Phang-lang Chen

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Hot-Spot p53Mutants Interact Specifically withTwoCellular Proteins during Progression oftheCellCycle

Yumay Chen, Phang-lang Chen, Wen-Hwa Lee, 1994 .

Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37.

Mutsuko Ouchi, N. Fujiuchi, T. Ouchi, 2008, Frontiers in bioscience : a journal and virtual library.

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

Peter R. Baker, Lan Huang, P. Baker, 2007, Biochemistry.

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.

Wen-Hwa Lee, P. Jeffrey, N. Pavletich, 2002, Science.

Expression of PCNA-binding domain of CtIP, a motif required for CtIP localization at DNA replication foci, causes DNA damage and activation of DNA damage checkpoint

Phang-lang Chen, Bingnan Gu, 2009, Cell cycle.

Structural requirements of chromokinesin Kif4A for its proper function in mitosis.

Phang-lang Chen, Guikai Wu, 2008, Biochemical and biophysical research communications.

NFBD1, a Novel Nuclear Protein with Signature Motifs of FHA and BRCT, and an Internal 41-Amino Acid Repeat Sequence, Is an Early Participant in DNA Damage Response*

Phang-lang Chen, Yong Lei Shang, A. Bodero, 2003, The Journal of Biological Chemistry.

Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.

Phang-lang Chen, Wen-Hwa Lee, T. Boyer, 2002, Cancer research.

Never-in-mitosis related Kinase 1 functions in DNA damage response and checkpoint control

D. Riley, Yumay Chen, Phang-lang Chen, 2008, Cell cycle.

Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.

Y. Jeng, M. Tsai, Phang-lang Chen, 2012, Molecular cell.

Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR

D. Riley, Yumay Chen, Phang-lang Chen, 2011, Cell cycle.

BRCA1 Facilitates Microhomology-mediated End Joining of DNA Double Strand Breaks*

Phang-lang Chen, Wen-Hwa Lee, Chi-Fen Chen, 2002, The Journal of Biological Chemistry.

region.through association at the basic zipper Fos and Jun repress transcription activation by

T. Curran, S. Chen‐Kiang, T. Kerppola, 2013 .

NFBD1, Like 53BP1, Is an Early and Redundant Transducer Mediating Chk2 Phosphorylation in Response to DNA Damage*

Phang-lang Chen, A. Peng, 2003, The Journal of Biological Chemistry.

Association of Human Purα with the Retinoblastoma Protein, Rb, Regulates Binding to the Single-stranded DNA Purα Recognition Element (*)

Phang-lang Chen, Wen-Hwa Lee, Edward M. Johnson, 1995, The Journal of Biological Chemistry.

Aberrant DNA damage response and DNA repair pathway in high glucose conditions.

D. Riley, Yumay Chen, Phang-lang Chen, 2018, Journal of cancer research updates.

Diabetes-Cancer Risk: Hyperglycemia on DNA Damage and Repair

Yumay Chen, Phang-lang Chen, Amy Zhong, 2019, American Journal of Biomedical Science & Research.

Identification of Cellular TSG1O1 Protein in Multiple Human Breast Cancer Cell Lines'

Yumay Chen, Phang-lang Chen, Wen-Hwa Lee, 2006 .

NFBD1/Mdc1 mediates ATR-dependent DNA damage response.

Phang-lang Chen, A. Peng, 2005, Cancer research.

NFBD 1 / Mdc 1 Mediates ATR-Dependent DNA Damage Response

Phang-lang Chen, A. Peng, 2005 .

NIMA-Related Protein Kinase 1 Is Involved Early in the Ionizing Radiation-Induced DNA Damage Response

D. Riley, R. Polci, Yumay Chen, 2004, Cancer Research.

Durfee, T. et al. The Retinoblastoma protein associates with protein phosphatase type 1 catalytic subunit. Genes Dev. 7, 555-569

S. Elledge, T. Durfee, Phang-lang Chen, 1993 .

FosandJunRepress Transcription Activation byNF-IL6 through Association attheBasicZipper Region

T. Curran, Phang-lang Chen, W. Hsu, 1994 .

Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues.

Wen-Hwa Lee, Phang-lang Chen, Wen-Hwa Lee, 2009, Journal of medicinal chemistry.

Regulation of Heterochromatic Silencing and Histone H 3 Lysine-9 Methylation by RNAi

P. Jeffrey, N. Pavletich, N. Zheng, 2002 .

Human Mitochondrial SUV3 and Polynucleotide Phosphorylase Form a 330-kDa Heteropentamer to Cooperatively Degrade Double-stranded RNA with a 3′-to-5′ Directionality*

Phang-lang Chen, Wen-Hwa Lee, Zhanyong Shu, 2009, The Journal of Biological Chemistry.

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

Phang-lang Chen, Wen-Hwa Lee, Jean Y. J. Wang, 1989, Cell.

Expression of BRC Repeats in Breast Cancer Cells Disrupts the BRCA2-Rad51 Complex and Leads to Radiation Hypersensitivity and Loss of G2/M Checkpoint Control*

Phang-lang Chen, Wen-Hwa Lee, Z. D. Sharp, 1999, The Journal of Biological Chemistry.

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

Y. Shiloh, E. Y. Lee, Phang-lang Chen, 2000, Nature.

The Nuclear Localization Sequences of the BRCA1 Protein Interact with the Importin-α Subunit of the Nuclear Transport Signal Receptor*

Yumay Chen, Phang-lang Chen, Wen-Hwa Lee, 1996, The Journal of Biological Chemistry.

Aberrant Subcellular Localization of BRCA1 in Breast Cancer

C. Osborne, Y. Chen, C. F. Chen, 1995, Science.

A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia

Phang-lang Chen, Wen-Hwa Lee, Chi-Fen Chen, 2013, EMBO molecular medicine.

Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.

Phang-lang Chen, Wen-Hwa Lee, Guikai Wu, 2008, Cancer research.

Phosphorylation of the Mitotic Regulator Protein Hec1 by Nek2 Kinase Is Essential for Faithful Chromosome Segregation*

D. Riley, Yumay Chen, Phang-lang Chen, 2002, The Journal of Biological Chemistry.

Cell lineage-specific effects associated with multiple deficiencies of tumor susceptibility genes in Msh2(-/-)Rb(+/-) mice.

Chia-Yang Liu, Phang-lang Chen, Wen-Hwa Lee, 2002, Cancer research.

Advances in Brief Cell Lineage-specific Effects Associated with Multiple Deficiencies of Tumor Susceptibility Genes in Msh 2 / Rb / Mice 1

Chia-Yang Liu, Phang-lang Chen, Wen-Hwa Lee, 2002 .

RINT-1, a Novel Rad50-interacting Protein, Participates in Radiation-induced G2/M Checkpoint Control*

Phang-lang Chen, Wen-Hwa Lee, Chang Liu, 2001, The Journal of Biological Chemistry.

Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching

T. Ludwig, M. Nussenzweig, A. Nussenzweig, 2012, The Journal of experimental medicine.

The Nijmegen Breakage Syndrome Protein Is Essential for Mre11 Phosphorylation upon DNA Damage*

Phang-lang Chen, Z. Dong, Q. Zhong, 1999, The Journal of Biological Chemistry.

Advances in Brief Identification of Cellular TSG 1 O 1 Protein in Multiple Human Breast Cancer Cell Lines '

Yumay Chen, Phang-lang Chen, Wen-Hwa Lee, 2006 .

Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1.

Phang-lang Chen, Wen-Hwa Lee, Xianzhi Jiang, 2003, Cancer research.

NBS1 and TRF1 Colocalize at Promyelocytic Leukemia Bodies during Late S/G2 Phases in Immortalized Telomerase-negative Cells

P. L. Chen, W. Lee, Phang-lang Chen, 2000, The Journal of Biological Chemistry.

Inactivation of CtIP Leads to Early Embryonic Lethality Mediated by G1 Restraint and to Tumorigenesis by Haploid Insufficiency

F. Liu, Yumay Chen, Phang-lang Chen, 2005, Molecular and Cellular Biology.

STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage

M. Hubank, R. Knight, D. Latchman, 2005, Journal of Cell Science.

Regulatory Networks of the Retinoblastoma Protein a

D. Riley, Phang-lang Chen, Wen-Hwa Lee, 1995, Annals of the New York Academy of Sciences.

Increased Nek1 expression in Renal Cell Carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment

D. Riley, R. Polci, Yumay Chen, 2014, Oncotarget.

Identification of a Novel Putative Non-selenocysteine Containing Phospholipid Hydroperoxide Glutathione Peroxidase (NPGPx) Essential for Alleviating Oxidative Stress Generated from Polyunsaturated Fatty Acids in Breast Cancer Cells*

K. Desai, S. Furuta, Yi-Chun J. Wang, 2004, Journal of Biological Chemistry.

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.

Lei Fang, Lan Huang, Lan Huang, 2008, Journal of proteome research.

Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature.

Wen-Hwa Lee, Yung-Ming Jeng, Y. Jeng, 2006, Cancer cell.

Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells.

S. Furuta, Phang-lang Chen, Wen-Hwa Lee, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability.

Phang-lang Chen, Wen-Hwa Lee, A. Flesken-Nikitin, 2002, Cancer research.

Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability

Huai-Chin Chiang, R. Edwards, D. Riley, 2011, Molecular Cancer.

Helicase SUV3, Polynucleotide Phosphorylase, and Mitochondrial Polyadenylation Polymerase Form a Transient Complex to Modulate Mitochondrial mRNA Polyadenylated Tail Lengths in Response to Energetic Changes*

Phang-lang Chen, Wen-Hwa Lee, Chi-Fen Chen, 2014, The Journal of Biological Chemistry.

Retinoblastoma Protein Enhances the Fidelity of Chromosome Segregation Mediated by hsHec1p

D. Riley, Yumay Chen, Phang-lang Chen, 2000, Molecular and Cellular Biology.

Uncoupling the Roles of the SUV3 Helicase in Maintenance of Mitochondrial Genome Stability and RNA Degradation*

Phang-lang Chen, Wen-Hwa Lee, Chi-Fen Chen, 2011, The Journal of Biological Chemistry.

Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan

D. Wallace, Yumay Chen, Phang-lang Chen, 2012, Oncogene.

Effect of DNA damage on a BRCA1 complex. Authors' reply

Phang-lang Chen, Wen-Hwa Lee, N. Ting, 2001 .

A novel role of the chromokinesin Kif4A in DNA damage response

Phang-lang Chen, Wankee Kim, T. Krasieva, 2008, Cell cycle.

Depletion of BRCA 1 impairs differentiation but enhances proliferation of mammary epithelial cells

S. Furuta, Phang-lang Chen, Wen-Hwa Lee, 2005 .

Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage*

C. Osborne, P. L. Chen, W. Lee, 1999, The Journal of Biological Chemistry.

SUV3 Helicase and Mitochondrial Homeostasis

Phang-lang Chen, 2023, International journal of molecular sciences.

Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change.

Phang-lang Chen, Wen-Hwa Lee, Zhanyong Shu, 2004, Biochemistry.

Genetic mechanism of tumor suppression

Phang-lang Chen, Wen-Hwa Lee, ホウァリーウェン, 1991 .

Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.

W. Lee, Phang-lang Chen, Wen-Hwa Lee, 1990, Science.

Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells.

P. L. Chen, W. Lee, E. Y. Lee, 1988, Science.

Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region

T. Curran, S. Chen‐Kiang, T. Kerppola, 1994, Molecular and cellular biology.

Genetic mechanisms of tumor suppression by the human p53 gene

Yumay Chen, Phang-lang Chen, Wen-Hwa Lee, 1990, Science.

Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1.

P. L. Chen, W. Lee, Phang-lang Chen, 2000, Molecular cell.

High risk of renal outcome of metabolic syndrome independent of diabetes in patients with CKD stage 1–4: The ICKD database

H. Y. Lin, Phang-lang Chen, Jer-Ming Chang, 2023, Diabetes/metabolism research and reviews.

A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock

Y. Chen, C. F. Chen, D. Riley, 1996, Molecular and cellular biology.

Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6.

D. Riley, W. Lee, S. Chen‐Kiang, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.

C. Wang, Y. Chen, C. F. Chen, 1999, Science.

Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs.

Y. Chen, D. Riley, W. Lee, 1996, Genes & development.

BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.

Y. Chen, C. F. Chen, W. Lee, 1996, Cancer research.

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.

Y. Chen, C. F. Chen, W. Lee, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F

W. Lee, T. Durfee, Phang-lang Chen, 1992, Molecular and cellular biology.

BRCA1 the Versatile Defender: Molecular to Environmental Perspectives

Yumay Chen, Phang-lang Chen, Amy X. Zhong, 2023, International journal of molecular sciences.

Thyroid hormone, T3-dependent phosphorylation and translocation of Trip230 from the Golgi complex to the nucleus.

Y. Chen, C. F. Chen, W. Lee, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.

Phang-lang Chen, Wen-Hwa Lee, Guikai Wu, 2008, Cancer research.

Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen.

W. Lee, Phang-lang Chen, R. Bookstein, 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Intraocular tumor suppression of retinoblastoma gene-reconstituted retinoblastoma cells.

W. Lee, Phang-lang Chen, J. Whittum-Hudson, 1991, Cancer research.

Hot-spot p53 mutants interact specifically with two cellular proteins during progression of the cell cycle

Y. Chen, W. Lee, Yumay Chen, 1994, Molecular and cellular biology.