Hua Lu

发表

Negative auto-regulators trap p53 in their web.

Xiaoping Zhou, B. Cao, Hua Lu, 2017, Journal of molecular cell biology.

Scission of the p53-MDM2 Loop by Ribosomal Proteins.

Xiaoping Zhou, Hua Lu, J. Liao, 2012, Genes & cancer.

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

Jijie Gu, Surender Kharbanda, Zhi-Min Yuan, 1999, Nature.

Identification of small molecules affecting p53-MDM2/MDMX interaction by fluorescence polarization.

Hua Lu, Qi Zhang, Hua Lu, 2013, Methods in molecular biology.

Nanoparticle encapsulation of non-genotoxic p53 activator Inauhzin-C for improved therapeutic efficacy

J. Paruch, Hua Lu, Binghe Wang, 2021, Theranostics.

Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactions.

W. Im, Sunhwan Jo, Hua Lu, 2011, Journal of the American Chemical Society.

Nucleophosmin Is Essential for Ribosomal Protein L5 Nuclear Export

M. Dai, Hua Lu, J. Weber, 2006, Molecular and Cellular Biology.

MDMX Promotes Proteasomal Turnover of p21 at G1 and Early S Phases Independently of, but in Cooperation with, MDM2

Xiao-xin Sun, Hua Lu, C. Blattner, 2007, Molecular and Cellular Biology.

Phosphorylation and Stabilization of TAp63γ by IκB Kinase-β*

Hua Lu, Shelya X. Zeng, M. Macpartlin, 2008, Journal of Biological Chemistry.

Ribosomal Stress Couples the Unfolded Protein Response to p53-dependent Cell Cycle Arrest*

M. Dai, R. Hamanaka, Hua Lu, 2006, Journal of Biological Chemistry.

14-3-3γ Inhibition of MDMX-mediated p21 Turnover Independent of p53*

Hua Lu, Jun-Ho Lee, Jun‐Ho Lee, 2010, The Journal of Biological Chemistry.

SCFβTrCP1 Activates and Ubiquitylates TAp63γ*

K. Nakayama, K. Nakayama, Hua Lu, 2008, Journal of Biological Chemistry.

SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection.

Hua Lu, Yi Sun, M. Tan, 2006, Neoplasia.

Single‐cell transcriptomes reveal heterogeneity of high‐grade serous ovarian carcinoma

Hua Lu, Xiaohua Wu, B. Xie, 2021, Clinical and translational medicine.

Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid Metabolism

S. Wang, E. Flores, Hua Lu, 2017, Scientific Reports.

POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status.

Z. Pursell, Z. Suo, Hua Lu, 2020, Molecular cell.

The Mettl3 epitranscriptomic writer amplifies p53 stress responses.

Howard Y. Chang, J. Demeter, M. Barna, 2022, Molecular cell.

Hypoxia Activates Tumor Suppressor p53 by Inducing ATR-Chk1 Kinase Cascade-mediated Phosphorylation and Consequent 14-3-3γ Inactivation of MDMX Protein*

G. Wahl, Hua Lu, Yunyuan V. Wang, 2012, The Journal of Biological Chemistry.

Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF

Xiao-xin Sun, M. Dai, Hua Lu, 2014, Oncogene.

Aberrantly activated Gli2-KIF20A axis is crucial for growth of hepatocellular carcinoma and predicts poor prognosis

Hua Lu, Libin Deng, Chao-jia Shi, 2016, Oncotarget.

Interferon-Inducible Protein IFIXα1 Functions as a Negative Regulator of HDM2

Hua Lu, Mong-Hong Lee, D. Yan, 2006, Molecular and Cellular Biology.

Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.

Hua Lu, Mong-Hong Lee, D. Yan, 2006, Molecular and cellular biology.

Methylselenol prodrug enhances MDV3100 efficacy for treatment of castration‐resistant prostate cancer

B. Cao, Hua Lu, Qi Zhang, 2013, International journal of cancer.

RNA-binding Motif Protein 10 Induces Apoptosis and Suppresses Proliferation by Activating p53

B. Cao, Hua Lu, Hyemin Lee, 2019, Oncogene.

GFZF, a Glutathione S-Transferase Protein Implicated in Cell Cycle Regulation and Hybrid Inviability, Is a Transcriptional Coactivator

M. Dai, D. Gilmour, Hua Lu, 2017, Molecular and Cellular Biology.

Global Effect of Inauhzin on Human p53-Responsive Transcriptome

Xiaoping Zhou, Hua Lu, J. Liao, 2012, PloS one.

Interferon-Inducible Protein IFIX (cid:2) 1 Functions as a Negative Regulator of HDM2

Hua Lu, Mong-Hong Lee, D. Yan, 2006 .

A potential synthetic lethal strategy with PARP inhibitors: perspective on ‘Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP’

Hua Lu, Q. Hao, Xiang Zhou, 2021, Journal of molecular cell biology.

Crosstalk between c‐Myc and ribosome in ribosomal biogenesis and cancer

M. Dai, Hua Lu, Hua Lu, 2008, Journal of cellular biochemistry.

Inhibition of c‐Myc activity by ribosomal protein L11

Xiao-xin Sun, M. Dai, R. Sears, 2022 .

Depletion of Nucleostemin in Response to GTP Ligase-independent Proteasomal Turnover Ubiquitin-and MDM 2 E 3 Protein Synthesis and Degradation :

Xiao-xin Sun, M. Dai, Hua Lu, 2012 .

The Acetylase Activity of p300 Is Dispensable for MDM2 Stabilization*

Hua Lu, P. Rotwein, D. Kuninger, 2003, The Journal of Biological Chemistry.

PHLD Class Proteins: A Family of New Players in the p53 Network

Hua Lu, Taylor T Fuselier, 2020, International journal of molecular sciences.

Editorial: Double-Edged Swords: Genetic Factors That Influence the Pathogenesis of Both Metabolic Disease and Cancer

M. Murphy, Hua Lu, Che-Pei Kung, 2019, Front. Endocrinol..

Phosphoinositide species and filamentous actin formation mediate engulfment by senescent tumor cells

Hua Lu, Hyemin Lee, Wesley D. Frey, 2022, PLoS biology.

MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

M. Dai, Hua Lu, Shelya X. Zeng, 2003, The EMBO journal.

MiR-1246: A new link of the p53 family with cancer and Down syndrome

Xiaoping Zhou, Hua Lu, J. Liao, 2012, Cell cycle.

p53 downregulates Down syndrome‐associated DYRK1A through miR‐1246

Hua Lu, J. Liao, Shelya X. Zeng, 2011, EMBO reports.

Ribosomal proteins: functions beyond the ribosome.

Xiang Zhou, Xiaoping Zhou, Hua Lu, 2015, Journal of molecular cell biology.

Gb3‐cSrc complex in glycosphingolipid‐enriched microdomains contributes to the expression of p53 mutant protein and cancer drug resistance via β‐catenin–activated RNA methylation

Hua Lu, J. Marshall, Yu-Teh Li, 2020, FASEB bioAdvances.

5-Fluorouracil Activation of p53 Involves an MDM2-Ribosomal Protein Interaction*

M. Dai, Hua Lu, Xiao-Xin Sun, 2007, Journal of Biological Chemistry.

Interferon‐alpha‐induced hepatitis C virus clearance restores p53 tumor suppressor more than direct‐acting antivirals

Hua Lu, A. Cohen, S. Dash, 2017, Hepatology communications.

Signaling to p53: ribosomal proteins find their way.

Yanping Zhang, Hua Lu, 2009, Cancer cell.

It takes a team: a gain-of-function story of p53-R249S

Hua Lu, Shelya X. Zeng, P. Liao, 2019, Journal of molecular cell biology.

Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding.

G. Del Sal, B. Cao, Hua Lu, 2017, Molecular cell.

Icariin‐induced inhibition of SIRT6/NF‐κB triggers redox mediated apoptosis and enhances anti‐tumor immunity in triple‐negative breast cancer

Hua Lu, Linjiang Song, Chi Liu, 2020, Cancer science.

LncRNA RNA Component of Mitochondrial RNA-Processing Endoribonuclease Promotes AKT-Dependent Breast Cancer Growth and Migration by Trapping MicroRNA-206

Hua Lu, Xiaohua Wu, B. Xie, 2021, Frontiers in Cell and Developmental Biology.

Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP

Shanshan Wang, Hua Lu, X. Weng, 2021, Proceedings of the National Academy of Sciences.

RBM10, a New Regulator of p53

Hua Lu, Hyemin Lee, J. Jung, 2020, Cells.

Ribosomal Protein S14 Negatively Regulates c-Myc Activity*

Xiang Zhou, Xiaoping Zhou, Hua Lu, 2013, The Journal of Biological Chemistry.

RGFP966, a Histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7.

Hua Lu, D. Kalvakolanu, Hongwu Zheng, 2020, Biochemical pharmacology.

Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth

Hua Lu, Libin Deng, Chao-jia Shi, 2021, Cell Death & Disease.

p53 Tumor Suppressor Opens Gateways for Cancer Therapy

M. Dai, Hua Lu, J. Gallegos, 2008 .

Mycophenolic Acid Activation of p53 Requires Ribosomal Proteins L5 and L11*

M. Dai, Hua Lu, Xiao-Xin Sun, 2008, Journal of Biological Chemistry.

Tumor Suppressor Opens Gateways for Cancer Therapy

M. Dai, Hua Lu, J. Gallegos, 2008 .

Reviving the guardian of the genome: Small molecule activators of p53

Hua Lu, Wenjuan Liao, Daniel Nguyen, 2017, Pharmacology & therapeutics.

Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator

Xiaoping Zhou, B. Cao, Hua Lu, 2016, eLife.

Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents.

Hua Lu, Qi Zhang, Yiwei Zhang, 2013, Neoplasia.

Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc.

M. Dai, Hua Lu, Yetao Jin, 2006, Neoplasia.

MDM2 Mediates p300/CREB-binding Protein-associated Factor Ubiquitination and Degradation*

Hua Lu, Shelya X. Zeng, Yetao Jin, 2004, Journal of Biological Chemistry.

New insights into p53 functions through its target microRNAs.

Xiaoping Zhou, B. Cao, Hua Lu, 2014, Journal of molecular cell biology.

Targeting p53-MDM2-MDMX loop for cancer therapy.

Hua Lu, Qi Zhang, Shelya X. Zeng, 2014, Sub-cellular biochemistry.

Role of JWA in acute promyelocytic leukemia cell differentiation and apoptosis triggered by retinoic acid, 12-tetradecanoylphorbol-13-acetate and arsenic trioxide

Hua Lu, C. Zou, Jianwei Zhou, 2002 .

Identification and characterization of a novel Drosophila melanogaster glutathione S-transferase-containing FLYWCH zinc finger protein.

M. Dai, J. Qin, Hua Lu, 2004, Gene.

PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53–MDM2 loop

Z. Yi, Dali Li, Jian Luo, 2010, Nucleic acids research.

Ribosomal Proteins L5 and L11 Cooperatively Inactivate c-Myc via RNA-induced Silencing Complex

Xiaoping Zhou, Hua Lu, J. Liao, 2013, Oncogene.

Ribosomopathies: Mechanisms of Disease

Xiaoping Zhou, Hua Lu, Wenjuan Liao, 2014, Clinical medicine insights. Blood disorders.

Inhibition of MDM2-mediated p53 Ubiquitination and Degradation by Ribosomal Protein L5*

M. Dai, Hua Lu, 2004, Journal of Biological Chemistry.

Ribosomal Protein L23 Activates p53 by Inhibiting MDM2 Function in Response to Ribosomal Perturbation but Not to Translation Inhibition

M. Dai, Hua Lu, L. David, 2004, Molecular and Cellular Biology.

Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF

A. Levine, M. Uesugi, G. Verdine, 1997 .

p300 Regulates p63 Transcriptional Activity*

Hua Lu, M. Thayer, D. Stauffer, 2005, Journal of Biological Chemistry.

The N-Terminal Domain of p73 Interacts with the CH1 Domain of p300/CREB Binding Protein and Mediates Transcriptional Activation and Apoptosis

Hua Lu, R. Goodman, Xiaorong Li, 2000, Molecular and Cellular Biology.

Monitoring p53 by MDM2 and MDMX is required for endocrine pancreas development and function in a spatio-temporal manner.

Hua Lu, Yiwei Zhang, Shelya X. Zeng, 2017, Developmental biology.

Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis.

Hua Lu, Xin Zhang, Yiwei Zhang, 2014, Developmental biology.

Arl13b Promotes Gastric Tumorigenesis by Regulating Smo Trafficking and Activation of the Hedgehog Signaling Pathway.

Hua Lu, Limin Chen, W. Shi, 2017, Cancer research.

p53 induces ARTS to promote mitochondrial apoptosis

Hua Lu, J. Liao, Jiaxiang Chen, 2020, Cell Death & Disease.

SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer

B. Cao, Hua Lu, J. Liao, 2018, eLife.

SPIN1 promotes tumorigenesis by blocking the uL18-MDM2-p53 pathway

B. Cao, Hua Lu, J. Liao, 2017, bioRxiv.

TP53 mutations in epithelial ovarian cancer.

Yu Zhang, Hua Lu, Hua Lu, 2016, Translational cancer research.

ChIP for identification of p53 responsive DNA promoters.

Hua Lu, J. Liao, Jun-Ming Liao, 2013, Methods in molecular biology.

14-3-3 c binds to MDMX that is phosphorylated by UV-activated Chk 1 , resulting in p 53 activation

M. Dai, Yingming Zhao, Hua Lu, 2013 .

Ubiquitin- and MDM2 E3 Ligase-independent Proteasomal Turnover of Nucleostemin in Response to GTP Depletion*

M. Dai, Hua Lu, Shelya X. Zeng, 2012, The Journal of Biological Chemistry.

Hydrophilic Residues Are Crucial for Ribosomal Protein L11 (RPL11) Interaction with Zinc Finger Domain of MDM2 and p53 Protein Activation*

Hua Lu, Qi Zhang, S. Chai, 2011, The Journal of Biological Chemistry.

Nucleostemin

Hua Lu, Dorothy Lo, 2010, Cell cycle.

Nucleostemin: Another nucleolar "Twister" of the p53-MDM2 loop.

Hua Lu, Dorothy Lo, 2010, Cell cycle.

MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3*

Hua Lu, D. Boyd, Hongbo Wang, 2010, The Journal of Biological Chemistry.

Aberrant Expression of Nucleostemin Activates p53 and Induces Cell Cycle Arrest via Inhibition of MDM2

M. Dai, Hua Lu, Xiao-Xin Sun, 2008, Molecular and Cellular Biology.

arrest via inhibition of MDM2

M. Dai, Hua Lu, Xiao-Xin Sun, 2008 .

Regulation of the MDM2-p53 Pathway by Ribosomal Protein L11 Involves a Post-ubiquitination Mechanism*

M. Dai, S. Grossman, Yanping Zhang, 2006, Journal of Biological Chemistry.

14‐3‐3γ binds to MDMX that is phosphorylated by UV‐activated Chk1, resulting in p53 activation

M. Dai, Yingming Zhao, Hua Lu, 2006, The EMBO journal.

Interaction of p53 with cellular proteins.

D. Keller, Hua Lu, Shelya X. Zeng, 2003, Methods in molecular biology.

p53 Serine 392 Phosphorylation Increases after UV through Induction of the Assembly of the CK2·hSPT16·SSRP1 Complex*

D. Keller, Hua Lu, 2002, The Journal of Biological Chemistry.

MDM2 Inhibits PCAF (p300/CREB-binding Protein-associated Factor)-mediated p53 Acetylation*

M. Dai, Hua Lu, Xiang-Jiao Yang, 2002, The Journal of Biological Chemistry.

Stabilization and Activation of p53 by the Coactivator Protein TAFII31*

J. Manfredi, L. Resnick-Silverman, Hua Lu, 2001, The Journal of Biological Chemistry.

p300 Does Not Require Its Acetylase Activity to Stimulate p73 Function*

X. Zeng, Hua Lu, Qinghong Zhang, 2001, The Journal of Biological Chemistry.

Cancer-mutated ribosome protein L22 (RPL22/eL22) suppresses cancer cell survival by blocking p53-MDM2 circuit

Xiaoping Zhou, B. Cao, Hua Lu, 2017, Oncotarget.

Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture

C. Hagedorn, Hua Lu, K. Reiss, 2017, Scientific Reports.

Serum miR-152, miR-148a, miR-148b, and miR-21 as novel biomarkers in non-small cell lung cancer screening

Hua Lu, Rui-xia Zhu, Chuan Lu, 2015, Tumor Biology.

UV Induces p21 Rapid Turnover Independently of Ubiquitin and Skp2*

Hunjoo Lee, Hua Lu, Hua Lu, 2006, Journal of Biological Chemistry.

A role for SSRP1 in recombination‐mediated DNA damage response

Hua Lu, A. Kumari, U. Shinde, 2009, Journal of cellular biochemistry.

SSRP1 functions as a co‐activator of the transcriptional activator p63

M. Dai, D. Keller, Hua Lu, 2002, The EMBO journal.

erratum: p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

R. Weichselbaum, Zhi-Min Yuan, D. Kufe, 1999, Nature.

Mutant p53 in cancer therapy—the barrier or the path

Xiaoping Zhou, Hua Lu, Q. Hao, 2018, Journal of molecular cell biology.

Inhibition of MDM 2-Mediated p 53 Ubiquitination and Degradation by Ribosomal Protein L 5

M. Dai, Hua Lu, 2004 .

Feedback Regulation of c-Myc by Ribosomal Protein L11

M. Dai, R. Sears, Hua Lu, 2007, Cell cycle.

Dual regulation of p53 by the ribosome maturation factor SBDS

Shanshan Wang, Hua Lu, Jieqiong Wang, 2020, Cell Death & Disease.

Inauhzin(c) Inactivates c-Myc Independently of p53

Xiaoping Zhou, B. Cao, Hua Lu, 2015, Cancer biology & therapy.

Physical and Functional Interaction between Ribosomal Protein L11 and the Tumor Suppressor ARF*

M. Dai, Hua Lu, R. Wek, 2012, The Journal of Biological Chemistry.

Inhibition of c‐Myc activity by ribosomal protein L11

M. Dai, R. Sears, Hua Lu, 2007, The EMBO journal.

Autoregulatory Suppression of c-Myc by miR-185-3p*

Hua Lu, J. Liao, Jun-Ming Liao, 2011, The Journal of Biological Chemistry.

Ribosomal Protein L11 Associates with c-Myc at 5 S rRNA and tRNA Genes and Regulates Their Expression*

M. Dai, Hua Lu, Xiao-Xin Sun, 2010, The Journal of Biological Chemistry.

The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress

Xiang Zhou, Xiaoping Zhou, A. Mosley, 2014, eLife.

Structure-Specific Recognition Protein 1 Facilitates Microtubule Growth and Bundling Required for Mitosis

Yingming Zhao, D. Keller, Hua Lu, 2009, Molecular and Cellular Biology.

Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53

Xiaoping Zhou, B. Cao, Hua Lu, 2016, Nature Communications.

TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene

B. Cao, Hua Lu, J. Liao, 2016, Scientific Reports.

Structure and Activity Analysis of Inauhzin Analogs as Novel Antitumor Compounds That Induce p53 and Inhibit Cell Growth

Hua Lu, Qi Zhang, Derong Ding, 2012, PloS one.

A ribosomal tactic to halt cancer

Hua Lu, 2011, Nature Medicine.

AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity

G. Wahl, B. Viollet, Hua Lu, 2013, Molecular and Cellular Biology.

Inhibition of tumor suppressor p73 by nerve growth factor receptor via chaperone-mediated autophagy

Yun Deng, Hua Lu, Daniel Nguyen, 2020, Journal of molecular cell biology.

Mdm2 mediates FMRP‐ and Gp1 mGluR‐dependent protein translation and neural network activity

H. J. Chung, Hua Lu, A. Kalsotra, 2017, Human molecular genetics.

Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth

L. Mayo, Hua Lu, Qi Zhang, 2012, Cancer biology & therapy.

Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation

B. Chen, T. Iwakuma, Hua Lu, 2019, EBioMedicine.

Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation

Xiaoping Zhou, B. Cao, Hua Lu, 2016, eLife.

Genetic Deficiency of p53 Leads to Structural, Functional, and Synaptic Deficits in Primary Somatosensory Cortical Neurons of Adult Mice

R. Mostany, Hua Lu, Jianmei Wang, 2022, Frontiers in Molecular Neuroscience.

Crotonylation at serine 46 impairs p53 activity.

W. Wimley, B. Cao, Hua Lu, 2020, Biochemical and biophysical research communications.

Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II

D. Reinberg, L. Zawel, Hua Lu, 1992, Nature.

CK2 Phosphorylates SSRP1 and Inhibits Its DNA-binding Activity*

John D. Scott, D. Keller, Hua Lu, 2005, Journal of Biological Chemistry.

Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein

D. Reinberg, Hua Lu, A. Usheva, 1992, Cell.

Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression

M. Bear, M. Colledge, L. Langeberg, 2003, Neuron.

SPA: Short peptide analyzer of intrinsic disorder status of short peptides

A. Dunker, V. Uversky, B. Xue, 2010, Genes to cells : devoted to molecular & cellular mechanisms.

Human SSRP1 Has Spt16-dependent and -independent Roles in Gene Transcription*

Hua Lu, I. Landais, Shelya X. Zeng, 2007, Journal of Biological Chemistry.

p53 and MDM2: their Yin-Yang intimacy.

Hua Lu, 2017, Journal of Molecular Cell Biology.

Determination of maximum tolerated dose and toxicity of Inauhzin in mice

Hua Lu, Qi Zhang, Shelya X. Zeng, 2015, Toxicology reports.

Cancer-derived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart

B. Cao, Hua Lu, O. Sartor, 2021, Journal of molecular cell biology.

Ubiquitin ligase DTX3 empowers mutant p53 to promote ovarian cancer development

Shanshan Wang, Hua Lu, Xiaohua Wu, 2020, Genes & diseases.

Valosin-Containing Protein Stabilizes Mutant p53 to Promote Pancreatic Cancer Growth

Hua Lu, Canhua Huang, Jieqiong Wang, 2021, Cancer Research.

Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53

Hua Lu, Canhua Huang, Jieqiong Wang, 2019, Cell Death & Disease.

Inactivating p53 is essential for nerve growth factor receptor to promote melanoma-initiating cell-stemmed tumorigenesis

Yuqing Xiong, Hua Lu, Jieqiong Wang, 2020, Cell Death & Disease.

Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs

Hua Lu, Hee-won Park, Yun Chen, 2016, PloS one.

Chimeric p53 as an alternative therapy for hypoxic tumors

Hua Lu, Jun‐Ho Lee, 2011, Cancer biology & therapy.

Methoxyacetic acid suppresses prostate cancer cell growth by inducing growth arrest and apoptosis.

Hua Lu, Qiuyang Zhang, Guangdi Wang, 2014, American journal of clinical and experimental urology.

Original Article Methoxyacetic acid suppresses prostate cancer cell growth by inducing growth arrest and apoptosis

Hua Lu, Qiuyang Zhang, Guangdi Wang, 2014 .

Co-targeting p53-R249S and CDK4 synergistically suppresses survival of hepatocellular carcinoma cells

Hua Lu, Shelya X. Zeng, P. Liao, 2019, Cancer biology & therapy.

miR-329 regulates the sensitivity of 5-FU in chemotherapy of colorectal cancer by targeting E2F1

Hua Lu, Jie Yin, Li Xu, 2018, Oncology letters.

IκB Kinase β (IKKβ) Inhibits p63 Isoform γ (TAp63γ) Transcriptional Activity*

E. Flores, Hua Lu, J. Liao, 2013, The Journal of Biological Chemistry.

Nutlin's two roads toward apoptosis

Hua Lu, Qi Zhang, 2010, Cancer biology & therapy.

Inhibition of MDM2-p53 feedback loop by various small molecules for potential cancer chemotherapy

Hua Lu, A. Khan, 2008, Cancer biology & therapy.

Ribosomal protein S14 unties the MDM2–p53 loop upon ribosomal stress

Qi Zhang, Q. Zhang, Hua Lu, 2013, Oncogene.

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

M. Kapoor, G. Lozano, D. Keller, 2001, Molecular cell.

The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro

A. Levine, P. Bailey, H. Lu, 1997, Molecular and cellular biology.

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

H. Lu, Hua Lu, A. Dvir, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

A. Levine, H. Lu, Hua Lu, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Disruption of the Putative Ribosome-Binding Motif of a Scaffold Protein Impairs Cytochrome c Oxidase Subunit Expression in Leishmania major

B. Cao, Hua Lu, B. Kelly, 2019, mSphere.