J. Šponer, G. Bussi, M. Otyepka, 2016, Biochimica et biophysica acta. General subjects.

A molecular modeling study of the interactions between the antiestrogen drug tamoxifen and several derivatives, and the calcium-binding protein calmodulin.

S. Neidle, C. Laughton, K. J. Edwards, 1992, Journal of medicinal chemistry.

Molecular Aspects of Anticancer Drug/DNA Interactions

M. Waring, S. Neidle, 1993 .

DNA sequence specificity of triplex-binding ligands.

S. Neidle, T. Brown, K. Fox, 2003, European journal of biochemistry.

Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations

J. Šponer, G. Bussi, M. Otyepka, 2017, Journal of chemical theory and computation.

Human telomerase inhibition by substituted acridine derivatives.

S. Neidle, L. Kelland, S. Gowan, 1999, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase.

B. Guyen, S. Neidle, C. Schultes, 2004, Organic & biomolecular chemistry.

Minor‐groove width and accessibility in B‐DNA drug and protein complexes

S. Neidle, 1992, FEBS letters.

Structural basis for binding of porphyrin to human telomeres.

G. Parkinson, S. Neidle, R. Ghosh, 2007, Biochemistry.

Challenges in developing small-molecule quadruplex therapeutics

S. Neidle, 2020 .

TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules.

Julie E Reed, S. Neidle, M. Gunaratnam, 2008, Analytical biochemistry.

X‐Ray crystallographic analysis of a ternary intercalation complex between proflavine and the dinucleoside monophosphates CpA and UpG

S. Neidle, A. Aggarwal, R. Kuroda, 1984, Biopolymers.

Structural and sequence-dependent aspects of drug intercalation into nucleic acids.

S. Neidle, Z. Abraham, 1984, CRC critical reviews in biochemistry.

Drug Nucleic Acid Interactions: Proflavine Intercalation into Double-Helical Fragments of RNA and DNA

S. Islam, S. Neidle, A. Aggarwal, 1983 .

Oligonucleotide and polynucleotide — drug complexes in the crystalline state

S. Neidle, 1981 .

Molecular and crystal structure of an intercalation complex: Proflavine–cytidylyl‐(3′,5′)‐guanosine

H. L. Carrell, H. Berman, W. Stallings, 1979 .

N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.

C. Leonetti, M. Porru, S. Neidle, 2011, Journal of medicinal chemistry.

Water spines and networks in G-quadruplex structures

S. Neidle, L. Yatsunyk, Kevin Li, 2020, Nucleic acids research.

Small-molecule binding to the DNA minor groove is mediated by a conserved water cluster.

S. Neidle, W. Wilson, D. Wei, 2013, Journal of the American Chemical Society.

Crystal structure of a berenil‐dodecanucleotide complex: the role of water in sequence‐specific ligand binding.

D. Stuart, E. Garman, S. Neidle, 1990, The EMBO journal.

Crystal structure of a berenil-d(CGCAAATTTGCG) complex. An example of drug-DNA recognition based on sequence-dependent structural features.

E. Garman, S. Neidle, M. Sanderson, 1992, Journal of molecular biology.

The crystallization and structure analysis of oligonucleotide sequences.

S. Neidle, 1996, Methods in molecular biology.

Introduction: Quadruplexes and their Biology

S. Neidle, 2012 .

A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene.

Stephen Neidle, Shankar Balasubramanian, Ashok R Venkitaraman, 2006, Biochemistry.

Targeting a c-MYC G-quadruplex DNA with a fragment library.

S. Balasubramanian, Neil M. Bell, S. Neidle, 2014, Chemical communications.

The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties.

T. Bui, A. Drake, S. Neidle, 2012, Chemical communications.

Mapping the sequences of potential guanine quadruplex motifs

S. Neidle, A. K. Todd, 2011, Nucleic acids research.

Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells.

S. Neidle, M. Gunaratnam, J. Riou, 2010, Bioorganic & medicinal chemistry letters.

Biaryl polyamides as a new class of DNA quadruplex-binding ligands.

S. Neidle, M. Gunaratnam, A. Reszka, 2009, Chemical communications.

Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers.

S. Neidle, W. Drewe, 2008, Chemical communications.

The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements

S. Neidle, A. K. Todd, 2008, Nucleic acids research.

Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter

G. Parkinson, S. Neidle, A. K. Todd, 2007, Nucleic acids research.

Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library.

S. Balasubramanian, S. Neidle, A. Reszka, 2006, Organic & biomolecular chemistry.

The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: biophysical and molecular modeling studies.

E. Novellino, B. Pagano, S. Neidle, 2011, Biochimie.

Molecular dynamics simulations of dinucleoside and dinucleoside-drug crystal hydrates.

J. Goodfellow, S. Neidle, P. Herzyk, 1991, Journal of biomolecular structure & dynamics.

Stability of DNA Triplexes on Shuttle Vector Plasmids in the Replication Pool in Mammalian Cells*

S. Neidle, A. Reszka, M. Seidman, 2000, The Journal of Biological Chemistry.

The structure of a platinum(II) complex of 1-(β-d-arabinofuranosyl)-cytosine

G. Taylor, S. Neidle, A. Robins, 1978 .

A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity.

S. Neidle, L. Kèlland, M. Valenti, 2002, Molecular pharmacology.

Energetics, Kinetics and Dynamics of Quadruplex Folding

S. Balasubramanian, S. Neidle, 2006 .

Targeting pancreatic cancer with a G-quadruplex ligand.

A. Schätzlein, S. Neidle, M. Gunaratnam, 2011, Bioorganic & medicinal chemistry.

8 – RNA Quadruplexes

S. Neidle, 2012 .

Crystal structure of the potassium form of an Oxytricha nova G-quadruplex.

Stephen Neidle, Shozeb Haider, Gary N Parkinson, 2002, Journal of molecular biology.

Structure-activity relationships among guanine-quadruplex telomerase inhibitors.

S. Neidle, A. Reszka, R. Harrison, 2000, Pharmacology & therapeutics.

Selectivity in ligand recognition of G-quadruplex loops.

Stephen Neidle, Gary N Parkinson, G. Parkinson, 2009, Biochemistry.

Synthesis, G‐Quadruplex Stabilisation, Docking Studies, and Effect on Cancer Cells of Indolo[3,2‐b]quinolines with One, Two, or Three Basic Side Chains

Stephan A. Ohnmacht, S. Neidle, J. Lavrado, 2013, ChemMedChem.

Telomeric Quadruplex Ligands I: Anthraquinones and Acridines

S. Neidle, 2012 .

Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation

G. Parkinson, S. Neidle, A. Reszka, 2012, Nucleic acids research.

Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes.

S. Neidle, S. Haider, I. Autiero, 2011, Biochimie.

Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells.

Stephen Neidle, B. Guyen, S. Neidle, 2009, Bioorganic & medicinal chemistry letters.

Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.

James M. Morrell, S. Neidle, L. Kèlland, 2004, Bioorganic & medicinal chemistry letters.

Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.

S. Neidle, J. Trent, A. Reszka, 1998, Journal of medicinal chemistry.

Nucleic acid binding drugs. 18: Calculated charges for a DNA intercalation complex; a study of the relative influence of polarization and conformational effects

B. Hudson, S. Neidle, 1987 .

Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure.

G. Parkinson, N. Campbell, S. Neidle, 2006, Bioorganic & medicinal chemistry letters.

A New Class of Symmetric Bisbenzimidazole‐Based DNA Minor Groove‐Binding Agents Showing Antitumor Activity.

G. Parkinson, S. Neidle, L. Kèlland, 2001 .

A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity.

G. Parkinson, S. Neidle, L. Kèlland, 2001, Journal of medicinal chemistry.

Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs.

S. Neidle, W. Wilson, T. C. Jenkins, 1992, Biochemistry.

The influence of intercalator structure on DNA binding strength: the importance of side chain orientation.

S. Neidle, W. Wilson, D. Boykin, 1987, Journal of biomolecular structure & dynamics.

Computer-aided design of new DNA intercalators.

S. Neidle, 1986, Basic life sciences.

Molecular models for the interaction of the anti-tumour drug nogalamycin with DNA.

J. R. Brown, S. Neidle, D. Collier, 1984, Biochemical pharmacology.

The Interactions of Daunomycin Adriamycin with Nucleic Acids

S. Neidle, M. Sanderson, 1983 .

X-ray crystallographic studies of nucleic acids and nucleic acid-drug complexes.

H. Berman, S. Neidle, 1983, Progress in biophysics and molecular biology.

THE STRUCTURE OF 6,9-DICHLORO-2-METHOXYACRIDINE

S. Neidle, 1982 .

Nucleic acid binding drugs. Part IV. The crystal structure of the anti-cancer agent daunomycin.

G. Taylor, S. Neidle, 1977, Biochimica et biophysica acta.

Nucleic Acids Research

S. Neidle, A. K. Aggarwal, 2022 .

Synthesis and structure of 3‐(4‐carbamoylphenyl)‐1,3‐dimethyltriazene 1‐oxide

S. Neidle, R. Kuroda, G. Webster, 1987 .

A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer

Stephan A. Ohnmacht, J. Šponer, J. Šponer, 2015, Scientific Reports.

Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models.

R. Angell, S. Neidle, W. Wilson, 2020, ACS medicinal chemistry letters.

Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule

Stephan A. Ohnmacht, S. Balasubramanian, S. Neidle, 2018, Journal of medicinal chemistry.

Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors.

S. Neidle, M. Gunaratnam, Pallavi Sharma, 2015, Organic & biomolecular chemistry.

Topics in Nucleic Acid Structure

S. Neidle, 1981 .

Effect of metal coordination on the interaction of substituted phenanthroline and pyridine ligands with quadruplex DNA.

Julie E Reed, S. Neidle, A. White, 2009, Dalton transactions.

Loop flexibility in human telomeric quadruplex small-molecule complexes

N. Campbell, S. Neidle, G. Collie, 2015, Nucleic acids research.

Telomeric Quadruplex Ligands II: Polycyclic and Non-fused Ring Compounds

S. Neidle, 2012 .

Symmetric bis-benzimidazoles are potent anti-staphylococcal agents with dual inhibitory mechanisms against DNA gyrase.

J. Hinds, S. Neidle, P. Taylor, 2012, Biochemistry.

Homology modelling of the enzyme P450 17 alpha-hydroxylase/17,20-lyase--a target for prostate cancer chemotherapy--from the crystal structure of P450BM-3.

S. Neidle, C. Laughton, D. Burke, 1997, Anti-cancer drug design.

A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands.

S. Neidle, C. M. Lombardo, S. Haider, 2010, Organic & biomolecular chemistry.

Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry.

S. Neidle, M. Gunaratnam, Michael J B Moore, 2006, Journal of the American Chemical Society.

A novel small-molecule inhibitor of IL-6 signalling.

S. Neidle, S. Haider, A. Wilderspin, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistry

S. Neidle, A. Reszka, M. O'Connell, 2012, ChemMedChem.

Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism

S. Chou, S. Neidle, M. Hou, 2022, Nucleic acids research.

Nucleic Acid Structure and Recognition

S. Neidle, 2002 .

Efficient triple helix formation by oligodeoxyribonucleotides containing α-or β2-amino-5-( 2-deoxy-D-ribofuranosyl ) pyridine residues

S. Neidle, P. Bates, C. Laughton, 1996 .

Recognition of GC base pairs by triplex forming oligonucleotides containing nucleosides derived from 2-aminopyridine.

S. Neidle, J. Trent, C. Reese, 1997, Nucleic acids research.

Efficient triple helix formation by oligodeoxyribonucleotides containing alpha- or beta-2-amino-5-(2-deoxy-D-ribofuranosyl) pyridine residues.

S. Neidle, P. Bates, C. Laughton, 1996, Nucleic acids research.

Nucleic acid binding drugs. Part 12. X-Ray crystallographic and conformational studies on the anti-cancer drug m-AMSA and its mesyl derivative

S. Neidle, R. Kuroda, Z. Abraham, 1985 .

The influence of the ethyl group on the conformational flexibility of aminoglutethimide.

S. Neidle, M. Jarman, 1988, Biochemical pharmacology.

G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

L. Partridge, A. Chiò, H. Zetterberg, 2017, EMBO molecular medicine.

RNA binding proteins

S. Neidle, M. Sanderson, 2022, Principles of Nucleic Acid Structure.

DNA Quadruplexes and Gene Regulation

S. Balasubramanian, S. Neidle, 2006 .

Water-mediated binding of agents that target the DNA minor groove.

S. Neidle, W. Wilson, Arvind Kumar, 2011, Journal of the American Chemical Society.

1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.

S. Neidle, A. Reszka, L. Kelland, 1998, Journal of medicinal chemistry.

A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells

Stephan A. Ohnmacht, S. Neidle, C. Marchetti, 2020, Scientific Reports.

The crystal structure of the DNA-binding drug berenil: molecular modelling studies of berenil-DNA complexes.

L. Pearl, B. Hudson, S. Neidle, 1987, Nucleic acids research.

Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex.

Julie E Reed, S. Neidle, R. Vilar, 2007, Chemical communications.

Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.

James M. Morrell, G. Chessari, S. Neidle, 2003, Journal of medicinal chemistry.

Thermodynamic studies on the interactions of di-substituted anthraquinones with DNA.

J. R. Brown, S. Neidle, A. Bell, 1989, Biochemical pharmacology.

Netropsin, a DNA-binding oligopeptide structural and binding studies.

H. Berman, S. Neidle, C. Zimmer, 1979, Biochimica et Biophysica Acta.

Molecular Aspects of Anti-Cancer Drug Action

M. Waring, S. Neidle, 1983 .

Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors.

B. Guyen, S. Neidle, C. Schultes, 2004, Bioorganic & medicinal chemistry letters.

The mechanism of resistance in Escherichia coli to ridinilazole and other antibacterial head-to-head bis-benzimidazole compounds

S. Neidle, A. Porcu, J. Mann, 2022, Medicinal Chemistry Research.

Induced-Fit Recognition of CCG Trinucleotide Repeats by a Nickel-Chromomycin Complex Resulting in Large-Scale DNA Deformation.

S. Neidle, C. Tzeng, Gene-Hsiang Lee, 2017, Angewandte Chemie.

The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic–industrial partnership

S. Neidle, P. Taylor, R. Vickers, 2015, MedChemComm.

The Building-Blocks of DNA and RNA

S. Neidle, 2008 .

Macrocyclic naphthalene diimides as G-quadruplex binders.

Stephan A. Ohnmacht, V. Tumiatti, A. Milelli, 2015, Bioorganic & medicinal chemistry.

Atomic Force Microscopy and Voltammetric Investigation of Quadruplex Formation between a Triazole-Acridine Conjugate and Guanine-Containing Repeat DNA Sequences.

R. Eritja, S. Neidle, A. Oliveira‐Brett, 2015, Analytical chemistry.

Triazole-linked phenyl derivatives: redox mechanisms and in situ electrochemical evaluation of interaction with dsDNA.

S. Neidle, A. Oliveira‐Brett, A. D. R. Pontinha, 2015, Bioelectrochemistry.

Microsoft Word-ND manuscript revision 26-11-12[1]

S. Neidle, A. Reszka, P. Boukamp, 2012 .

Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove.

C. Bailly, D. Hamelberg, S. Neidle, 2002, Journal of the American Chemical Society.

diimide G-quadruplex ligands

S. Neidle, A. Reszka, P. Boukamp, 2012 .

Preliminary crystallographic data for NAD(P)H quinone reductase isolated from the Walker 256 rat carcinoma cell line.

D. Stuart, E. Garman, S. Neidle, 1989, Journal of molecular biology.

Inhibition of aromatase expression by a psoralen‐linked triplex‐forming oligonucleotide targeted to a coding sequence

A. Ashworth, S. Neidle, P. Bates, 1995, FEBS letters.

Rationally designed analogues of tamoxifen with improved calmodulin antagonism.

S. Neidle, J. Trent, C. Laughton, 1995, Journal of medicinal chemistry.

Mechanistic and anti-proliferative studies of two novel, biologically active bis-benzimidazoles.

C. Bailly, S. Neidle, J. Mann, 2003, European journal of cancer.

Non‐random usage of ‘degenerate’ codons is related to protein three‐dimensional structure

Stephen Neidle, S. Neidle, A. Adzhubei, 1996, FEBS letters.

The Biology and Pharmacology of Telomeric Quadruplex Ligands

S. Neidle, 2012 .

Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.

T. Barata, M. Zloh, S. Neidle, 2010, Journal of medicinal chemistry.

Natural and synthetic G-quadruplex interactive berberine derivatives.

S. Neidle, C. Schultes, G. Ortaggi, 2006, Bioorganic & medicinal chemistry letters.

Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form.

W. Denny, G. Parkinson, S. Neidle, 2003, Journal of medicinal chemistry.

Stabilisation of TG- and AG-containing antiparallel DNA triplexes by triplex-binding ligands.

S. Neidle, K. Fox, M. Keppler, 2001, Nucleic acids research.

Sequence-dependent effects in drug-DNA interaction: the crystal structure of Hoechst 33258 bound to the d(CGCAAATTTGCG)2 duplex.

S. Neidle, N. Spink, J. V. Skelly, 1994, Nucleic acids research.

DNA structure and perturbation by drug binding.

L. Pearl, S. Neidle, J. V. Skelly, 1987, The Biochemical journal.

Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7nr03875e

V. T. Forsyth, P. Rannou, E. Mitchell, 2018, Nanoscale.

9-beta-D-Arabinofuranosyl-8-n-butylaminoadenine, a C-8 substituted nucleoside in the anti conformation. Crystallographic and NMR studies.

S. Neidle, J. Chattopadhyaya, R. Kuroda, 1979, Biochimica et biophysica acta.

Structure of the oligonucleotide d(CGTATATACG) as a site-specific complex with nickel ions.

L. Malinina, S. Neidle, N. Abrescia, 1999, Nucleic acids research.

The crystal and molecular structure of an osmium bispyridine adduct of thymine.

D. Stuart, S. Neidle, 1976, Biochimica et biophysica acta.

Nucleic acid statics and dynamics

S. Neidle, 1979, Nature.

Synthesis of the farnesyl ether 2,3,5-trifluoro-6-hydroxy-4-[(E,E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yloxy]nitrobenzene, and related compounds containing a substituted hydroxytrifluorophenyl residue: novel inhibitors of protein farnesyltransferase, geranylgeranyltransferase I and squalene syntha

S. Neidle, I. Hardcastle, M. Rowlands, 2000 .

Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA.

Stephen Neidle, David O'Hagan, N. Campbell, 2011, Organic & biomolecular chemistry.

Bioactive pyridine-N-oxide disulfides from Allium stipitatum.

Stephen Neidle, Simon Gibbons, Mekala Gunaratnam, 2009, Journal of natural products.

Characterization of a novel DNA minor-groove complex.

Binh Nguyen, Stephen Neidle, Donald Hamelberg, 2004, Biophysical journal.

"...the tyranny of the lattice...".

D. Goodsell, R. Dickerson, S. Neidle, 1994, Proceedings of the National Academy of Sciences of the United States of America.

DNA minor-groove recognition by small molecules.

S Neidle, S. Neidle, 2001, Natural product reports.

Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents.

S. Neidle, J. Hartley, L. Hurley, 1996, The Journal of organic chemistry.

New renin inhibitors containing novel analogues of statine.

S. Neidle, R. Kuroda, J. Morton, 2009, The journal of peptide research : official journal of the American Peptide Society.

ANALYSIS OF VAN-DER-WAALS AND ELECTROSTATIC CONTRIBUTIONS IN THE INTERACTIONS OF MINOR-GROOVE BINDING BENZIMIDAZOLES WITH DNA

Min Zhao, Stephen Neidle, Christine M. Nunn, 1995 .

Crystallographic insights into DNA minor groove recognition by drugs

Stephen Neidle, S. Neidle, 1997 .

DNA Minor‐Groove Recognition by Small Molecules

S. Neidle, 2010 .

Nucleic acid binding drugs. XVII. Structures of 4-substituted analogues of the antitumour drug amsacrine

S. Neidle, Z. Abraham, R. Acheson, 1987 .

Symmetric bis-benzimidazoles: new sequence-selective DNA-binding molecules

S. Neidle, L. Kèlland, J. Hartley, 1999 .

Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties.

S Neidle, S. Neidle, T. C. Jenkins, 1992, Biochemistry.

2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase.

S. Neidle, A. Reszka, L. Kelland, 1999, Journal of medicinal chemistry.

Principles of small molecule–DNA recognition

S. Neidle, M. Sanderson, 2022, Principles of Nucleic Acid Structure.

Principles of Small Molecule-DNA Recognition

S. Neidle, 2008 .

Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking.

S. Neidle, L. Hurley, T. C. Jenkins, 1994, Journal of medicinal chemistry.

Perturbations in DNA structure upon interaction with porphyrins revealed by chemical probes, DNA footprinting and molecular modelling.

S. Neidle, K. Ford, 1995, Bioorganic & medicinal chemistry.

The crystal structure of an orthorhombic form of adenosine-5'-monophosphate

W. Kühlbrandt, S. Neidle, A. Achari, 1976 .

Quinazoline antifolates inhibiting thymidylate synthase: computer modelling of the N10 substituent.

S. Neidle, A. Jackman, A. Calvert, 1989, Anti-cancer drug design.

New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity.

S. Neidle, M. Gunaratnam, J. Mann, 2006, Organic & biomolecular chemistry.

Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.

Stephen Neidle, Javier Cuesta, Mekala Gunaratnam, 2006, Journal of medicinal chemistry.

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives.

G. Prencipe, S. Ley, S. Neidle, 2007, Angewandte Chemie.

The structure of a pseudo intercalated complex between actinomycin and the DNA binding sequence d(GpC)

H. Berman, S. Neidle, F. Takusagawa, 1982, Nature.

Oxidative ring contraction of benzeneselenenate adducts of glycal ethers. synthesis of showdomycin analogues

S. Neidle, C. Reese, Andrew M. Kaye, 1988 .

Reaction between glycal benzyl ethers and thallium(III) nitrate. Synthesis of showdomycin analogues.

S. Neidle, C. Reese, Andrew M. Kaye, 1988 .

Chemoenzymatic preparation of the novel antifolate thymidylate synthase inhibitor N-(4-{N-[(6S)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoyl)-L-glutamic acid and its glutamyl cleavage product

S. Neidle, A. Jackman, V. Bavetsias, 1999 .

Synthesis of Sequence-Selective C8-Linked Pyrrolo(2,1-c)(1,4) benzodiazepine DNA Interstrand Cross-Linking Agents.

S. Neidle, J. Hartley, L. Hurley, 1997 .

DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand

Stephen Neidle, Juan Aymami, Christine M. Nunn, 1999, Nucleic Acids Res..

Anthracene-9,10-diones as potential anticancer agents: bacterial mutation studies of amido-substituted derivatives reveal an unexpected lack of mutagenicity.

S. Venitt, S. Neidle, T. C. Jenkins, 1998, Journal of medicinal chemistry.

Anthracene‐9,10‐diones as Potential Anticancer Agents. Synthesis, DNA‐ Binding, and Biological Studies on a Series of 2,6‐Disubstituted Derivatives.

S. Neidle, A. Reszka, T. C. Jenkins, 1993 .

Synthesis of 9-[cis-3-(hydroxymethyl)cyclobutyl]-adenine and -guanine

S. Neidle, C. Reese, V. Kaiwar, 1995 .

Effect of linker length on DNA-binding affinity, cross-linking efficiency and cytotoxicity of C8-linked pyrrolobenzodiazepine dimers

M. Berardini, S. Neidle, J. Hartley, 1992 .

Chemical approaches to the discovery and development of cancer therapies

Stephen Neidle, David E. Thurston, S. Neidle, 2005, Nature Reviews Cancer.

The structure of the antitumor complex cis-(diammino) (1,1-cyclobutanedicarboxylato)-Pt(II): X ray and nmr studies

P. Sadler, S. Neidle, I. Ismail, 1980 .

G-quadruplex nucleic acids as therapeutic targets.

S. Balasubramanian, S. Neidle, 2009, Current opinion in chemical biology.

Glycal Ethers as Starting Materials in C-Nucleoside Synthesis

S. Neidle, C. Reese, Andrew M. Kaye, 1988 .

The non-covalent interaction of pyrrolo[2, 1-c] [1, 4]benzodiazepine-5, 11-diones with DNA.

S. Neidle, G. Kneale, D. Thurston, 1990, Anti-cancer drug design.

Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system

M. Berardini, S. Neidle, J. Hartley, 1992 .

Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954).

U. Baumann, S. Neidle, S. Hobbs, 1999, Journal of medicinal chemistry.

Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives.

S. Neidle, A. Reszka, T. C. Jenkins, 1992, Journal of medicinal chemistry.

Crystal structure of proflavine, a DNA binding agent

T. Jones, S. Neidle, S. NEIDLE, 1975, Nature.

Crystal and molecular structure of three isomers of dichlorodiamminedihydroxoplatinum(IV): cis-trans isomerization on recrystallization from water

P. Sadler, S. Neidle, R. Kuroda, 1983 .

The design of G-quadruplex ligands as telomerase inhibitors.

Stephen Neidle, Javier Cuesta, S. Neidle, 2003, Mini reviews in medicinal chemistry.

Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors

Stephen Neidle, W. David Wilson, S. Neidle, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Solid-phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates.

S. Balasubramanian, S. Neidle, S. Ladame, 2002, Organic Letters.

Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells.

Stephen Neidle, Mekala Gunaratnam, Stephan A. Ohnmacht, 2013, Journal of medicinal chemistry.

Human telomeric G‐quadruplex: The current status of telomeric G‐quadruplexes as therapeutic targets in human cancer

Stephen Neidle, S. Neidle, 2010, The FEBS journal.

Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge.

S. Neidle, W. Wilson, D. Boykin, 2007, Biophysical chemistry.

Synthesis of distamycin A polyamides targeting G-quadruplex DNA.

Stephen Neidle, Mark Searcey, S. Neidle, 2006, Organic & biomolecular chemistry.

Quadruplex nucleic acids as targets for anticancer therapeutics

Stephen Neidle, S. Neidle, 2017 .

Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition.

Gianni Chessari, Stephen Neidle, John Mann, 2003, Nucleic acids research.

Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates.

Stephen Neidle, Shankar Balasubramanian, S. Balasubramanian, 2009, Organic & biomolecular chemistry.

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands.

I. Hickson, S. Neidle, V. Bohr, 2001, Biochemistry.

Structural characterization of a guanine-quadruplex ligand complex.

S. Neidle, M. Read, 2000, Biochemistry.

Principles of nucleic acid structure

Stephen Neidle, S. Neidle, 2007 .

Binding of unfused aromatic cations to DNA. The influence of molecular twist on intercalation

L. Strekowski,, S. Neidle, W. Wilson, 1988 .

X-Ray crystal structure of sodium bis(N-methylhydantoinato)gold(I) tetrahydrate; a linear, planar complex of pharmacological interest stabilised by two nitrogen ligands

P. Sadler, G. Taylor, S. Neidle, 1978 .

Conformations of the sugar-phosphate backbone in helical DNA crystal structures.

H M Berman, S Neidle, H. Berman, 1997, Biopolymers.

Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel.

G. Parkinson, S. Neidle, P. Hazel, 2007, Journal of the American Chemical Society.

The molecular basis for the action of some DNA-binding drugs.

S. Neidle, 1979, Progress in medicinal chemistry.

Telomere maintenance as a target for anticancer drug discovery

Gary Parkinson, Stephen Neidle, G. Parkinson, 2002, Nature Reviews Drug Discovery.

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.

S. Neidle, Rupesh K. Nanjunda, W. Wilson, 2008, Bioorganic & medicinal chemistry letters.

Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.

J. Fletcher, S. Neidle, M. Gunaratnam, 2009, Journal of medicinal chemistry.

Indolo[3,2‐c]quinoline G‐Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G‐Quadruplex

Stephan A. Ohnmacht, S. Neidle, J. Lavrado, 2015, ChemMedChem.

Flexibility and structural conservation in a c-KIT G-quadruplex

S. Neidle, D. Wei, J. Husby, 2014, Nucleic acids research.

A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells.

Stephen Neidle, S. Neidle, L. Kèlland, 2004, Molecular cancer therapeutics.

Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes.

B. Pagano, S. Neidle, C. Giancola, 2009, The journal of physical chemistry. B.

G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo.

S. Neidle, L. Kèlland, M. Gunaratnam, 2009, Biochemical pharmacology.

Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes.

G. Parkinson, S. Neidle, Francisco Cuenca, 2008, Journal of molecular biology.

Quadruplex nucleic acids.

Stephen Neidle, Shankar Balasubramanian, S. Balasubramanian, 2006 .

DNA Quadruplex–Ligand Recognition: Structure and Dynamics

S. Balasubramanian, S. Neidle, 2006 .

Structure of the first parallel DNA quadruplex-drug complex.

S. Neidle, C. Squire, G. Clark, 2003, Journal of the American Chemical Society.

G‐quadruplexes as therapeutic targets

S. Neidle, M. Read, 2000, Biopolymers.

Triazole-acridine conjugates: redox mechanisms and in situ electrochemical evaluation of interaction with double-stranded DNA.

S. Neidle, A. Oliveira‐Brett, A. D. R. Pontinha, 2013, Bioelectrochemistry.

C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: anticancer profile and G-quadruplex stabilization.

S. Neidle, J. Lavrado, A. Reszka, 2010, Bioorganic & medicinal chemistry letters.

A role for water molecules in DNA-ligand minor groove recognition.

S. Neidle, W. Wilson, Binh Nguyen, 2009, Accounts of chemical research.

DNA minor groove interactions and the biological activity of 2,5-bis.

S. Neidle, D. Boykin, A. Kumar, 2000, Bioorganic & medicinal chemistry letters.

Telomerase inhibitors in cancer therapy: current status and future directions.

S. Neidle, Christopher M Incles, C. Schultes, 2003, Current opinion in investigational drugs.

Nucleic acid binding drugs. Some conformational properties of the anti‐cancer drug daunomycin and several of its derivatives:

G. Taylor, S. Neidle, 1979, FEBS letters.

A thermodynamic and structural analysis of DNA minor-groove complex formation.

S Neidle, W D Wilson, S. Neidle, 2000, Journal of molecular biology.

Truncated azinomycin analogues intercalate into DNA.

S. Neidle, L. Patterson, M. Casely-Hayford, 2005, Bioorganic & medicinal chemistry letters.

The antitumor complex ethylenediamine platinum (II) malonate: x-ray structure analysis, and studies of its stability in solution.

S. Neidle, R. Kuroda, A. Robins, 1983, Journal of inorganic biochemistry.

A standard reference frame for the description of nucleic acid base-pair geometry.

H M Berman, M Gerstein, S Neidle, 2001, Journal of molecular biology.

The structure of the ribodinucleoside monophosphate guanylyl‐3',5'‐cytidine as its ammonium octahydrate salt

H. Berman, S. Islam, S. Neidle, 1983 .

Crystal structure of d(CGCGAATTCGCG) complexed with propamidine, a short-chain homologue of the drug pentamidine.

S. Neidle, C. M. Nunn, T. C. Jenkins, 1993, Biochemistry.

Molecular modeling of drug-DNA interactions: Facts and fantasies

Stephen Neidle, John O. Trent, S. Neidle, 1996 .

Crystallisation of tRNACUGLeu from Escherichia coli after purification with hydroxyapatite

T. Jones, S. Neidle, M. Spencer, 1979 .

Crystal and molecular structure of viridin

S. Neidle, M. Hursthouse, D. Rogers, 1972 .

The structures of quadruplex nucleic acids and their drug complexes.

Stephen Neidle, S. Neidle, 2009, Current opinion in structural biology.

Can we Execute Reliable MM-PBSA Free Energy Computations of Relative Energies of Different Guanine Quadruplex Folds ?

J. Šponer, S. Neidle, S. Haider, 2017 .

Can We Execute Reliable MM-PBSA Free Energy Computations of Relative Stabilities of Different Guanine Quadruplex Folds?

Stephen Neidle, Shozeb Haider, Barira Islam, 2016, The journal of physical chemistry. B.

Extended molecular dynamics of a c-kit promoter quadruplex

Stephen Neidle, Jaroslav Koca, Shozeb Haider, 2015, Nucleic acids research.

Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex.

G. Parkinson, S. Neidle, P. Hazel, 2006, Journal of the American Chemical Society.

The building blocks of DNA and RNA

S. Neidle, M. Sanderson, 2022, Principles of Nucleic Acid Structure.

The crystal structure of a-D-glucose monohydrate

Stephen Neidle, E. Hough, Donald Rogers, 1973 .

Bioactive Compounds from Carissa spinarum

S. Neidle, M. Gunaratnam, V. Lipipun, 2012, Phytotherapy research : PTR.

Drug action at the molecular level

S. Neidle, 1976, Nature.

Synthesis, molecular modeling, DNA binding, and antitumor properties of some substituted amidoanthraquinones.

S. Neidle, D. Collier, 1988, Journal of medicinal chemistry.

Drug-nucleic acid interactions: conformational flexibility at the intercalation site.

R. K. Stodola, H. Berman, S. Neidle, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Drug-DNA Recognition: Sequence-Specificity of the DNA Minor Groove Binder Berenil

S. Neidle, C. Laughton, T. C. Jenkins, 1990 .

Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.

S. Neidle, L. Kèlland, M. Gunaratnam, 2007, Bioorganic & medicinal chemistry letters.

The structure of telomeric DNA.

G. Parkinson, S. Neidle, 2003, Current opinion in structural biology.

A molecular anchor for stabilizing triple-helical DNA.

S. Neidle, T. C. Jenkins, K. Fox, 1995, Proceedings of the National Academy of Sciences of the United States of America.

A crystallographic and spectroscopic study of the complex between d(CGCGAATTCGCG)2 and 2,5-bis(4-guanylphenyl)furan, an analogue of berenil. Structural origins of enhanced DNA-binding affinity.

S Neidle, W D Wilson, S. Neidle, 1995, Biochemistry.

Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter.

Sarah W. Burge, A. Phan, D. Patel, 2007, Journal of the American Chemical Society.

Putative DNA quadruplex formation within the human c-kit oncogene.

Stephen Neidle, Mire Zloh, Alan K Todd, 2005, Journal of the American Chemical Society.

A Personal History of Quadruplex-Small Molecule Targeting.

S. Neidle, 2015, Chemical record.

Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives.

S. Moro, G. Parkinson, S. Neidle, 2008, Bioorganic & Medicinal Chemistry.

Computer modelling and drug design

S. Neidle, C. A. Laughton, S. Neidle, 1992 .

Stabilization of DNA triple helices by a series of mono- and disubstituted amidoanthraquinones.

S. Neidle, J. Trent, A. Reszka, 1999, European journal of biochemistry.

Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships.

S Neidle, A A Wood, J R Harrison, 1999, Journal of medicinal chemistry.

A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline.

S. Neidle, S. Gowan, V. Caprio, 2000, Bioorganic & medicinal chemistry letters.

Comparative computer graphics and solution studies of the DNA interaction of substituted anthraquinones based on doxorubicin and mitoxantrone.

J R Brown, S A Islam, S Neidle, 1985, Journal of medicinal chemistry.

Antibacterial activity of head-to-head bis-benzimidazoles.

S. Neidle, P. Taylor, Timothy D McHugh, 2013, International journal of antimicrobial agents.

Therapeutic Applications of Quadruplex Nucleic Acids

S. Neidle, 2011 .

Crystallographic and molecular mechanics calculations on the anti-tumor drugs N-[(2-dimethylamino)ethyl]-and N-[(2-dimethyl-amino)butyl]-9-aminoacridine-4-carboxamides and their dications: implications for models of DNA-binding.

B. Hudson, W. Denny, S. Neidle, 1987, Journal of biomolecular structure & dynamics.

A structural analysis of G-quadruplex/ligand interactions.

G. Parkinson, S. Neidle, S. Haider, 2011, Biochimie.

Characteristics of triplex-directed photoadduct formation by psoralen-linked oligodeoxynucleotides.

S. Neidle, P. Bates, C. Laughton, 1995, Nucleic acids research.

Structure‐Dependent Binding of Arylimidamides to the DNA Minor Groove

N. Campbell, S. Neidle, W. Wilson, 2014, Chembiochem : a European journal of chemical biology.

Synthesis and biophysical studies of short oligodeoxynucleotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynucleotide synthesis.

S. Neidle, J. Gunning, M. Eaton, 1984, Nucleic acids research.

A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.

S. Balasubramanian, P. Várnai, S. Neidle, 2009, Journal of the American Chemical Society.

2′,3′-Anhydrouridine. A useful synthetic intermediate

S. Neidle, C. Reese, I. Simpson, 1998 .

A model for the [C+‐G⋅C]n triple helix derived from observation of the C+‐G⋅C base triplet in a crystal structure

S. Neidle, C. M. Nunn, J. Trent, 1997, FEBS letters.

2′,3′-Anhydrouridine. A Useful Synthetic Intermediate.

S. Neidle, C. Reese, I. Simpson, 1999 .

Origins of stereospecificity in DNA damage by anti‐benzo[a]pyrene diol‐epoxides

L. Pearl, S. Neidle, 1986, FEBS letters.

High-resolution crystal structure of the intramolecular d(TpA) thymine–adenine photoadduct and its mechanistic implications

J. Malone, S. Neidle, Michael P H Lee, 2007, Nucleic acids research.

Derivatives of 2',3'-dithiouridine and [1-β-D-(2,3-dithioxylofuranosyl)]uracil

S. Neidle, C. Reese, B. Joshi, 1992 .

The crystal and molecular structure of streptomycin oxime selenate tetrahydrate

S. Neidle, M. Hursthouse, D. Rogers, 1978, Proceedings of the Royal Society of London. A. Mathematical and Physical Sciences.

The crystal and molecular structure of streptomycin oxime selenate.

S. Neidle, M. Hursthouse, D. Rogers, 1968, Tetrahedron letters.

The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments

Helen M. Berman, Stephen Neidle, H. S. Shieh, 1980, Nucleic Acids Res..

Comparative structural studies of [3.1.0]-fused 2',3'-modified β-D-nucleosides by X-ray crystallography, NMR spectroscopy, and molecular mechanics calculations

Stephen Neidle, Weimin Tong, Jyoti Chattopadhyaya, 1991 .

Non-standard and higher-order DNA structures: DNA–DNA recognition

S. Neidle, M. Sanderson, 2022, Principles of Nucleic Acid Structure.

Nonstandard and Higher-Order DNA Structures: DNA–DNA Recognition

S. Neidle, 2008 .

Computer modelling studies of the covalent interactions between DNA and the enantiomers of anti-7,8-diol,9,10-epoxy-benzo[a]pyrene.

S. Islam, S. Neidle, A. Aggarwal, 1983, Journal of biomolecular structure & dynamics.

Molecular structure of (+/-)-7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene determined by x-ray crystallography.

S. Neidle, C. S. Cooper, R. Kuroda, 1982, Cancer research.

A new crystal form for the dodecamer C-G-C-G-A-A-T-T-C-G-C-G: symmetry effects on sequence-dependent DNA structure.

G. Parkinson, S. Neidle, E. Johansson, 2000, Journal of molecular biology.

Developing and paying for medicines for orphan indications in oncology: utilitarian regulation vs equitable care?

S. Neidle, D. G. Taylor, J. E. Davies, 2012, British Journal of Cancer.

DNA sequence preferences for an intercalating porphyrin compound revealed by footprinting.

M. Waring, S. Neidle, K. Ford, 1987, Nucleic acids research.

Recent developments in triple-helix regulation of gene expression.

S. Neidle, 1997, Anti-cancer drug design.

The anti-conformation of 2',3'-dideoxy nucleosides may be essential for anti-HIV activity: evidence from the crystal structure of 2',3'-dideoxy formycin A.

S. Neidle, D. Whitby, L. Urpí, 1989, Biochemical and biophysical research communications.

Detection and kinetic studies of triplex formation by oligodeoxynucleotides using real-time biomolecular interaction analysis (BIA).

S Neidle, S Kumar, S. Neidle, 1995, Nucleic acids research.

Molecular modelling of the interactions of tetra-(4-N-methylpyridyl) porphin with TA and CG sites on DNA.

L. Pearl, S. Neidle, K. Ford, 1987, Nucleic acids research.

Beyond the double helix: DNA structural diversity and the PDB

S. Neidle, 2021, The Journal of biological chemistry.

Conformation and dynamics of drug-DNA intercalation.

J. Goodfellow, S. Neidle, P. Herzyk, 1992, Journal of biomolecular structure & dynamics.

The Structures of Human Telomeric DNA Quadruplexes

S. Neidle, 2012 .

Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures

G. Parkinson, S. Neidle, P. Hazel, 2006, Nucleic acids research.

Interaction of berenil with the tyrT DNA sequence studied by footprinting and molecular modelling. Implications for the design of sequence-specific DNA recognition agents.

S Neidle, S. Neidle, C. Laughton, 1990, Nucleic acids research.

A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line.

G. Parkinson, S. Neidle, M. Gunaratnam, 2018, Bioorganic & medicinal chemistry.

Genomic Quadruplexes as Therapeutic Targets

S. Neidle, 2012 .

A homology‐based molecular model of the proline‐rich homeodomain protein Prh, from haematopoietic cells

S. Neidle, G. Goodwin, 1994, FEBS letters.

Downregulation of androgen receptor transcription by promoter g-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer.

Stephan A. Ohnmacht, S. Balasubramanian, M. Micco, 2013, Biochemistry.

Highly structured water network in crystals of a deoxydinucleoside–drug complex

Helen M. Berman, Stephen Neidle, H. Berman, 1980, Nature.

Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).

S. Neidle, B. F. Li, I. Tickle, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids

S. Neidle, 2021, Pharmaceuticals.

Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology.

Stephan A. Ohnmacht, R. Angell, S. Neidle, 2020, ACS medicinal chemistry letters.

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

Stephan A. Ohnmacht, S. Neidle, J. Lavrado, 2015, Scientific Reports.

Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands.

Stephen Neidle, Gary N Parkinson, Gavin W Collie, 2012, Journal of the American Chemical Society.

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

G. Parkinson, S. Neidle, S. Haider, 2010, Nucleic acids research.

Loop-length-dependent folding of G-quadruplexes.

Stephen Neidle, Shankar Balasubramanian, S. Balasubramanian, 2004, Journal of the American Chemical Society.

Structural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular Target.

G. Parkinson, S. Neidle, S. Haider, 2016, Journal of the American Chemical Society.

Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs.

Stephen Neidle, Mekala Gunaratnam, Gary N Parkinson, 2008, Journal of medicinal chemistry.

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes.

G. Parkinson, S. Neidle, A. Reszka, 2009, Chemical communications.

The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds.

Stephan A. Ohnmacht, S. Neidle, M. Gunaratnam, 2013, Bioorganic & medicinal chemistry.

Quadruplex DNA crystal structures and drug design.

Stephen Neidle, Gary N Parkinson, G. Parkinson, 2008, Biochimie.

Structural basis of telomeric RNA quadruplex--acridine ligand recognition.

G. Parkinson, S. Neidle, G. Collie, 2011, Journal of the American Chemical Society.

Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures.

E. De Pauw, G. Parkinson, S. Neidle, 2010, Journal of the American Chemical Society.

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.

Stephan A. Ohnmacht, E. Novellino, B. Pagano, 2016, Journal of medicinal chemistry.

DNA structure as observed in fibres and crystals

S. Neidle, M. Sanderson, 2022, Principles of Nucleic Acid Structure.

Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction

P. Jin, S. Neidle, M. Hou, 2021, Nucleic acids research.

DNA Structure as Observed in Fibers and Crystals

S. Neidle, 2008 .

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X‐ray crystallography

G. Parkinson, T. Bui, A. Drake, 2013, FEBS letters.

Hitting the target

Stephen Neidle, S. Neidle, 1999, Nature.

Approaches to effective anti-cancer drugs

S. Neidle, 1977, Nature.

Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands.

Stephen Neidle, Shozeb Haider, Mekala Gunaratnam, 2008, Molecular bioSystems.

Mechanism of acridine-based telomerase inhibition and telomere shortening.

Stephen Neidle, Hamid Morjani, Mekala Gunaratnam, 2007, Biochemical pharmacology.

A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells †

S. Neidle, A. Ahmed, 2020, Molecules.

Equilibrium and Kinetic Measurements Reveal Rapidly Reversible Binding of Ras to Raf (*)

S. Neidle, R. Skinner, P. N. Lowe, 1996, The Journal of Biological Chemistry.

An approach to protein homology modelling based on an ensemble of NMR structures: application to the Sox-5 HMG-box protein.

S Neidle, A A Adzhubei, S. Neidle, 1995, Protein engineering.

Reply: Comment on ‘Developing and paying for medicines for orphan indications in oncology: utilitarian regulation vs equitable care?’

S. Neidle, D. G. Taylor, J. E. Davies, 2012, British Journal of Cancer.

Targeting Promoter Quadruplex Nucleic Acids for Cancer Therapy

S. Neidle, A. Paulo, C. C. Castillo, 2017 .

An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells.

Stephen Neidle, Mekala Gunaratnam, S. Neidle, 2010, Methods in molecular biology.

Design Principles for Quadruplex-binding Small Molecules

S. Neidle, 2012 .

Selective G-quadruplex ligands: the significant role of side chain charge density in a series of perylene derivatives.

S. Neidle, M. Savino, M. Franceschin, 2009, Bioorganic & medicinal chemistry letters.

The crystal and molecular structure of streptomycin

S. Neidle, M. Hursthouse, D. ROGERSt, 2016 .

Structure-based design of selective high-affinity telomeric quadruplex-binding ligands.

E. De Pauw, S. Neidle, S. Haider, 2010, Chemical communications.

Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif.

S. Neidle, M. Gunaratnam, S. Haider, 2010, Chemical communications.

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

Stephan A. Ohnmacht, S. Neidle, J. Lavrado, 2015, PloS one.

Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes.

Stephen Neidle, Mekala Gunaratnam, Silvia Sparapani, 2010, Journal of the American Chemical Society.

Telomerase as an anti-cancer target: current status and future prospects.

S. Neidle, L. Kelland, 1999, Anti-cancer drug design.

Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation.

S. Neidle, M. Palumbo, G. Zagotto, 2008, Journal of medicinal chemistry.

A benzoquinone Di-imine from the oxidation of pentafluoroaniline by hypochlorite. X-Ray crystal structure and possible formation via pentafluorophenylnitrene

J. Deadman, S. Neidle, R. McKenna, 1989 .

A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes.

S. Neidle, S. Haider, 2009, Biochemical Society transactions.

Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule

S. Neidle, S. Welsh, A. Schatzlein, 2013, Scientific Reports.

Cancer: Science and Society : by John Cairns W. H. Freeman; San Francisco, 1978 xiv + 200 pages. £2.90 (softcover), £6.20 (hardcover)

S. Neidle, 1980 .

Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets.

Andrew J. P. White, L. Buluwela, S. Neidle, 2012, Journal of medicinal chemistry.

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

S. Neidle, M. Gunaratnam, V. Petrucci, 2013, Beilstein journal of organic chemistry.

The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer

Jane Worthington, Zoë A. E. Waller, W. Greenhalf, 2023, Molecules.

Experimental and computer graphics simulation analyses of the DNA interaction of 1,8-bis-(2-diethylaminoethylamino)-anthracene-9,10-dione, a compound modelled on doxorubicin.

J. R. Brown, S. Islam, S. Neidle, 1983, Biochemical pharmacology.

Experimental DNA-binding and computer modelling studies on an analogue of the anti-tumor drug amsacrine.

S. Neidle, M. Agbandje, Z. Abraham, 1988, Journal of biomolecular structure & dynamics.

Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy.

Stephen Neidle, S. Neidle, S. Haider, 2010, Journal of molecular biology.

Principles of protein–DNA recognition

S. Neidle, M. Sanderson, 2022, Principles of Nucleic Acid Structure.

Principles of Protein-DNA Recognition

S. Neidle, 2008 .

Structure of a bis-amidinium derivative of hoechst 33258 complexed to dodecanucleotide d(CGCGAATTCGCG)2: the role of hydrogen bonding in minor groove drug-DNA recognition.

S. Neidle, D. Boykin, G. Clark, 1997, Nucleic acids research.

Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries.

S. Neidle, A. Reszka, D. Thurston, 2012, Bioorganic & medicinal chemistry letters.

Mechanism of the Antiproliferative Activity of Some Naphthalene Diimide G-Quadruplex Ligands

S. Neidle, A. Reszka, P. Boukamp, 2013, Molecular Pharmacology.

Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects

S. Neidle, M. Hou, R. Satange, 2023, Nucleic acids research.

A hypothesis concerning possible new derivatives of daunorubicin and adriamycin with enhanced DNA-binding properties.

S. Neidle, 1977, Cancer treatment reports.

Quadruplex nucleic acids as targets in cancer drug discovery

S. Neidle, 2020 .

Small‐molecule G‐quadruplex interactions: Systematic exploration of conformational space using multiple molecular dynamics

J. Platts, S. Neidle, A. K. Todd, 2013, Biopolymers.

CRYSTAL STRUCTURE OF THE DB 985-D(CGCAAATTTGCG)2 COMPLEX AT 1.20 A RESOLUTION

E. Mitchell, S. Neidle, S. Teixeira, 2013 .

Hierarchical Nanotube Self‐Assembly of DNA Minor Groove‐Binding Ligand DB921 via Alkali Halide Triggering

P. Rannou, E. Mitchell, T. Narayanan, 2019, Macromolecular Symposia.

Crystal structures of nucleic acids and their drug complexes.

S. Neidle, C. M. Nunn, 1998, Natural product reports.

Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study.

R. L. Jones, G. Zon, E. Garman, 1990, Nucleic acids research.

Molecular Dynamics Studies of the STAT3 Homodimer: DNA Complex: Relationships between STAT3 Mutations and Protein-DNA Recognition

Stephen Neidle, David E. Thurston, Jarmila Husby, 2012, J. Chem. Inf. Model..

Bis(acetato)amminedichloro(cyclohexylamine)platinum(IV), an orally active anticancer drug.

S. Neidle, B. Murrer, C. Barnard, 1995, Acta crystallographica. Section C, Crystal structure communications.

Conformational flexibility and its potential influence on metabolic reactions for the anti-tumour compound a-ammine-bd-bis(butyrato)-cf-dichloro-e-cyclohexylamine platinum(IV)

S. Neidle, B. Murrer, C. Barnard, 1996 .

Conformational properties of 3'-azido-3'deoxy-thymidine (AZT), an inhibitor of HIV reverse transcriptase.

S. Neidle, P. Herzyk, A. Beveridge, 1987, Biochemical and biophysical research communications.

Molecular dynamics and principal components analysis of human telomeric quadruplex multimers.

Stephen Neidle, Shozeb Haider, Gary N Parkinson, 2008, Biophysical journal.

On the determination of heavy‐atom positions in various elastase derivatives

S. Neidle, 1973 .

A molecular model for proflavine-DNA intercalation.

L. Pearl, H. Berman, S. Neidle, 1988, Nucleic acids research.

Virtual screening of DNA minor groove binders.

Stephen Neidle, S. Neidle, David A Evans, 2006, Journal of medicinal chemistry.

Studies on the conformation and dynamics of the C8-substituted guanine adduct of the carcinogen acetylaminofluorene; model for a possible Z-DNA modified structure.

R. Levine, B. Hingerty, S. Broyde, 1984, Nucleic acids research.

Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex.

Stephen Neidle, Christian Bailly, Yang Liu, 2007, Journal of the American Chemical Society.

Visualisation of extensive water ribbons and networks in a DNA minor-groove drug complex.

S. Neidle, A. Guerri, I. Simpson, 1998, Nucleic acids research.

Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2.

S. Neidle, W. Wilson, J. Trent, 1996, Journal of medicinal chemistry.

Sequence-dependent drug binding to the minor groove of DNA: crystal structure of the DNA dodecamer d(CGCAAATTTGCG)2 complexed with propamidine.

S. Neidle, C. M. Nunn, 1995, Journal of medicinal chemistry.

Molecular structures of three hydroxyl derivatives of the hepatic carcinogen acetylaminofluorene. Evidence for preferred orientation of the acetylamino side-chain.

S. Neidle, S. Islam, A. Mason, 1981, Carcinogenesis.

The molecular structure of (±)- 7α, 8β-dihydroxy-7,8-dihydrobenzo[a]pyrene, an early metabolite of benzo[a]pyrene

S. Neidle, M. Osborne, A. Subbiah, 1981 .

Variability in the geometry of RNA double helices generated from dinucleoside building-blocks.

S. Neidle, A. Aggarwal, 1985, Journal of biomolecular structure & dynamics.

Isohelicity and phasing in drug--DNA sequence recognition: crystal structure of a tris(benzimidazole)--oligonucleotide complex.

S. Neidle, W. Leupin, G. Clark, 1996, Biochemistry.

Structure of a dinucleoside phosphate–drug complex as model for nucleic acid–drug interaction

H. L. Carrell, H. Berman, W. Stallings, 1977, Nature.

Crystal structure of an oligonucleotide duplex containing G.G base pairs: influence of mispairing on DNA backbone conformation.

S. Neidle, T. C. Jenkins, K. J. Edwards, 1993, Proceedings of the National Academy of Sciences of the United States of America.

DNA sequence preferences for the anti‐cancer drug mitoxanthrone and related anthraquinones revealed by DNase I footprinting

M. Waring, S. Neidle, K. Fox, 1986, FEBS letters.

Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme.

G. Parkinson, S. Neidle, J. V. Skelly, 2000, Journal of medicinal chemistry.

Carcinogens and DNA

S. Neidle, 1980, Nature.

Design, synthesis and evaluation of human telomerase inhibitors based upon a tetracyclic structural motif.

S. Neidle, L. Kelland, S. Gowan, 1999, Anti-cancer drug design.

Crystallographic studies in the pyrrole series. Part II. Crystal and molecular structure of 5,5′-diethoxycarbonyl-3,3′,4,4′-tetraethyldipyrrol-2-ylmethane

S. Neidle, R. Bonnett, M. Hursthouse, 1972 .

Crystallographic studies in the pyrrole series. Part I. Crystal and molecular structure of ethyl 4-acetyl-3-ethyl-5-methylpyrrole-2-carboxylate

S. Neidle, R. Bonnett, M. Hursthouse, 1972 .

The crystal and molecular structure of 8,2'-cycloadenosine trihydrate

G. Taylor, S. Neidle, P. Cowling, 1979 .

Crystallography of DNA and RNA G‐Quadruplex Nucleic Acids and Their Ligand Complexes

N. Campbell, S. Neidle, G. Collie, 2012, Current protocols in nucleic acid chemistry.

A 1:2 crystalline complex of ApA:proflavine: a model for binding to single-stranded regions in RNA.

G. Taylor, S. Neidle, M. Sanderson, 1978, Nucleic acids research.

Combining 1,3‐Ditriazolylbenzene and Quinoline to Discover a New G‐Quadruplex‐Interactive Small Molecule Active against Cancer Stem‐Like Cells

S. Neidle, J. Lavrado, Jorge Vítor, 2019, ChemMedChem.

Xanthene and Xanthone Derivatives as G-Quadruplex Stabilizing Ligands

Stephan A. Ohnmacht, S. Neidle, G. Ortaggi, 2013, Molecules.

Antibiotics affecting DNA function

S. Neidle, 1983 .

G-quadruplexes and metal ions.

N. Campbell, S. Neidle, 2012, Metal ions in life sciences.

RNA Structures and Their Diversity

S. Neidle, 2008 .

A detailed molecular model for human aromatase

S. Neidle, C. A. Laughton, C. Laughton, 1993, The Journal of Steroid Biochemistry and Molecular Biology.

Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove.

G. Parkinson, S. Neidle, W. Wilson, 2005, Biochemistry.

Crystal and molecular structure of three isomers of dichlorodiamminedihydroxoplatinum(IV): cis-trans isomerization on recrystallization from water

P. Sadler, S. Neidle, R. Kuroda, 1984 .

Cytotoxicity of bis(phenylamidinium)furan alkyl derivatives in human tumour cell lines: Relation to DNA minor groove binding

S. Neidle, J. Trent, L. Kèlland, 1997 .

Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2. An examination of propeller twist and minor-groove water structure at 2.2 A resolution.

S Neidle, S. Neidle, K. J. Edwards, 1992, Journal of molecular biology.

NMR and molecular modeling studies of the interaction of berenil and pentamidine with d(CGCAAATTTGCG)2.

S Neidle, A. Lane, S. Neidle, 1993, European journal of biochemistry.

Methods for studying nucleic acid structure

S. Neidle, 2022, Principles of Nucleic Acid Structure.

Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines.

S. Balasubramanian, J. Fletcher, S. Neidle, 2010, ACS medicinal chemistry letters.

A Role for Water Molecules in DNA—Ligand Minor Groove Recognition

S. Neidle, W. Wilson, Binh Nguyen, 2009 .

Comment on "Dark Nudges and Sludge in Big Alcohol: Behavioral Economics, Cognitive Biases, and Alcohol Industry Corporate Social Responsibility".

S. Neidle, J. Chick, Fiona Sim, 2020, The Milbank quarterly.

Designer DNA-binding drugs: the crystal structure of a meta-hydroxy analogue of Hoechst 33258 bound to d(CGCGAATTCGCG)2.

S. Neidle, C. Squire, W. Leupin, 1996, Nucleic acids research.

Crystal structure of gamma-oxapentamidine complexed with d(CGCGAATTCGCG)2. The effects of drug structural change on DNA minor-groove recognition.

S. Neidle, C. M. Nunn, T. C. Jenkins, 1994, European journal of biochemistry.

Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation

S. Neidle, M. Hou, C. Chuang, 2019, Nucleic acids research.

Conformational effects of nucleotide exchange in ras p21 proteins as studied by fluorescence spectroscopy

J. Hancock, A. Drake, S. Neidle, 1990, FEBS letters.

Discovery of new G-quadruplex binding chemotypes.

Stephan A. Ohnmacht, S. Neidle, Rupesh K. Nanjunda, 2014, Chemical communications.

Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale

J. Šponer, M. Orozco, M. Sgobba, 2013, Nucleic acids research.

Interactions with DNA: Into the minor groove.

S. Neidle, 2012, Nature chemistry.

Cancer drug design and discovery

Stephen Neidle, S. Neidle, 2008 .

The structure of Miracil D, a DNA-binding drug.

S. Neidle, 1976, Biochimica et biophysica acta.

Crystal structure of a DNA decamer showing a novel pseudo four-way helix-helix junction.

H M Berman, S Neidle, H. Berman, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein.

Stephen Neidle, Shankar Balasubramanian, S. Balasubramanian, 2006, Biochemistry.

The relevance of drug DNA sequence specificity to anti-tumour activity.

S. Neidle, D. Thurston, M. Puvvada, 1994, European journal of cancer.

Cancer Drug Design and Discovery: Second Edition

S Neidle, S. Neidle, 2013 .

New insights into sequence-dependent DNA structure

S. Neidle, 1998, Nature Structural Biology.

Sequence-selective targeting of long stretches of the DNA minor groove by a novel dimeric bis-benzimidazole.

C. Bailly, S. Neidle, J. Mann, 2003, Biochemistry.

Synthesis of a novel dimeric bis-benzimidazole with site-selective DNA-binding properties

S. Neidle, J. Mann, Xiao‐Wen Sun, 2002 .

A novel di-platinum(II) octaphosphite complex showing metal–metal bonding and intense luminescence; a potential probe for basic proteins. X-Ray crystal and molecular structure

P. Sadler, S. Neidle, R. Kuroda, 1980 .

Molecular-mechanics modelling of drug-DNA structures; the effects of differing dielectric treatment on helix parameters and comparison with a fully solvated structural model.

M. Orozco, S. Neidle, C. Laughton, 1990, Journal of biomolecular structure & dynamics.

Sequence-dependent crossed helix packing in the crystal structure of a B-DNA decamer yields a detailed model for the Holliday junction.

S. Neidle, C. M. Nunn, J. Trent, 1997, Journal of molecular biology.

Nucleic acid binding drugs. VII. Molecular-mechanics studies on the conformational properties of the anti-cancer drug daunomycin: some observations on the use of differing potential-energy functions

S. Islam, S. Neidle, 1983 .

A molecular model for the enzyme cytochrome P45017α, a major target for the chemotherapy of prostatic cancer

Stephen Neidle, C. A. Laughton, M. Sternberg, 1990 .

Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform.

S. Balasubramanian, S. Neidle, S. Ladame, 2004, Organic & biomolecular chemistry.

Molecular aspects of anticancer drug-DNA interactions (vol. 1)

M. Waring, G. Margison, S. Neidle, 1994 .

The structure of chain-linked DNA as a possible model for the transcription bubble

S. Neidle, C. M. Nunn, 1995, Nature Structural Biology.

Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity.

S. Neidle, C. Laughton, 1990, Journal of medicinal chemistry.

Variability in DNA minor groove width recognised by ligand binding: the crystal structure of a bis-benzimidazole compound bound to the DNA duplex d(CGCGAATTCGCG)2.

S. Neidle, C. M. Nunn, D. Boykin, 1995, Nucleic acids research.

Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.

S. Neidle, C. Laughton, M. Rowlands, 1990, Journal of medicinal chemistry.

The preparation and isomerization of platinum metronidazole complexes: X-ray crystal and molecular structures of cis- and trans-dichlorobis[1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole]-platinum(II)

P. Sadler, S. Neidle, M. Mazid, 1983 .

RNA binding proteins

S. Neidle, M. Sanderson, 2022, Principles of Nucleic Acid Structure.

In silico studies of nucleic acid complexes with proteins, and therapeutic small molecules

S. Neidle, J. Husby, née Chladová, 2013 .

Structures of two DNA minor-groove binders, based on pyrrolo[2,1-c][1,4]-benzodiazepines

S. Neidle, D. Thurston, G. B. Jones, 1991 .

Structures of Two DNA Minor‐Groove Binders, Based on Pyrrolo(2,1‐c)(1, 4)benzodiazepines.

S. Neidle, D. Thurston, G. B. Jones, 1992 .

Nucleic acid binding drugs--XIV. The crystal structure of 1-methyl amsacrine hydrochloride; relationships to DNA-binding ability and anti-tumour activity.

W. Denny, S. Neidle, B. Baguley, 1986, Biochemical pharmacology.

The structure of 3,5-di-O-benzoyl-1,2-dideoxy-1-phenyl-β-D-ribofuranose, C25H22O5

S. Neidle, M. Eaton, J. Gunning, 1985 .

X-Ray crystallographic determination of the molecular structures of cis- and trans-isomers of (±)-5-fluorocyclophosphamide {2-[bis-(2-chloroethyl)amino]-5-fluorotetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide]}

S. Neidle, G. Taylor, S. Cutbush, 1981 .

Structure of 2,3‐dihydro‐1H‐imidazo[1,2‐b]pyrazole (IMPY), an inhibitor of DNA synthesis, C5H7N3

S. Neidle, D. E. Wilman, S. Cutbush, 1983 .

X-ray studies on anti-tumour triazenes. Structures of 1-(4-carbamoylphenyl)-3,3-dimethyltriazene 1-oxide and 3,3-dimethyl-1-(4-nitrophenyl)triazene.

S. Neidle, D. E. Wilman, 1992, Acta crystallographica. Section B, Structural science.

Prediction of the structure of the Y+.R-.R(+)-type DNA triple helix by molecular modelling.

S. Neidle, C. Laughton, 1992, Nucleic acids research.

Molecular dynamics simulation of the DNA triplex d(TC)5.d(GA)5.d(C+T)5.

S Neidle, S. Neidle, C. Laughton, 1992, Journal of molecular biology.

Folding of guanine quadruplex molecules-funnel-like mechanism or kinetic partitioning? An overview from MD simulation studies.

J. Šponer, G. Bussi, M. Otyepka, 2016, Biochimica et biophysica acta. General subjects.

Structural basis of telomeric RNA quadruplex--acridine ligand recognition.

G. Parkinson, S. Neidle, G. Collie, 2011, Journal of the American Chemical Society.

Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes.

G. Parkinson, S. Neidle, Francisco Cuenca, 2008, Journal of molecular biology.

Small-molecule binding to the DNA minor groove is mediated by a conserved water cluster.

S. Neidle, W. Wilson, D. Wei, 2013, Journal of the American Chemical Society.

Mercaptoacyl matrix metalloproteinase inhibitors: The effect of substitution at the mercaptoacyl moiety

D. Manallack, J. Montana, S. Neidle, 1997 .

Drugs and nucleic acids

S. Neidle, 1975, Nature.

Hitting the target

S. Neidle, 1999, Nature.

Structure‐Dependent Binding of Arylimidamides to the DNA Minor Groove

N. Campbell, S. Neidle, W. Wilson, 2014, Chembiochem : a European journal of chemical biology.

The Determination of Quadruplex Structures

S. Neidle, 2012 .

Carcinogen binding to DNA

S. Neidle, 1978, Nature.

Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries.

S. Neidle, A. Reszka, D. Thurston, 2012, Bioorganic & medicinal chemistry letters.

Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines.

S. Balasubramanian, J. Fletcher, S. Neidle, 2010, ACS medicinal chemistry letters.

Nucleic acids and their constituents

L. E. Sutton, S. Neidle, M. Truter, 1978 .

Discovery of new anticancer drugs by computer-aided drug design.

S. Neidle, 1994, Annals of oncology : official journal of the European Society for Medical Oncology.

Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase

D. Burke, S. Neidle, C. Laughton, 1995 .

Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes.

S. Neidle, S. Haider, 2010, Methods in molecular biology.

Drug-nucleic acid interactions: conformational flexibility at the intercalation site.

R. K. Stodola, H. Berman, S. Neidle, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Monte Carlo studies on water in the dCpG/proflavin crystal hydrate.

M. Mezei, H. Berman, J. Goodfellow, 1983, Journal of biomolecular structure & dynamics.