Craig E. Higgins

发表

The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney

David M. Jones, Craig E. Higgins, Jiaqi Tang, 2021, Frontiers in Cell and Developmental Biology.

TGF-β1/p53 signaling in renal fibrogenesis.

Yi Tang, Craig E. Higgins, Stephen P. Higgins, 2018, Cellular signalling.

SERPINE1 expression discriminates site‐specific metastasis in human melanoma

D. Bernstein, Craig E. Higgins, Stephen P. Higgins, 2012, Experimental dermatology.

PAI-1: An Integrator of Cell Signaling and Migration

Paul J. Higgins, Craig E. Higgins, Stephen P. Higgins, 2011, International journal of cell biology.

TGF-β1-Induced Expression of the Anti-Apoptotic PAI-1 Protein Requires EGFR Signaling.

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2009, Cell communication insights.

Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2011, PloS one.

TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling.

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2008, Journal of molecular and cellular cardiology.

TGF- b 1 – p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications

Craig E. Higgins, Jiaqi Tang, Stephen P. Higgins, 2019 .

A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage.

Craig E. Higgins, Stephen P. Higgins, P. Higgins, 2015, Cellular signalling.

Plasminogen activator inhibitor type‐1 gene expression and induced migration in TGF‐β1‐stimulated smooth muscle cells is pp60c‐src/MEK‐dependent

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2005, Journal of cellular physiology.

Novel Combinatorial Therapeutic Targeting of PAI-1 (SERPINE1) Gene Expression in Alzheimer's Disease.

Craig E. Higgins, P. Higgins, S. Kutz, 2012, Molecular Medicine & Therapeutics.

Chemical Antagonists of Plasminogen Activator Inhibitor-1: Mechanisms of Action and Therapeutic Potential in Vascular Disease

Craig E. Higgins, Stephen P. Higgins, P. Higgins, 2014, Journal of molecular and genetic medicine : an international journal of biomedical research.

Ureteral Obstruction-Induced Renal Fibrosis: An In Vivo Platform for Mechanistic Discovery and Therapeutic Intervention.

Amy D. Dobberfuhl, Craig E. Higgins, Stephen P. Higgins, 2012, Cell & developmental biology.

PAI-1 mediates the TGF-beta1+EGF-induced "scatter" response in transformed human keratinocytes.

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2010, The Journal of investigative dermatology.

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2019, Biomolecules.

PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma

J. Foidart, G. V. van Dongen, Craig E. Higgins, 2010, Journal of oncology.

TGF-β1-Induced Expression of the Poor Prognosis SERPINE1/PAI-1 Gene Requires EGFR Signaling: A New Target for Anti-EGFR Therapy

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2009, Journal of oncology.

PAI-1 is a Critical Upstream Regulator of the TGF-β1/EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous Squamous Cell Carcinoma

Craig E. Higgins, Stephen P. Higgins, P. Higgins, 2007, Journal of biomedicine & biotechnology.

Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair: Functional Interactions between the Serine Protease and Matrix Metalloproteinase Cascades

Craig E. Higgins, Stephen P. Higgins, P. Higgins, 2012, Biochemistry research international.

SERPINE1: A Molecular Switch in the Proliferation-Migration Dichotomy in Wound-"Activated" Keratinocytes.

Craig E. Higgins, Stephen P. Higgins, P. Higgins, 2014, Advances in wound care.

TGF-beta 1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling.

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2006, Experimental cell research.

TGF‐β1–p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications

Craig E. Higgins, Jiaqi Tang, Stephen P. Higgins, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

SERPINE1 (PAI-1) is deposited into keratinocyte migration “trails” and required for optimal monolayer wound repair

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2008, Archives of Dermatological Research.

Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruption.

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2009, Cellular signalling.

Expression of the TGF- (cid:1) 1/p53 Target SERPINE1 Gene in Alzheimer’s Dementia: Molecular Mechanisms and Therapeutic Opportunities

Craig E. Higgins, P. Higgins, S. Kutz, 2014 .

SERPINE1 (PAI-1) is a prominent member of the early G0 --> G1 transition "wound repair" transcriptome in p53 mutant human keratinocytes.

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2008, The Journal of investigative dermatology.

PAI‐1 transcriptional regulation during the G0 → G1 transition in human epidermal keratinocytes

Craig E. Higgins, P. Higgins, L. Staiano‐Coico, 2006, Journal of cellular biochemistry.

The Basic Helix‐Loop‐Helix/Leucine Zipper Transcription Factor USF2 Integrates Serum‐Induced PAI‐1 Expression and Keratinocyte Growth

Craig E. Higgins, Stephen P. Higgins, B. Law, 2014, Journal of cellular biochemistry.

PAI-1 Expression Is Required for HDACi-Induced Proliferative Arrest in ras-Transformed Renal Epithelial Cells

Craig E. Higgins, Stephen P. Higgins, P. Higgins, 2011, International journal of cell biology.

PAI-1 mediates the TGF-beta1+EGF-induced "scatter" response in transformed human keratinocytes.

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2010, The Journal of investigative dermatology.

SERPINE1: Role in Cholangiocarcinoma Progression and a Therapeutic Target in the Desmoplastic Microenvironment

Craig E. Higgins, Stephen P. Higgins, R. Samarakoon, 2024, Cells.