I. Horikawa

发表

Balancing and Differentiating p53 Activities toward Longevity and No Cancer?

I. Horikawa, 2020, Cancer Research.

Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

I. Horikawa, A. Nakamura, W. Bonner, 2008, Epigenetics & Chromatin.

Identification of a ≦600-kb region on human chromosome 1q42.3 inducing cellular senescence

N. Nomura, M. Oshimura, J. Barrett, 2003, Oncogene.

Functional evidence for a telomerase repressor gene on human chromosome 10p15.1

M. Oshimura, S. Hirohashi, A. Gazdar, 2001, Oncogene.

Cellular senescence of a human bladder carcinoma cell line (JTC-32) induced by a normal chromosome 11.

M. Oshimura, K. Kihara, T. Schulz, 2000, Cancer genetics and cytogenetics.

DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene.

J. Barrett, C. Afshari, I. Horikawa, 1999, Cancer research.

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence

C. Harris, E. Appella, D. Lane, 2014, Nature Communications.

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence

C. Harris, E. Appella, D. Lane, 2010, Nature Cell Biology.

Spontaneous immortalization of cultured skin fibroblasts obtained from a high-dose atomic bomb survivor.

M. Oshimura, I. Horikawa, M. Watanabe, 1996, Mutation research.

Targeting Cellular Senescence in Cancer and Aging: Roles of p53 and its Isoforms.

C. Harris, I. Horikawa, J. Beck, 2020, Carcinogenesis.

EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in immortalized normal human cells

M. Seike, C. Harris, Mohammed A. Khan, 2020 .

Telomerase‐independent senescence of human immortal cells induced by microcell‐mediated chromosome transfer

M. Oshimura, J. Barrett, I. Horikawa, 1999, Molecular carcinogenesis.

Targeted Disruption of Ing2 Results in Defective Spermatogenesis and Development of Soft-Tissue Sarcomas

K. Kumamoto, J. Yokota, C. Harris, 2010, PloS one.

Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element.

J. Barrett, V. Larionov, I. Horikawa, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for a putative telomerase repressor gene in the 3p14.2–p21.1 region

M. Oshimura, J. Yokota, J. Barrett, 1998, Genes, chromosomes & cancer.

Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induces cellular senescence

M. Oshimura, J. Barrett, I. Horikawa, 1998, Molecular carcinogenesis.

Cytokine Storms in Cancer and COVID-19

C. Harris, I. Horikawa, B. Harris, 2020, Cancer Cell.

Cellular Senescence: Mechanisms, Morphology, and Mouse Models

C. Harris, I. Horikawa, J. Beck, 2020, Veterinary pathology.

p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes.

C. Harris, E. Appella, M. Blasco, 2013, The Journal of clinical investigation.

EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells

A. Gemma, M. Seike, C. Harris, 2020, BMC Cancer.

Radiation-induced astrocyte senescence is rescued by &Dgr;133p53

C. Harris, D. Lane, B. Vojtesek, 2019, Neuro-oncology.

cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome.

J. Barrett, I. Horikawa, 2001, Journal of the National Cancer Institute.

Evidence for inactivation of distinct telomerase repressor genes in different types of human cancers

M. Oshimura, J. Barrett, J. C. Barrett, 2005, International journal of cancer.

cDNA Cloning of the Human Polybromo-1 Gene on Chromosome 3p21

J. Barrett, I. Horikawa, 2002, DNA sequence : the journal of DNA sequencing and mapping.

Human Papillomavirus E2 Down-regulates the Human Telomerase Reverse Transcriptase Promoter*

J. Choe, J. Barrett, I. Horikawa, 2002, The Journal of Biological Chemistry.

Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms.

J. Barrett, I. Horikawa, 2003, Carcinogenesis.

Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression.

E. Appella, J. Barrett, C. Afshari, 2002, Molecular biology of the cell.

MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers

A. Schetter, A. Gemma, T. Okano, 2009, Proceedings of the National Academy of Sciences.

Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells

C. Harris, M. Serrano, A. Robles, 2017, Cell Death and Differentiation.

Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence

C. Harris, A. Robles, I. Horikawa, 2013, Oncogene.

Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis.

M. Oshimura, S. Hirohashi, J. Shay, 1997, Cancer genetics and cytogenetics.

Normal Human Chromosome 1 Carries Suppressor Activity for Various Phenotypes of a Kirsten Murine Sarcoma Virus‐transformed NIH/3T3 Cell Line

M. Oshimura, I. Horikawa, H. Hashiba, 1990, Japanese journal of cancer research : Gann.

Subchromosomal Mapping of a Putative Transformation Suppressor Gene on Human Chromosome 1

M. Oshimura, I. Horikawa, H. Yamada, 1995, Japanese journal of cancer research : Gann.

Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity.

M. Oshimura, I. Horikawa, Y. Hoshino, 1991, Biochemical and biophysical research communications.

The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions

J. Barrett, N. Kouprina, V. Larionov, 2002, Oncogene.

HIF‐1α induces cell cycle arrest by functionally counteracting Myc

L. Huang, I. Horikawa, J. C. Barrett, 2004 .

Role of Ets/Id proteins for telomerase regulation in human cancer cells.

D. Dimitrov, I. Horikawa, I. Sidorov, 2003, Experimental and molecular pathology.

Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 Oncoprotein

T. Veldman, J. Barrett, J. C. Barrett, 2001, Journal of Virology.

Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 Oncoprotein

T. Veldman, J. Barrett, J. C. Barrett, 2001, Journal of Virology.

Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.

J. Barrett, C. Afshari, I. Horikawa, 1999, Cancer research.

Cellular Senescence Mechanisms Independent of Telomere Shortening and Telomerase: Other Barriers to Cell Immortalization and Carcinogenesis

J. Barrett, I. Horikawa, T. Yawata, 2000 .

Normal human chromosome 2 induces cellular senescence in the human cervical carcinoma cell line SiHa

K. Mitsuya, M. Oshimura, I. Horikawa, 1995, Genes, chromosomes & cancer.

Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.

Izumi Horikawa, Jun Yokota, Seiichi Takenoshita, 2008, Cancer research.

Regulation of hTERT transcription: a target of cellular and viral mechanisms for immortalization and carcinogenesis

J. Barrett, I. Horikawa, E. Michishita, 2004, Cytotechnology.

Forced expression of YL-1 protein suppresses the anchorage-independent growth of Kirsten sarcoma virus-transformed NIH3T3 cells.

M. Oshimura, I. Horikawa, H. Tanaka, 1995, Experimental cell research.

Telomerase as an Important Target of Androgen Signaling Blockade for Prostate Cancer Treatment

Yubin Ge, Paul S. Rennie, Izumi Horikawa, 2010, Molecular Cancer Therapeutics.

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

J. Barrett, I. Horikawa, D. Zimonjic, 2004, Nature Cell Biology.

Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells

I. Horikawa, R. Schlegel, Xuefeng Liu, 2018, Cell Death & Disease.

Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells

C. Harris, I. Horikawa, R. Schlegel, 2018, Cell Death & Disease.

Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease

Jane J. Sohn, A. Schetter, E. Bowman, 2012, PloS one.

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.

Izumi Horikawa, J Carl Barrett, J. Barrett, 2005, Molecular biology of the cell.

Increased MicroRNA-34b and -34c Predominantly Expressed in Stromal Tissues Is Associated with Poor Prognosis in Human Colon Cancer

A. Schetter, E. Bowman, C. Harris, 2015, PloS one.

p53 isoforms regulate premature aging in human cells

C. Harris, D. Lane, I. Horikawa, 2017, Oncogene.

Delayed kinetics of DNA double‐strand break processing in normal and pathological aging

Izumi Horikawa, I. Horikawa, D. Zimonjic, 2008, Aging cell.

Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.

Izumi Horikawa, Antti Kokko, Päivi Laiho, 2007, Cancer research.

Loss of heterozygosity at chromosome segment Xq25‐26.1 in advanced human ovarian carcinomas

A. Berchuck, G. Chenevix-Trench, I. Horikawa, 1997, Genes, chromosomes & cancer.

Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells.

J. Barrett, I. Horikawa, E. Michishita, 2004, Blood.

Astrocyte senescence and SASP in neurodegeneration: tau joins the loop

C. Harris, I. Horikawa, B. Harris, 2021, Cell cycle.

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

J. Barrett, L. Huang, I. Horikawa, 2004, The EMBO journal.

Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells

J. C. Barrett, I. Horikawa, G. Solomon, 2001, Journal of cellular biochemistry.

p53 governs telomere regulation feedback too, via TRF2

C. Harris, I. Horikawa, K. Fujita, 2011, Aging.

Identification and characterization of rapidly dividing U937 clones with differential telomerase activity and gene expression profiles: role of c-Myc/Mad1 and Id/Ets proteins

R. Lempicki, X. Xiao, I. Horikawa, 2002, Leukemia.

transformed cells - HTLV-I B pathway in κ Transcriptional activation of hTERT through the NF-

J. Barrett, I. Horikawa, E. Michishita, 2013 .

The Δ133p53 Isoforms, Tuners of the p53 Pathway

C. Harris, I. Horikawa, J. Beck, 2020, Cancers.

Upregulation of the KIAA1199 gene is associated with cellular mortality.

Izumi Horikawa, J Carl Barrett, J. Barrett, 2006, Cancer letters.

p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

Borivoj Vojtesek, Curtis C. Harris, Izumi Horikawa, 2009, Nature Cell Biology.

Genetic heterogeneity of chromosome 11 associated with tumorigenicity in HeLa D98-OR cells.

M. Oshimura, A. Okamoto, J. Yokota, 1995, Cancer genetics and cytogenetics.

Meeting Report : American Aging Association 40 th Annual Meeting , Raleigh , North Carolina , June 3 – 6 , 2011

N. Sharpless, I. Horikawa, H. Scrable, 2011 .

p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration

C. Harris, Xin Lu, E. Major, 2016, Cell Death and Differentiation.

Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system

J. Barrett, I. Horikawa, U. Hengge, 2002, Oncogene.

Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells

C. Harris, I. Horikawa, R. Schlegel, 2018, Cell Death & Disease.

Δ133p53: A p53 isoform enriched in human pluripotent stem cells

C. Harris, I. Horikawa, 2017, Cell cycle.

“Δ133p53α Protects Human Astrocytes from Amyloid-Beta Induced Senescence and Neurotoxicity”

C. Harris, I. Horikawa, Delphine Lissa, 2021, bioRxiv.

Studies on Tumor-suppressor Genes by Monochromosome Transfer

M. Oshimura, I. Horikawa, 1991 .

Multiple chromosomes carrying tumor suppressor activity, via microcell-mediated chromosome transfer, for various tumor cell lines.

M. Oshimura, I. Horikawa, M. Sasaki, 1989, Princess Takamatsu symposia.

Increased MicroRNA-34b and -34c Predominantly Expressed in Stromal Tissues Is Associated with Poor Prognosis in Human Colon Cancer

E. Bowman, C. Harris, S. Leung, 2015, PloS one.

Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.

C. Afshari, I. Horikawa, P. L. Cable, 1999, Cancer research.

Human Telomerase Reverse Transcriptase Cloning and Characterization of the Promoter Region of Updated

C. Afshari, I. Horikawa, P. L. Cable, 1999 .

Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.

K. Kumamoto, J. Yokota, C. Harris, 2008, Cancer research.

Abstract 922: Delta133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells

C. Harris, M. Serrano, A. Robles, 2017 .