C. Thornton

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7 – Mechanisms of Cell Death in the Developing Brain

C. Thornton, H. Hagberg, 2017 .

Cellular Mechanisms of Toll-Like Receptor-3 Activation in the Thalamus Are Associated With White Matter Injury in the Developing Brain

P. Gressens, M. Rutherford, C. Thornton, 2015, Journal of neuropathology and experimental neurology.

Moderate-to-severe hypoxic–ischaemic encephalopathy (HIE), caused by a lack of oxygen or blood flow to the brain around the time of birth, affects 1–2 babies in every 1000 in the UK and far more in the developing world

P. Gressens, C. Thornton, H. Hagberg, 2015 .

Neuroprotective Strategies for Newborns

P. Gressens, C. Thornton, B. Fleiss, 2016 .

Identification of a Novel AMP-activated Protein Kinase β Subunit Isoform That Is Highly Expressed in Skeletal Muscle*

C. Thornton, D. Carling, M. A. Snowden, 1998, The Journal of Biological Chemistry.

TWEAK Receptor Deficiency Has Opposite Effects on Female and Male Mice Subjected to Neonatal Hypoxia–Ischemia

P. Gressens, C. Thornton, H. Hagberg, 2018, Front. Neurol..

Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Signaling and Cell Death in the Immature Central Nervous System after Hypoxia-Ischemia and Inflammation

P. Gressens, C. Thornton, H. Hagberg, 2014, The Journal of Biological Chemistry.

Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy

C. Thornton, H. Hagberg, A. Rahim, 2018, Brain : a journal of neurology.

The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway.

C. Thornton, A. Baracca, G. Solaini, 2020, Biochimica et biophysica acta. Molecular cell research.

Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury

P. Gressens, H. Stolp, C. Thornton, 2015, International journal of molecular sciences.

AMPK: keeping the (power)house in order?

C. Thornton, 2017, Neuronal signaling.

139 IDENTIFICATION OF A NOVEL AMPKβ SUBUNIT THAT IS HIGHLY EXPRESSED IN SKELETAL MUSCLE

C. Thornton, D. Carling, M. A. Snowden, 1997 .

Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human

A. Edwards, P. Gressens, H. Stolp, 2019, Front. Physiol..

A dual role for AMP‐activated protein kinase (AMPK) during neonatal hypoxic–ischaemic brain injury in mice

P. Gressens, C. Thornton, H. Hagberg, 2015, Journal of neurochemistry.

Implicating Receptor Activator of NF-κB (RANK)/RANK Ligand Signalling in Microglial Responses to Toll-Like Receptor Stimuli

P. Gressens, C. Thornton, H. Hagberg, 2017, Developmental Neuroscience.

Mitochondria and perinatal brain injury

C. Thornton, H. Hagberg, A. Baburamani, 2012, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

AMPK: keeping the (power)house in order?

C. Thornton, 2017, Neuronal signaling.

A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference

K. Rosenblum, C. Thornton, E. Grad, 2022, Translational Psychiatry.

Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity

P. Gressens, H. Stolp, R. Dimitrova, 2022, Journal of Neuroinflammation.

Differential Effects of Urban Particulate Matter on BV2 Microglial-Like and C17.2 Neural Stem/Precursor Cells

S. Counsell, I. McGonnell, C. Thornton, 2022, Developmental Neuroscience.

H-Ras modulates NMDA receptor function via inhibition of Src tyrosine kinase activity

C. Thornton, D. Ron, R. Yaka, 2003 .

Mitochondria, Bioenergetics and Excitotoxicity: New Therapeutic Targets in Perinatal Brain Injury

C. Thornton, H. Hagberg, C. Mallard, 2017, Front. Cell. Neurosci..

Neuroprotection strategies for the newborn

P. Gressens, C. Thornton, B. Fleiss, 2017 .

The regulation and function of mammalian AMPK‐related kinases

C. Thornton, D. Carling, D Carling, 2009, Acta physiologica.

Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic‐ischemic brain injury

M. Dragunow, S. Barnum, C. Thornton, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1

A. Bonci, C. Thornton, D. Ron, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Mitochondria: hub of injury responses in the developing brain

C. Thornton, H. Hagberg, C. Mallard, 2014, The Lancet Neurology.

Cell Death in the Developing Brain after Hypoxia-Ischemia

C. Thornton, H. Hagberg, C. Mallard, 2017, Front. Cell. Neurosci..

Spatial and Temporal Regulation of RACK1 Function and N-methyl-D-aspartate Receptor Activity through WD40 Motif-mediated Dimerization*

K. Tang, C. Thornton, D. Ron, 2004, Journal of Biological Chemistry.

AMP-activated protein kinase: new regulation, new roles?

C. Thornton, D. Carling, A. Woods, 2012, The Biochemical journal.

Mitochondrial dynamics in the neonatal brain – a potential target following injury?

C. Thornton, Adam Jones, 2022, Bioscience reports.

Investigating the Regulation of Brain-specific Kinases 1 and 2 by Phosphorylation*

C. Thornton, D. Carling, N. J. Bright, 2008, Journal of Biological Chemistry.

Molecular Mechanisms of Neonatal Brain Injury

P. Gressens, C. Thornton, H. Hagberg, 2012, Neurology research international.

The role of mitochondria in cocaine addiction.

C. Thornton, E. Grad, R. Yaka, 2021, The Biochemical journal.

Lipopolysaccharide‐induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo

P. Gressens, C. Thornton, H. Hagberg, 2019, Glia.

Does Caspase-6 Have a Role in Perinatal Brain Injury?

P. Gressens, M. Rutherford, C. Thornton, 2015, Developmental Neuroscience.

H-Ras Modulates N-Methyl-D-aspartate Receptor Function via Inhibition of Src Tyrosine Kinase Activity*

C. Thornton, D. Ron, R. Yaka, 2003, Journal of Biological Chemistry.

Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic‐ischaemic brain injury

C. Thornton, H. Hagberg, C. Mallard, 2018, FEBS letters.

Death Associated Protein Kinases: Molecular Structure and Brain Injury

C. Thornton, H. Hagberg, C. Mallard, 2013, International journal of molecular sciences.

Toll-Like Receptor 3 Expression in Glia and Neurons Alters in Response to White Matter Injury in Preterm Infants

P. Gressens, M. Rutherford, C. Thornton, 2013, Developmental Neuroscience.

Oxidative stress and endoplasmic reticulum (ER) stress in the development of neonatal hypoxic–ischaemic brain injury

C. Thornton, H. Hagberg, A. Baburamani, 2017, Biochemical Society transactions.

Role of mitochondria in apoptotic and necroptotic cell death in the developing brain

C. Thornton, H. Hagberg, 2015, Clinica chimica acta; international journal of clinical chemistry.

Neuroprotective Effects of Diabetes Drugs for the Treatment of Neonatal Hypoxia-Ischemia Encephalopathy

C. Thornton, H. Hagberg, A. Rahim, 2020, Frontiers in Cellular Neuroscience.

Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment

S. Counsell, I. McGonnell, C. Thornton, 2021, BioEssays : news and reviews in molecular, cellular and developmental biology.

γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice

Changlian Zhu, C. Thornton, H. Hagberg, 2017, Journal of Neuroinflammation.

γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice

Changlian Zhu, C. Thornton, Xiaoyang Wang, 2017, Journal of Neuroinflammation.

Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection

P. Gressens, C. Thornton, H. Hagberg, 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Magnesium sulphate induces preconditioning in preterm rodent models of cerebral hypoxia-ischemia

P. Gressens, C. Thornton, H. Hagberg, 2018, International Journal of Developmental Neuroscience.

Mind Bomb-2 Is an E3 Ligase That Ubiquitinates the N-Methyl-d-aspartate Receptor NR2B Subunit in a Phosphorylation-dependent Manner*

C. Thornton, Jun Wang, D. Ron, 2008, Journal of Biological Chemistry.

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.

David Carling, Claire Thornton, C. Thornton, 2011, The Biochemical journal.

Muscarinic Receptor Activation of AMP-activated Protein Kinase Inhibits Orexigenic Neuropeptide mRNA Expression*

A. Sardini, C. Thornton, D. Carling, 2008, Journal of Biological Chemistry.

The Anti-Inflammatory Effects of the Small Molecule Pifithrin-µ on BV2 Microglia

P. Gressens, C. Thornton, H. Hagberg, 2015, Developmental Neuroscience.

Editorial: Experimental and Clinical Approaches in the Pursuit of Novel Therapeutic Strategies for Perinatal Brain Injury and Its Neurological Sequelae

Changlian Zhu, C. Thornton, Chao Chen, 2021, Frontiers in Cellular Neuroscience.