J. Manley

发表

High mobility group protein-1 (HMG-1) is a unique activator of p53.

C. Prives, M. Bustin, L. Jayaraman, 1998, Genes & development.

Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein.

C. Prives, P. Friedlander, J. Manley, 1996, Nucleic acids research.

Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo

C. Prives, J. Manley, G. Farmer, 1996, Molecular and cellular biology.

Cell signalling and the control of pre-mRNA splicing

C. Shin, J. Manley, James L. Manley, 2004, Nature Reviews Molecular Cell Biology.

Mechanism and regulation of mRNA polyadenylation.

J. Manley, D. Colgan, J L Manley, 1997, Genes & development.

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

J. Manley, Mo Chen, 2009, Nature Reviews Molecular Cell Biology.

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

L. Tong, R. Medzhitov, J. Manley, 2000, Nature.

Function and Control of RNA Polymerase II C-Terminal Domain Phosphorylation in Vertebrate Transcription and RNA Processing

J. Manley, J. Hsin, K. Xiang, 2014, Molecular and Cellular Biology.

Alternative cleavage and polyadenylation: the long and short of it.

B. Tian, J. Manley, 2013, Trends in biochemical sciences.

Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity

J. Manley, B. Shen, L. Zheng, 2001, Insect molecular biology.

Mechanisms and consequences of alternative polyadenylation.

K. Nishida, J. Manley, D. C. Di Giammartino, 2011, Molecules and Cells.

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged.

J. Manley, Charles J David, Charles J. David, 2010, Genes & development.

The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation.

K. Murthy, J. Manley, 1995, Genes & development.

The Polyadenylation Factor CstF-64 Regulates Alternative Processing of IgM Heavy Chain Pre-mRNA during B Cell Differentiation

J. Manley, M. L. Peterson, R. Seipelt, 1996, Cell.

RNA recognition by the human polyadenylation factor CstF

J. Manley, Y. Takagaki, 1997, Molecular and cellular biology.

Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation.

J. Manley, Y. Takagaki, Yoshio Takagaki, 1998, Molecular cell.

Alternative polyadenylation of mRNA precursors

B. Tian, J. Manley, 2016, Nature Reviews Molecular Cell Biology.

The TET family of proteins: functions and roles in disease.

J. Manley, Adelene Y. Tan, 2009, Journal of molecular cell biology.

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

M. Assanah, P. Canoll, J. Manley, 2010, Nature.

New Insights into Mitotic Chromosome Condensation: A Role for the Prolyl Isomerase Pin1

J. Manley, Yu-Xin Xu, 2007, Cell cycle.

Molecular architecture of the human pre-mRNA 3' processing complex.

J. Yates, J. Frank, W. Rice, 2009, Molecular cell.

New Links between mRNA Polyadenylation and Diverse Nuclear Pathways

J. Manley, D. C. Di Giammartino, 2014, Molecules and cells.

Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities

Alexander V Penson, R. Rabadán, J. Manley, 2015, Proceedings of the National Academy of Sciences.

The C-Terminal Domain of RNA Polymerase II Functions as a Phosphorylation-Dependent Splicing Activator in a Heterologous Protein

J. Manley, S. Millhouse, 2005, Molecular and Cellular Biology.

E. Fraenkel, J. Broach, J. Dubnau, 2018, eLife.

Poly(A) Polymerase Phosphorylation Is Dependent on Novel Interactions with Cyclins

C. Prives, J. Manley, G. Bond, 2000, Molecular and Cellular Biology.

Inhibition of poly(A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non‐consensus sites

C. Prives, K. Murthy, J. Manley, 1998, The EMBO journal.

Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.

J. Manley, J. Wu, J L Manley, 1989, Genes & development.

Determinants of SR protein specificity.

J. Manley, J L Manley, R. Tacke, 1999, Current opinion in cell biology.

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

J. Manley, James L. Manley, H. Ge, 1990, Cell.

Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways.

J. Manley, J. Wang, 1995, RNA.

The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.

J. Manley, J L Manley, R. Tacke, 1995, The EMBO journal.

Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer.

J. Manley, J L Manley, R. Tacke, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Transcription and RNA processing factors play complex roles in DT40 cells.

J. Manley, S. Bush, 2006, Sub-cellular biochemistry.

ASF/SF2-Regulated CaMKIIδ Alternative Splicing Temporally Reprograms Excitation-Contraction Coupling in Cardiac Muscle

Xiang-Dong Fu, Pao-Hsien Chu, Ju Chen, 2005, Cell.

SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors

J. Manley, L. Shkreta, Johanne Toutant, 2016, Cell reports.

Misregulation of pre-mRNA alternative splicing in cancer.

Jian Zhang, J. Manley, Jian Zhang, 2013, Cancer discovery.

RNA polymerase II and the integration of nuclear events.

J. Manley, J L Manley, Y. Hirose, 2000, Genes & development.

C. Prives, K. Murthy, J. Manley, 1996, Nature.

Roles of Sumoylation in mRNA Processing and Metabolism.

J. Manley, P. Richard, Vasupradha Vethantham, 2017, Advances in experimental medicine and biology.

Emerging Roles for SUMO in mRNA Processing and Metabolism

J. Manley, Vasupradha Vethantham, 2009 .

The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription

J. Manley, O. Calvo, Olga Calvo, 2005, The EMBO journal.

The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3′ mRNA processing factors

M. Meyerson, O. Rozenblatt-Rosen, J. Francis, 2009, Proceedings of the National Academy of Sciences.

Primary structure and expression of bovine poly(A) polymerase

J. Manley, F. Bollum, T. Raabe, 1991, Nature.

Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus.

K. Murthy, J. Manley, 1992, The Journal of biological chemistry.

Creatine Phosphate, Not ATP, Is Required for 3′ End Cleavage of Mammalian Pre-mRNA in Vitro *

J. Manley, Y. Hirose, Yutaka Hirose, 1997, The Journal of Biological Chemistry.

Identification of a sequence element on the 3' side of AAUAAA which is necessary for simian virus 40 late mRNA 3'-end processing

J. Manley, J. Alwine, M. Sadofsky, 1985, Molecular and cellular biology.

Requirements for accurate and efficient mRNA 3' end cleavage and polyadenylation of a simian virus 40 early pre-RNA in vitro

J. Manley, L. Ryner, 1987, Molecular and cellular biology.

Sequences downstream of AAUAAA signals affect pre-mRNA cleavage and polyadenylation in vitro both directly and indirectly

J. Manley, L. Ryner, Y. Takagaki, 1989, Molecular and cellular biology.

The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs.

J. Manley, T. Shenk, Y. Takagaki, 1992, Proceedings of the National Academy of Sciences of the United States of America.

U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.

M. Garcia-Blanco, C. Will, R. Lührmann, 1995, Nucleic acids research.

TLS Inhibits RNA Polymerase III Transcription

J. Manley, Adelene Y. Tan, 2009, Molecular and Cellular Biology.

Transcription initiation by RNA polymerase II is inhibited by S-adenosylhomocysteine.

R. Jove, J. Manley, 1982, Proceedings of the National Academy of Sciences of the United States of America.

The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites.

J. Manley, P. Zuo, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.

C. Will, R. Lührmann, J. Manley, 1993, Nucleic acids research.

The prolyl isomerase Pin1 functions in mitotic chromosome condensation.

J. Manley, Yu-Xin Xu, 2007, Molecular cell.

Heterozygous Disruption of the TATA-Binding Protein Gene in DT40 Cells Causes Reduced cdc25B Phosphatase Expression and Delayed Mitosis

S. Kato, J. Manley, M. Um, 2001, Molecular and Cellular Biology.

Identiﬁcation and Functional Characterization of Neo-Poly(A) Polymerase, an RNA Processing Enzyme Overexpressed in Human Tumors

J. Manley, G. Bond, Y. Ward, 2022 .

Accurate and specific polyadenylation of mRNA precursors in a soluble whole-cell lysate

J. Manley, 1983, Cell.

Synthesis in vitro of an exceptionally long RNA transcript promoted by an AluI sequence

J. Manley, M. Colozzo, 1982, Nature.

Sumoylation regulates multiple aspects of mammalian poly(A) polymerase function.

J. Manley, Vasupradha Vethantham, Nishta Rao, 2008, Genes & development.

In vitro transcription: whole-cell extract.

P. Sharp, A. Fire, J. Manley, 1983, Methods in enzymology.

Functions of SR and Tra2 proteins in pre-mRNA splicing regulation.

J. Manley, R. Tacke, 1999, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Molecular basis for the recognition of the human AAUAAA polyadenylation signal

T. Walz, L. Tong, K. Hamilton, 2017, Proceedings of the National Academy of Sciences.

Allosteric regulation of even-skipped repression activity by phosphorylation.

J. Manley, C. Li, J. L. Manley, 1999, Molecular cell.

The RNA polymerase II CTD “orphan” residues: Emerging insights into the functions of Tyr-1, Thr-4, and Ser-7

J. Manley, N. Yurko, 2018, Transcription.

XRN2 Links Transcription Termination to DNA Damage and Replication Stress

J. Manley, J. Morales, D. Boothman, 2016, PLoS genetics.

Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation

J. Manley, L. Ryner, Y. Takagaki, 1988, Cell.

Oxidative stress induces Ser 2 dephosphorylation of the RNA polymerase II CTD and premature transcription termination

J. Manley, Lizhi Liu, T. Yamazaki, 2021, Transcription.

Multiple ways to a dead end: diverse mechanisms by which ALS mutant genes induce cell death

J. Manley, Yueh-Lin Tsai, 2021, Cell cycle.

MPK1/SLT2 Links Multiple Stress Responses with Gene Expression in Budding Yeast by Phosphorylating Tyr1 of the RNAP II CTD.

B. Tian, J. Manley, M. Hoque, 2017, Molecular cell.

SETX sumoylation

J. Manley, P. Richard, Patricia Richard, 2014, Rare diseases.

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

J. Manley, Shuang Feng, P. Richard, 2013, Genes & development.

Structure and function of the S1 nuclease-sensitive site in the adenovirus late promoter

J. Manley, Yie-Teh Yu, Yie-Teh Yu, 1986, Cell.

TRANSCRIPTION OF ANIMAL VIRUS GENES IN VITRO1

P. Sharp, H. Handa, M. Gefter, 1980 .

RNA synthesis in isolated nuclei: identification and comparison of adenovirus 2 encoded transcripts synthesized in vitro and vivo.

P. Sharp, M. Gefter, J. Manley, 1979, Journal of molecular biology.

ALS mutations in TLS/FUS disrupt target gene expression

J. Manley, Tristan H. Coady, 2015, Genes & development.

Nuclear RNA transcript levels modulate nucleocytoplasmic distribution of ALS/FTD-associated protein FUS

J. Manley, Yueh-Lin Tsai, Yu Chun Mu, 2022, Scientific Reports.

Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation

B. Tian, J. Manley, Chiwei Lu, 2020, Nature Communications.

Corrigendum

J. Manley, Chiwei Lu, P. Yeung, 2022, Journal of thrombosis and haemostasis : JTH.

Corrigendum

J. Manley, Chiwei Lu, P. Yeung, 2016, Environmental toxicology and chemistry.

Regulation and Substrate Specificity of the SR Protein Kinase Clk/Sty

J. Manley, J. Prasad, 2003, Molecular and Cellular Biology.

Sumoylation Modulates the Assembly and Activity of the Pre-mRNA 3′ Processing Complex

J. Manley, Vasupradha Vethantham, Nishta Rao, 2007, Molecular and Cellular Biology.

PARP1 represses PAP and inhibits polyadenylation during heat shock.

J. Manley, D. C. Di Giammartino, Yongsheng Shi, 2013, Molecular cell.

The Drosophila TATA binding protein contains a strong but masked activation domain.

J. Manley, M. Um, 2001, Gene expression.

Transcription | mRNA Polyadenylation in Eukaryotes

Hani S. Zaher, J. Manley, D. C. Di Giammartino, 2021, Encyclopedia of Biological Chemistry III.

mRNA Polyadenylation in Eukaryotes

J. Manley, D. C. D. Giammartino, 2013 .

From transcription to mRNA: PAF provides a new path.

J. Manley, E. Rosonina, 2005, Molecular cell.

Poly(A) polymerase contains multiple functional domains

K. Murthy, J. Manley, T. Raabe, 1994, Molecular and cellular biology.

A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II.

J. Manley, S. Connelly, 1988, Genes & development.

RNA polymerase II transcription termination is mediated specifically by protein binding to a CCAAT box sequence

J. Manley, S. Connelly, 1989, Molecular and cellular biology.

BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.

J. Manley, S. Kaneko, R. Baer, 2005, Genes & development.

RNA polymerase II terminates transcription in vitro in the SV40 origin region.

R. Jove, J. Manley, D. Grass, 1987, Nucleic acids research.

Multiple functional domains of human U2 small nuclear RNA: strengthening conserved stem I can block splicing

J. Manley, J. Wu, J. Wu, 1992, Molecular and cellular biology.

7 – Factors That Influence Alternative Splice Site Selection in Vitro

Xin-Yuan Fu, J. Manley, H. Ge, 1987 .

A polyadenylation factor subunit is the human homologue of theDrosophila suppressor of forked protein

J. Manley, Y. Takagaki, 1994, Nature.

RNA 3' ends: formation and function--meeting review.

N. Proudfoot, J. Manley, 1994, Genes & development.

A human polyadenylation factor is a G protein beta-subunit homologue.

J. Manley, Y. Takagaki, 1992, The Journal of biological chemistry.

TLS Inhibits RNA Polymerase III Transcription (cid:1)

J. Manley, Adelene Y. Tan, 2009 .

Alternative polyadenylation blooms.

J. Manley, E. Rosonina, 2010, Developmental cell.

hnRNP A1 functions with specificity in repression of SMN2 exon 7 splicing.

J. Manley, Charles J David, Charles J. David, 2007, Human molecular genetics.

Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator

J. Manley, Mo Chen, Ying Feng, 2008, Nature Structural &Molecular Biology.

A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).

A. Krainer, J. Manley, 2010, Genes & development.

A novel protein factor is required for use of distal alternative 5' splice sites in vitro

J. Manley, J. Harper, 1991, Molecular and cellular biology.

SYNTHESIS OF ADENOVIRUS 2 RNA in vitro: PROPERTIES OF THE MAJOR LATER TRANSCRIPT AND ITS PROMOTER

M. Gefter, J. Manley, Shiu-Lok Hu, 1980 .

The RNA polymerase C-terminal domain

J. Manley, Charles J David, 2011, Transcription.

The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U 2 AF 65 – Prp 19 complex

J. Manley, Charles J David, S. Millhouse, 2011 .

Functions of SR and Tra2 Proteins in Pre-mRNA Splicing Regulation

J. Manley, R. Tacke, 1999 .

A human homologue of the Escherichia coli DnaJ heat-shock protein.

J. Manley, T. Raabe, Tobias Raabe, 1991, Nucleic acids research.

Target specificity among canonical nuclear poly(A) polymerases in plants modulates organ growth and pathogen response

M. Lenhard, T. Laux, W. Gray, 2013, Proceedings of the National Academy of Sciences.

InVitro Polyadenylation of SV40 Early Pre-mRNA

J. Manley, L. Ryner, M. Chaudhuri, 1987 .

RNA sequence containing hexanucleotide AAUAAA directs efficient mRNA polyadenylation in vitro

J. Manley, L. Ryner, H. Yu, 1985, Molecular and cellular biology.

Localization of active promoters for eucaryotic RNA polymerase II in the long terminal repeat of avian sarcoma virus DNA

J. Manley, S. A. Mitsialis, R. Guntaka, 1983, Molecular and cellular biology.

Rna synthesis in isolated nuclei processing of adenovirus serotype 2 late messenger rna precursors.

P. Sharp, M. Gefter, J. Manley, 1982, Journal of molecular biology.

SYNTHESIS AND PROCESSING OF ADENOVIRUS 2 RNA IN VITRO

P. Sharp, M. Gefter, J. Manley, 1979 .

TLS/FUS

J. Manley, Adelene Y. Tan, 2012, Cell cycle.

How bidirectional becomes unidirectional

J. Manley, P. Richard, Patricia Richard, 2013, Nature Structural &Molecular Biology.

Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing.

J. Manley, A. Mohammadi, S. Valadkhan, 2007, RNA.

DNA sequence required for initiation of transcription in vitro from the major late promoter of adenovirus 2.

J. Manley, S. Hu, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Repression of simian virus 40 early transcription by viral DNA replication in human 293 cells

J. Manley, E. D. Lewis, 1985, Nature.

The human papillomavirus type 16 negative regulatory RNA element interacts with three proteins that act at different posttranscriptional levels.

J. Manley, S. Graham, J. Clements, 2000, Proceedings of the National Academy of Sciences of the United States of America.

A functional simian virus 40 origin of replication is required for the generation of a super T antigen with a molecular weight of 100,000 in transformed mouse cells

J. Manley, R. Pollack, G. Blanck, 1983, Journal of virology.

cFLIP expression is altered in severe corticosteroid-resistant asthma

Hai-Ri Li, J. Manley, Charlotte J. Logan, 2014, Genomics data.

Pin1 modulates RNA polymerase II activity during the transcription cycle.

J. Manley, Yu-Xin Xu, 2007, Genes & development.

Drosophila Pelle phosphorylates Dichaete protein and influences its subcellular distribution in developing oocytes.

A. Mukherjee, J. Manley, B. Shen, 2010, The International journal of developmental biology.

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

M. Levine, C. Rushlow, J. Manley, 1989, Cell.

Cell-free synthesis of SU + 3 tyrosyl transfer RNA: characterization of the 4S product.

M. Gefter, J. Manley, G. Zubay, 1973, Archives of biochemistry and biophysics.

On the nature of β-galactosidase synthesized by the DNA-directed cell-free system

J. Manley, D. A. Chambers, 2004, Molecular and General Genetics MGG.

In vitro transcription of adenovirus

P. Sharp, A. Fire, J. Manley, 1981, Journal of Virology.

Transcription of Simian virus 40 DNA in a HeLa whole cell extract.

P. Sharp, H. Handa, M. Gefter, 1981, The Journal of biological chemistry.

In vitro splicing of simian virus 40 early pre mRNA.

C. Prives, J. Manley, J. Noble, 1986, Nucleic acids research.

Multiple forms of poly(A) polymerases purified from HeLa cells function in specific mRNA 3'-end formation

J. Manley, L. Ryner, Y. Takagaki, 1989, Molecular and cellular biology.

Factor interactions with the simian virus 40 early pre-mRNA influence branch site selection and alternative splicing

J. Manley, H. Ge, M. Chaudhuri, 1989, Molecular and cellular biology.

Cell- and promoter-specific activation of transcription by DNA replication.

J. Manley, D. Grass, E. D. Lewis, 1987, Genes & development.

Effects of the adenovirus 2 late promoter on simian virus 40 transcription and replication

J. Manley, D. Grass, 1986, Journal of virology.

Pinning Down Transcription: Regulation of RNA Polymerase II Activity During the Cell Cycle

J. Manley, Yu-Xin Xu, 2004, Cell cycle.

The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy

S. Stamm, J. Manley, F. Ciccosanti, 2010, The EMBO journal.

Suppression of amber mutants in vitro induced by low temperature.

R. Gesteland, J. Manley, Raymond F. Gesteland, 1978, Journal of molecular biology.

A functional .mRNA polyadeny.lation signal is required for transcnpnon termination by RNA polymerase II

J. Manley, 2007 .

In vitro sumoylation of recombinant proteins and subsequent purification for use in enzymatic assays.

J. Manley, Vasupradha Vethantham, 2009, Cold Spring Harbor Protocols.

Methylation of simian virus 40 Hpa II site affects late, but not early, viral gene expression.

C. Prives, J. Manley, A. Fradin, 1982, Proceedings of the National Academy of Sciences of the United States of America.

SELEX to identify protein-binding sites on RNA.

J. Manley, 2013, Cold Spring Harbor protocols.

Synthesis of internal re-initiation fragments of beta-galactosidase in vitro and in vivo.

J. Manley, 1978, Journal of molecular biology.

Variations in Intracellular Levels of TATA Binding Protein Can Affect Specific Genes by Different Mechanisms

J. Manley, S. Bush, P. Richard, 2007, Molecular and Cellular Biology.

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

T Pawson, T. Pawson, B. Andrews, 1996, The EMBO journal.

Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.

Paul Tempst, Danny Reinberg, Hediye Erdjument-Bromage, 2007, Molecular cell.

A complex protein assembly catalyzes polyadenylation of mRNA precursors.

J. Manley, J L Manley, 1995, Current opinion in genetics & development.

Human capping enzyme promotes formation of transcriptional R loops in vitro

A. Shatkin, J. Manley, S. Kaneko, 2007, Proceedings of the National Academy of Sciences.

Cotranscriptional processes and their influence on genome stability.

J. Manley, Xialu Li, 2006, Genes & development.

Delineating the Structural Blueprint of the Pre-mRNA 3′-End Processing Machinery

L. Tong, J. Manley, K. Xiang, 2014, Molecular and Cellular Biology.

The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex.

J. Manley, Charles J David, S. Millhouse, 2011, Genes & development.

Pin1 modulates the structure and function of human RNA polymerase II.

Xiao Zhen Zhou, K. Lu, J. Manley, 2003, Genes & development.

Requirements of the RNA Polymerase II C-Terminal Domain for Reconstituting Pre-mRNA 3′ Cleavage

K. Ryan, K. Murthy, J. Manley, 2002, Molecular and Cellular Biology.

Requirements of the RNA Polymerase II C-Terminal Domain for Reconstituting Pre-mRNA 3 (cid:2) Cleavage

K. Murthy, J. Manley, S. Kaneko, 2002 .

The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity

L. Tong, J. Manley, K. Xiang, 2012, Nature Communications.

Synergistic activation and repression of transcription by Drosophila homeobox proteins

M. Levine, J. Manley, Kyuhyung Han, 1989, Cell.

A direct interaction between a glutamine-rich activator and the N terminus of TFIIB can mediate transcriptional activation in vivo

J. Manley, J. Colgan, H. Ashali, 1995, Molecular and cellular biology.

Interaction between a transcriptional activator and transcription factor IIB in vivo

J. Manley, J. Colgan, S. Wampler, 1993, Nature.

Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex.

K. Ryan, K. Murthy, J. Manley, 2000, Molecular cell.

Characterization of the catalytic activity of U2 and U6 snRNAs.

J. Manley, S. Valadkhan, 2003, RNA.

Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1

Liang Tong, Jeong Ho Chang, Song Xiang, 2010, Nature Structural &Molecular Biology.

Sequence specificity of the human mRNA N6-adenosine methylase in vitro.

R J Roberts, R. Roberts, J. Manley, 1990, Nucleic acids research.

Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation.

R. Loomis, J. Manley, D. Chakravarti, 2009, Molecular cell.

Control of adenovirus late promoter expression in two human cell lines

J. Manley, E. D. Lewis, 1985, Molecular and cellular biology.

Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability

J. Manley, James L. Manley, Xialu Li, 2005, Cell.

can block splicing. nuclear RNA: strengthening conserved stem I Multiple functional domains of human U2 small

J. Manley, J. Wu, J. Wu, 2013 .

A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast.

J. Manley, S. Valadkhan, 2000, RNA.

A UV-crosslinkable interaction in human U6 snRNA.

J. Manley, S. Valadkhan, J. Sun, 1998, RNA.

A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing.

J. Manley, J S Sun, J L Manley, 1995, Genes & development.

Multiple Functional DomainsofHumanU2SmallNuclear RNA:Strengthening Conserved StemICanBlockSplicing

J. Manley, 1992 .

DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.

P. Sharp, A. Fire, M. Gefter, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Base substitution in an intervening sequence of a beta+-thalassemic human globin gene.

P. A. Biro, James T. Elder, S. Weissman, 1981, Proceedings of the National Academy of Sciences of the United States of America.

The Role of Alternative Splicing During the Cell Cycle and Programmed Cell Death

J. Manley, Xialu Li, 2010 .

Transcription factor TFIID recruits factor CPSF for formation of 3′ end of mRNA

J. Dantonel, L. Tora, K. Murthy, 1997, Nature.

RNA-binding proteins in neurodegeneration: mechanisms in aggregate

J. Manley, Erin G. Conlon, 2017, Genes & development.

Primary structure of the human splicing factor asf reveals similarities with drosophila regulators

J. Manley, H. Ge, P. Zuo, 1991, Cell.

A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock.

J. Manley, Yongsheng Shi, 2007, Molecular cell.

Phosphorylation–dephosphorylation differentially affects activities of splicing factor ASF/SF2

J. Manley, Shou‐Hua Xiao, James L. Manley, 1998, The EMBO journal.

Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.

J. Manley, S. Xiao, S. Xiao, 1997, Genes & development.

An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression

J. Yates, Wencheng Li, B. Tian, 2017, Genes & development.

Factors influencing alternative splice site utilization in vivo

J. Manley, X. Fu, 1987, Molecular and cellular biology.

SR proteins and splicing control.

J. Manley, R. Tacke, 1996, Genes & development.

J. Manley, S. Valadkhan, 2001, Nature.

Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase*

T. Ouchi, J. Manley, Angus Chen, 2002, The Journal of Biological Chemistry.

Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1

J. Manley, Wenjian Gan, H. Ohmori, 2012, Proceedings of the National Academy of Sciences.

Messenger RNA polyadenylylation: a universal modification.

J. Manley, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Pelle kinase is activated by autophosphorylation during Toll signaling in Drosophila.

J. Manley, B. Shen, 2002, Development.

Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation

J. Manley, B. Shen, E. Skolnik, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Even-skipped Represses Transcription by Binding TATA Binding Protein and Blocking the TFIID-TATA Box Interaction

J. Manley, Chi Li, 1998, Molecular and Cellular Biology.

Mechanisms of transcriptional activation and repression can both involve TFIID.

J. Manley, C. Li, M. Um, 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal.

J. Manley, J L Manley, J L Norris, 1996, Genes & development.

The transcriptional repressor even-skipped interacts directly with TATA-binding protein

J. Manley, C. Li, M. Um, 1995, Molecular and cellular biology.

Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain.

J. Manley, J L Manley, K Han, 1993, Genes & development.

Transcriptional regulators of Drosophila embryogenesis.

J. Manley, D. Read, 1992, Biochimica et biophysica acta.

TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters.

J. Manley, J. Colgan, 1992, Genes & development.

Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells.

M. Levine, J. Manley, J. Colgan, 1991, Genes & development.

The Drosophila even-skipped promoter is transcribed in a stage-specific manner in vitro and contains multiple, overlapping factor-binding sites

J. Manley, T. Nishigaki, D. Read, 1990, Molecular and cellular biology.

Transcriptional repression of eukaryotic promoters

M. Levine, J. Manley, 1989, Cell.

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.

C. Prives, A. J. Donner, J. Espinosa, 2009, Genes & Development.

R-loop-mediated genomic instability is caused by impairment of replication fork progression.

J. Manley, Wenjian Gan, K. Shen, 2011, Genes & development.

TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency

J. Manley, S. M. Chambers, L. Studer, 2018, Genes & development.

Threonine-4 of the budding yeast RNAP II CTD couples transcription with Htz1-mediated chromatin remodeling

Wencheng Li, B. Tian, J. Manley, 2014, Proceedings of the National Academy of Sciences.

Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins.

R. Lafyatis, J. Manley, R. Lemaire, 2002, Genes & development.

Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing.

J. Manley, J. Wang, Shouhua Xiao, 1998, Genes & development.

Human Tra2 Proteins Are Sequence-Specific Activators of Pre-mRNA Splicing

M. Tohyama, J. Manley, Masaya Tohyama, 1998, Cell.

Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability.

J. Manley, Y. Takagaki, J. Wang, 1996, Genes & development.

The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2.

B. S. Baker, Y. J. Kim, J. Manley, 1992, Genes & development.

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells

A. Børresen-Dale, B. Tian, J. Bargonetti, 2015, Genes & development.

Mutant p 53 cooperates with the SWI / SNF chromatin remodeling complex to regulate VEGFR 2 in breast cancer cells

A. Børresen-Dale, B. Tian, J. Bargonetti, 2015 .

Transcription termination by nuclear RNA polymerases.

Patricia Richard, J. Manley, James L Manley, 2009, Genes & development.

Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair

Shwu‐Yuan Wu, C. Chiang, W. Hittelman, 2014, Nucleic acids research.

The RNA polymerase II CTD coordinates transcription and RNA processing.

J. Manley, J. Hsin, 2012, Genes & development.

Transcriptional activators enhance polyadenylation of mRNA precursors

J. Manley, Takashi Nagaike, 2011, RNA biology.

Transcriptional activators enhance polyadenylation of mRNA precursors.

Matthew Meyerson, Takashi Nagaike, Orit Rozenblatt-Rosen, 2011, Molecular cell.

The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination.

O. Rozenblatt-Rosen, J. Manley, M. Meyerson, 2007, Genes & development.

Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease

L. Tong, J. Manley, S. Kaneko, 2006, Nature.

Terminating the transcript: breaking up is hard to do.

Syuzo Kaneko, J. Manley, S. Kaneko, 2006, Genes & development.

Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease.

K. Ryan, J. Manley, O. Calvo, 2004, RNA.

Strange bedfellows: polyadenylation factors at the promoter.

J. Manley, James L Manley, O. Calvo, 2003, Genes & development.

Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination.

J. Manley, O. Calvo, Olga Calvo, 2001, Molecular cell.

Complex Protein Interactions within the Human Polyadenylation Machinery Identify a Novel Component

J. Manley, Y. Takagaki, 2000, Molecular and Cellular Biology.

RNA polymerase II is an essential mRNA polyadenylation factor

J. Manley, Y. Hirose, Yutaka Hirose, 1998, Nature.

The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms.

M. Wollerton, N. Proudfoot, J. Manley, 1998, Genes & development.

A CCAAT box sequence in the adenovirus major late promoter functions as part of an RNA polymerase II termination signal

J. Manley, S. Connelly, 1989, Cell.

SUMO functions in constitutive transcription and during activation of inducible genes in yeast.

J. Manley, James L Manley, Emanuel Rosonina, 2010, Genes & development.

Sub1 Functions in Osmoregulation and in Transcription by both RNA Polymerases II and III

Ian M. Willis, J. Manley, I. Willis, 2009, Molecular and Cellular Biology.

Sub1 Globally Regulates RNA Polymerase II C-Terminal Domain Phosphorylation

J. Manley, Alicia García, O. Calvo, 2010, Molecular and Cellular Biology.

A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy

J. Manley, T. Kashima, 2003, Nature Genetics.

TCF3 mutually exclusive alternative splicing is controlled by long-range cooperative actions between hnRNPH1 and PTBP1

J. Manley, Lizhi Liu, T. Yamazaki, 2019, RNA.

Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation

Zhiqin Xie, Wenwu Wu, Xuexia Zhou, 2014, Nucleic acids research.

Far upstream element-binding protein 1 and RNA secondary structure both mediate second-step splicing repression

J. Manley, Ying Feng, Xuexia Zhou, 2013, Proceedings of the National Academy of Sciences.

Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins

J. Manley, Mo Chen, Charles J David, 2012, Nature Structural &Molecular Biology.

Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA.

J. Manley, Mo Chen, Jian Zhang, 2010, Cancer research.

Alternative Splicing of Pyruvate Kinase mRNA Turning on a Fuel Switch of Cancer : hnRNP Proteins Regulate

J. Manley, 2010 .

The splicing regulator Sam 68 binds to a novel exonic splicing silencer and functions in SMN 2 alternative splicing in spinal muscular atrophy

S. Stamm, J. Manley, F. Ciccosanti, 2010 .

SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart.

R. Bronson, S. Firestein, J. Manley, 2009, Developmental cell.

The search for alternative splicing regulators: new approaches offer a path to a splicing code.

J. Manley, Charles J David, James L Manley, 2008, Genes & development.

An intronic element contributes to splicing repression in spinal muscular atrophy

J. Manley, T. Kashima, Nishta Rao, 2007, Proceedings of the National Academy of Sciences.

Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock

C. Shin, J. Manley, Ying Feng, 2004, Nature.

The SR Protein SRp38 Represses Splicing in M Phase Cells

C. Shin, J. Manley, James L. Manley, 2002, Cell.

Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

M. Garcia-Blanco, C. Will, R. Lührmann, 1994, Nature.

Burkitt lymphoma-related TCF3 mutations alter TCF3 alternative splicing by disrupting hnRNPH1 binding

J. Manley, Lizhi Liu, Erin G. Conlon, 2020, RNA biology.

Selective translation initiation on bicistronic simian virus 40 late mRNA

J. Manley, D. Grass, 1987, Journal of virology.

RNA synthesis in isolated nuclei: in vitro initiation of adenovirus 2 major late mRNA precursor.

P. Sharp, M. Gefter, J. Manley, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Nuclear coupling: RNA processing reaches back to transcription

J. Manley, 2002, Nature Structural Biology.

SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation

F. Chédin, Wencheng Li, B. Tian, 2020, Autophagy.

ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs

B. Tian, N. Shneider, J. Manley, 2020, Genes & development.

TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements

H. Bussemaker, Todd Riley, J. Manley, 2012, Proceedings of the National Academy of Sciences.

R Loops and Links to Human Disease.

J. Manley, P. Richard, Patricia Richard, 2017, Journal of molecular biology.

PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins.

J. Manley, Yongsheng Shi, B. Reddy, 2006, Molecular cell.

The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site

J. Manley, Yongsheng Shi, James L Manley, 2015, Genes & development.

Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

Auinash Kalsotra, Bin Tian, Samuel I. Gunderson, 2015, PLoS genetics.

RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3′ UTRs

Wencheng Li, B. Tian, J. Manley, 2014, Genes & development.

The Role of Cotranscriptional Recruitment of RNA‐Binding Proteins in the Maintenance of Genomic Stability

J. Manley, Jennifer A. Aoki, 2013 .

In Vivo Functional Analysis of the Histone 3-like TAF9 and a TAF9-related Factor, TAF9L*

J. Manley, Zheng Chen, 2003, Journal of Biological Chemistry.

Four factors are required for 3'-end cleavage of pre-mRNAs.

J. Manley, L. Ryner, Y. Takagaki, 1989, Genes & development.

Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA

J. Manley, Jian Wu, 1991, Nature.

The Mechanism and Control of Pre-mRNA Splicing

J. Manley, J. Noble, 1989 .

Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs

R. Jove, C. Prives, J. Manley, 1984, Cell.

Analysis of the expression of genes encoding animal mRNA by in vitro techniques.

J. Manley, 1983, Progress in nucleic acid research and molecular biology.

INTERVENING SEQUENCE MUTATION IN A CLONED HUMAN β + -THALASSEMIC GLOBIN GENE

P. A. Biro, S. Weissman, R. Spritz, 1981 .

Structure and in vitro transcription of human globin genes.

T. Maniatis, M. Gefter, N. Proudfoot, 1980, Science.

Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase.

L. Tong, J. Manley, J. Chang, 2011, Molecular cell.

Symplekin and xGLD-2 Are Required for CPEB-Mediated Cytoplasmic Polyadenylation

K. Ryan, J. Manley, D. Barnard, 2004, Cell.

Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites

Carol Prives, C. Prives, J. Manley, 1987, Cell.

Oligonucleotide-targeted degradation of U1 and U2 snRNAs reveals differential interactions of simian virus 40 pre-mRNAs with snRNPs.

C. Prives, J. Manley, Z. Pan, 1989, Nucleic acids research.

A frameshift mutation affecting the carboxyl terminus of the simian virus 40 large tumor antigen results in a replication- and transformation-defective virus.

A. Kumar, J. Manley, R. Pollack, 1983, Proceedings of the National Academy of Sciences of the United States of America.

The C9ORF72 Gene, Implicated in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, Encodes a Protein That Functions in Control of Endothelin and Glutamate Signaling

B. Tian, C. Prives, J. Manley, 2018, Molecular and Cellular Biology.

The role of the polypyrimidine stretch at the SV40 early pre‐mRNA 3′ splice site in alternative splicing.

J. Manley, X. Fu, H. Ge, 1988, The EMBO journal.

Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues.

Shuxing Zhang, J. Manley, Lisa S. Chen, 2010, Biochemical pharmacology.

Polyadenylation of mRNA precursors.

J. Manley, J L Manley, 1988, Biochimica et biophysica acta.

Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization.

M. Chalfie, X. Jacq, C. Prives, 2003, Molecular cell.

Why Is p53 Acetylated?

C. Prives, J. Manley, 2001, Cell.

REGULATION OF ADENOVIRUS mRNA SYNTHESIS *

A. Fire, M. Gefter, J. Manley, 1980, Annals of the New York Academy of Sciences.

Transcription of mammalian genes in vitro.

M. Gefter, J. Manley, 1981, Gene amplification and analysis.

Transcription of methylated eukaryotic viral genes in a soluble in vitro system.

R. Jove, J. Manley, D. Sperber, 1984, Nucleic acids research.

Concurrent splicing and transcription are not sufficient to enhance splicing efficiency.

J. Manley, D. Lazarev, 2007, RNA.

A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates

J. Manley, T. Shenk, J. Wilusz, 1990, Molecular and cellular biology.

SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes

R. Rabadán, J. Manley, X. An, 2020, Proceedings of the National Academy of Sciences.

Pan-cancer analysis identifies mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation

R. Rabadán, Yiwei Sun, J. Manley, 2020, Proceedings of the National Academy of Sciences.

Mdm2 and MdmX as Regulators of Gene Expression.

C. Prives, J. Manley, L. Biderman, 2012, Genes & cancer.

Multiple cis-acting sequence elements are required for efficient splicing of simian virus 40 small-t antigen pre-mRNA

J. Manley, J. Colgan, X. Fu, 1988, Molecular and cellular biology.

NRDE-2, the human homolog of fission yeast Nrl1, prevents DNA damage accumulation in human cells

J. Yates, J. Manley, J. Moresco, 2018, RNA biology.

Deregulation of Poly(A) Polymerase Interferes with Cell Growth

J. Manley, W. Zhao, 1998, Molecular and Cellular Biology.

Regulation of dorsal in cultured cells by Toll and tube: tube function involves a novel mechanism.

J. Manley, J. Norris, 1995, Genes & development.

Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation

B. Tian, J. Manley, Chiwei Lu, 2020, Nature Communications.

CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3′ processing

John R Yates, Jernej Ule, Lingjie Weng, 2014, Genes & development.

The Protein Kinase Clk/Sty Directly Modulates SR Protein Activity: Both Hyper- and Hypophosphorylation Inhibit Splicing

T. Pawson, K. Colwill, J. Manley, 1999, Molecular and Cellular Biology.

Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms

J. Manley, J L Manley, W Zhao, 1996, Molecular and cellular biology.

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

J. Onuchic, K. Mikoshiba, N. Rothman, 2018, Cell Death & Differentiation.

Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases.

A. Kornblihtt, S. Kadener, R. Lin, 2003, Molecular and biochemical parasitology.

Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1.

R. Rabadán, J. Manley, A. Raza, 2019, Molecular cell.

The ends of the affair: Capping and polyadenylation

Aaron J. Shatkin, A. Shatkin, J. Manley, 2000, Nature Structural Biology.

CPSF 30 and Wdr 33 directly bind to AAUAAA in mammalian mRNA 3 9 processing

J. Ule, J. Yates, Lingjie Weng, 2014 .

RNA Surveillance by the Nuclear RNA Exosome: Mechanisms and Significance

J. Manley, Yaqiong Chen, K. Ogami, 2018, Non-coding RNA.

Phosphorylated RNA polymerase II stimulates pre-mRNA splicing.

J. Manley, R. Tacke, Y. Hirose, 1999, Genes & development.

Cooperation between core promoter elements influences transcriptional activity in vivo.

J. Manley, J. Colgan, J L Manley, 1995, Proceedings of the National Academy of Sciences of the United States of America.

In vitro analysis of transcriptional activators and polyadenylation.

J. Manley, Takashi Nagaike, 2014, Methods in molecular biology.

RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells

Wencheng Li, B. Tian, J. Manley, 2014, eLife.

RNAP II CTD Phosphorylated on Threonine-4 Is Required for Histone mRNA 3′ End Processing

Amit P. Sheth, J. Manley, J. Hsin, 2011, Science.

Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex

Liang Tong, Song Xiang, Takashi Nagaike, 2010, Nature.

The BARD1-CstF-50 Interaction Links mRNA 3′ End Formation to DNA Damage and Tumor Suppression

J. Manley, F. E. Kleiman, 2001, Cell.

Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.

J. Manley, J L Manley, F E Kleiman, 1999, Science.

The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

N. Shneider, J. Manley, Erin G. Conlon, 2016, eLife.

Widespread intron retention impairs protein homeostasis in C9orf72 ALS brains

D. Rio, J. Manley, Erin G. Conlon, 2020, Genome research.

Comparative analysis of alternative polyadenylation in S. cerevisiae and S. pombe

Bin Tian, Mainul Hoque, Nathan Yurko, 2017, Genome research.

Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors.

Liang Tong, L. Tong, J. Manley, 2007, Molecular cell.

New Talents for an Old Acquaintance: the SR Protein Splicing Factor ASF/SF2 Functions in the Maintenance of Genome Stability

J. Manley, Xialu Li, 2005, Cell cycle.

ASAP, a Novel Protein Complex Involved in RNA Processing and Apoptosis

D. Reinberg, H. Erdjument-Bromage, P. Tempst, 2003, Molecular and Cellular Biology.

ASAP, a Novel Protein Complex Involved in RNA Processing and Apoptosis

D. Reinberg, H. Erdjument-Bromage, P. Tempst, 2003, Molecular and Cellular Biology.

A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs.

J. Manley, T. Shenk, J. Wilusz, 1990, Genes & development.

Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro.

K. Murthy, J. Manley, J. Alwine, 1996, Genes & development.

Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis

J. Manley, Shuang Feng, 2022, Genes & development.

A nuclear micrococcal-sensitive, ATP-dependent exoribonuclease degrades uncapped but not capped RNA substrates.

K. Murthy, J. Manley, K G Murthy, 1991, Nucleic acids research.

Regulation of pre-mRNA splicing in metazoa.

J. Manley, J. Wang, Jin Wang, 1997, Current opinion in genetics & development.

Multiple Properties of the Splicing Repressor SRp38 Distinguish It from Typical SR Proteins

C. Shin, J. Manley, F. E. Kleiman, 2005, Molecular and Cellular Biology.

Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities.

J. Manley, D. Read, D. Read, 1992, The EMBO journal.

Structure and function of the 5’→3’ exoribonuclease Rat1 and its activating partner Rai1

L. Tong, J. Manley, Xinfu Jiao, 2009, Nature.

Alternative splicing of SV40 early pre-mRNA is determined by branch site selection.

C. Prives, J. Manley, J L Manley, 1988, Genes & development.

Regulation of Plant Developmental Processes by a Novel Splicing Factor

A. Reddy, J. Manley, G. S. Ali, 2007, PloS one.

Multiple activities of the human splicing factor ASF.

J. Manley, J. Harper, 1992, Gene expression.

Heat Shock-Induced SRSF10 Dephosphorylation Displays Thermotolerance Mediated by Hsp27

K. Nishida, J. Manley, Yongsheng Shi, 2010, Molecular and Cellular Biology.

Hsp27 enhances recovery of splicing as well as rephosphorylation of SRp38 after heat shock.

C. Shin, J. Manley, N. Lubsen, 2005, Molecular biology of the cell.

Core Promoter Elements and TAFs Contribute to the Diversity of Transcriptional Activation in Vertebrates

J. Manley, Zheng Chen, 2003, Molecular and Cellular Biology.

DNA-protein complexes spread on N2-discharged carbon film and characterized by molecular weight and its projected distribution.

P. Hough, J. Hainfeld, J. Wall, 1982, Journal of molecular biology.

Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation.

J. Manley, Jin Wang, Xialu Li, 2005, Genes & development.

Functional domains of the human splicing factor ASF/SF2.

J. Manley, P. Zuo, J. L. Manley, 1993, The EMBO journal.

The 3′ processing factor CstF functions in the DNA repair response

M. Cevher, J. Manley, D. Fonseca, 2008, Nucleic acids research.

Ectopic expression of the Drosophila tramtrack gene results in multiple embryonic defects, including repression of even-skipped and fushi tarazu

M. Levine, J. Manley, D. Read, 1992, Mechanisms of Development.

Sumoylation of transcription factor Gcn4 facilitates its Srb10-mediated clearance from promoters in yeast.

J. Manley, E. Rosonina, S. Duncan, 2012, Genes & development.

The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3' end formation.

J. Manley, S. Kaneko, 2005, Molecular cell.

Robust mRNA Transcription in Chicken DT40 Cells Depleted of TAFII31 Suggests Both Functional Degeneracy and Evolutionary Divergence

J. Manley, Zheng Chen, 2000, Molecular and Cellular Biology.

In vitro transcription from the adenovirus 2 major late promoter utilizing templates truncated at promoter-proximal sites.

R. Jove, J. Manley, 1984, The Journal of biological chemistry.

MdmX Is Required for p53 Interaction with and Full Induction of the Mdm2 Promoter after Cellular Stress

C. Prives, Yael Assia, J. Manley, 2012, Molecular and Cellular Biology.

Tumor metabolism: hnRNP proteins get in on the act

J. Manley, Mo Chen, Charles J David, 2010, Cell cycle.

Polyadenylylation of an mRNA precursor occurs independently of transcription by RNA polymerase II in vivo.

J. Manley, E. D. Lewis, 1986, Proceedings of the National Academy of Sciences of the United States of America.

An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.

L. Tong, J. Manley, K. Xiang, 2012, Genes & development.

Ssu 72 phosphorylated at Ser 7 in the active site of the CTD phosphatase An unexpected binding mode for a Pol II CTD peptide

L. Tong, J. Manley, K. Xiang, 2012 .

Generation and functional analyses for base-substitution mutants of the adenovirus 2 major late promoter.

J. Manley, Y. Yu, Y. Yu, 1984, Nucleic acids research.

The Drosophila homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the suppressor of forked gene.

K. O'hare, J. Manley, L. Figueiredo, 2000, Nucleic acids research.

The Spliced Messenger RNAs of Adenovirus-2

R. Roberts, D. Klessig, J. Manley, 1979 .

The End of the Message--Another Link Between Yeast and Mammals

J. Manley, Y. Takagaki, J L Manley, 1996, Science.

Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube.

J. Manley, B. Shen, 1998, Development.

RNA 3'-end formation.

N. Proudfoot, J. Manley, T. Platt, 1989, Genes & development.

Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A.

J. Manley, J. Norris, 1992, Genes & development.

Sumoylation controls the timing of Tup1-mediated transcriptional deactivation

J. Manley, Justin M. Burgener, E. Rosonina, 2015, Nature Communications.

SV40 T-antigen-binding sites within the 5'-flanking regions of human U1 and U2 genes.

C. Prives, J. Manley, E. Lund, 1991, Gene.

Functional domains of the Drosophila Engrailed protein.

J. Manley, K. Han, Kyuhyung Han, 1993, The EMBO journal.

CHAPTER 320 – Role of Alternative Splicing During the Cell Cycle and Programmed Cell Death

C. Shin, J. Manley, 2003 .

C9orf72 and triplet repeat disorder RNAs: G-quadruplex formation, binding to PRC2 and implications for disease mechanisms

T. Cech, J. Manley, Erin G. Conlon, 2019, RNA.

The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability.

J. Manley, T. Niu, Xialu Li, 2007, RNA.

SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3

E. Kandel, P. Fraser, J. Manley, 2015, Cell reports.

Synthesis and degradation of termination and premature-termination fragments of β-galactosidase in vitro and in vivo

J. Manley, 1978 .

Splicing of mRNA precursors: the role of RNAs and proteins in catalysis.

J. Manley, Chaim Wachtel, 2009, Molecular bioSystems.

The use of simple model systems to study spliceosomal catalysis.

J. Manley, S. Valadkhan, 2008, RNA.

Alternative Splicing and Control of Apoptotic DNA Fragmentation

J. Manley, Xialu Li, 2006, Cell cycle.

The homeo box and mammalian development

M. Levine, J. Manley, 1985, Cell.

Regulation of Nuclear Transport and Activity of the Drosophila Morphogen Dorsal

J. Manley, J. Norris, 1995 .

DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer

Yue Huang, L. Tong, J. Manley, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2).

C. Sapienza, K. Arden, J. Manley, 1995, Genomics.