B. Gumbiner

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p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling

Nam-Gyun Kim, Sanghyuk Lee, Inhan Lee, 2011, Science Signaling.

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

B. Gumbiner, B M Gumbiner, 1996, Cell.

Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin

B. Gumbiner, F. Fagotto, U. Glück, 1998, Current Biology.

Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin

B. Gumbiner, A. Wong, 2003, The Journal of cell biology.

Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength

D. Kelsell, B. Gumbiner, I. Leigh, 2002, The Journal of cell biology.

A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin.

C W Turck, C. Turck, P. McCrea, 1991, Science.

Identification of targets of the Wnt pathway destruction complex in addition to β-catenin

Nam‐Gyun Kim, B. Gumbiner, Chong Xu, 2009, Proceedings of the National Academy of Sciences.

A single amino acid in E‐cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes

P. Cossart, B. Gumbiner, S. Dramsi, 1999, The EMBO journal.

Localized barriers in the plasma membrane: a common way to form domains

B. Gumbiner, D. Louvard, 1985 .

The distribution of E-cadherin during Xenopus laevis development.

J. Thiery, B. Gumbiner, G. Levi, 1991, Development.

Cadherin-6B stimulates an epithelial mesenchymal transition and the delamination of cells from the neural ectoderm via LIMK/cofilin mediated non-canonical BMP receptor signaling.

B. Gumbiner, Ki-Sook Park, 2012, Developmental biology.

N-cadherin mediates the migration of MCF-10A cells undergoing bone morphogenetic protein 4-mediated epithelial mesenchymal transition

B. Gumbiner, Ki-Sook Park, M. Dubon, 2015, Tumor Biology.

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

B. Gumbiner, T. Lowenkopf, D. Apatira, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The tight junction does not allow lipid molecules to diffuse from one epithelial cell to the next

B. Gumbiner, G. Meer, K. Simons, 1986, Nature.

Zygotic Wnt activity is required for Brachyury expression in the early Xenopus laevis embryo.

B. Gumbiner, A. Vonica, 2002, Developmental biology.

Catenins as mediators of the cytoplasmic functions of cadherins

P. McCrea, B. Gumbiner, 1993, Journal of Cell Science.

A cadherin-like protein in eggs and cleaving embryos of Xenopus laevis is expressed in oocytes in response to progesterone

P. McCrea, Y. S. Choi, B. Gumbiner, 1990, The Journal of cell biology.

beta-Catenin has Wnt-like activity and mimics the Nieuwkoop signaling center in Xenopus dorsal-ventral patterning.

B. Gumbiner, K. Guger, B. Gumbiner, 1995, Developmental biology.

Cadherins: a family of Ca2+-dependent adhesion molecules.

B. Gumbiner, 1988, Trends in biochemical sciences.

Selective disruption of E-cadherin function in early Xenopus embryos by a dominant negative mutant.

B. Gumbiner, E. Levine, C. Kintner, 1994, Development.

A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

B. Gumbiner, V. Wong, 1997, The Journal of cell biology.

Breaking through the tight junction barrier

B. Gumbiner, 1993, The Journal of cell biology.

E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions.

B. Gumbiner, M. Perrais, M. Perez-Moreno, 2007, Molecular biology of the cell.

Epithelial morphogenesis

B. Gumbiner, 1992, Cell.

Chloroquine diverts ACTH from a regulated to a constitutive secretory pathway in AtT-20 cells

R. Kelly, B. Gumbiner, H. Moore, 1983, Nature.

E-cadherin activating antibodies limit barrier dysfunction and inflammation in mouse inflammatory bowel disease

B. Gumbiner, Chirosree Bandyopadhyay, L. Schecterson, 2021, Tissue barriers.

Two distinct intracellular pathways transport secretory and membrane glycoproteins to the surface of pituitary tumor cells

R. Kelly, B. Gumbiner, 1982, Cell.

Adhesion signaling: how beta-catenin interacts with its partners.

B. Gumbiner, C. Gottardi, 2001, Current biology : CB.

Cadherin 6B induces BMP signaling and de-epithelialization during the epithelial mesenchymal transition of the neural crest

B. Gumbiner, Ki-Sook Park, 2010, Development.

Analysis of C-cadherin Regulation during Tissue Morphogenesis with an Activating Antibody

B. Gumbiner, W. Brieher, Y. Zhong, 1999, The Journal of cell biology.

Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model

B. Gumbiner, Y. Petrova, Stephanie Maiden, 2016, PloS one.

Secretory granules of an anterior pituitary cell line, AtT-20, contain only mature forms of corticotropin and beta-lipotropin.

R. Kelly, B. Gumbiner, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Mini-Review Regulation of Cadherin Adhesive Activity

B. Gumbiner, 2000 .

The Xenopus Nieuwkoop center and Spemann-Mangold organizer share molecular components and a requirement for maternal Wnt activity.

B. Gumbiner, A. Vonica, 2007, Developmental biology.

TCF is the nuclear effector of the beta-catenin signal that patterns the sea urchin animal-vegetal axis.

B. Gumbiner, J. M. Venuti, W. Weng, 2000, Developmental biology.

Role for ICAT in β-catenin-dependent nuclear signaling and cadherin functions

B. Gumbiner, C. Gottardi, 2004 .

Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps

B. Gumbiner, W. Brieher, 1994, The Journal of cell biology.

A mode of regulation of beta-catenin signaling activity in Xenopus embryos independent of its levels.

B. Gumbiner, K. Guger, Kathleen A. Guger, 2000, Developmental biology.

E-Cadherin Suppresses Cellular Transformation by Inhibiting (cid:2) -Catenin Signaling in an Adhesion-independent Manner

B. Gumbiner, C. Gottardi, E. Wong, 2001 .

Cell contact and Nf2/Merlin-dependent regulation of TEAD palmitoylation and activity

Nam‐Gyun Kim, B. Gumbiner, 2019, Proceedings of the National Academy of Sciences.

A Protocadherin-Cadherin-FLRT3 Complex Controls Cell Adhesion and Morphogenesis

B. Gumbiner, Xuejun Chen, M. Yoder, 2009, PloS one.

A subclass of proteins and sulfated macromolecules secreted by AtT-20 (mouse pituitary tumor) cells is sorted with adrenocorticotropin into dense secretory granules

R. Kelly, B. Gumbiner, H. Moore, 1983, The Journal of cell biology.

A Ca2+-triggered molecular switch in neurons

B. Gumbiner, 1986 .

C-Cadherin Ectodomain Structure and Implications for Cell Adhesion Mechanisms

T. Boggon, L. Shapiro, B. Gumbiner, 2002, Science.

Desmosomal Cadherin Binding Domains of Plakoglobin (*)

B. Gumbiner, P. Cowin, S. Puttagunta, 1996, The Journal of Biological Chemistry.

Carcinogenesis: A balance between β-catenin and APC

B. Gumbiner, Barry M. Gumbiner, 1997, Current Biology.

Cadherin-mediated cell sorting not determined by binding or adhesion specificity

Carien M. Niessen, B. Gumbiner, C. Niessen, 2002, The Journal of cell biology.

Multiple cadherin extracellular repeats mediate homophilic binding and adhesion

C. Kay, B. Gumbiner, E. Wong, 2001, The Journal of cell biology.

Proteins associated with with cytoplasmic surface of adhesion molecules

B. Gumbiner, Barry M. Gumbiner, 1993, Neuron.

The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn

Carien M. Niessen, Alpha S. Yap, B. Gumbiner, 1998, The Journal of cell biology.

The Hippo-YAP signaling pathway and contact inhibition of growth

Nam‐Gyun Kim, B. Gumbiner, 2014, Journal of Cell Science.

Penetration of Salmonella through a polarized Madin-Darby canine kidney epithelial cell monolayer

B. Finlay, S. Falkow, B. Gumbiner, 1988, The Journal of cell biology.

Embryonic axis induction by the armadillo repeat domain of beta- catenin: evidence for intracellular signaling

P. McCrea, B. Gumbiner, F. Fagotto, 1995, The Journal of cell biology.

Structure, biochemistry, and assembly of epithelial tight junctions.

B. Gumbiner, B Gumbiner, 1987, The American journal of physiology.

A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide

B. Gumbiner, K. Simons, 1986, The Journal of cell biology.

PI3K-AKT, JAK2-STAT3 pathways and cell–cell contact regulate maspin subcellular localization

B. Gumbiner, N. Cella, M. Pereira, 2021, Cell communication and signaling : CCS.

Molecular and functional analysis of cadherin-based adherens junctions.

B. Gumbiner, W. Brieher, A. Yap, 1997, Annual review of cell and developmental biology.

Cadherin Conformations Associated with Dimerization and Adhesion*

B. Gumbiner, Liang Xu, H. Tsuiji, 2007, Journal of Biological Chemistry.

Regulation of cadherin-mediated adhesion in morphogenesis

B. Gumbiner, Barry M. Gumbiner, 2005, Nature Reviews Molecular Cell Biology.

Binding of N-hydroxy acetylaminofluorene to eu- and heterochromatin fractions of rat liver in vivo.

B. Gumbiner, G. Austin, G. Moyer, 1977, Cancer letters.

E-cadherin in Contact Inhibition and Cancer

B. Gumbiner, Alisha M. Mendonsa, T. Na, 2018, Oncogene.

The Mouse Fused Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

Wei Hsu, Frank Costantini, Thomas J Vasicek, 1997, Cell.

Cell contact-dependent signaling.

B. Gumbiner, F. Fagotto, B M Gumbiner, 1996, Developmental biology.

The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties

E. Wieschaus, P. McCrea, M. Peifer, 1992, The Journal of cell biology.

Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin). Characterization and extractability of the protein complex from the cell cytostructure.

P. McCrea, B. Gumbiner, 1991, The Journal of biological chemistry.

The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex

B. Gumbiner, A. Grimaldi, B. Stevenson, 1988, The Journal of cell biology.

E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

B. Gumbiner, C. Gottardi, E. Wong, 2001, The Journal of cell biology.

Roles for E-cadherin cell surface regulation in cancer

B. Gumbiner, Y. Petrova, L. Schecterson, 2016, Molecular biology of the cell.

The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin

B. Gumbiner, I. Macara, Yi Qin, 2005, The Journal of cell biology.

Cadherin Engagement Regulates Rho family GTPases*

B. Gumbiner, K. Burridge, C. Niessen, 2001, The Journal of Biological Chemistry.

Signal transduction of beta-catenin.

B. Gumbiner, 1995, Current opinion in cell biology.

Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography

P. Myler, B. Gumbiner, B. Staker, 2022, bioRxiv.

Functional analysis of the structural basis of homophilic cadherin adhesion.

D. Leckband, B. Gumbiner, E. Wong, 2003, Biophysical journal.

Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function

B. Gumbiner, M. Pruschy, W. Brieher, 1997, Current Biology.

Lateral dimerization is required for the homophilic binding activity of C-cadherin

B. Gumbiner, W. Brieher, A. Yap, 1996, The Journal of cell biology.

Zipping together a cell adhesion interface

D. Patel, B. Gumbiner, 1995, Nature.

Translocation of beta-catenin into the nucleus independent of interactions with FG-rich nucleoporins.

B. Gumbiner, E. Suh, 2003, Experimental cell research.

Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus

B. Gumbiner, F. Fagotto, N. Funayama, 1996, The Journal of cell biology.

Regulation of Cadherin Adhesive Activity

B. Gumbiner, Barry M. Gumbiner, 2000, The Journal of cell biology.

Beta-catenin localization during Xenopus embryogenesis: accumulation at tissue and somite boundaries.

B. Gumbiner, F. Fagotto, François Fagotto, 1994, Development.

Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

P. McCrea, B. Gumbiner, C. Kintner, 1994, Cell.

Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes

B. Gumbiner, C. Gottardi, 2004, The Journal of cell biology.

Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis

B. Gumbiner, P. Polakis, B. Rubinfeld, 1997, The Journal of cell biology.

Crosstalk between different adhesion molecules.

B. Gumbiner, Xuejun Chen, 2006, Current opinion in cell biology.

Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions.

B. Gumbiner, C. Gottardi, 2004, American journal of physiology. Cell physiology.

Induction of a secondary body axis in Xenopus by antibodies to beta- catenin

P. McCrea, B. Gumbiner, W. Brieher, 1993, The Journal of cell biology.

Regulation of protein stability by GSK3 mediated phosphorylation

Nam‐Gyun Kim, B. Gumbiner, Chong Xu, 2009, Cell cycle.

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

Nam‐Gyun Kim, B. Gumbiner, 2015, The Journal of cell biology.

p120-catenin phosphorylation status alters E-cadherin mediated cell adhesion and ability of tumor cells to metastasize

B. Gumbiner, Alisha M. Mendonsa, Chirosree Bandyopadhyay, 2020, PloS one.

Apical Membrane Localization of the Adenomatous Polyposis Coli Tumor Suppressor Protein and Subcellular Distribution of the β-Catenin Destruction Complex in Polarized Epithelial Cells

B. Gumbiner, A. Reinacher-Schick, 2001, The Journal of cell biology.

Adhesion signaling: How β-catenin interacts with its partners

B. Gumbiner, C. Gottardi, 2001, Current Biology.

Allosteric Regulation of E-Cadherin Adhesion*

D. Leckband, T. Ha, B. Gumbiner, 2015, The Journal of Biological Chemistry.

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

Nam‐Gyun Kim, B. Gumbiner, Xiao Chen, 2011, Proceedings of the National Academy of Sciences.

Antagonism of Cell Adhesion by an α-Catenin Mutant, and of the Wnt-signaling Pathway by α-Catenin in Xenopus Embryos

B. Gumbiner, L. Reichardt, R. Sehgal, 1997, The Journal of cell biology.

Plakoglobin and β-catenin : distinct but closely related : authors' reply

C. Turck, S. Butz, P. McCrea, 1992 .

A Cell-Free Assay System for β-Catenin Signaling That Recapitulates Direct Inductive Events in the Early Xenopus laevis Embryo

B. Gumbiner, R. Nelson, 1999, The Journal of cell biology.

Expression of cell adhesion molecule E-cadherin in Xenopus embryos begins at gastrulation and predominates in the ectoderm

B. Gumbiner, B Gumbiner, Y S Choi, 1989, The Journal of cell biology.

Structural Elements Necessary for Oligomerization, Trafficking, and Cell Sorting Function of Paraxial Protocadherin*

B. Gumbiner, Xuejun Chen, Li Liu, 2007, Journal of Biological Chemistry.

The functional activity of E-cadherin controls tumor cell metastasis at multiple steps

B. Gumbiner, Alisha M. Mendonsa, T. Na, 2020, Proceedings of the National Academy of Sciences.

Generation and maintenance of epithelial cell polarity.

B. Gumbiner, 1990, Current opinion in cell biology.

Disruption of gastrulation movements in Xenopus by a dominant-negative mutant for C-cadherin.

B. Gumbiner, C. H. Lee, C. Lee, 1995, Developmental biology.

The roles of distinct Ca2+ signaling mediated by Piezo and inositol triphosphate receptor (IP3R) in the remodeling of E-cadherin during cell dissemination

B. Gumbiner, Y. V. Kwon, A. Cabrera, 2021, bioRxiv.

Title Adhesion-independent mechanism for suppression of tumor cellinvasion by E-cadherin

B. Gumbiner, A. Wong, 2003 .

Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion

B. Gumbiner, MarthaJoy M. Spano, Y. Petrova, 2012, Molecular biology of the cell.

Paraxial protocadherin mediates cell sorting and tissue morphogenesis by regulating C-cadherin adhesion activity

B. Gumbiner, Xuejun Chen, 2006, The Journal of cell biology.

Membrane glycoprotein choreography

B. Gumbiner, 1991, Current Biology.

The role of uvomorulin in the formation of epithelial occluding junctions.

B. Gumbiner, K. Simons, 2007, Ciba Foundation symposium.

Induction of the primary dorsalizing center in Xenopus by the Wnt/GSK/beta-catenin signaling pathway, but not by Vg1, Activin or Noggin.

B. Gumbiner, F. Fagotto, K. Guger, 1997, Development.

Deregulation of the Hippo pathway in mouse mammary stem cells promotes mammary tumorigenesis

B. Gumbiner, Hongbin Li, 2016, Mammalian Genome.

Amines and secretory pathways (reply)

R. Kelly, B. Gumbiner, H. P. Moore, 1983, Nature.

Characterization of a 60S complex of the adenomatous polyposis coli tumor suppressor protein.

B. Gumbiner, Chong Xu, Sreekala Mahadevaiyer, 2007, Biochimica et biophysica acta.

Characterization of a 60 S complex of the adenomatous polyposis coli tumor suppressor protein

B. Gumbiner, Chong Xu, Sreekala Mahadevaiyer, 2007 .

Reconstitution of the full transmembrane cadherin-catenin complex.

B. Gumbiner, A. Maker, 2022, Protein expression and purification.

Convergence and extension at gastrulation require a myosin IIB-dependent cortical actin network

Ana Rolo, Paul Skoglund, Ray Keller, 2008, Development.

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

Nam‐Gyun Kim, B. Gumbiner, Runping Fan, 2013, Proceedings of the National Academy of Sciences.

β‐Catenin Directly Induces Expression of the Siamois Gene, and Can Initiate Signaling Indirectly via a Membrane‐Tethered Form a

B. Gumbiner, RICHARD W. Nelson, 1998, Annals of the New York Academy of Sciences.

Propagation and localization of Wnt signaling.

B. Gumbiner, 1998, Current opinion in genetics & development.

Coordinate gene regulation by two different catenins.

B. Gumbiner, 2005, Developmental cell.

Results Salmonella Association with Polarized MDCK Cell Monolayers Requires Bacterial Protein Synthesis and Causes Loss of Host MicroviUi

B. Finlay, B. Gumbiner, Stanley, 2002 .

Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody

P. Myler, B. Gumbiner, B. Staker, 2022, bioRxiv.

Strengthening E-cadherin adhesion via antibody mediated binding stabilization

B. Gumbiner, S. Sivasankar, L. Schecterson, 2023, bioRxiv.

Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains.

D. Leckband, B. Gumbiner, S. Sivasankar, 2001, Biophysical journal.

Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains.

D. Leckband, N. Lavrik, B. Gumbiner, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Enhanced endothelial barrier function by monoclonal antibody activation of vascular endothelial cadherin.

B. Gumbiner, Ki-Sook Park, L. Schecterson, 2021, American journal of physiology. Heart and circulatory physiology.