Carolyn L. Smith

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Activation of p53 Transcriptional Activity by SMRT: a Histone Deacetylase 3-Independent Function of a Transcriptional Corepressor

Anbu K. Adikesavan, S. Karmakar, P. Pardo, 2014, Molecular and Cellular Biology.

Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression.

Anna Frolov, M. Ittmann, Carolyn L. Smith, 2005, Cancer research.

Tensile forces attenuate estrogen-stimulated collagen synthesis in the ACL.

Zong-ping Luo, Xiaoliu Zhang, Carolyn L. Smith, 2004, Biochemical and biophysical research communications.

The combined regulation of estrogen and cyclic tension on fibroblast biosynthesis derived from anterior cruciate ligament.

Zong-ping Luo, Xiaoliu Zhang, Carolyn L. Smith, 2004, Matrix biology : journal of the International Society for Matrix Biology.

Coupling of Receptor Conformation and Ligand Orientation Determine Graded Activity

Min Zhao, Paul D. Adams, Pavel V. Afonine, 2010, Nature chemical biology.

The SMRT coregulator enhances growth of estrogen receptor-α-positive breast cancer cells by promotion of cell cycle progression and inhibition of apoptosis.

S. Karmakar, Liguo Wang, Wei Li, 2014, Endocrinology.

Unique roles of p160 coactivators for regulation of breast cancer cell proliferation and estrogen receptor-alpha transcriptional activity.

S. Karmakar, Carolyn L. Smith, Sudipan Karmakar, 2009, Endocrinology.

Rapid Glucocorticoid Receptor Exchange at a Promoter Is Coupled to Transcription and Regulated by Chaperones and Proteasomes

James G. McNally, J. McNally, G. Hager, 2004, Molecular and Cellular Biology.

Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line.

S. Karmakar, Carolyn L. Smith, Estrella A. Foster, 2010, Endocrine-related cancer.

Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma.

G. Sonpavde, H. Weiss, S. Lerner, 2007, Urology.

Chapter 127 – Estrogen and Progesterone Action

Carolyn L. Smith, N. Weigel, 2016 .

Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity.

Carolyn L. Smith, B. Zhu, Xiang-Rong Jiang, 2013, Journal of medicinal chemistry.

HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes.

S. Hilsenbeck, C. Creighton, R. Lanz, 2016, Cancer research.

Chemoprevention of BBN-Induced Bladder Carcinogenesis by the Selective Estrogen Receptor Modulator Tamoxifen.

S. Hilsenbeck, Yiqun Zhang, S. Lerner, 2013, Translational oncology.

Expression of estrogen receptors-alpha and -beta in bladder cancer cell lines and human bladder tumor tissue.

G. Sonpavde, S. Lerner, Carolyn L. Smith, 2006, Cancer.

CK 1 d modulates the transcriptional activity of ER a via AIB 1 in an estrogen-dependent manner and regulates ER a – AIB 1 interactions

Ross S. Thomas, U. Knippschild, Carolyn L. Smith, 2009 .

Cooperative Activation of Gene Expression by Agonists and Antagonists Mediated by Estrogen Receptor Heteroligand Dimer Complexes

Carolyn L. Smith, Shuang Liu, S. Han, 2013, Molecular Pharmacology.

Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor‐α and the REA corepressor

S. Karmakar, Carolyn L. Smith, Estrella A. Foster, 2009, International journal of cancer.

Title : HER 2 signaling drives DNA anabolism and proliferation through SRC-3 phosphorylation and E 2 F 1-regulated genes

S. Hilsenbeck, C. Creighton, R. Lanz, 2016 .

Mechanistic differences in the activation of estrogen receptor-alpha (ER alpha)- and ER beta-dependent gene expression by cAMP signaling pathway(s).

Carolyn L. Smith, N. Weigel, B. Rowan, 2003, The Journal of biological chemistry.

Differential skeletal responses of hindlimb unloaded rats on a vitamin D-deficient diet to 1,25-dihydroxyvitamin D3 and its analog, seocalcitol (EB1089).

Carolyn L. Smith, N. Weigel, D. Gaddy, 2004, Bone.

The 26S Proteasome Is Required for Estrogen Receptor-α and Coactivator Turnover and for Efficient Estrogen Receptor-α Transactivation

B. O’Malley, Z. Nawaz, Carolyn L. Smith, 2000 .

Distinctive functions of p 160 steroid receptor coactivators in proliferation of an estrogen-independent , tamoxifen-resistant breast cancer cell line

S. Karmakar, Carolyn L. Smith, Estrella A. Foster, 2010 .

Identification of four novel phosphorylation sites in estrogen receptor α : impact on receptor-dependent gene expression and phosphorylation by protein kinase CK 2

Carolyn L. Smith, B. Rowan, A. El-Gharbawy, 2015 .

Coregulator function: a key to understanding tissue specificity of selective receptor modulators.

Bert W O'Malley, B. O’Malley, Carolyn L. Smith, 2004, Endocrine reviews.

Evolutionary identification of a subtype specific functional site in the ligand binding domain of steroid receptors

Olivier Lichtarge, O. Lichtarge, Carolyn L. Smith, 2006, Proteins.

FRAP reveals that mobility of oestrogen receptor-α is ligand- and proteasome-dependent

B. O’Malley, Carolyn L. Smith, M. Mancini, 2000, Nature Cell Biology.

Subnuclear Trafficking of Estrogen Receptor-α and Steroid Receptor Coactivator-1

Carolyn L. Smith, M. Mancini, D. Stenoien, 2000 .

Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase, E6-AP, Results in Tissue-Selective Steroid Hormone Resistance and Defects in Reproduction

A. Beaudet, B. O’Malley, Z. Nawaz, 2002, Molecular and Cellular Biology.

Dopaminergic Regulation of Progesterone Receptors: Brain D5 Dopamine Receptors Mediate Induction of Lordosis by D1-Like Agonists in Rats

S. Watson, Carolyn L. Smith, J. Garai, 1996, The Journal of Neuroscience.

Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer.

M. Ittmann, Carolyn L. Smith, N. Weigel, 2006, Cancer research.

Cooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressor.

S. Oesterreich, S. Karmakar, Carolyn L. Smith, 2010, Molecular endocrinology.

The Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor (SMRT) Corepressor Is Required for Full Estrogen Receptor α Transcriptional Activity

S. Karmakar, Carolyn L. Smith, Margaret C. Pace, 2007, Molecular and Cellular Biology.

Effects of Androgen and Estrogen Receptor Signaling Pathways on Bladder Cancer Initiation and Progression

Carolyn L. Smith, G. Gakis, G. Godoy, 2016, Bladder cancer.

The Angelman Syndrome-Associated Protein, E6-AP, Is a Coactivator for the Nuclear Hormone Receptor Superfamily

M. Tsai, Z. Nawaz, S. Tsai, 1999, Molecular and Cellular Biology.

Ligand-Mediated Assembly and Real-Time Cellular Dynamics of Estrogen Receptor α-Coactivator Complexes in Living Cells

Anne E Carpenter, A. Belmont, Carolyn L. Smith, 2001, Molecular and Cellular Biology.

Elevated nuclear expression of the SMRT corepressor in breast cancer is associated with earlier tumor recurrence

D. Edwards, S. Hilsenbeck, S. Oesterreich, 2012, Breast Cancer Research and Treatment.

Expression of estrogen receptors‐α and ‐β in bladder cancer cell lines and human bladder tumor tissue

G. Sonpavde, S. Lerner, Carolyn L. Smith, 2006 .

Efficacy of selective estrogen receptor modulators (SERMs) in a murine xenograft model bearing human bladder cancer

G. Sonpavde, H. Weiss, S. Lerner, 2005 .

591: Efficacy of Selective Estrogen Receptor Modulators (SERMS) in a Murine Xenograft Model Bearing Human Bladder Cancer

G. Sonpavde, H. Weiss, S. Lerner, 2005 .

SRC-1 is involved in the control of the gene expression of myelin protein po

Carolyn L. Smith, M. Motta, R. Melcangi, 2007, Journal of Molecular Neuroscience.

Molecular perspectives on selective estrogen receptor modulators (SERMs): progress in understanding their tissue-specific agonist and antagonist actions

Carolyn L. Smith, D. Lonard, 2002, Steroids.

Functional subnuclear partitioning of transcription factors

Carolyn L. Smith, Z. D. Sharp, M. Mancini, 1998, Journal of cellular biochemistry.

Mechanistic Differences in the Activation of Estrogen Receptor-α (ERα)- and ERβ-dependent Gene Expression by cAMP Signaling Pathway(s)*

Carolyn L. Smith, N. Weigel, B. Rowan, 2003, The Journal of Biological Chemistry.

Raloxifene Inhibits Growth of RT4 Urothelial Carcinoma Cells via Estrogen Receptor-Dependent Induction of Apoptosis and Inhibition of Proliferation

S. Lerner, Carolyn L. Smith, K. Hoffman, 2012, Hormones and Cancer.

Rapid Estrogen-Induced Phosphorylation of the SRC-3 Coactivator Occurs in an Extranuclear Complex Containing Estrogen Receptor

B. O’Malley, Carolyn L. Smith, R. Wu, 2005, Molecular and Cellular Biology.

Transcriptional regulation by steroid receptor coactivator phosphorylation.

B. O’Malley, Carolyn L. Smith, R. Wu, 2005, Endocrine reviews.

Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains.

Carolyn L. Smith, M. Dutertre, Martin Dutertre, 2003, Molecular endocrinology.

Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation.

B. O’Malley, C. F. Bennett, Carolyn L. Smith, 2002, Molecular endocrinology.

Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator.

Bert W O'Malley, B. O’Malley, S. Karmakar, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The pure estrogen receptor antagonist ICI 182,780 promotes a novel interaction of estrogen receptor-alpha with the 3',5'-cyclic adenosine monophosphate response element-binding protein-binding protein/p300 coactivators.

S. Karmakar, Carolyn L. Smith, Luping Huang, 2006, Molecular endocrinology.

Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators

Carolyn L. Smith, 2004 .

SKF-82958 Is a Subtype-selective Estrogen Receptor-α (ERα) Agonist That Induces Functional Interactions between ERα and AP-1*

Carolyn L. Smith, M. Dutertre, M. Walters, 2002, The Journal of Biological Chemistry.

Cellular and genetic characterization of human adult bone marrow-derived neural stem-like cells: a potential antiglioma cellular vector.

H. Fine, P. Albert, A. Elkahloun, 2003, Cancer research.

Antiglioma Cellular Vector Marrow-Derived Neural Stem-Like Cells : A Potential Cellular and Genetic Characterization of Human Adult Bone

H. Fine, P. Albert, A. Elkahloun, 2003 .

SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity.

R. Lanz, Carolyn L. Smith, K. M. Coleman, 2004, Biochemical and biophysical research communications.

Activation of Estrogen Receptor-Beta-Dependent Transcription by Estrogen-Independent Pathways

Carolyn L. Smith, 1999 .

A-Ring Reduced Metabolites of 19-nor Synthetic Progestins as Subtype Selective Agonists for ERα.

A. Cooney, Carolyn L. Smith, F. Larrea, 2001, Endocrinology.

Estrogen Receptor Activation by Ligand-Dependent and Ligand-Independent Pathways

B. O’Malley, Carolyn L. Smith, O. Conneely, 1994 .

B. Komm, Carolyn L. Smith, R. Santen, 2014, Breast Cancer Research.

Mammalian Cell Culture

Carolyn L. Smith, 2006 .

The terminal substituents of 7α, 6-hexanyl derivatives of estradiol determine their selective estrogen receptor modulator versus agonist activities

Carolyn L. Smith, K. Hoffman, Estrella A. Foster, 2012, Steroids.

Synthetic 19-nortestosterone derivatives as estrogen receptor alpha subtype-selective ligands induce similar receptor conformational changes and steroid receptor coactivator recruitment than natural estrogens

A. Cooney, Carolyn L. Smith, R. García-Becerra, 2006, The Journal of Steroid Biochemistry and Molecular Biology.

CK1δ modulates the transcriptional activity of ERα via AIB1 in an estrogen-dependent manner and regulates ERα–AIB1 interactions

Ross S. Thomas, U. Knippschild, Carolyn L. Smith, 2009, Nucleic acids research.

735: Differential Expression of Estrogen Receptor α and β in Bladder Cancer Cell Lines and Human Bladder Tumor Tissue

G. Sonpavde, S. Lerner, Carolyn L. Smith, 2004 .

Marinobufagenin interferes with the function of the mineralocorticoid receptor.

Carolyn L. Smith, Qiang He, J. Puschett, 2007, Biochemical and biophysical research communications.

Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus.

C. Smith, Carolyn L. Smith, H. Koprowski, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Proteasome-dependent degradation of the human estrogen receptor.

B. O’Malley, Z. Nawaz, Carolyn L. Smith, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Intracellular signaling pathways: nongenomic actions of estrogens and ligand-independent activation of estrogen receptors.

Carolyn L. Smith, C. Smith, K. M. Coleman, 2001, Frontiers in bioscience : a journal and virtual library.

Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen.

B. O’Malley, Z. Nawaz, Carolyn L. Smith, 1997, Molecular endocrinology.

CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.

B. O’Malley, M. Tsai, Carolyn L. Smith, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Molecular mechanisms of selective estrogen receptor modulator (SERM) action.

Carolyn L. Smith, M. Dutertre, C. Smith, 2000, The Journal of pharmacology and experimental therapeutics.

A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils.

W. Sibbald, Carolyn L. Smith, G. Hammond, 1990, The Journal of clinical endocrinology and metabolism.

Cross-talk between peptide growth factor and estrogen receptor signaling pathways.

Carolyn L. Smith, C. Smith, C. Smith, 1998, Biology of reproduction.

Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors.

Carolyn L. Smith, G. Hammond, I. Goping, 1987, Proceedings of the National Academy of Sciences of the United States of America.

An alternative ligand-independent pathway for activation of steroid receptors.

B. O’Malley, Carolyn L. Smith, N. Weigel, 1995, Recent progress in hormone research.

Rabbit corticosteroid-binding globulin: primary structure and biosynthesis during pregnancy.

Carolyn L. Smith, G. Hammond, G. Séralini, 1990, Molecular endocrinology.

Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone.

B. O’Malley, Carolyn L. Smith, O. Conneely, 1993, Proceedings of the National Academy of Sciences of the United States of America.