D. Brash

发表

Tumor Suppressor Gene Mutations and Photocarcinogenesis

A. Ziegler, A. Jonason, J. Simon, 1996, Photochemistry and photobiology.

Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice.

D. Brash, Y. P. Lu, Y. Lou, 2000, Cancer research.

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

Matthew J. Davis, S. Ariyan, K. Kidd, 2012, Nature Genetics.

New careers for antioxidants

D. Brash, P. Havre, 2002, Proceedings of the National Academy of Sciences of the United States of America.

UV Signature Mutations

D. Brash, 2015, Photochemistry and photobiology.

Rethinking Causation for Data‐intensive Biology: Constraints, Cancellations, and Quantized Organisms

D. Brash, 2020, BioEssays : news and reviews in molecular, cellular and developmental biology.

A call for a better understanding of causation in cell biology

M. Bizzarri, V. Grieneisen, D. Brash, 2019, Nature Reviews Molecular Cell Biology.

Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.

C. Harris, J. Rhim, R. Reddel, 1988, Cancer research.

Frontiers in pigment cell and melanoma research

S. Swetter, M. Herlyn, R. Spritz, 2018, Pigment cell & melanoma research.

Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling

D. Brash, D. Knezevic, Wengeng Zhang, 2007, Proceedings of the National Academy of Sciences.

Regulation of TNFα production and release in human and mouse keratinocytes and mouse skin after UV‐B irradiation

C. Elmets, D. Brash, D. Yarosh, 2000, Photodermatology, photoimmunology & photomedicine.

DNA repair assays as tests for environmental mutagens. A report of the U.S. EPA Gene-Tox Program.

D. Brash, J. Cleaver, R. Painter, 1982, Mutation research.

Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure

R. Halaban, E. Bechara, K. Wakamatsu, 2015, Science.

Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin.

Shosuke Ito, Kazumasa Wakamatsu, K. Wakamatsu, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Carcinogenesis: UV Radiation

R. Cho, D. Brash, T. Heffernan, 2015 .

Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion.

A. Ziegler, A. Jonason, J. Simon, 1996, The journal of investigative dermatology. Symposium proceedings.

The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes.

D. Cheo, E. Friedberg, D. Brash, 2001, The Journal of investigative dermatology.

Ultraviolet radiation induced signature mutations in photocarcinogenesis.

D. Brash, N. Wikonkál, 1999, The journal of investigative dermatology. Symposium proceedings.

Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53.

D. Brash, D. Altieri, D. Grossman, 2001, The Journal of clinical investigation.

Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice

Hongyu Zhao, D. Brash, T. R. Berton, 2003, Nature Cell Biology.

Target Organ Specificity: Diethylnitrosamine-and Dibenzylnitrosamine-induced Single-strand Breaks Plus Alkali-labile Bonds

D. Brash, H. Nabi, R. Hart, 1984 .

Melanoma to Vitiligo: The Melanocyte in Biology & Medicine-Joint Montagna Symposium on the Biology of Skin/PanAmerican Society for Pigment Cell Research Annual Meeting.

G. Barsh, W. Pavan, M. Kulesz-Martin, 2020, The Journal of investigative dermatology.

UV-induced Melanin Chemiexcitation

D. Brash, 2016, Toxicologic pathology.

Exome sequencing identifies recurrent somatic RAC 1 mutations in melanoma

Matthew J. Davis, S. Ariyan, K. Kidd, 2016 .

Sunlight and skin cancer.

D. Leffell, D. Brash, 1996, Scientific American.

Local recurrence versus new primary: clinical analysis of 82 breast relapses and potential applications for genetic fingerprinting.

J. Simons, A. Ziegler, D. Brash, 1993, International journal of radiation oncology, biology, physics.

Roles of the transcription factor p53 in keratinocyte carcinomas

D. Brash, 2006, The British journal of dermatology.

Excision repair at individual bases of the Escherichia coli lacI gene: relation to mutation hot spots and transcription coupling activity.

D. Brash, S. Kunala, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-xL reduction thereby enhancing UV-light induced apoptosis

D. Brash, B. Nickoloff, J. Curry, 2005, Oncogene.

Photosensitizing dyes for the selection of nontumorigenic revertants from human lung cancer cell lines.

A. Oseroff, C. Harris, D. Brash, 1990, Cancer research.

Antigen-specific immunity does not mediate acute regression of UVB-induced p53-mutant clones

D. Brash, É. Remenyik, N. Wikonkál, 2003, Oncogene.

A method for quantitative measurement of DNA damage and repair in vivo

D. Brash, 1979 .

Strontium phosphate transfection of human cells in primary culture: stable expression of the simian virus 40 large-T-antigen gene in primary human bronchial epithelial cells

C. Harris, R. Reddel, D. Brash, 1987, Molecular and cellular biology.

Intragenic domains of strand-specific repair in Escherichia coli.

D. Brash, S. Kunala, 1995, Journal of molecular biology.

Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells.

D. Brash, M. Seidman, S. Seetharam, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Photocopying cancer cells.

D. Brash, 2003, The Journal of investigative dermatology.

Chemical excitation of electrons: A dark path to melanoma.

D. Brash, S. Premi, 2016, DNA repair.

A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen

R. Flavell, D. Brash, T. Cedervall, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences.

W. Haseltine, D. Brash, J. Lippke, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Cyclobutane Pyrimidine Dimer Hyperhotspots as Sensitive Indicators of Keratinocyte UV Exposure †

D. Brash, K. Kornacker, Alejandro Garcia‐Ruiz, 2022, Photochemistry and photobiology.

Rapid repair kinetics of pyrimidine(6-4)pyrimidone photoproducts in human cells are due to excision rather than conformational change.

D. Brash, D. Mitchell, R. Nairn, 1990, Nucleic acids research.

Transformation of human neonatal prostate epithelial cells by strontium phosphate transfection with a plasmid containing SV40 early region genes.

C. Harris, R. Reddel, D. Brash, 1989, Cancer research.

Ultraviolet photoproducts at the ochre suppressor mutation site in the gln U gene of Escherichia coli: Relevance to “mutation frequency decline”

D. Brash, E. Witkin, N. Garvey, 1989, Molecular and General Genetics MGG.

Photoreactivation of Escherichia coli reverses umuC induction by UV light

W. Haseltine, D. Brash, 1985, Journal of bacteriology.

Induction of cyclin-dependent kinase inhibitors and G(1) prolongation by the chemopreventive agent N-acetylcysteine.

D. Brash, M. Liu, N. Wikonkál, 1999, Carcinogenesis.

Clonal growth of human melanocytes using cell‐free extracellular matrix

R. Halaban, Antonella Bacchiocchi, D. Brash, 2013, Pigment cell & melanoma research.

Substrate range of the 40,000-dalton DNA-photoreactivating enzyme from Escherichia coli.

P. Hanawalt, W. Haseltine, D. Brash, 1986, Biochemistry.

DNA damage and repair in vivo.

D. Brash, R. Hart, 1978, Journal of environmental pathology and toxicology.

UV induces p21WAF1/CIP1 protein in keratinocytes without p53.

D. Brash, N. Wikonkál, M. Liu, 1999, The Journal of investigative dermatology.

Slip versus Slop: A Head-to-Head Comparison of UV-Protective Clothing to Sunscreen

Rajan P. Kulkarni, D. Brash, P. Cassidy, 2022, Cancers.

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

J. Simon, D. Brash, J. Pontén, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Acetyl zingerone: An efficacious multifunctional ingredient for continued protection against ongoing DNA damage in melanocytes after sun exposure ends

D. Brash, S. Premi, R. Chaudhuri, 2019, International journal of cosmetic science.

Sunburn and p53 in the onset of skin cancer

T. Jacks, A. Ziegler, A. Jonason, 1994, Nature.

IN VITRO ASSESSMENT AND MECHANISM OF ACTION OF ENVIRONMENTAL POLLUTANTS *

D. Brash, F. Daniel, N. Lewis, 1977, Annals of the New York Academy of Sciences.

Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma.

A. Ziegler, D. Leffell, D. Brash, 1996, Journal of the National Cancer Institute.

PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer

F. Pontén, J. Lundeberg, D. Leffell, 2005, The British journal of dermatology.

Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair

D. Brash, P. Rochette, 2010, PLoS genetics.

Enhancing the detection of barcoded reads in high throughput DNA sequencing data by controlling the false discovery rate

Rong Zhang, Tilo Buschmann, Douglas E. Brash, 2014, BMC Bioinformatics.

Is human patched the gatekeeper of common skin cancers?

Michael Dean, Douglas E. Brash, Peter G. Zaphiropoulos, 1996, Nature Genetics.

Keratinocyte apoptosis in epidermal development and disease.

D. Brash, D. Grossman, D. Raj, 2006, The Journal of investigative dermatology.

Frequent clones of p53-mutated keratinocytes in normal human skin.

R. Tarone, R. Restifo, A. Jonason, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Longevity-dependent organ-specific accumulation of DNA damage in two closely related murine species

D. Brash, A. Turturro, R. Hart, 1984, Mechanisms of Ageing and Development.

Triplet-Energy Quenching Functions of Antioxidant Molecules

D. Brash, M. Palmatier, S. Amar, 2022, Antioxidants.

UV MUTAGENIC PHOTOPRODUCTS IN Escherichia coli AND HUMAN CELLS: A MOLECULAR GENETICS PERSPECTIVE ON HUMAN SKIN CANCER *

D. Brash, 1988, Photochemistry and photobiology.

The C-C (6-4) UV photoproduct is mutagenic in Escherichia coli.

R. Schaaper, W. Haseltine, D. Brash, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Defective DNA repair in humans: clinical and molecular studies of xeroderma pigmentosum.

R. Parshad, R. Tarone, D. Brash, 1990, Basic life sciences.

Determination of DNA superhelicity and extremely low levels of DNA strand breaks in low numbers of nonradiolabeled cells by DNA-4',6-diamidino-2-phenylindole fluorescence in nucleoid gradients.

D. Brash, R. E. Stephens, L. E. Lantry, 1982, Analytical biochemistry.

Role of gene expression in mechanisms of toxicity/carcinogenicity relative to environmental cancer, heart, and lung disease

D. Brash, 1982 .

How Do Mutant Clones Expand in Normal Tissue

D. Brash, 2016 .

Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death

T. Hasan, D. Brash, E. Maytin, 2017, Molecular Cancer Therapeutics.

Antioxidant action via p53-mediated apoptosis.

D. Brash, E. Chu, J. Pelling, 1998, Cancer research.

Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL

D. Brash, P. Rochette, 2008, Mechanisms of Ageing and Development.

Overview of human cells in genetic research: Altered phenotypes in human cells caused by transferred genes

M. P. Farrell, C. Harris, D. Brash, 1987, Somatic cell and molecular genetics.

UVB-induced apoptosis drives clonal expansion during skin tumor development.

D. Brash, S. Florell, D. Grossman, 2004, Carcinogenesis.

Donor DNA in a renal cell carcinoma metastasis from a bone marrow transplant recipient

F. Pontén, A. Chakraborty, D. Brash, 2004, Bone Marrow Transplantation.

Common Contaminants in Next-Generation Sequencing That Hinder Discovery of Low-Abundance Microbes

Douglas E. Brash, Christos Hatzis, C. Hatzis, 2014, PloS one.

Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine.

D. Brash, J. Mccormick, P. Havre, 2002, Cancer research.

Colonization of adjacent stem cell compartments by mutant keratinocytes.

D. Brash, D. Grossman, Wengeng Zhang, 2005, Seminars in cancer biology.

Escaping the stem cell compartment: Sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations

D. Zelterman, D. Brash, É. Remenyik, 2001, Proceedings of the National Academy of Sciences of the United States of America.

UV-induced mutation hotspots occur at DNA damage hotspots

W. Haseltine, D. Brash, 1982, Nature.

Keratinocyte Apoptosis in Epidermal Development and

D. Brash, D. Grossman, 2006 .

Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion?

A. Chakraborty, D. Brash, J. Pawelek, 2006, Contributions to microbiology.

Skin precancer.

D. Brash, J. Pontén, 1998, Cancer surveys.

Influence of cytosine methylation on ultraviolet-induced cyclobutane pyrimidine dimer formation in genomic DNA.

N. Bastien, R. Drouin, D. Brash, 2009, Mutation research.

The mysterious steps in carcinogenesis

J. Cairns, D. Brash, 2009, British Journal of Cancer.

Genomic sites hypersensitive to ultraviolet radiation

D. Brash, J. Knight, Dejian Zhao, 2019, Proceedings of the National Academy of Sciences.

Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia

Allon M. Klein, P. Jones, D. Brash, 2009, Proceedings of the National Academy of Sciences.

Sunlight and the onset of skin cancer.

D. Brash, D E Brash, 1997, Trends in genetics : TIG.

Unanticipated role of melanin in causing carcinogenic cyclobutane pyrimidine dimers

D. Brash, Douglas E Brash, Sanjay Premi, 2016, Molecular & cellular oncology.

DNA Repair and Mutagenesis Induced by Dimer and Non-Dimer Photoproducts Measured with Plasmid Vectors in Xeroderma Pigmentosum Cells

D. Brash, M. Seidman, S. Seetharam, 1989 .

Genetics of Ultraviolet Radiation and Reactive Oxygen in the Origin of Melanoma

D. Brash, M. Karaghiosoff, Mathias Müller, 2011 .

Preneoplastic lesion growth driven by the death of adjacent normal stem cells

C. Maley, D. Chao, E. Luebeck, 2008, Proceedings of the National Academy of Sciences.

Chemiexcitation and Its Implications for Disease.

E. Bechara, D. Brash, L. C. P. Gonçalves, 2018, Trends in molecular medicine.

Status of the p53 tumor suppressor gene in human squamous carcinoma cell lines.

M. Reiss, A. Ziegler, J. Simon, 1992, Oncology research.

New approaches to DNA damage and repair: the ultraviolet light example.

W. Haseltine, D. Brash, J. Lippke, 1982, Basic life sciences.

Chemiexcitation: Mammalian Photochemistry in the Dark†

D. Brash, L. C. P. Gonçalves, 2023, Photochemistry and photobiology.

Induction of single-strand breaks plus alkali-labile bonds by N-nitrosoureas in rat tissues in vivo: ethylnitrosourea versus benzylnitrosourea.

D. Brash, S. D'Ambrosio, R. Hart, 1983, Mutation research.

Escherichia coli DNA photolyase reverses cyclobutane pyrimidine dimers but not pyrimidine-pyrimidone (6-4) photoproducts.

W. Haseltine, D. Brash, W. Franklin, 1985, The Journal of biological chemistry.

Ultraviolet Mutagenesis of a Shuttle Vector Plasmid in Repair Proficient and Deficient Human Cells

D. Brash, M. Seidman, A. Bredberg, 1991 .

Molecular Biology of Aging

D. Brash, R. Hart, 1978 .

Molecular Studies of Mutagenesis using Plasmid Vectors in Xeroderma Pigmentosum Cells

D. Brash, M. Seidman, S. Seetharam, 1989 .

The mysterious steps in carcinogenesis: addendum

J. Cairns, D. Brash, 2009, British Journal of Cancer.

Photobiology. Wrinkles waiting for GoDoT.

B. Gilchrest, D. Brash, 1996, Nature.

Rethinking Causation for Data‐intensive Biology: Constraints, Cancellations, and Quantized Organisms

D. Brash, 2020, BioEssays.

Accelerating cancer without mutations

D. Brash, 2019, eLife.

Bruce Nathan Ames - Paradigm shifts inside the cancer research revolution.

E. Zeiger, J. T. Macgregor, R. Maronpot, 2021, Mutation research.

Cellular proofreading

D. Brash, 1996, Nature Medicine.

Role of E2F1 in Apoptosis: A case Study in Feedback Loops

D. Brash, D. Knezevic, 2004, Cell cycle.

Defective postreplication repair of UV photoproducts in melanoma: a mutator phenotype

D. Brash, M. Seidman, 2019, Molecular oncology.

Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.

A. Ziegler, J. Simon, D. Leffell, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Chemiexcited Neurotransmitters and Hormones Create DNA Photoproducts in the Dark.

D. Brash, P. Di Mascio, E. L. Bastos, 2023, ACS chemical biology.