V. Janssens

发表

The role and therapeutic potential of Ser/Thr phosphatase PP2A in apoptotic signalling networks in human cancer cells.

V. Janssens, A. Rebollo, Veerle Janssens, 2012, Current molecular medicine.

The Phosphotyrosyl Phosphatase Activator Gene Is a Novel p53 Target Gene*

C. van Hoof, I. de Baere, V. Janssens, 2000, The Journal of Biological Chemistry.

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling.

V. Janssens, J. Goris, 2001, The Biochemical journal.

Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

Otto Hudecz, Karl Mechtler, Anthony A. Hyman, 2010, Nature Cell Biology.

Targeted Therapies in Type II Endometrial Cancers: Too Little, but Not Too Late

V. Janssens, Michiel Remmerie, 2018, International journal of molecular sciences.

The Saccharomyces cerevisiae homologue YPA1 of the mammalian phosphotyrosyl phosphatase activator of protein phosphatase 2A controls progression through the G1 phase of the yeast cell cycle.

J. D. de Winde, J. Winderickx, J. Thevelein, 2000, Journal of molecular biology.

SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma cells

V. Janssens, C. Erneux, R. Derua, 2016, Journal of Cell Science.

The broad phenotypic spectrum of PPP2R1A-related neurodevelopmental disorders correlates with the degree of biochemical dysfunction

W. Chung, K. Devriendt, Alison M. Male, 2020, Genetics in Medicine.

Identification and characterization of B"-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues.

C. van Hoof, V. Janssens, J. Goris, 2003, European journal of biochemistry.

Suppression of Scant Identifies Endos as a Substrate of Greatwall Kinase and a Negative Regulator of Protein Phosphatase 2A in Mitosis

V. Janssens, D. Glover, M. Dadlez, 2011, PLoS genetics.

Targeted disruption of the mouse Lipoma Preferred Partner gene.

W. V. D. Van de Ven, V. Janssens, Marleen M. R. Petit, 2009, Biochemical and biophysical research communications.

Mice lacking phosphatase PP2A subunit PR61/B’δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β

I. Landrieu, G. Lippens, V. Janssens, 2011, Proceedings of the National Academy of Sciences.

Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene.

C. van Hoof, I. de Baere, V. Janssens, 2000, European journal of biochemistry.

Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice.

J. Vermeesch, C. van Hoof, V. Janssens, 2004, Journal of molecular biology.

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

B. Turk, P. Storz, H. Döppler, 2017, Scientific Reports.

Increased LGR6 Expression Sustains Long-Term Wnt Activation and Acquisition of Senescence in Epithelial Progenitors in Chronic Lung Diseases

T. Roskams, W. Janssens, S. Verleden, 2021, Cells.

PP2A binds to the LIM domains of lipoma-preferred partner through its PR130/B″ subunit to regulate cell adhesion and migration

C. Rossé, P. Parker, V. Janssens, 2016, Journal of Cell Science.

PP 2 A binds the LIM-domains of Lipoma Preferred Partner via its PR 130 / B ” subunit to regulate cell adhesion and migration

C. Rossé, P. Parker, V. Janssens, 2016 .

The Saccharomyces cerevisiae phosphotyrosyl phosphatase activator proteins are required for a subset of the functions disrupted by protein phosphatase 2A mutations.

J. D. de Winde, J. Winderickx, J. Thevelein, 2001, Experimental cell research.

Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo

P. Pauwels, V. Janssens, A. Sablina, 2018, Oncogene.

Specific regulation of protein phosphatase 2A PR72/B'' subunits by calpain.

V. Janssens, J. Goris, R. Derua, 2009, Biochemical and biophysical research communications.

The role of serine/threonine phosphatases in human development: Evidence from congenital disorders

V. Janssens, Iris Verbinnen, Pieter Vaneynde, 2022, Frontiers in Cell and Developmental Biology.

PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development.

P. Carmeliet, J. Westermarck, V. Janssens, 2017, Cancer research.

Clinical, neuroimaging and molecular characteristics of PPP2R5D-related neurodevelopmental disorders: an expanded series with functional characterisation and genotype–phenotype analysis

V. Janssens, G. Mirzaa, R. Derua, 2022, Journal of Medical Genetics.

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.

Luca Mazzarella, Wolfram Weckwerth, Giuseppe Curigliano, 2019, Cancer cell.

Proceedings of the Frontiers of Retrovirology Conference 2016

R. König, D. Elleder, R. Sachidanandam, 2016, Retrovirology.

Protein phosphatase 2A regulates deoxycytidine kinase activity via Ser‐74 dephosphorylation

V. Janssens, C. Smal, F. Bontemps, 2014, FEBS letters.

Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis

D. Vertommen, Maud Martin, F. Dequiedt, 2008, Proceedings of the National Academy of Sciences.

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).

V. Janssens, J. Goris, Sari Longin, 2008, Trends in biochemical sciences.

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

C. Sotiriou, C. Decaestecker, I. Salmon, 2020, Nature.

Spatial control of protein phosphatase 2A (de)methylation.

Karen Zwaenepoel, Veerle Janssens, V. Janssens, 2008, Experimental cell research.

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit

R. König, V. Janssens, R. Derua, 2018, Nature Communications.

Clinical and molecular characteristics of a novel rare de novo variant in PPP2CA in a patient with a developmental disorder, autism, and epilepsy

Katherine A. King, C. Ulens, V. Janssens, 2022, Frontiers in Cell and Developmental Biology.

Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease.

V. Janssens, G. Houge, R. Derua, 2021, Biochemical Society transactions.

PP2A: A Promising Biomarker and Therapeutic Target in Endometrial Cancer

V. Janssens, Michiel Remmerie, 2019, Front. Oncol..

M. Hurles, L. Vissers, A. Hoischen, 2015, The Journal of clinical investigation.

The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity

V. Janssens, E. Ivanova, C. Lambrecht, 2013, The FEBS journal.

Structure, regulation, and pharmacological modulation of PP2A phosphatases.

V. Janssens, E. Ivanova, C. Lambrecht, 2013, Methods in molecular biology.

Selection of Protein Phosphatase 2A Regulatory Subunits Is Mediated by the C Terminus of the Catalytic Subunit*

V. Janssens, J. Goris, S. Dilworth, 2007, Journal of Biological Chemistry.

The B″/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A

Angus C Nairn, Paul Greengard, Veerle Janssens, 2007, Proceedings of the National Academy of Sciences.

PP2A: the expected tumor suppressor.

C. van Hoof, V. Janssens, J. Goris, 2005, Current opinion in genetics & development.

Identification and Functional Analysis of Two Ca2+-binding EF-hand Motifs in the B"/PR72 Subunit of Protein Phosphatase 2A*

Etienne Waelkens, Yves Engelborghs, Veerle Janssens, 2003, The Journal of Biological Chemistry.

Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification.

V. Janssens, B. Meeusen, 2017, The international journal of biochemistry & cell biology.

The Basic Biology of PP2A in Hematologic Cells and Malignancies

K. Lemaire, V. Janssens, Y. Hoorne, 2014, Front. Oncol..

Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras

J. Thevelein, P. Tompa, C. B. González-Blas, 2017, Nature Communications.

Reversible Ser/Thr SHIP phosphorylation: A new paradigm in phosphoinositide signalling?

V. Janssens, C. Erneux, E. Waelkens, 2012, BioEssays : news and reviews in molecular, cellular and developmental biology.

An okadaic acid fragment analogue prevents nicotine-induced resistance to cisplatin by recovering PP2A activity in non-small cell lung cancer cells.

V. Janssens, C. Montiel, C. de los Ríos, 2020, Bioorganic chemistry.

Differential Proteomic Analysis of Hepatocellular Carcinomas from Ppp2r5d Knockout Mice and Normal (Knockout) Livers

C. Mathieu, V. Janssens, L. Libbrecht, 2020, Cancer Genomics & Proteomics.

Protein kinase D displays intrinsic Tyr autophosphorylation activity: insights into mechanism and regulation

P. Parker, V. Janssens, Mathias Cobbaut, 2018, FEBS letters.

Inhibition of the Wnt Signaling Pathway by the PR61 Subunit of Protein Phosphatase 2A*

H. Usui, A. Fukui, T. Michiue, 2001, The Journal of Biological Chemistry.

Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

A. Leitner, J. Nilsson, J. Westermarck, 2023, Nature Communications.

Molecular Implication of PP2A and Pin1 in the Alzheimer's Disease Specific Hyperphosphorylation of Tau

I. Landrieu, J. Wieruszeski, G. Lippens, 2011, PloS one.

De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders.

Ellen F. Macnamara, L. Vissers, B. D. de Vries, 2019, American journal of human genetics.

Physiologic functions of PP2A: Lessons from genetically modified mice.

V. Janssens, S. Reynhout, 2019, Biochimica et biophysica acta. Molecular cell research.

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

C. Sotiriou, C. Decaestecker, I. Salmon, 2020, Nature.

PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7

P. Carmeliet, N. Simonis, Maud Martin, 2013, The EMBO journal.

PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.

D. Burgess, V. Janssens, J. Goris, 2010, Molecular cell.

Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth.

F. Amant, V. Janssens, A. Sablina, 2016, Cancer research.

Zinc deficiency leads to reduced interleukin-2 production by active gene silencing due to enhanced CREMα expression in T cells.

V. Janssens, L. Rink, W. Wagner, 2020, Clinical nutrition.

Cellular inhibitors of Protein Phosphatase PP2A in cancer.

V. Janssens, E. Ivanova, C. Lambrecht, 2012 .

Protein phosphatase 2A PR130/B”α:1 subunit binds to the SH2 domain‐containing inositol polyphosphate 5‐phosphatase 2 and prevents epidermal growth factor (EGF)‐induced EGF receptor degradation sustaining EGF‐mediated signaling

P. Parker, V. Janssens, J. Goris, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A

V. Janssens, J. Goris, J. Louis, 2008, BMC Genomics.

PP1 and PP2A phosphatases – cooperating partners in modulating retinoblastoma protein activation

V. Janssens, V. Kolupaeva, 2013, The FEBS journal.

An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator.

C. van Hoof, I. de Baere, V. Janssens, 2004, The Biochemical journal.

Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2.

C. van Hoof, V. Janssens, J. Goris, 2005, The Biochemical journal.

Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy

R. Dolmetsch, Y. Mori, V. Janssens, 2012, The EMBO journal.

Evidence of SHIP2 Ser132 phosphorylation, its nuclear localization and stability.

Takeshi Nakamura, V. Janssens, C. Erneux, 2011, The Biochemical journal.

Kinases/Phosphatases | Serine/Threonine Protein Phosphatases

V. Janssens, 2020 .

Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast

Johan M Thevelein, Veerle Janssens, J. Thevelein, 2012, Cell Research.

Serine/Threonine-Protein Phosphatase 2A

V. Janssens, 2017 .

C-glycosides analogues of the okadaic acid central fragment exert neuroprotection via restoration of PP2A-phosphatase activity: A rational design of potential drugs for Alzheimer's disease targeting tauopathies.

E. M. García-Frutos, V. Janssens, A. Romero, 2023, European journal of medicinal chemistry.

PPP2R4 dysfunction promotes KRAS-mutant lung adenocarcinoma development and mediates opposite responses to MEK and mTOR inhibition.

V. Janssens, A. Sablina, J. Ventura, 2021, Cancer letters.

The Protein Phosphatase 2A Phosphatase Activator Is a Novel Peptidyl-Prolyl cis/trans-Isomerase*

Etienne Waelkens, Yves Engelborghs, Veerle Janssens, 2006, Journal of Biological Chemistry.

Molecular mechanisms and clinical relevance of protein phosphatase 2A deficiency in hepatocellular carcinoma

C. Mathieu, V. Janssens, L. Libbrecht, 2010 .

Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality

E. Van Cutsem, C. Verslype, V. Janssens, 2023, Journal of Translational Medicine.

Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras

J. Thevelein, P. Tompa, C. B. González-Blas, 2017, Nature Communications.

Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.

C Van Hoof, C. van Hoof, I. de Baere, 1999, Biochemistry.

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit

R. König, V. Janssens, Baek Kim, 2016, Nature Communications.

Identification of PP2A/Set Binding Sites and Design of Interacting Peptides with Potential Clinical Applications

J. Bravo, V. Janssens, A. Rebollo, 2018, International Journal of Peptide Research and Therapeutics.

Proceedings of the Frontiers of Retrovirology Conference 2016

Sebastian A. Wagner, R. König, D. Elleder, 2016, Retrovirology.

Interaction of the protein phosphatase 2A with the regulatory domain of the cystic fibrosis transmembrane conductance regulator channel

Lishuang Cao, V. Janssens, J. Goris, 2005, FEBS letters.

A Novel Mouse Model of Combined Hepatocellular-Cholangiocarcinoma Induced by Diethylnitrosamine and Loss of Ppp2r5d

T. Roskams, V. Janssens, F. Cubero, 2023, Cancers.

De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders.

Ellen F. Macnamara, L. Vissers, B. D. de Vries, 2019, American journal of human genetics.

TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer

V. Janssens, A. Sablina, R. Derua, 2023, bioRxiv.

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).

V. Janssens, J. Goris, Sari Longin, 2008, Trends in biochemical sciences.

Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

A. Hyman, J. Peters, D. Gerlich, 2010, Nature Cell Biology.