K. Ogata

发表

Structural Analyses of DNA Recognition by the AML1/Runx-1 Runt Domain and Its Allosteric Control by CBFβ

Takashi Kumasaka, Masaki Yamamoto, Kazumi Kimura, 2001, Cell.

Foxo1 links insulin signaling to C/EBPα and regulates gluconeogenesis during liver development

A. Fukamizu, K. Ogata, A. Miyajima, 2007, The EMBO journal.

KDM6A Point Mutations Cause Kabuki Syndrome

N. Niikawa, N. Matsumoto, M. Shiina, 2013, Human mutation.

The tryptophan cluster: a hypothetical structure of the DNA-binding domain of the myb protooncogene product.

A. Sarai, S. Ishii, H. Nakagoshi, 1990, The Journal of biological chemistry.

Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices

Haruki Nakamura, Kazuhiro Ogata, Akinori Sarai, 1994, Cell.

De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy

Naomichi Matsumoto, Mitsuhiro Kato, Hitoshi Osaka, 2008, Nature Genetics.

GRIN1 mutations cause encephalopathy with infantile‐onset epilepsy, and hyperkinetic and stereotyped movement disorders

D. Lev, N. Matsumoto, M. Shiina, 2015, Epilepsia.

Erratum: Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFβ (Cell 104:5(755-767))

T. Tahirov, T. Inoue-Bungo, H. Morii, 2001 .

The C-Myb Dna Binding Domain

S. Ishii, T. Tahirov, K. Ogata, 2004 .

Expanding the phenotypic spectrum of TUBB4A-associated hypomyelinating leukoencephalopathies

N. Matsumoto, M. Shiina, K. Ogata, 2014, Neurology.

Biallelic Mutations in MYPN, Encoding Myopalladin, Are Associated with Childhood-Onset, Slowly Progressive Nemaline Myopathy.

J. Towbin, I. Nonaka, Y. Hayashi, 2017, American journal of human genetics.

Determination of the NMR solution structure of a specific DNA complex of the Myb DNA-binding domain

A. Sarai, S. Ishii, K. Ogata, 1995, Journal of biomolecular NMR.

Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids

T. Katoh, K. Hirata, K. Ogata, 2020, Nature Chemistry.

Molecular mechanisms of cooperative binding of transcription factors Runx1–CBFβ–Ets1 on the TCRα gene enhancer

Haruki Nakamura, I. Fukuda, M. Shiina, 2017, PloS one.

Phenotypic spectrum of GNAO1 variants: epileptic encephalopathy to involuntary movements with severe developmental delay

Naomichi Matsumoto, Nobuhiko Okamoto, Yukifumi Monden, 2015, European Journal of Human Genetics.

The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b.

Y. Hayashi, K. Ogata, A. Suzuki, 2010, Biochemical and biophysical research communications.

Heterozygous Mutations in OAS1 Cause Infantile-Onset Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia

H. Kanegane, N. Matsumoto, M. Shiina, 2018, The American Journal of Human Genetics.

Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2

O. Nureki, H. Kono, T. Nishizawa, 2021, Nature Communications.

Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42

S. Tsuji, Yukihiro Nakamura, N. Matsumoto, 2019, Neurobiology of Disease.

This information is current as Beclin 1 Processes through an Association with NLRP 4 Negatively Regulates Autophagic

K. Ishii, M. Shiina, K. Ogata, 2010 .

LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates

K. Ogata, D. T. Nguyen, H. Suga, 2022, Nature Catalysis.

Genetic landscape of Rett syndrome-like phenotypes revealed by whole exome sequencing

T. Matsuishi, A. Fattal-Valevski, A. Takata, 2019, Journal of Medical Genetics.

Deep sequencing detects very-low-grade somatic mosaicism in the unaffected mother of siblings with nemaline myopathy

Y. Hayashi, I. Nishino, N. Matsumoto, 2014, Neuromuscular Disorders.

Short-lasting unilateral neuralgiform headache attacks with ispilateral facial flushing is a new variant of paroxysmal extreme pain disorder

S. Manaka, N. Matsumoto, M. Shiina, 2015, The Journal of Headache and Pain.

Biallelic COLGALT1 variants are associated with cerebral small vessel disease

K. Yokochi, M. Frith, H. Mori, 2018, Annals of neurology.

A novel mutation in SLC1A3 causes episodic ataxia

A. Takata, N. Matsumoto, M. Shiina, 2017, Journal of Human Genetics.

Investigation of the Pyrimidine Preference by the c-Myb DNA-binding Domain at the Initial Base of the Consensus Sequence*

A. Sarai, H. Nakamura, M. Oda, 1997, The Journal of Biological Chemistry.

Crystals of ternary protein–DNA complexes composed of DNA-binding domains of c-Myb or v-Myb, C/EBPα or C/EBPβ and tom-1A promoter fragment

T. Tahirov, T. Inoue-Bungo, A. Fujikawa, 2001 .

Crystallization and preliminary X-ray analyses of quaternary, ternary and binary protein–DNA complexes with involvement of AML1/Runx-1/CBFα Runt domain, CBFβ and the C/EBPβ bZip region

T. Tahirov, T. Inoue-Bungo, M. Sasaki, 2001 .

Crystallization and preliminary X-ray analysis of the C/EBPbeta C-terminal region in complex with DNA.

T. Tahirov, T. Inoue-Bungo, A. Fujikawa, 2001, Acta crystallographica. Section D, Biological crystallography.

Crystallization and preliminary X-ray analysis of wild-type and V103L mutant Myb R2 DNA-binding domain.

A. Sarai, T. Tahirov, H. Morii, 1999, Acta crystallographica. Section D, Biological crystallography.

FOXC2 Mutations in Familial and Sporadic Spinal Extradural Arachnoid Cyst

Y. Toyama, M. Shiina, K. Ogata, 2013, PloS one.

Exome sequencing identifies a novel INPPL1 mutation in opsismodysplasia

N. Matsumoto, M. Shiina, K. Ogata, 2013, Journal of Human Genetics.

Thermal stability of the DNA-binding domain of the Myb oncoprotein.

A. Sarai, S. Ishii, H. Morii, 1993, Biochemistry.

Brain monoamine vesicular transport disease caused by homozygous SLC18A2 variants: A study in 42 affected individuals.

A. Pagnamenta, J. Lupski, D. Misceo, 2022, Genetics in medicine : official journal of the American College of Medical Genetics.

Structure and function of the proteins encoded by the myb gene family.

A. Sarai, S. Ishii, K. Ogata, 1996, Current topics in microbiology and immunology.

Loss-of-function and gain-of-function mutations in PPP3CA cause two distinct disorders

A. Takata, N. Matsumoto, M. Shiina, 2018, Human molecular genetics.

Biallelic TBCD Mutations Cause Early-Onset Neurodegenerative Encephalopathy.

A. Kakita, A. Fattal-Valevski, I. Nishino, 2016, American journal of human genetics.

Amelioration of a neurodevelopmental disorder by carbamazepine in a case having a gain-of-function GRIA3 variant

A. Bayat, N. Matsumoto, K. Ogata, 2022, Human Genetics.

Structural basis of transcription regulation by CNC family transcription factor, Nrf2

M. Shiina, Ko Sato, K. Ogata, 2022, Nucleic acids research.

Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay.

M. Komada, N. Matsumoto, S. Saitoh, 2010, American journal of human genetics.

De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors

K. Ogata, H. Onaka, H. Suga, 2022, Journal of the American Chemical Society.

Mechanism of c-Myb–C/EBPβ Cooperation from Separated Sites on a Promoter

Takashi Kumasaka, Masaki Yamamoto, Kazumi Kimura, 2002, Cell.

Comparison of the free and DNA-complexed forms of the DMA-binding domain from c-Myb

A. Sarai, S. Ishii, K. Ogata, 1995, Nature Structural Biology.

Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA

A. Rizzino, T. Tahirov, M. Shiina, 2010, Cell cycle.

Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy.

N. Matsumoto, M. Shiina, K. Ogata, 2011, American journal of human genetics.

Pharmacokinetics of fluconazole and fosfluconazole after intraperitoneal administration to peritoneal dialysis rats.

M. Shimizu, K. Ogata, K. Kimura, 2005, Drug metabolism and pharmacokinetics.

The cavity in the hydrophobic core of Myb DNA-binding domain is reserved for DNA recognition and trans-activation

A. Sarai, S. Ishii, M. Sasaki, 1996, Nature Structural Biology.

A hemizygous GYG2 mutation and Leigh syndrome: a possible link?

N. Matsumoto, M. Shiina, K. Ogata, 2013, Human Genetics.

Recognition of specific DNA sequences by the c-myb protooncogene product: role of three repeat units in the DNA-binding domain.

A. Sarai, S. Ishii, K. Ogata, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Solution structure of a DNA-binding unit of Myb: a helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core.

A. Sarai, H. Nakamura, S. Ishii, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Mitochondrial Complex III Deficiency Caused by a Homozygous UQCRC2 Mutation Presenting with Neonatal‐Onset Recurrent Metabolic Decompensation

N. Matsumoto, M. Shiina, K. Ogata, 2013, Human mutation.

Mutations in KLHL40 are a frequent cause of severe autosomal-recessive nemaline myopathy.

E. Bertini, F. Muntoni, R. Bryson-Richardson, 2013, American journal of human genetics.

A novel GFI1B mutation at the first zinc finger domain causes congenital macrothrombocytopenia

A. Takata, N. Matsumoto, M. Shiina, 2018, British journal of haematology.

NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1

K. Ishii, M. Shiina, K. Ogata, 2011, The Journal of Immunology.

Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter.

S. Ishii, T. Tahirov, T. Inoue-Bungo, 2002, Cell.

De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy.

Naomichi Matsumoto, Masaya Kubota, Mitsuhiro Kato, 2013, American journal of human genetics.

De novo mutations of the ATP6V1A gene cause developmental encephalopathy with epilepsy

F. Benfenati, V. Narayanan, L. Maragliano, 2018, Brain : a journal of neurology.

Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb

H. Kitaura, A. Kakita, S. Kameyama, 2015, Annals of neurology.

Amelioration of a neurodevelopmental disorder by carbamazepine in a case having a gain-of-function GRIA3 variant

A. Bayat, N. Matsumoto, K. Ogata, 2022, Human Genetics.

Germline-Derived Gain-of-Function Variants of Gsα-Coding GNAS Gene Identified in Nephrogenic Syndrome of Inappropriate Antidiuresis.

S. Takada, T. Ogata, M. Shiina, 2019, Journal of the American Society of Nephrology : JASN.

Late-onset spastic ataxia phenotype in a patient with a homozygous DDHD2 mutation

S. Tsuji, N. Matsumoto, M. Shiina, 2014, Scientific Reports.

De novo hotspot variants in CYFIP2 cause early‐onset epileptic encephalopathy

D. Lev, N. Matsumoto, M. Shiina, 2018, Annals of neurology.

New from NPG

Tadashi Kaname, Kenji Naritomi, Hiroshi Doi, 2012, Nature Medicine.

Biallelic Mutations in the 3’ Exonuclease TOE1 Cause Pontocerebellar Hypoplasia and Uncover a Role in snRNA Processing

Gene W. Yeo, S. Gabriel, F. Baas, 2016, Nature Genetics.

Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder

N. Matoba, A. Takata, M. Ikeda, 2021, Nature Communications.

A PLK4 mutation causing azoospermia in a man with Sertoli cell‐only syndrome

N. Matsumoto, M. Shiina, K. Ogata, 2016, Andrology.

Phosphorylation of an intrinsically disordered region of Ets1 shifts a multi-modal interaction ensemble to an auto-inhibitory state

Haruki Nakamura, Junichi Higo, Kazuhiro Ogata, 2018, Nucleic acids research.

GRIN2D variants in three cases of developmental and epileptic encephalopathy

A. Takata, N. Matsumoto, M. Shiina, 2018, Clinical genetics.

Homozygous splicing mutation in NUP133 causes Galloway–Mowat syndrome

M. Kitajima, N. Matsumoto, M. Shiina, 2018, Annals of neurology.

De novo SOX11 mutations cause Coffin–Siris syndrome

K. Yoshiura, N. Matsumoto, M. Shiina, 2014, Nature Communications.

Missense mutations in the DNA-binding/dimerization domain of NFIX cause Sotos-like features

N. Matsumoto, K. Ogata, Y. Makita, 2012, Journal of Human Genetics.

De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders

K. Yokochi, H. Mutoh, T. Shiihara, 2018, Annals of clinical and translational neurology.

Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways.

Hiroyuki Osada, Tony Hunter, Kazuhiro Ogata, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Thermodynamics of specific and non-specific DNA binding by the c-Myb DNA-binding domain.

K Furukawa, A. Sarai, H. Nakamura, 1998, Journal of molecular biology.

Two families with TET3-related disorder showing neurodevelopmental delay with craniofacial dysmorphisms

N. Matsumoto, K. Ogata, A. Itakura, 2021, Journal of Human Genetics.

Pathogenic variants in the survival of motor neurons complex gene GEMIN5 cause cerebellar atrophy

N. Matsumoto, K. Ogata, Makoto Kobayashi, 2021, Clinical genetics.

De novo ARF3 variants cause neurodevelopmental disorder with brain abnormality.

N. Matsumoto, K. Ogata, A. Suzuki, 2021, Human molecular genetics.

Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy.

F. Muntoni, C. Brownstein, F. Alkuraya, 2013, American journal of human genetics.

Crystals of ternary protein-DNA complexes composed of DNA-binding domains of c-Myb or v-Myb, C/EBPalpha or C/EBPbeta and tom-1A promoter fragment.

T. Tahirov, T. Inoue-Bungo, A. Fujikawa, 2001, Acta crystallographica. Section D, Biological crystallography.

Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.

A. Takata, N. Matsumoto, M. Shiina, 2019, American journal of human genetics.

A homozygous NOP14 variant is likely to cause recurrent pregnancy loss

N. Matsumoto, M. Shiina, K. Ogata, 2018, Journal of Human Genetics.

Distant N- and C-terminal Domains Are Required for Intrinsic Kinase Activity of SMG-1, a Critical Component of Nonsense-mediated mRNA Decay*

K. Ogata, A. Yamashita, S. Ishiura, 2007, Journal of Biological Chemistry.

A novel PAK1 variant causative of neurodevelopmental disorder with postnatal macrocephaly

N. Matsumoto, K. Ogata, S. Mitsuhashi, 2020, Journal of Human Genetics.

Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar.

T. Tahirov, Ko Sato, K. Ogata, 2003, Current opinion in structural biology.

Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst

Y. Toyama, N. Matsumoto, M. Shiina, 2015, PloS one.

A case of atypical Kabuki syndrome arising from a novel missense variant in HNRNPK

A. Takata, N. Matsumoto, M. Shiina, 2017, Clinical genetics.

Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome.

A. Ryo, N. Matsumoto, N. Imamoto, 2015, American journal of human genetics.

A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.

T. Inoue-Bungo, M. Shiina, Ko Sato, 2015, Journal of molecular biology.

Crystal structure of methionine aminopeptidase from hyperthermophile, Pyrococcus furiosus.

H. Oki, T. Tsukihara, T. Tahirov, 1998, Journal of molecular biology.

De novo DNM1 mutations in two cases of epileptic encephalopathy

N. Matsumoto, M. Shiina, K. Ogata, 2016, Epilepsia.

The first report of Japanese patients with asparagine synthetase deficiency

N. Matsumoto, M. Shiina, K. Ogata, 2017, Brain and Development.

OTUD5 Variants Associated With X-Linked Intellectual Disability and Congenital Malformation

Mahshid S. Azamian, S. Lalani, T. Ogata, 2021, Frontiers in Cell and Developmental Biology.

De novo ATP1A3 variants cause polymicrogyria

T. Tsunoda, T. Hara, A. Takata, 2021, Science Advances.

An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β-Factor XIIa in a Cyclotide Scaffold.

D. Craik, Yen‐Hua Huang, K. Ogata, 2021, Journal of the American Chemical Society.

Structure of the human Bre1 complex bound to the nucleosome

O. Nureki, T. Nishizawa, Ko Sato, 2023, bioRxiv.

Filling a cavity dramatically increases pressure stability of the c‐Myb R2 subdomain

A. Sarai, H. Morii, K. Ogata, 2001, Proteins.

Novel compound heterozygous LIAS mutations cause glycine encephalopathy

N. Matsumoto, M. Shiina, K. Ogata, 2015, Journal of Human Genetics.

Identification of indispensable residues for specific DNA-binding in the imperfect tandem repeats of c-Myb R2R3.

K Furukawa, A. Sarai, H. Nakamura, 1997, Protein engineering.

A hemizygous GYG2 mutation and Leigh syndrome: a possible link?

N. Matsumoto, M. Shiina, K. Ogata, 2014, Human Genetics.

Multi-state thermal transitions of proteins - DNA-binding domain of the c-Myb oncoprotein

A. Sarai, S. Ishii, H. Morii, 1998 .

A novel mutation in SLC1A3 causes episodic ataxia

A. Takata, N. Matsumoto, M. Shiina, 2018, Journal of Human Genetics.

A missense variant at the RAC1-PAK1 binding site of RAC1 inactivates downstream signaling in VACTERL association

K. Misawa, K. Nagata, N. Matsumoto, 2023, Scientific reports.

PARS2 and NARS2 mutations in infantile-onset neurodegenerative disorder

H. Mandel, N. Matsumoto, M. Shiina, 2017, Journal of Human Genetics.

Shape and energetics of a cavity in c-Myb probed by natural and non-natural amino acid mutations.

A. Sarai, S. Ishii, H. Morii, 1999, Journal of molecular biology.

Crystallization of the Ets1-Runx1-CBFβ-DNA complex formed on the TCRα gene enhancer.

T. Inoue-Bungo, M. Shiina, Ko Sato, 2014, Acta crystallographica. Section F, Structural biology communications.

Solution structures of Myb DNA-binding domain and its complex with DNA.

A. Sarai, S. Ishii, M. Sasaki, 1993, Nucleic acids symposium series.

Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration

Karin, A. Need, M. Kayikci, 2022, medRxiv.

Phenotype–genotype correlations in patients with GNB1 gene variants, including the first three reported Japanese patients to exhibit spastic diplegia, dyskinetic quadriplegia, and infantile spasms

N. Matsumoto, K. Ogata, S. Miyatake, 2019, Brain and Development.

A novel CYCS mutation in the α‐helix of the CYCS C‐terminal domain causes non‐syndromic thrombocytopenia

A. Takata, N. Matsumoto, M. Shiina, 2018, Clinical genetics.

Biallelic structural variations within FGF12 detected by long-read sequencing in epilepsy

M. Frith, K. Misawa, N. Matsumoto, 2023, Life Science Alliance.

The recurrent postzygotic pathogenic variant p.Glu47Lys in RHOA causes a novel recognizable neuroectodermal phenotype

C. Dieterich, N. Matsumoto, K. Ogata, 2019, Human mutation.

[Structure and dynamics of the transcription factor, Myb, in DNA-sequence recognition].

K. Ogata, 1998, Seikagaku. The Journal of Japanese Biochemical Society.

[Specific DNA recognition by Myb protein].

K. Ogata, Y. Nishimura, 1995, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

A novel missense mutation affecting the same amino acid as the recurrent PACS1 mutation in Schuurs‐Hoeijmakers syndrome

A. Takata, N. Matsumoto, M. Shiina, 2018, Clinical genetics.

Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration

A. Need, M. Kayikci, D. Smedley, 2023, American journal of human genetics.

A novel GFI1B mutation at the first zinc finger domain causes congenital macrothrombocytopenia

A. Takata, N. Matsumoto, M. Shiina, 2018, British journal of haematology.

Cavity-Filling Mutations Enhance Protein Stability by Lowering the Free Energy of Native State

Hidetoshi Kono, Tahir H. Tahirov, Kazuhiro Ogata, 2000 .