D. Braddock

发表

Molecular basis of sequence‐specific single‐stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single‐stranded DNA

G. Clore, D. Levens, J. Baber, 2002, The EMBO journal.

MicroRNA silencing for cancer therapy targeted to the tumor microenvironment

Christopher J. Cheng, F. Slack, D. Engelman, 2014, Nature.

Improving the Pharmacodynamics and In Vivo Activity of ENPP1‐Fc Through Protein and Glycosylation Engineering

K. Yarema, D. Braddock, W. Cao, 2020, Clinical and translational science.

ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy

J. Shiloach, A. Sinusas, S. Thorn, 2015, Nature Communications.

NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter.

G. Clore, P. Hajduk, J. R. Huth, 2004, Journal of medicinal chemistry.

Musculoskeletal Comorbidities and Quality of Life in ENPP1‐Deficient Adults and the Response of Enthesopathy to Enzyme Replacement Therapy in Murine Models

C. Ferreira, D. Braddock, G. Khursigara, 2021, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

NPP4 is a procoagulant enzyme on the surface of vascular endothelium.

D. Braddock, W. Cao, E. M. De La Cruz, 2012, Blood.

Phylogeny and Chemistry of Biological Mineral Transport.

P. Schlesinger, D. Braddock, H. Blair, 2020, Bone.

Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency

Steven M. Tommasini, D. Braddock, U. Kornak, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson–Gilford progeria syndrome

J. Humphrey, H. Ahmadzadeh, D. Braddock, 2020, Journal of the Royal Society Interface.

Paradoxical Aortic Stiffening and Subsequent Cardiac Dysfunction in Hutchinson-Gilford Progeria Syndrome

J. Humphrey, D. Braddock, Sae-Il Murtada, 2019, bioRxiv.

Response of the ENPP1‐Deficient Skeletal Phenotype to Oral Phosphate Supplementation and/or Enzyme Replacement Therapy: Comparative Studies in Humans and Mice

C. Ferreira, D. Braddock, Xiaofeng Li, 2021, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice

D. Braddock, Chuanlong Zhu, C. Bergwitz, 2017, PloS one.

In vivo correction of anaemia in beta-thalassemic mice by gammaPNA-mediated gene editing with nanoparticle delivery

Christopher J. Cheng, D. Ly, P. Glazer, 2019 .

In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery

Christopher J. Cheng, D. Ly, P. Glazer, 2016, Nature Communications.

Catalysis‐Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass

Steven M. Tommasini, D. Braddock, M. Somerman, 2022, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Characterization of hearing-impairment in Generalized Arterial Calcification of Infancy (GACI)

C. Brewer, D. Braddock, C. Zalewski, 2022, Orphanet Journal of Rare Diseases.

Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome.

R. D'Agostino, C. Gordon, B. Snyder, 2019, Bone.

Identification of ENPP1 Haploinsufficiency in Patients With Diffuse Idiopathic Skeletal Hyperostosis and Early‐Onset Osteoporosis

M. Nangaku, D. Braddock, T. Takamura, 2022, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Quantitative characterization of the interactions among c-myc transcriptional regulators FUSE, FBP, and FIR.

D. Braddock, E. Rhoades, A. Nath, 2010, Biochemistry.

Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion

D. Braddock, E. M. De La Cruz, R. Misra, 2008, Molecular Cancer Therapeutics.

Strategies for Glycoengineering Therapeutic Proteins

Jamie B. Spangler, K. Yarema, D. Braddock, 2022, Frontiers in Chemistry.

Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization.

D. Braddock, N. Jue, K. Zimmerman, 2020, Bone.

Unraveling the mechanism of recognition of the 3’ splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60

D. Braddock, E. Lolis, G. Crichlow, 2020, PloS one.

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Michael J. MacDonald, Richard G. Kibbey, Gary W. Cline, 2014, Nature.

Direct targeting of amplified gene loci for pro-apoptotic anticancer therapy

D. Braddock, E. Song, Elias Quijano, 2021, Nature Biotechnology.

Next generation miRNA inhibition using short anti-seed PNAs encapsulated in PLGA nanoparticles.

F. Slack, D. Braddock, R. Bahal, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair

M. Sharpley, M. Pellegrini, T. Graeber, 2022, The Journal of Clinical Investigation.

Histopathologic and Molecular Aspects of CD56+ Natural Killer/ T-Cell Lymphoma of the Testis

D. Braddock, C. Bifulco, J. G. Howe, 2008, International journal of surgical pathology.

Structure and dynamics of KH domains from FBP bound to single-stranded DNA

G. Clore, J. Louis, D. Levens, 2002, Nature.

Clinical and Biochemical Phenotypes in a Family With ENPP1 Mutations

R. Kumar, V. Murthy, M. Zimmermann, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition

David Levens, Chengpeng Fan, Gregg V Crichlow, 2007, The EMBO journal.

Molecular Basis of Purinergic Signal Metabolism by Ectonucleotide Pyrophosphatase/Phosphodiesterases 4 and 1 and Implications in Stroke*♦

D. Braddock, W. Cao, E. M. De La Cruz, 2013, The Journal of Biological Chemistry.

Genetic and pharmacologic modulation of cementogenesis via pyrophosphate regulators.

J. Millán, D. Braddock, M. Somerman, 2020, Bone.

Kinetic Analysis of Autotaxin Reveals Substrate-specific Catalytic Pathways and a Mechanism for Lysophosphatidic Acid Distribution*

Wenxiang Cao, D. Braddock, W. Cao, 2011, The Journal of Biological Chemistry.

Biophysical Characterization of gp41 Aggregates Suggests a Model for the Molecular Mechanism of HIV-associated Neurological Damage and Dementia*

L. Pannell, L. Liotta, G. Clore, 2000, The Journal of Biological Chemistry.

Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome

J. Humphrey, D. Braddock, G. Tellides, 2021, bioRxiv.

Autotaxin and lipid signaling pathways as anticancer targets.

D. Braddock, 2010, Current opinion in investigational drugs.

Rapid identification of medium- to large-scale interdomain motion in modular proteins using dipolar couplings.

G. Clore, J. Baber, D. Braddock, 2001, Journal of the American Chemical Society.

Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments

D. Braddock, N. Ito, H. Kato, 2023, Current Osteoporosis Reports.

Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair

M. Sharpley, M. Pellegrini, T. Graeber, 2021, The Journal of clinical investigation.

Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition

Kendra B Frederick, David Levens, D. Braddock, 2007, The EMBO journal.

ENPP1 in Blood and Bone: Skeletal and Soft Tissue Diseases Induced by ENPP1 Deficiency

D. Braddock, Carlos R Ferreira, Thomas O. Carpenter, 2023, Annual review of pathology.

Structural and thermodynamic characterization of a bioactive peptide model of apolipoprotein E: side-chain lactam bridges to constrain the conformation.

D. Braddock, S. Meredith, D. Lynn, 1994, Biochemistry.