A. Takahashi

发表

Expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines after spaceflight in a frozen state

A. Takahashi, Hiromi Suzuki, Katsunori Omori, 2011 .

The First Life Science Experiments in ISS: Reports of "Rad Gene"-Space Radiation Effects on Human Cultured Cells-

A. Takahashi, Hiromi Suzuki, Katsunori Omori, 2010 .

Correlation between γ-ray-induced G2 arrest and radioresistance in two human cancer cells

H. Ohishi, H. Uchida, A. Takahashi, 1999 .

Accumulation of a tumor suppressor p53 protein in rat muscle during a space flight.

Y. Ohira, A. Takahashi, T. Ohnishi, 1999, Mutation research.

Contribution of protein kinase C to p53-dependent WAF1 induction pathway after heat treatment in human glioblastoma cell lines.

A. Takahashi, T. Ohnishi, K. Ohnishi, 1998, Experimental cell research.

p53-dependent Induction of WAF1 by Heat Treatment in Human Glioblastoma Cells*

A. Takahashi, T. Ohnishi, H. Matsumoto, 1996, The Journal of Biological Chemistry.

Accumulation of mutant p53 and hsp72 by heat treatment, and their association in a human glioblastoma cell line.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1995, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

p53‐independent WAF1 induction by ACNU in human glioblastoma cells

Mitsutoshi Nakamura, A. Takahashi, T. Ohnishi, 1996, Molecular carcinogenesis.

Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation

Premkumar B. Saganti, H. Souda, A. Takahashi, 2018, International journal of molecular sciences.

Molecular mechanisms involved in adaptive responses to radiation, UV light, and heat.

A. Takahashi, T. Ohnishi, 2009, Journal of radiation research.

UV-B light induces an adaptive response to UV-C exposure via photoreactivation activity in Euglena gracilis

A. Takahashi, N. Ishioka, T. Ohnishi, 2006, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[Space radiation biology].

A. Takahashi, T. Ohnishi, 2001, Uchu Seibutsu Kagaku.

Glycerol as a chemical chaperone enhances radiation-induced apoptosis in anaplastic thyroid carcinoma cells

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, Molecular Cancer.

Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, BMC biotechnology.

Glycerol restores p53-dependent radiosensitivity of human head and neck cancer cells bearing mutant p53

A. Takahashi, T. Ohnishi, K. Ohnishi, 2000, British Journal of Cancer.

Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone.

A. Takahashi, T. Ohnishi, K. Ohnishi, 1999, Radiation research.

Space Radiation Biology for “Living in Space”

A. Miyawaki, Asako Sakaue-Sawano, Michiyo Suzuki, 2020, BioMed research international.

High LET heavy ion radiation induces p53-independent apoptosis.

A. Takahashi, T. Ohnishi, T. Kirita, 2009, Journal of radiation research.

DNA damage recognition proteins localize along heavy ion induced tracks in the cell nucleus.

A. Takahashi, Katsunori Omori, N. Ishioka, 2008, Journal of radiation research.

Detection of DNA damages and repair in human culture cells with simulated space radiation.

A. Takahashi, T. Ohnishi, K. Ohnishi, 1999, Acta astronautica.

Accumulation of tumor suppressor p53 in rat muscle after a space flight.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2000, Advances in space research : the official journal of the Committee on Space Research.

How does spaceflight affect the acquired immune system?

T. Akiyama, A. Takahashi, Manami Hiraiwa, 2020, npj Microgravity.

Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice

Y. Ohira, A. Takahashi, Y. Yoshida, 2018, International journal of molecular sciences.

A New System for Three-dimensional Clinostat Synchronized X-irradiation with a High-speed Shutter for Space Radiation Research

H. Souda, A. Takahashi, H. Ikeda, 2016 .

Heat‑induced Signal Transduction Pathways Leading to Cell Death and Cell Survival in Cancer Cells

A. Takahashi, T. Ohnishi, A. Kajihara, 2009 .

siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells

A. Takahashi, T. Ohnishi, K. Ohnishi, 2011, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

siRNA Targeting NBS1 or XIAP Increases Radiation Sensitivity of Human Cancer Cells Independent of TP53 Status

R. Schiestl, A. Takahashi, T. Ohnishi, 2006, Radiation research.

Heat‐induced phosphorylation of NBS1 in human skin fibroblast cells

R. Schiestl, A. Takahashi, T. Ohnishi, 2006, Journal of cellular biochemistry.

Vanguards of paradigm shift in radiation biology: radiation-induced adaptive and bystander responses.

A. Takahashi, T. Ohnishi, H. Matsumoto, 2007, Journal of radiation research.

Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small-cell lung cancer cell line H460

Yoshiyuki Suzuki, K. Murata, Takeo Takahashi, 2015, Journal of radiation research.

Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation.

A. Takahashi, T. Ohnishi, T. Kirita, 2012, Biochemical and biophysical research communications.

Detection of space radiation-induced double strand breaks as a track in cell nucleus.

A. Takahashi, Hiromi Suzuki, Katsunori Omori, 2009, Biochemical and biophysical research communications.

High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase‐9 activation

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, Cancer Science.

Heat-induced growth inhibition and apoptosis in transplanted human head and neck squamous cell carcinomas with different status of p53

H. Ohishi, A. Takahashi, T. Ohnishi, 2003, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

High-LET radiation enhanced apoptosis but not necrosis regardless of p53 status.

A. Takahashi, T. Ohnishi, H. Matsumoto, 2004, International journal of radiation oncology, biology, physics.

Radiation-induced adaptive responses and bystander effects.

A. Takahashi, T. Ohnishi, H. Matsumoto, 2004, Uchu Seibutsu Kagaku.

WAF1 accumulation by carbon-ion beam and alpha-particle irradiation in human glioblastoma cultured cells.

A. Takahashi, T. Ohnishi, H. Matsumoto, 2000, International journal of radiation biology.

ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating.

David J. Chen, A. Takahashi, T. Ohnishi, 2010, Journal of radiation research.

Protein microarray analysis of apoptosis-related protein expression following heat shock in human tongue squamous cell carcinomas containing different p53 phenotypes

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Induction of radiation resistance by a heat shock protein inhibitor, KNK437, in human glioblastoma cells

A. Takahashi, T. Ohnishi, K. Ohnishi, 2006, International journal of radiation biology.

Bifunctional effects of a protein kinase inhibitor (H-7) on heat-induced p53-dependent WAF1 accumulation.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1996, Experimental cell research.

The expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight

A. Takahashi, Hiromi Suzuki, Katsunori Omori, 2010, International journal of radiation biology.

The Role of p53 Molecule in Radiation and Hyperthermic Therapies

A. Takahashi, T. Ohnishi, K. Ohnishi, 2003 .

Impact of the p53 Status of the Tumor Cells on the Effect of Reactor Neutron Beam Irradiation, with Emphasis on the Response of Intratumor Quiescent Cells

A. Takahashi, T. Ohnishi, K. Ono, 2002, Japanese journal of cancer research : Gann.

Radiobiological characteristics of solid tumours depending on the p53 status of the tumour cells, with emphasis on the response of intratumour quiescent cells.

A. Takahashi, T. Ohnishi, K. Ono, 2002, European Journal of Cancer.

p53-dependent induction of WAF1 by a low-pH culture condition in human glioblastoma cells.

A. Takahashi, T. Ohnishi, T. Ohtsubo, 1997, Cancer research.

Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1997, International journal of radiation oncology, biology, physics.

Glycerol enhances radiosensitivity in a human oral squamous cell carcinoma cell line (Ca9-22) bearing a mutant p53 gene via Bax-mediated induction of apoptosis.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2005, Oral oncology.

Transfection of mutant p53 gene depresses X-ray- or CDDP-induced apoptosis in a human squamous cell carcinoma of the head and neck

A. Takahashi, T. Ohnishi, H. Matsumoto, 2002, Apoptosis.

Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2000, International journal of radiation oncology, biology, physics.

Effects of protein kinase inhibitors on heat-induced hsp72 gene expression in a human glioblastoma cell line.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1998, Cellular signalling.

Accumulation of stress protein 72 (HSP72) in muscle and spleen of goldfish taken into space.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1998, Advances in space research : the official journal of the Committee on Space Research.

8‐METHOXYPSORALEN PLUS UVA INDUCES THE 72 kDa HEAT SHOCK PROTEIN IN ORGAN‐CULTURED NORMAL HUMAN SKIN

A. Takahashi, T. Ohnishi, N. Kobayashi, 1993, Photochemistry and photobiology.

p53-dependent induction of WAF1 by cold shock in human glioblastoma cells

A. Takahashi, T. Ohnishi, K. Ohnishi, 1998, Oncogene.

The protein kinase inhibitor, H-7, suppresses heat-induced activation of heat shock transcription factor 1

A. Takahashi, T. Ohnishi, H. Matsumoto, 1999, Molecular and Cellular Biochemistry.

Ultrasound-induced DNA damage and signal transductions indicated by gammaH2AX

Y. Tabuchi, I. Takasaki, Qing‐Li Zhao, 2011 .

Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation

A. Takahashi, T. Ohnishi, K. Ohnishi, 1998, Oncogene.

Degradation of initiator tRNAMet by Xrn1/2 via its accumulation in the nucleus of heat-treated HeLa cells

A. Takahashi, K. Ijiri, R. Mizuno, 2013, Nucleic acids research.

A Priming Heat Treatment Can Induce the Development of Heat- and Radio-resistance via HSPs, Regardless of p53-gene Status

A. Takahashi, T. Ohnishi, 2009 .

Apoptosis induced by high-LET radiations is not affected by cellular p53 gene status

A. Takahashi, N. Ishioka, T. Ohnishi, 2005, International journal of radiation biology.

Synergistic Autophagy Effect of miR-212-3p in Zoledronic Acid-Treated In Vitro and Orthotopic In Vivo Models and in Patient-Derived Osteosarcoma Cells

Eun Ho Kim, A. Takahashi, Youn Kyoung Jeong, 2019, Cancers.

X-ray irradiation induces disruption of the blood–brain barrier with localized changes in claudin-5 and activation of microglia in the mouse brain

T. Nakano, A. Takahashi, Y. Yoshida, 2018, Neurochemistry International.

The effects of microgravity on induced mutation in Escherichia coli and Saccharomyces cerevisiae.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2001, Advances in space research : the official journal of the Committee on Space Research.

Depression of Bone Density at the Weight-Bearing Joints in Wistar Hannover Rats by a Simulated Mechanical Stress Associated With Partial Gravity Environment

Y. Ohira, A. Takahashi, Y. Yoshida, 2021, Frontiers in Cell and Developmental Biology.

BRCA2 protects mammalian cells from heat shock

A. Takahashi, T. Ohnishi, M. Hasegawa, 2018, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Inhibition of DNA Repair System Activity

A. Takahashi, 2016 .

p53 Targeting can enhance cancer therapy via radiation, heat and anti-cancer agents.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, Anti-cancer agents in medicinal chemistry.

Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA targeting XIAP.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, Oncology reports.

DNA‐Damaging Agents Induce the 72‐kD Heat Shock Protein in SV40 Transformed Normal Human Fibroblasts

A. Takahashi, T. Ohnishi, T. Muramatsu, 1996, The Journal of dermatology.

Adaptation and Changes in Actin Dynamics and Cell Motility as Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector

Z. Ju, A. Takahashi, M. Hada, 2022, International journal of molecular sciences.

Sensitization by glycerol for CDDP-therapy against human cultured cancer cells and tumors bearing mutated p53 gene

A. Takahashi, T. Ohnishi, K. Ohnishi, 2004, Apoptosis.

Effects of mild temperature hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, with reference to the effect in intratumor quiescent cell populations.

A. Takahashi, T. Ohnishi, K. Ono, 2004, International journal of radiation oncology, biology, physics.

Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors: its independence of p53 status

A. Takahashi, T. Ohnishi, K. Ono, 2003, Cancer science.

Radiation-induced apoptosis in SCID mouse spleen after low dose or low dose-rate irradiation

A. Takahashi, T. Ohnishi, K. Ohnishi, 2004 .

Radiation-induced apoptosis in scid mice spleen after low dose irradiation.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2003, Advances in Space Research.

Pre-irradiation at a low dose-rate blunted p53 response.

A. Takahashi, 2002, Journal of radiation research.

Radiation-induced apoptosis in the scid mouse spleen after low dose-rate irradiation

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, International journal of radiation biology.

Different inducibility of radiation- or heat-induced p53 -dependent apoptosis after acute or chronic irradiation in human cultured squamous cell carcinoma cells

A. Takahashi, 2001, International journal of radiation biology.

The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells.

A. Takahashi, T. Ohnishi, T. Kirita, 2014, Oncology reports.

The BRCA 2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells

A. Takahashi, T. Ohnishi, T. Kirita, 2014 .

Effects of p53 status and wortmannin treatment on potentially lethal damage repair, with emphasis on the response of intratumor quiescent cells.

A. Takahashi, T. Ohnishi, K. Ono, 2003, Radiation medicine.

Anti-Metastatic Benefits Produced by Hyperthermia and a CCL3 Derivative

A. Takahashi, Liqiu Ma, S. Kanegasaki, 2019, Cancers.

A low dose pre-irradiation induces radio- and heat-resistance via HDM2 and NO radicals, and is associated with p53 functioning

A. Takahashi, T. Ohnishi, 2009 .

Nitric oxide radicals choreograph a radioadaptive response.

A. Takahashi, T. Ohnishi, H. Matsumoto, 2007, Cancer research.

Radiation response of apoptosis in C57BL/6N mouse spleen after whole-body irradiation

A. Takahashi, T. Ohnishi, H. Matsumoto, 2001, International journal of radiation biology.

Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1997, International journal of radiation oncology, biology, physics.

Role of High-Linear Energy Transfer Radiobiology in Space Radiation Exposure Risks.

A. Takahashi, H. Ikeda, Y. Yoshida, 2018, International journal of particle therapy.

Expression of p53-regulated proteins in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight.

A. Takahashi, Hiromi Suzuki, Katsunori Omori, 2012, Journal of radiation research.

Heat Induces Histone γH2AX Formation under Hypoxia

A. Takahashi, Y. Yoshida, Liqiu Ma, 2018, Thermal Medicine.

Detection of DNA damage induced by space radiation in Mir and space shuttle.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, Journal of radiation research.

Biphasic effects of nitric oxide radicals on radiation-induced lethality and chromosome aberrations in human lung cancer cells carrying different p53 gene status.

A. Takahashi, T. Ohnishi, Xiaomin Su, 2010, International journal of radiation oncology, biology, physics.

DNA ligase IV is a potential molecular target in ACNU sensitivity

H. Nakase, A. Takahashi, T. Ohnishi, 2010, Cancer science.

Effects of p53 Status of Tumor Cells and Combined Treatment With Mild Hyperthermia, Wortmannin or Caffeine on Recovery From Radiation-Induced Damage

A. Takahashi, K. Ono, Minoru Suzuki, 2019, World journal of oncology.

Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population.

A. Takahashi, T. Ohnishi, K. Ono, 2007, Oncology reports.

Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status

A. Takahashi, T. Ohnishi, K. Ohnishi, 2004, International journal of radiation biology.

Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 gene.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2003, Journal of radiation research.

p53 -Dependent thermal enhancement of cellular sensitivity in human squamous cell carcinomas in relation to LET

A. Takahashi, T. Ohnishi, H. Matsumoto, 2001, International journal of radiation biology.

Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage.

T. Helleday, L. Thompson, A. Takahashi, 2011, Biochemical and biophysical research communications.

Correction: FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ

T. Helleday, L. Thompson, A. Takahashi, 2011, PLoS ONE.

FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ

T. Helleday, L. Thompson, A. Takahashi, 2011, PloS one.

Heat induces gammaH2AX foci formation in mammalian cells.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, Mutation research.

What is the Critical Hyperthermia Target in Cancer Cells

A. Takahashi, T. Ohnishi, 2006 .

Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure

Y. Tabuchi, A. Takahashi, A. Nagamatsu, 2022, Journal of pineal research.

Light-Induced Anthocyanin Reduces the Extent of Damage to DNA in UV-Irradiated Centaurea cyanus Cells in Culture

A. Takahashi, T. Ohnishi, K. Takeda, 1991 .

Usefulness of hexamethylenetetramine as an adjuvant to radiation and cisplatin in the treatment of solid tumors: its independency of p53 status.

A. Takahashi, T. Ohnishi, K. Ono, 2010, Journal of radiation research.

Analysis of deletion mutations of the rpsL gene in the yeast Saccharomyces cerevisiae detected after long-term flight on the Russian space station Mir.

A. Takahashi, T. Ohnishi, T Ohnishi, 2000, Mutation research.

Effects of Charged Particles on Human Tumor Cells

A. Takahashi, H. Willers, Y. Yoshida, 2016, Front. Oncol..

p 53-dependent Induction of WAF 1 by Heat Treatment in Human Glioblastoma Cells

A. Takahashi, T. Ohnishi, H. Matsumoto, 1996 .

DNA Damage Induced by Alkylating Agents and Repair Pathways

A. Takahashi, T. Ohnishi, K. Ono, 2010, Journal of nucleic acids.

DNA ligase IV as a new molecular target for temozolomide.

H. Nakase, A. Takahashi, T. Ohnishi, 2009, Biochemical and biophysical research communications.

Melatonin is a potential drug for the prevention of bone loss during space flight

K. Kitamura, Y. Tabuchi, I. Takasaki, 2019, Journal of pineal research.

The combination of olaparib and camptothecin for effective radiosensitization

Masato Hareyama, Hideki Matsumoto, Y. Matsumoto, 2012, Radiation oncology.

DNA double-strand breaks: their production, recognition, and repair in eukaryotes.

A. Takahashi, T. Ohnishi, Eiichiro Mori, 2009, Mutation research.

Does γH2AX foci formation depend on the presence of DNA double strand breaks

Takeo Ohnishi, A. Takahashi, T. Ohnishi, 2005 .

Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells

Christopher E. Mason, A. Beheshti, J. McDonald, 2021, International journal of molecular sciences.

Simultaneous Exposure of Cultured Human Lymphoblastic Cells to Simulated Microgravity and Radiation Increases Chromosome Aberrations

Premkumar B. Saganti, A. Takahashi, J. Mao, 2020, Life.

Preliminary results of space experiment: Implications for the effects of space radiation and microgravity on survival and mutation induction in human cells

A. Takahashi, Hiromi Suzuki, Katsunori Omori, 2012 .

Frozen human cells can record radiation damage accumulated during space flight: mutation induction and radioadaptation

Kaoru Sugasawa, Tomoko Abe, Masamitsu Honma, 2011, Radiation and environmental biophysics.

Expression of p53-Regulated Genes in Cultured Mammalian Cells After Exposure to A Space Environment

Toru Shimazu, Takeo Ohnishi, Noriaki Ishioka, 2009 .

Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells

T. Nakano, A. Takahashi, T. Ohno, 2017, Journal of radiation research.

RADIOSENSITIVITY AND CANCER-RELATED GENES

A. Takahashi, T. Ohnishi, 1997 .

Low-dose-rate radiation attenuates the response of the tumor suppressor TP53.

A. Takahashi, T. Ohnishi, K. Ohnishi, 1999, Radiation research.

Therapeutic strategies for head and neck cancer based on p53 status.

A. Takahashi, T. Ohnishi, I. Ota, 2012, Experimental and therapeutic medicine.

Therapeutic strategies for head and neck cancer based on p 53 status ( Review )

A. Takahashi, T. Ohnishi, I. Ota, 2012 .

Hdm2 and nitric oxide radicals contribute to the p53-dependent radioadaptive response.

A. Takahashi, T. Ohnishi, H. Matsumoto, 2008, International journal of radiation oncology, biology, physics.

Computational Image Processing and Analysis of Heat-induced γ H2AX Foci

A. Takahashi, T. Ohnishi, Eiichiro Mori, 2009 .

Computational Image Processing and Analysis of Heat-induced .GAMMA.H2AX Foci

A. Takahashi, T. Ohnishi, Eiichiro Mori, 2009 .

The Biology of Heat‑induced DNA Double‑Strand Breaks

A. Takahashi, T. Ohnishi, Eiichiro Mori, 2008 .

p53 accumulation in the organs of low-dose X-ray-irradiated mice.

K. Okaichi, A. Takahashi, T. Ohnishi, 1996, Cancer letters.

Recent advances in the biology of heavy-ion cancer therapy.

Takamitsu A Kato, R. Okayasu, T. Teshima, 2010, Journal of radiation research.

Increased resistance of the radiosensitive M10 mutant cells of the L5178Y mouse lymphoma cell line to heat-induced apoptosis.

A. Takahashi, T. Ohnishi, V. Ostapenko, 1999, Radiation research.

Hibernation as a Tool for Radiation Protection in Space Exploration

A. Takahashi, Y. Yoshida, M. Cerri, 2021, Life.

Molecular mechanisms underlying the enhancement of carbon ion beam radiosensitivity of osteosarcoma cells by miR-29b.

Eun Ho Kim, A. Takahashi, T. Ohno, 2020, American journal of cancer research.

DNA Double-Strand Breaks Induced by Cavitational Mechanical Effects of Ultrasound in Cancer Cell Lines

Paul Campbell, Yukihiro Furusawa, Ichiro Takasaki, 2012, PloS one.

Effects of accelerated carbon-ions on growth inhibition of transplantable human esophageal cancer in nude mice.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1998, Cancer letters.

Studies about space radiation promote new fields in radiation biology.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, Journal of radiation research.

Radiation Biology in Space; DNA Damage and Biological Effects of Space Radiation

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002 .

DNA damage formation and p53 accumulation in mammalian cells exposed to the space environment.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1999, Uchu Seibutsu Kagaku.

Targeting of Carbon Ion-Induced G2 Checkpoint Activation in Lung Cancer Cells Using Wee-1 Inhibitor MK-1775

T. Nakano, A. Takahashi, T. Ohno, 2015, Radiation research.

The foci of DNA double strand break-recognition proteins localize with gammaH2AX after heat treatment.

A. Takahashi, T. Ohnishi, Eiichiro Mori, 2010, Journal of radiation research.

Phospho-Nbs 1 and Mre 11 proteins which recognize DSBs co-localize with γ H 2 AX in the nucleus after heat treatment

A. Takahashi, T. Ohnishi, Eiichiro Mori, 2007 .

Phospho-Nbs1 and Mre11 proteins which recognize DSBs co-localize with γH2AX in the nucleus after heat treatment

A. Takahashi, T. Ohnishi, Eiichiro Mori, 2007 .

Evidence for the Involvement of Double-Strand Breaks in Heat-Induced Cell Killing

Ken Ohnishi, Takeo Ohnishi, Hidenori Tanaka, 2004, Cancer Research.

The dependence of p53 on the radiation enhancement of thermosensitivity at different let.

A. Takahashi, T. Ohnishi, H. Matsumoto, 2000, International journal of radiation oncology, biology, physics.

Synthetic torpor protects rats from exposure to accelerated heavy ions

M. Durante, A. Takahashi, Y. Yoshida, 2022, Scientific Reports.

Time course and spacial distribution of UV effects on human skin in organ culture.

Masakatsu Watanabe, A. Takahashi, T. Ohnishi, 2008, Journal of radiation research.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2004, Cancer letters.

C-terminal peptides of p53 molecules enhance radiation-induced apoptosis in human mutant p53 cancer cells

A. Takahashi, T. Ohnishi, K. Ohnishi, 2004, Apoptosis.

Photoreactivation in Paramecium tetraurelia under Conditions of Various Degrees of Ozone Layer Depletion¶

A. Takahashi, T. Ohnishi, T. Seki, 2005 .

Photoreactivation in Paramecium tetraurelia under Conditions of Various Degrees of Ozone Layer Depletion ¶

A. Takahashi, T. Ohnishi, T. Seki, 2005, Photochemistry and photobiology.

The significance of the study about the biological effects of solar ultraviolet radiation using the Exposed Facility on the International Space Station.

A. Takahashi, T. Ohnishi, 2004, Uchu Seibutsu Kagaku.

Nitric oxide radical-induced radioadaptation and radiosensitization are G2/M phase-dependent.

A. Takahashi, T. Ohnishi, Xiaomin Su, 2011, Journal of radiation research.

Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells

A. Shibata, T. Nakano, A. Takahashi, 2015, Journal of radiation research.

Induction of cdk2 after gamma-ray irradiation is dependent on p53 status.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1997, International journal of oncology.

p53-dependent adaptive responses in human cells exposed to space radiations.

Toru Shimazu, Takeo Ohnishi, Noriaki Ishioka, 2010, International journal of radiation oncology, biology, physics.

X-irradiation of developing hippocampal neurons causes changes in neuron population phenotypes, dendritic morphology and synaptic protein expression in surviving neurons at maturity

T. Shirao, T. Nakano, A. Takahashi, 2019, Neuroscience Research.

Development of thermotolerance requires interaction between polymerase‐β and heat shock proteins

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, Cancer science.

Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways

A. Takahashi, M. Hasegawa, G. Kashino, 2020, The Journal of Biological Chemistry.

ATR inhibition enhances 5-fluorouracil sensitivity independent of non-homologous end-joining and homologous recombination repair pathway

A. Takahashi, M. Hasegawa, G. Kashino, 2020, bioRxiv.

Restoration by glycerol of p53-dependent apoptosis in cells bearing the mutant p53 gene.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1999, International journal of radiation biology.

p53- dependent hyperthermic enhancement of tumour growth inhibition by X-ray or carbon-ion beam irradiation

A. Takahashi, T. Ohnishi, H. Matsumoto, 2003, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Hyperthermic enhancement of tumour growth inhibition by accelerated carbon-ions in transplantable human esophageal cancer.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1998, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic acid Effectively Kills Osteosarcoma Cells

Eun Ho Kim, A. Takahashi, T. Ohno, 2020, Cancers.

LOH Analyses for Biological Effects of Space Radiation: Human Cell Culture in "Kibo" of International Space Station

A. Takahashi, Hiromi Suzuki, Katsunori Omori, 2009 .

Combined Environment Simulator for Low-Dose-Rate Radiation and Partial Gravity of Moon and Mars

Tohru Takahashi, A. Takahashi, A. Nagamatsu, 2020, Life.

Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2010, International journal of oncology.

Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells

T. Nakano, A. Takahashi, T. Ohno, 2015, Radiation oncology.

LY 294002 , an inhibitor of PI-3 K , enhances heat sensitivity independently of p 53 status in human lung cancer cells

A. Takahashi, T. Ohnishi, K. Ohnishi, 2022 .

Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells.

A. Takahashi, T. Ohnishi, K. Ono, 2005, Oncology reports.

How does spaceflight affect the acquired immune system?

T. Akiyama, A. Takahashi, Manami Hiraiwa, 2020, npj Microgravity.

Carbon-Ion Beams Efficiently Induce Cell Killing in X-Ray Resistant Human Squamous Tongue Cancer Cells

T. Nakano, A. Takahashi, T. Ohno, 2014 .

Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells

A. Takahashi, T. Ohnishi, M. Hasegawa, 2017, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Does gammaH2AX foci formation depend on the presence of DNA double strand breaks?

Takeo Ohnishi, A. Takahashi, T. Ohnishi, 2005, Cancer letters.

Differentiation of Dictyostelium discoideum vegetative cells into spores during Earth orbit in space.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2001, Advances in space research : the official journal of the Committee on Space Research.

Expression Profile of Cell Cycle-Related Genes in Human Fibroblasts Exposed Simultaneously to Radiation and Simulated Microgravity

M. Muratani, H. Souda, A. Takahashi, 2019, International journal of molecular sciences.

Development and performance evaluation of a three-dimensional clinostat synchronized heavy-ion irradiation system.

H. Souda, A. Takahashi, H. Ikeda, 2017, Life sciences in space research.

Mutation frequency of Dictyostelium discoideum spores exposed to the space environment.

A. Takahashi, T. Ohnishi, K. Ohnishi, 1997, Uchu Seibutsu Kagaku.

Alkylating agent (MNU)-induced mutation in space environment.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2001, Advances in space research : the official journal of the Committee on Space Research.

The effects of microgravity on ligase activity in the repair of DNA double-strand breaks.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2000, International journal of radiation biology.

Mutation frequency of plasmid DNA and Escherichia coli following long-term space flight on Mir.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, Journal of radiation research.

64Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity

A. Shibata, A. Takahashi, T. Ohno, 2021, Cancers.

Nonhomologous End-Joining Repair Plays a More Important Role than Homologous Recombination Repair in Defining Radiosensitivity after Exposure to High-LET Radiation

T. Nakano, A. Takahashi, T. Ohno, 2014, Radiation research.

Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells

Yoshiyuki Suzuki, K. Murata, Takeo Takahashi, 2014, Journal of radiation research.

Suppression of X-ray-induced apoptosis by low dose pre-irradiation in the spleen of C57BL/6 mice

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002 .

Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status.

H. Ohishi, A. Takahashi, T. Ohnishi, 2002, Anticancer research.

CDDP induces p53-dependent apoptosis in tongue cancer cells.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2000, International journal of oncology.

Characterization of a Novel Murine Colon Carcinoma Subline with High-Metastatic Activity Established by In Vivo Selection Method

A. Takahashi, T. Shimokawa, K. Kakimi, 2020, International journal of molecular sciences.

Cell growth and morphology of Dictyostelium discoideum in space environment.

K. Okaichi, A. Takahashi, T. Ohnishi, 1997, Uchu Seibutsu Kagaku.

Molecular Damage: Hyperthermia Alone

A. Takahashi, 2016 .

rpsL mutation induction after space flight on MIR.

A. Takahashi, T. Ohnishi, S. Nagaoka, 2000, Mutation research.

Brief communication: heat-induced accumulation of p53 and hsp72 is suppressed in lung fibroblasts from the SCID mouse.

A. Takahashi, T. Ohnishi, H. Matsumoto, 2000, International journal of radiation biology.

Restraint Plus Water‑immersion Stress (RWIS‑induced Stomach Ulcers in Mice are Depressed by a Conditioning Heat Treatment

A. Takahashi, T. Ohnishi, Xiaomin Su, 2009 .

Correlation between gamma-ray-induced G2 arrest and radioresistance in two human cancer cells.

H. Ohishi, H. Uchida, A. Takahashi, 1999, International Journal of Radiation Oncology, Biology, Physics.

Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells

T. Nakano, A. Takahashi, T. Ohno, 2015, Radiation Oncology.

Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation

Premkumar B. Saganti, H. Souda, A. Takahashi, 2018, International journal of molecular sciences.

Comparative study of otolith organs between two species of upside-down swimming catfish Synodontis nigriventris showing converse swimming postures

A. Takahashi, T. Ohnishi, K. Ohnishi, 2005 .

High transmittance of X-rays in the utricular otolith of upside-down swimming catfish, Synodontis nigriventris.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, Uchu Seibutsu Kagaku.

High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase‐9 activation

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, Cancer Science.

Studies about space radiation promote new fields in radiation biology.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, Journal of radiation research.

Heat shock transcription factor, HSF, is activated by ultraviolet irradiation.

A. Takahashi, K. Ohnishi, X. Wang, 1996, Photochemistry and photobiology.