P. Kussie

发表

Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain

A. Levine, N. Pavletich, S. Gorina, 1996, Science.

Structural basis for inhibition of the epidermal growth factor receptor by cetuximab.

P. Jeffrey, P. Kussie, K. Ferguson, 2005, Cancer cell.

Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2.

P. Bohlen, P. Kussie, A. Kiselyov, 2009, Bioorganic & medicinal chemistry.

Identification of a plasminogen binding region in streptokinase that is necessary for the creation of a functional streptokinase-plasminogen activator complex.

G. Reed, P. Kussie, L. F. Lin, 1995, Biochemistry.

Conservation of receptor antagonist anti-tumor activity by epidermal growth factor receptor antibody expressed in transgenic corn seed.

Peter Bohlen, Dipa Patel, Xiaoqiang Kang, 2004, Human antibodies.

A functional analysis of the antigenicity of streptokinase using monoclonal antibody mapping and recombinant streptokinase fragments.

G. Reed, P. Kussie, B. Parhami-Seren, 1993, Journal of immunology.

Molecular determinants of plasma cholesteryl ester transfer protein binding to high density lipoproteins

A. Tall, P. Kussie, R. Ghosh, 1995, The Journal of Biological Chemistry.

Defective Binding of Neutral Lipids by a Carboxyl-terminal Deletion Mutant of Cholesteryl Ester Transfer Protein

A. Tall, P. Kussie, Suke Wang, 1995, The Journal of Biological Chemistry.

A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins.

S. Yamashita, P. Kussie, X. Jiang, 1993, The Journal of clinical investigation.

Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability.

F. Liao, D. Hicklin, P. Bohlen, 2002, Cancer Research.

Heparanase promotes the spontaneous metastasis of myeloma cells to bone.

L. Suva, Y. Huang, P. Kussie, 2004, Blood.

Paul bone Heparanase promotes the spontaneous metastasis of myeloma cells to

L. Suva, Y. Huang, P. Kussie, 2004 .

Plasma kinetics of cholesteryl ester transfer protein in the rabbit. Effects of dietary cholesterol.

A. Tall, R. McPherson, P. Kussie, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Antitumor Activity of IMC-038525, a Novel Oral Tubulin Polymerization Inhibitor.

A. Malikzay, P. Kussie, M. C. Tuma, 2010, Translational oncology.

Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors.

A. Malikzay, P. Kussie, M. C. Tuma, 2005, Bioorganic & medicinal chemistry letters.

Structure-function relationships of human cholesteryl ester transfer protein: analysis using monoclonal antibodies.

E. Rassart, A. Tall, P. Kussie, 1996, Journal of lipid research.

ratssecretion and sympathetic outflow in Acidic fibroblast growth factor activates

H. Berthoud, P. Bohlen, Y. Oomura, 2013 .

Signaling and Inhibits Human Tumor Growth Growth Factor I Receptor Blocks Ligand-Dependent A Fully Human Monoclonal Antibody to the Insulin-Like Updated

D. Hicklin, P. Bohlen, Zhen-ping Zhu, 2003 .

Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor alpha in a subset of normal and systemic sclerosis patient sera.

P. Kussie, L. Hummers, F. Wigley, 2009, Arthritis and rheumatism.

Suppression of leukemia expressing wild-type or ITD-mutant FLT3 receptor by a fully human anti-FLT3 neutralizing antibody.

D. Hicklin, P. Bohlen, Zhen-ping Zhu, 2004, Blood.

High heparanase activity in multiple myeloma is associated with elevated microvessel density.

F. Zhan, B. Barlogie, J. Shaughnessy, 2003, Cancer research.

Identification of the Residues in the Extracellular Region of KDR Important for Interaction with Vascular Endothelial Growth Factor and Neutralizing Anti-KDR Antibodies*

P. Bohlen, Zhen-ping Zhu, P. Kussie, 2000, The Journal of Biological Chemistry.

Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity

S. Rafii, K. Hattori, P. Bohlen, 2003, Leukemia.

Cardiovascular and hemodynamic consequences of recombinant placental growth factor administration in Guinea pigs

Courtney J. Jenkins, P. Kussie, S. A. Karumanchi, 2022, Hypertension in pregnancy.

Administration of recombinant human placental growth factor decreases blood pressure in obese hypertensive pregnant rats

P. Kussie, Adelene Y. Tan, C. Anderson, 2020, Journal of hypertension.

Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension

P. Kussie, S. Karumanchi, J. Granger, 2016, Hypertension.

Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases.

P. Kussie, Xin Chen, M. Labelle, 2005, Bioorganic & medicinal chemistry letters.

Interfacial properties of recombinant human cholesterol ester transfer protein.

A. Tall, J. B. Jones, P. Kussie, 1994, Journal of Biological Chemistry.

A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.

Peter Bohlen, Dan Lu, D. Hicklin, 2003, Cancer research.

Development of heparanase inhibitors for anti-cancer therapy.

Zhen-ping Zhu, P. Kussie, H. Miao, 2006, Current medicinal chemistry.

Inhibition of acetylcholinesterase by caffeine, anabasine, methyl pyrrolidine and their derivatives.

P. Kussie, D. Linthicum, N. Karadsheh, 1991, Toxicology letters.

A single engineered amino acid substitution changes antibody fine specificity.

L. Wysocki, P. Kussie, B. Parhami-Seren, 1994, Journal of immunology.

1-[4-(1H-Benzoimidazol-2-yl)-phenyl]-3-[4-(1H-benzoimidazol-2-yl)-phenyl]-urea derivatives as small molecule heparanase inhibitors.

P. Kussie, A. Kiselyov, A. Lahiji, 2006, Bioorganic & medicinal chemistry letters.

Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys.

Peter Bohlen, H. Berthoud, P. Bohlen, 2007, American journal of physiology. Endocrinology and metabolism.

rodents and monkeys cause potent but reversible hypophagia and weight loss in Monoclonal antibody antagonists of hypothalamic FGFR 1

H. Berthoud, P. Bohlen, O. McGuinness, 2007 .

Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8.

P. Kussie, K. Ferguson, Shiqing Li, 2008, Structure.

Cloning and functional expression of a human heparanase gene.

P. Bohlen, S. Patel, P. Kussie, 1999, Biochemical and biophysical research communications.

Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature.

F. Liao, D. Hicklin, P. Bohlen, 2005, Blood.

Conservation of Structure and Mechanism between Eukaryotic Topoisomerase I and Site-Specific Recombinases

Chonghui Cheng, N. Pavletich, P. Kussie, 1998, Cell.

Targeting the platelet-derived growth factor receptor α with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: Implications as a potential therapeutic target

Peter Bohlen, Dan Lu, D. Hicklin, 2005, Molecular Cancer Therapeutics.

Defining the structural correlates responsible for loss of arsonate affinity in an IDCR antibody isolated from an autoimmune mouse.

P. Kussie, A. Marshak‐Rothstein, B. Parhami-Seren, 1993, Molecular immunology.

Prenatal exposure to drugs of abuse in humans: effects on placental neurotransmitter receptors.

S. Schnoll, P. Kussie, B. Perry, 1984, Neurobehavioral toxicology and teratology.

The structural basis for the function of two anti-VEGF receptor 2 antibodies.

P. Kussie, Leyi Shen, Amtul Bari, 2011, Structure.

Modulation of antibody affinity by an engineered amino acid substitution.

P. Kussie, Y. Wong, B. Parhami-Seren, 1995, Journal of immunology.

Cloning, expression, and purification of mouse heparanase.

P. Bohlen, P. Kussie, D. Ludwig, 2002, Protein expression and purification.

Structure and specificity of the anti-digoxin antibody 40-50.

J. Schildbach, M. N. Margolies, P. Jeffrey, 1995, Journal of molecular biology.

Production and characterization of monoclonal idiotypes and anti-idiotypes for small ligands.

P. Kussie, D. Linthicum, G. Albright, 1989, Methods in enzymology.

Molecular analysis of monoclonal idiotypes and anti-idiotypes.

P. Kussie, M. Sherman, D. Linthicum, 1989, Methods in enzymology.

Analysis of idiotypic and anti-idiotypic antibodies as models of receptor and ligand.

P. Kussie, M. Bolger, D. Linthicum, 1988, Clinical chemistry.

Activation of FGFR1β signaling pathway promotes survival, migration and resistance to chemotherapy in acute myeloid leukemia cells

S. Rafii, P. Bohlen, S. Shmelkov, 2006, Leukemia.

N-(4-{[4-(1H-Benzoimidazol-2-yl)-arylamino]-methyl}-phenyl)-benzamide derivatives as small molecule heparanase inhibitors.

P. Kussie, A. Kiselyov, Yongjiang Xu, 2006, Bioorganic & medicinal chemistry letters.

Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension

P. Kussie, J. Granger, Adelene Y. Tan, 2016, Hypertension.