Y. Haupt

发表

Specific loss of apoptotic but not cell‐cycle arrest function in a human tumor derived p53 mutant.

M. Oren, K. Vousden, S. Rowan, 1996, The EMBO journal.

P53 and Cell Death

Y. Haupt, K. Wolyniec, S. Haupt, 2009 .

c-Jun and p53 Activity Is Modulated by SUMO-1 Modification*

A. Dejean, S. Müller, Y. Haupt, 2000, The Journal of Biological Chemistry.

c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination

A. Ciechanover, Y. Haupt, M. Berger, 2001, Molecular and Cellular Biology.

Mdm2 promotes the rapid degradation of p53

M. Oren, Y. Haupt, R. Maya, 1997, Nature.

Apoptosis - the p53 network

Michael Berger, Y. Haupt, S. Haupt, 2003, Journal of Cell Science.

The cellular response to p53: the decision between life and death

Ronit Vogt Sionov, Y. Haupt, 1999, Oncogene.

The long and the short of it: the MDM4 tail so far

Y. Haupt, S. Haupt, Javier Octavio Mejía-Hernández, 2019, Journal of molecular cell biology.

MDM4 is a key therapeutic target in cutaneous melanoma

Hubing Shi, A. Jochemsen, J. Marine, 2012, Nature Medicine.

Apoptosis by p53: mechanisms, regulation, and clinical implications

Ronit Vogt Sionov, Y. Haupt, 2004, Springer Seminars in Immunopathology.

Targeting Mdmx to treat breast cancers with wild-type p53

S. Fox, S. Hiddingh, A. Jochemsen, 2015, Cell Death and Disease.

Immune molecular profiling of a multiresistant primary prostate cancer with a neuroendocrine-like phenotype: a case report

S. Fox, Y. Haupt, S. Haupt, 2020, BMC Urology.

Treatment of Chronic Myeloid Leukemia Cells with Imatinib (STI571) Impairs p53 Accumulation in Response to DNA Damage

S. Krichevsky, Y. Haupt, Zehavit Goldberg, 2004, Cell cycle.

PML tumour suppression and beyond: Therapeutic implications

Y. Haupt, S. Haupt, C. Gamell, 2014, FEBS letters.

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

A. Bush, P. Adlard, Y. Haupt, 2017, Redox biology.

High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot

Y. Haupt, S. Haupt, S. Keam, 2020, Journal for immunotherapy of cancer.

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non–small cell lung cancer

S. Fox, B. Solomon, P. Russell, 2017, Science Signaling.

p53-mediated apoptosis in HeLa cells can be overcome by excess pRB.

M. Oren, S. Rowan, Y. Haupt, 1995, Oncogene.

Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): therapeutic indication for prostate cancer.

Y. Haupt, M. Cater, 2011, The Biochemical journal.

The E6AP E3 ubiquitin ligase regulates the cellular response to oxidative stress

Y. Haupt, K. Wolyniec, S. Haupt, 2013, Oncogene.

TP53 Status, Patient Sex, and the Immune Response as Determinants of Lung Cancer Patient Survival

B. Solomon, Y. Haupt, S. Haupt, 2020, Cancers.

E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts

Y. Haupt, K. Wolyniec, S. Haupt, 2012, Oncogene.

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

S. Fox, R. Vessella, E. Takano, 2016, Oncogene.

A novel p 53-inducible gene , PAG 608 , encodes a nuclear zinc finger protein whose overexpression promotes apoptosis interactions between p 53 and these genes are generally

D. Israeli, M. Oren, Y. Haupt, 2013 .

Fate Regulator Numb The Mdm2 Oncoprotein Interacts with the Cell

T. Unger, M. Oren, O. Shifman, 2014 .

The Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb

T. Unger, M. Oren, O. Shifman, 1998, Molecular and Cellular Biology.

Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes

S. Lade, N. Lawrentschuk, D. Murphy, 2022, Journal for ImmunoTherapy of Cancer.

T cell survival and function requires the c-Abl tyrosine kinase

A. Strasser, Ronit Vogt Sionov, Y. Haupt, 2008, Cell cycle.

Deconstruction of p53 functions and regulation

V. Rotter, C. Prives, A. Robles, 2002, Oncogene.

E6ap Ubiquitin Ligase Regulates Pml-induced Senescence in Myc-driven Lymphomagenesis Neoplastic Transformation Requires the Elimination of Key Tumor Suppressors, Which May Result from E3 Ligase-mediated Proteasomal Degradation. We Previously Demonstrated a Key Role for the E3 Ubiqui- Tin Ligase E6ap

P. Pandolfi, S. Fox, S. Lowe, 2022 .

A Role for the Polyproline Domain of p53 in Its Regulation by Mdm2*

A. Levine, Y. Haupt, M. Berger, 2001, The Journal of Biological Chemistry.

Gene and Genome Structure in Diptera: Comparative Molecular Analysis of an Eye Colour Gene in Three Species

R. Tearle, Y. Haupt, A. Elizur, 1990 .

Retroviral infection accelerates T lymphomagenesis in E mu-N-ras transgenic mice by activating c-myc or N-myc.

Y. Haupt, A. W. Harris, J. M. Adams, 1992, Oncogene.

p53 and thymic ‘death by neglect’: thymic epithelial cell-induced apoptosis of CD4+8+ thymocytes is p53-independent

Y. Haupt, E. Yefenof, Y. Zilberman, 2000, Cell Death and Differentiation.

ArticleTP53 Status

B. Solomon, Y. Haupt, S. Haupt, 2020 .

Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss

G. Lozano, Y. Haupt, S. Haupt, 2022, Cell Death & Disease.

Targeting MDM4 as a Novel Therapeutic Approach in Prostate Cancer Independent of p53 Status

S. Fox, A. Jochemsen, L. Abrahmsén, 2022, Cancers.

P53 at the start of the 21st century: lessons from elephants

Y. Haupt, S. Haupt, 2017, F1000Research.

c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity.

O. Schueler‐Furman, M. Scheffner, P. Pilling, 2013, Biochemistry.

Expression of E6AP and PML predicts for prostate cancer progression and cancer-specific death.

J. Kench, S. Fox, L. Horvath, 2014, Annals of oncology : official journal of the European Society for Medical Oncology.

p53: An Internal Investigation

Y. Haupt, I. Hayon, 2002, Cell cycle.

Increasing intracellular bioavailable copper selectively targets prostate cancer cells.

A. Bush, Y. Haupt, K. Wolyniec, 2013, ACS chemical biology.

p53 mediated apoptosis in HeLa cells: transcription dependent and independent mechanisms.

E. Shaulian, M. Oren, K. Vousden, 1997, Leukemia.

SLC7A11 Is a Superior Determinant of APR-246 (Eprenetapopt) Response than TP53 Mutation Status

Y. Haupt, S. Haupt, W. Phillips, 2020, Molecular Cancer Therapeutics.

Clinical Overview of MDM2/X-Targeted Therapies

David M. Thomas, Elgene Lim, Andrew Burgess, 2016, Front. Oncol..

Tumour suppression by p53: the importance of apoptosis and cellular senescence

Ronit Vogt Sionov, Y. Haupt, K. Wolyniec, 2009, The Journal of pathology.

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity

P. Howley, T. Unger, M. Oren, 1999, Oncogene.

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

E. Shaulian, M. Oren, K. Vousden, 1995, Genes & development.

Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma.

Adrian V. Lee, D. Dabbs, S. Oesterreich, 2019, Cancer letters.

Regulation of Nucleotide Metabolism by Mutant p53 Contributes to its Gain-of-Function Activities

Y. Haupt, K. Watabe, S. Haupt, 2015, Nature Communications.

MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer

W. Tilley, Y. Haupt, Ensar Halilovic, 2020, bioRxiv.

Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

R. Pearson, A. Papenfuss, G. McArthur, 2019, Proceedings of the National Academy of Sciences.

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects.

A. Strasser, G. Smyth, Yifang Hu, 2019, Cell reports.

Role of p53 in the progression of gastric cancer

Stephen Fox, Alex Boussioutas, Stephen Q. Wong, 2014, Oncotarget.

Manipulation of the tumor suppressor p53 for potentiating cancer therapy.

Y. Haupt, S. Haupt, 2004, Seminars in cancer biology.

Improving Cancer Therapy through p53 Management

Y. Haupt, S. Haupt, 2004, Cell cycle.

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice

W. Alexander, Y. Haupt, S. Klinken, 1991, Cell.

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.

R. C. Poulos, J. W. Wong, C. Arrowsmith, 2015, Cancer research.

Faculty Opinions recommendation of Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.

Y. Haupt, S. Haupt, 2015 .

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

Y. Haupt, S. Haupt, P. Neeson, 2020, International journal of molecular sciences.

C-Abl as a modulator of p53.

Y. Haupt, S. Haupt, Zehavit Goldberg, 2005, Biochemical and biophysical research communications.

A quantitative model to predict pathogenicity of missense variants in the TP53 gene

David M. Thomas, A. Spurdle, M. Olivier, 2019, Human mutation.

Regulation of Mutant p53 Protein Expression

Y. Haupt, S. Haupt, R. Vijayakumaran, 2015, Front. Oncol..

Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner

P. Pandolfi, S. Fox, G. Lozano, 2013, Cell cycle.

Mdm2 in growth signaling and cancer

Y. Haupt, S. Haupt, Y. Levav-Cohen, 2005, Growth factors.

Tyrosine phosphorylation of Mdm2 by c‐Abl: implications for p53 regulation

Michael Berger, Moshe Oren, Yoichi Taya, 2002, The EMBO journal.

Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33ING1 in T.Tn human esophageal carcinoma cells

M. Oka, Y. Haupt, H. Shimada, 2002, Oncogene.

Cell type‐specific inhibition of p53‐mediated apoptosis by mdm2.

M. Oren, Y. Haupt, Y. Barak, 1996, The EMBO journal.

Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network

T. Speed, Han Liang, T. Soussi, 2019, Nature Communications.

New Strategies to Direct Therapeutic Targeting of PML to Treat Cancers

Y. Haupt, K. Wolyniec, S. Haupt, 2013, Front. Oncol..

E6AP promotes the degradation of the PML tumor suppressor

M. Scheffner, Y. Haupt, S. Haupt, 2009, Cell Death and Differentiation.

The role of MDM2 and MDM4 in breast cancer development and prevention

Y. Haupt, S. Haupt, R. Vijayakumaran, 2017, Journal of molecular cell biology.

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

R. Pearson, Y. Haupt, Rachel S. Lee, 2011, Oncogene.

P53-Mediated Apoptosis

E. Shaulian, M. Oren, E. Gottlieb, 1996 .

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice.

Ashley P Ng, Y. Haupt, S. Haupt, 2018, Blood advances.

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

K. Wiman, Y. Haupt, S. Haupt, 2015, Gut.

bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis.

Y. Haupt, A. W. Harris, Jerry M. Adams, 1993, Oncogene.

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

T. Unger, M. Oren, G. Lozano, 1999, The EMBO journal.

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

L. Abrahmsén, K. Wiman, Y. Haupt, 2017, Nature Communications.

The p53-Mdm2 loop: a critical juncture of stress response.

Y. Haupt, S. Haupt, Zehavit Goldberg, 2014, Sub-cellular biochemistry.

Cancer and Tumour Suppressor p53 Encounters at the Juncture of Sex Disparity

Y. Haupt, S. Haupt, 2021, Frontiers in Genetics.

MDM4 is a rational target for treating breast cancers with mutant p53

S. Fox, A. Jochemsen, J. Marine, 2017, The Journal of pathology.

Critical role for Ser 20 of human p 53 in the negative regulation of p 53 by Mdm 2

T. Unger, M. Oren, Ronit Vogt Sionov, 2013 .

The Promyelocytic Leukemia Protein Protects p53 from Mdm2-mediated Inhibition and Degradation*

Pier Paolo Pandolfi, P. Pandolfi, Ronit Vogt Sionov, 2003, Journal of Biological Chemistry.

c-Abl Neutralizes the Inhibitory Effect of Mdm2 on p53*

M. Oren, Ronit Vogt Sionov, Y. Haupt, 1999, The Journal of Biological Chemistry.

Chromatin immunoprecipitation-on-chip reveals stress-dependent p53 occupancy in primary normal cells but not in established cell lines.

I. Simon, Z. Siegfried, Y. Haupt, 2008, Cancer research.

MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation

E. Shaulian, Y. Haupt, L. Guerrini, 2010, Journal of Cell Science.

Ubiquitin ligase E 6 AP mediates nonproteolytic polyubiquitylation of b-catenin independent of the E 6 oncoprotein

Y. Haupt, A. Jackman, L. Sherman, 2016 .

Sex disparities matter in cancer development and therapy

S. Klein, Y. Haupt, S. Haupt, 2021, Nature Reviews Cancer.

Sex disparities matter in cancer development and therapy

S. Klein, Y. Haupt, S. Haupt, 2021, Nature Reviews Cancer.

Ubiquitin ligase E6AP mediates nonproteolytic polyubiquitylation of β-catenin independent of the E6 oncoprotein.

Y. Haupt, A. Jackman, L. Sherman, 2016, The Journal of general virology.

HPV16 E6 and E6AP differentially cooperate to stimulate or augment Wnt signaling.

Y. Haupt, A. Jackman, L. Sherman, 2014, Virology.

HPV16 E6 augments Wnt signaling in an E6AP-dependent manner.

Y. Haupt, A. Jackman, P. Gonen, 2010, Virology.

HPV 16 E 6 augments Wnt signaling in an E 6 AP-dependent manner

Y. Haupt, A. Jackman, P. Gonen, 2009 .

Immune molecular profiling of a multiresistant primary prostate cancer with a neuroendocrine-like phenotype: a case report

Y. Haupt, S. Haupt, S. Keam, 2020, BMC Urology.

Promyelocytic leukemia protein is required for gain of function by mutant p53.

G. Blandino, Y. Haupt, S. Haupt, 2009, Cancer research.

Celecoxib can induce cell death independently of cyclooxygenase-2, p53, Mdm2, c-Abl and reactive oxygen species

Y. Haupt, S. Haupt, A. Rubinstein, 2006, Anti-cancer drugs.

An analysis of a multiple biomarker panel to better predict prostate cancer metastasis after radical prostatectomy

J. Kench, S. Fox, L. Horvath, 2018, International journal of cancer.

E6AP Promotes a Metastatic Phenotype in Prostate Cancer

S. Fox, E. Gallo, L. Horvath, 2019, iScience.

Faculty of 1000 evaluation for Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53 on Drosha complex activity.

Y. Haupt, S. Haupt, 2017 .

Mutations in Proline 82 of p53 Impair Its Activation by Pin1 and Chk2 in Response to DNA Damage

G. Del Sal, Y. Haupt, M. Berger, 2005, Molecular and Cellular Biology.

Mutant p53 Drives Cancer by Subverting Multiple Tumor Suppression Pathways

Y. Haupt, S. Haupt, D. Raghu, 2016, Front. Oncol..

Importance of p53 for cancer onset and therapy

Y. Haupt, S. Haupt, 2006, Anti-cancer drugs.

Transactivation-deficient p73α (p73Δexon2) inhibits apoptosis and competes with p53

M. Gatei, K. Khanna, Y. Haupt, 2001, Oncogene.

Clues from worms: a Slug at Puma promotes the survival of blood progenitors

Y. Haupt, S. Haupt, O. Alsheich-Bartok, 2006, Cell Death and Differentiation.

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

C. Prives, M. Oren, P. Friedlander, 1996, Molecular and cellular biology.

E6AP goes viral: the role of E6AP in viral- and non-viral-related cancers.

Y. Haupt, S. Haupt, S. Keam, 2019, Carcinogenesis.

p53 Calls upon CIA (Calcium Induced Apoptosis) to Counter Stress

Y. Haupt, S. Haupt, D. Raghu, 2015, Front. Oncol..

A novel p53‐inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

D. Israeli, M. Oren, Y. Haupt, 1997, The EMBO journal.

A functional p53-responsive intronic promoter is contained within the human mdm2 gene.

M. Oren, Y. Haupt, A. Zauberman, 1995, Nucleic acids research.

PML enhances the regulation of p53 by CK1 in response to DNA damage

E. Appella, Y. Haupt, S. Haupt, 2008, Oncogene.

Tumor suppressor p53 regulates heparanase gene expression

Y. Haupt, T. Peretz, I. Vlodavsky, 2006, Oncogene.

p53 controls hPar1 function and expression

V. Rotter, Y. Haupt, S. Haupt, 2008, Oncogene.

apoptosis . p 53-responsive genes cannot induce A mutant p 53 that discriminates between

C. Prives, M. Oren, P. Friedlander, 1996 .

Editorial: Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins

G. Blandino, Y. Haupt, 2016, Front. Oncol..

Proteotranscriptomic Measurements of E6-Associated Protein (E6AP) Targets in DU145 Prostate Cancer Cells*

Y. Haupt, S. Haupt, S. Keam, 2018, Molecular & Cellular Proteomics.

Certainly No ARFterthought: Oncogenic Cooperation in ARF Induction —A Key Step in Tumor Suppression

Y. Haupt, 2003, Cell cycle.

P53 licensed to kill? Operating the assassin

Y. Haupt, S. Haupt, I. Louria‐Hayon, 2003, Journal of cellular biochemistry.

E6AP promotes prostate cancer by reducing p27 expression

S. Fox, E. Gallo, G. Blandino, 2017, Oncotarget.

Interplay between p53 and VEGF: how to prevent the guardian from becoming a villain

Y. Haupt, K. Wolyniec, S. Haupt, 2013, Cell Death and Differentiation.

Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53.

M. Gatei, K. Khanna, Y. Haupt, 2001, Oncogene.

Uncovering a novel pathway for p16 silencing: Therapeutic implications for lung cancer

B. Solomon, Y. Haupt, S. Haupt, 2017, Molecular & cellular oncology.

Biodosimetric transcriptional and proteomic changes are conserved in irradiated human tissue

Gisela Mir Arnau, Y. Haupt, S. Keam, 2018, Radiation and Environmental Biophysics.

Biodosimetric transcriptional and proteomic changes are conserved in irradiated human tissue

Gisela Mir Arnau, Y. Haupt, S. Keam, 2018, Radiation and environmental biophysics.

Apoptotic cell death in disease—Current understanding of the NCCD 2023

S. Lipton, A. Ciechanover, T. Luedde, 2023, Cell Death & Differentiation.

c-Abl Phosphorylates Hdmx and Regulates Its Interaction with p53*

T. Holak, A. Jochemsen, G. Popowicz, 2009, Journal of Biological Chemistry.

Synchronized release of Doxil and Nutlin-3 by remote degradation of polysaccharide matrices and its possible use in the local treatment of colorectal cancer

Y. Barenholz, Y. Haupt, S. Haupt, 2011, Journal of drug targeting.

Exploring the oncoproteomic response of human prostate cancer to therapeutic radiation using data‐independent acquisition (DIA) mass spectrometry

Y. Haupt, S. Keam, O. Kleifeld, 2018, The Prostate.

Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells.

B. Solomon, G. McArthur, Y. Haupt, 2014, International journal of radiation oncology, biology, physics.

The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.

S. Fox, S. Loi, Y. Haupt, 2016, Cancer research.

New exciting possibilities for the development of precision medicine therapies to restore the expression of the INK4/ARF locus

Y. Haupt, S. Haupt, C. Gamell, 2017 .

Restoring PML tumor suppression to combat cancer

Y. Haupt, K. Wolyniec, S. Haupt, 2012, Cell cycle.

Moloney virus induction of T‐cell lymphomas in a plasmacytomagenic strain of Eμ‐V‐ABL transgenic mice

Y. Haupt, A. W. Harris, Jerry M. Adams, 1993, International journal of cancer.

Nucleotide sequence ofbup, an upstream gene in thebmi-1 proviral insertion locus

Y. Haupt, J. M. Adams, G. Barri, 2005, Molecular Biology Reports.

Correction for AbuHammad et al., Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

R. Pearson, A. Papenfuss, G. McArthur, 2020, Proceedings of the National Academy of Sciences.

Introduction: p53 Regulation—A Family Affair

Y. Haupt, 2004 .

p53 Regulation: a family affair.

Y. Haupt, 2004, Cell cycle.

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice.

Ashley P Ng, Y. Haupt, S. Haupt, 2018, Blood advances.

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

L. Abrahmsén, K. Wiman, Y. Haupt, 2017, Nature Communications.

Biodosimetric transcriptional and proteomic changes are conserved in irradiated human tissue

Gisela Mir Arnau, Y. Haupt, S. Keam, 2018, Radiation and Environmental Biophysics.

Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner

P. Pandolfi, S. Fox, G. Lozano, 2013, Cell cycle.

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis.

P. Pandolfi, S. Fox, S. Lowe, 2012, Blood.

Establishing the Link between X-Chromosome Aberrations and TP53 Status, with Breast Cancer Patient Outcomes

Y. Haupt, S. Haupt, F. Caramia, 2023, Cells.