J. Hoflack

发表

Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms.

Shibing Deng, Jiri Aubrecht, Ronald D Snyder, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Monitoring Cyp2b10 mRNA expression at cessation of 2-year carcinogenesis bioassay in mouse liver provides evidence for a carcinogenic mechanism devoid of human relevance: the dalcetrapib experience.

T. Singer, J. Hoflack, A. Roth, 2012, Toxicology and applied pharmacology.

Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells.

K. Kolaja, Michael Weber, H. Stahlberg, 2014, Cell reports.

Cardiac spheroids as promising in vitro models to study the human heart microenvironment

G. Figtree, J. Hoflack, L. Badi, 2017, Scientific Reports.

HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model

Álvaro Cortés Cabrera, O. Schilling, T. Dunkley, 2017, EBioMedicine.

Epithelial Cells as Active Player In Fibrosis: Findings from an In Vitro Model

M. Prunotto, J. Hoflack, M. Ebeling, 2013, PloS one.

Primary endothelial damage is the mechanism of cardiotoxicity of tubulin-binding drugs.

M. Fielden, I. Mikaelian, A. Buness, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Characterization of post-surgical alterations in the bile duct-cannulated rat

T. Singer, Guido Steiner, J. Hoflack, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Characterization of anti-peptide antibodies directed towards the automodification domain and apoptotic fragment of poly (ADP-ribose) polymerase.

J. Hoflack, G. Poirier, G. Shah, 1997, Biochimica et biophysica acta.

Biochemical properties and function of poly(ADP-ribose) glycohydrolase.

J. Hoflack, G. Poirier, G. Shah, 1995, Biochimie.

Activation of neurotensin receptors and purinoceptors in human colonic adenocarcinoma cells detected with the microphysiometer.

J. Hoflack, A. Zimmermann, B. Lesur, 1997, Biochemical pharmacology.

Combining in vivo and organotypic in vitro approaches to assess the human relevance of Basimglurant (RG7090), a potential CAR activator.

A. Hierlemann, J. Hoflack, K. Renggli, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Alteration in methyl-methanesulfonate-induced poly(ADP-ribosyl)ation by 2-butoxyethanol in Syrian hamster embryo cells.

P. Vasseur, J. Hoflack, G. Poirier, 1997, Carcinogenesis.

A novel orally available small molecule that inhibits hepatitis B virus expression.

Wenzhe Lu, Guido Steiner, T. Racek, 2017, Journal of hepatology.

Complete inhibition of poly(ADP-ribose) polymerase activity prevents the recovery of C3H10T1/2 cells from oxidative stress.

J. Hoflack, G. Poirier, G. Shah, 1996, Biochimica et biophysica acta.

Inhibition of myo-inositol monophosphatase isoforms by aromatic phosphonates.

J. Hoflack, S. Piettre, F. Strasser, 1998, Bioorganic & medicinal chemistry.

Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor torcetrapib involve L-type calcium channels

J. Hoflack, A. Capponi, J. Funder, 2010, Journal of hypertension.

Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo.

J. Hoflack, G. Poirier, G. Shah, 1995, Analytical biochemistry.

The role of poly(ADP-ribose) metabolism in response to active oxygen cytotoxicity.

J. Hoflack, G. Poirier, J. Kirkland, 1994, Biochimica et biophysica acta.

Serum cardiac troponin I concentrations transiently increase in rats given rosiglitazone.

T. Singer, I. Mikaelian, A. Buness, 2011, Toxicology letters.

Glycol ethers induce death and necrosis in human leukemia cells.

P. Vasseur, J. Hoflack, G. Poirier, 1997, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Use of toxicogenomics in drug safety evaluation: Current status and an industry perspective

John L. Vahle, J. Hoflack, E. Blomme, 2018, Regulatory toxicology and pharmacology : RTP.

Mutagenicity of ethylene glycol ethers and of their metabolites in Salmonella typhimurium his-.

P. Vasseur, J. Hoflack, Z. Elias, 1995, Mutation research.

Comparison of Coumarin-Induced Toxicity between Sandwich-Cultured Primary Rat Hepatocytes and Rats in Vivo: A Toxicogenomics Approach

R. Stierum, J. Kleinjans, J. Hoflack, 2006, Drug Metabolism and Disposition.

Tailoring in silico model to electrophysiology of individual iPSC-derived cardiomyocyte lines: One-size fits all?

Michael Clerx, Liudmila Polonchuk, Gary R. Mirams, 2018, Journal of Pharmacological and Toxicological Methods.