Jian-Dong Li

Steve D. M. Brown, A. Ryan, Jian-Dong Li, 2013, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

MKP1 Regulates the Induction of MUC5AC Mucin by Streptococcus pneumoniae Pneumolysin by Inhibiting the PAK4-JNK Signaling Pathway*

Jian-Dong Li, J. Lim, U. Ha, 2008, Journal of Biological Chemistry.

A practical community-based response strategy to interrupt Ebola transmission in sierra Leone, 2014–2015

Qun Li, G. Shi, T. Samba, 2016, Infectious Diseases of Poverty.

Gastrointestinal , Hepatobiliary and Pancreatic Pathology Vitamin D Receptor Negatively Regulates Bacterial-Stimulated NF-B Activity in Intestine

Yinglin Xia, Jun Sun, Jian-Dong Li, 2010 .

Vitamin D receptor negatively regulates bacterial-stimulated NF-kappaB activity in intestine.

Yinglin Xia, Jun Sun, Jian-Dong Li, 2010, The American journal of pathology.

Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short

Jian-Dong Li, Byung-Cheol Lee, S. Matsuyama, 2016, Scientific Reports.

Nontypeable Haemophilus influenzae-Induced MyD88 Short Expression Is Regulated by Positive IKKβ and CREB Pathways and Negative ERK1/2 Pathway

Kensei Komatsu, Jian-Dong Li, M. Miyata, 2015, PloS one.

Vinpocetine Attenuates Pathological Cardiac Remodeling by Inhibiting Cardiac Hypertrophy and Fibrosis

Jian-Dong Li, Chen Yan, Xiangbin Xu, 2017, Cardiovascular Drugs and Therapy.

PKCθ Synergizes with TLR-Dependent TRAF6 Signaling Pathway to Upregulate MUC5AC Mucin via CARMA1

Jian-Dong Li, H. Jono, J. Lim, 2012, PloS one.

Novel Cytoplasmic Proteins of Nontypeable Haemophilus influenzae Up-regulate Human MUC5AC Mucin Transcription via a Positive p38 Mitogen-activated Protein Kinase Pathway and a Negative Phosphoinositide 3-Kinase-Akt Pathway*

Jiahuai Han, Jian-Dong Li, C. Basbaum, 2002, The Journal of Biological Chemistry.

The PDE1A-PKCα Signaling Pathway Is Involved in the Upregulation of α-Smooth Muscle Actin by TGF-β1 in Adventitial Fibroblasts

Ling-Yun Wu, Jian-Dong Li, P. Gao, 2009, Journal of Vascular Research.

NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway.

Lin-Feng Chen, Jian-Dong Li, G. Mosialos, 2004, The Journal of biological chemistry.

Andrographolide plays an important role in bleomycin-induced pulmonary fibrosis treatment.

Jian-Dong Li, Shi-bo Li, Ya-nan Li, 2015, International journal of clinical and experimental medicine.

Streptococcus pneumoniae synergizes with nontypeable Haemophilus influenzae to induce inflammation via upregulating TLR2

Jian-Dong Li, J. Lim, S. Kweon, 2008, BMC Immunology.

Synergistic induction of MUC5AC mucin by nontypeable Haemophilus influenzae and Streptococcus pneumoniae.

Jian-Dong Li, H. Jono, Huahao Shen, 2008, Biochemical and biophysical research communications.

cAMP-dependent protein kinase A acts as a negative regulator for nontypeable Haemophilus influenzae-induced GM-CSF expression via inhibition of MEK-ERK signaling pathway

Kensei Komatsu, Jian-Dong Li, H. Kai, 2016 .

Panel 8: Vaccines and immunology.

L. Hammitt, A. Kurabi, Jian-Dong Li, 2019, International journal of pediatric otorhinolaryngology.

An update on vinpocetine: New discoveries and clinical implications

Jian-Dong Li, Chen Yan, Yishuai Zhang, 2018, European journal of pharmacology.

Activation of Epidermal Growth Factor Receptor Is Required for NTHi-Induced NF-κB-Dependent Inflammation

Jian-Dong Li, J. Lim, Haidong Xu, 2011, PloS one.

Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury

M. Murakami, Tomoaki Koga, Jian-Dong Li, 2016, Scientific Reports.

Directed differentiation of airway epithelial cells of human bone marrow mesenchymal stem cells

Jian-Dong Li, 2016, Artificial cells, nanomedicine, and biotechnology.

The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll‐like receptor 7 expression

Tomoaki Koga, Jian-Dong Li, H. Kai, 2007, The FEBS journal.

Glucocorticoids synergize with IL-1β to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells

Jiahuai Han, S. Akira, Jian-Dong Li, 2004, BMC Molecular Biology.

Dexamethasone Inhibits Synergistic Induction of PDE4B Expression by Roflumilast and Bacterium NTHi

Jian-Dong Li, Chen Yan, Byung-Cheol Lee, 2018, International journal of molecular sciences.

Up-Regulation of Interleukin-8 by Novel Small Cytoplasmic Molecules of Nontypeable Haemophilus influenzae via p38 and Extracellular Signal-Regulated Kinase Pathways

Jian-Dong Li, Haidong Xu, P. Cleary, 2003, Infection and Immunity.

A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae.

J. Pouysségur, G. Pagès, Tomoaki Koga, 2007, Journal of immunology.

Epidermal Growth Factor Receptor Acts as a Negative Regulator for Bacterium Nontypeable Haemophilus influenzae-induced Toll-like Receptor 2 Expression via an Src-dependent p 38 Mitogen-activated Protein Kinase Signaling Pathway *

Jian-Dong Li, H. Kai, H. Jono, 2005 .

Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKβ- IκBα-NF-κB signaling pathways

Jian-Dong Li, H. Jono, J. Lim, 2004 .

Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha.

Jiahuai Han, Jian-Dong Li, H. Jono, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Glucocorticoids Synergistically Enhance NontypeableHaemophilus influenzae-induced Toll-like Receptor 2 Expression via a Negative Cross-talk with p38 MAP Kinase*

Jiahuai Han, S. Akira, F. Linthicum, 2002, The Journal of Biological Chemistry.

Phosphodiesterase 4B Mediates Extracellular Signal-regulated Kinase-dependent Up-regulation of Mucin MUC5AC Protein by Streptococcus pneumoniae by Inhibiting cAMP-protein Kinase A-dependent MKP-1 Phosphatase Pathway*

Kensei Komatsu, Jian-Dong Li, H. Kai, 2012, The Journal of Biological Chemistry.

Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B

Tomoaki Koga, Jian-Dong Li, J. Lim, 2008, Respiratory research.

Nogo-B promotes epithelial-mesenchymal transition in lung fibrosis via PERK branch of the endoplasmic reticulum stress pathway

Qiang Li, Jian-Dong Li, Meng Yang, 2021, Annals of translational medicine.

Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases

M. Suico, T. Shuto, Jian-Dong Li, 2016, Scientific Reports.

Bacterial LPS up-regulated TLR3 expression is critical for antiviral response in human monocytes: evidence for negative regulation by CYLD.

Shuang Huang, Jian-Dong Li, Z. Pan, 2011, International immunology.

Panel 3: Genetics and Precision Medicine of Otitis Media

Steve D. M. Brown, Jian-Dong Li, D. Preciado, 2017, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

Statin-conferred enhanced cellular resistance against bacterial pore-forming toxins in airway epithelial cells.

Jian-Dong Li, J. Lim, R. Wu, 2015, American journal of respiratory cell and molecular biology.

Bmc Infectious Diseases

T. Ganz, Jian-Dong Li, S. Moon, 2008 .

Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF.

Tomoaki Koga, Jian-Dong Li, H. Kai, 2007, Biochemical and biophysical research communications.

Ca2+/calmodulin‐stimulated PDE1 regulates the beta‐catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells

Clint L. Miller, Xuan Liu, Jian-Dong Li, 2010, The FEBS journal.

PKC (cid:1) decreases eNOS protein stability via inhibitory phosphorylation of ERK5

Jian-Dong Li, K. Fujiwara, J. Lim, 2010 .

The regulation of human beta-defensin 2 by the ETS transcription factor MEF (myeloid Elf-1-like factor) is enhanced by promyelocytic leukemia protein.

M. Nakao, M. Suico, T. Shuto, 2004, Journal of pharmacological sciences.

Negative Cross-Talk between TLR2/4-Independent AMPKα1 and TLR2/4-Dependent JNK Regulates S. pneumoniae–Induced Mucosal Innate Immune Response

T. Shuto, Kensei Komatsu, Jian-Dong Li, 2022, The Journal of Immunology.

Differential regulation of Streptococcus pneumoniae-induced human MUC5AC mucin expression through distinct MAPK pathways.

Kensei Komatsu, Jian-Dong Li, H. Kai, 2009, American journal of translational research.

Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.

Lindsey C. Szymczak, M. Mrksich, Kensei Komatsu, 2017, Bioorganic & medicinal chemistry.

Curcumin suppresses NTHi-induced CXCL5 expression via inhibition of positive IKKβ pathway and up-regulation of negative MKP-1 pathway

Jian-Dong Li, Anuhya S. Konduru, Byung-Cheol Lee, 2016, Scientific Reports.

TGF- b induces p65 acetylation to enhance bacteria-induced NF- j B activation

Lin-Feng Chen, Tomoaki Koga, Jian-Dong Li, 2007 .

Intratracheal GLP-1 receptor agonist treatment up-regulates mucin via p38 and exacerbates emphysematous phenotype in mucus hypersecretory obstructive lung diseases.

M. Suico, T. Shuto, Jian-Dong Li, 2020, Biochemical and biophysical research communications.

Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways.

Jian-Dong Li, H. Jono, J. Lim, 2004, Biochemical and biophysical research communications.

Potential use of EGFR-targeted molecular therapies for tumor suppressor CYLD-negative and poor prognosis oral squamous cell carcinoma with chemoresistance

S. Okada, Jian-Dong Li, R. Kariya, 2022, Cancer Cell International.

TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation.

Lin-Feng Chen, Tomoaki Koga, Jian-Dong Li, 2007, The EMBO journal.

Cleaved Cochlin: One Guard with Two Roles in Surveillance.

Kensei Komatsu, Jian-Dong Li, 2019, Cell host & microbe.

Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1

Kensei Komatsu, Jian-Dong Li, Anuhya S. Konduru, 2017, International journal of inflammation.

Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M

R. Flavell, Jian-Dong Li, H. Kai, 2015, Nature Communications.

A Novel Role for IκB Kinase (IKK) α and IKKβ in ERK-Dependent Up-Regulation of MUC5AC Mucin Transcription by Streptococcus pneumoniae1

J. Pouysségur, G. Pagès, Tomoaki Koga, 2007, The Journal of Immunology.

Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice

Guoying Yu, M. Prausnitz, R. Compans, 2018, Proceedings of the National Academy of Sciences.

CYLD: a critical regulator of hypoxia-mediated inflammation in tumors

Jian-Dong Li, H. Jono, Y. Ando, 2015 .

Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy

J. Kuratsu, Jian-Dong Li, H. Jono, 2014, Oncotarget.

IL-36γ signaling controls the induced regulatory T cell – TH9 cell balance via NFκB activation and STAT transcription factors

T. Denning, Jian-Dong Li, A. Nusrat, 2017, Mucosal Immunology.

Vinpocetine inhibits NF-κB–dependent inflammation via an IKK-dependent but PDE-independent mechanism

Toru Aizawa, Jian-Dong Li, H. Jono, 2010, Proceedings of the National Academy of Sciences.

Promoter hypomethylation of Toll‐like receptor‐2 gene is associated with increased proinflammatory response towardbacterial peptidoglycan in cystic fibrosis bronchial epithelial cells

M. Suico, T. Shuto, Jian-Dong Li, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Epidermal Growth Factor Receptor Acts as a Negative Regulator for Bacterium Nontypeable Haemophilus influenzae-induced Toll-like Receptor 2 Expression via an Src-dependent p38 Mitogen-activated Protein Kinase Signaling Pathway*

Jian-Dong Li, H. Kai, H. Jono, 2005, Journal of Biological Chemistry.

Inhibition of p38 MAPK by Glucocorticoids via Induction of MAPK Phosphatase-1 Enhances Nontypeable Haemophilus influenzae-induced Expression of Toll-like Receptor 2*

Jiahuai Han, S. Akira, Jian-Dong Li, 2002, The Journal of Biological Chemistry.

Activation of NF-κB by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK–IKKα/β–IκBα and MKK3/6–p38 MAP kinase signaling pathways in epithelial cells

Jiahuai Han, T. Shuto, Jian-Dong Li, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Transforming Growth Factor- (cid:1) -Smad Signaling Pathway Negatively Regulates Nontypeable Haemophilus influenzae -induced MUC5AC Mucin Transcription via Mitogen-activated Protein Kinase (MAPK) Phosphatase-1-dependent Inhibition of p38 MAPK*

Jian-Dong Li, H. Kai, Xin-Hua Feng, 2022 .

Exploitation of host epithelial signaling networks by respiratory bacterial pathogens.

Jian-Dong Li, 2003, Journal of pharmacological sciences.

Transforming Growth Factor-β-Smad Signaling Pathway Cooperates with NF-κB to Mediate NontypeableHaemophilus influenzae-induced MUC2 Mucin Transcription*

T. Shuto, Jian-Dong Li, H. Kai, 2002, The Journal of Biological Chemistry.

CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

P. Bourne, Lin-Feng Chen, Tomoaki Koga, 2012, Nature Communications.

Integrative expression analysis identifies a novel interplay between CFTR and linc-SUMF1-2 that involves CF-associated gene dysregulation.

Shingo Suzuki, M. Suico, T. Shuto, 2019, Biochemical and biophysical research communications.

Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells☆

M. Suico, T. Shuto, Jian-Dong Li, 2017, EBioMedicine.

Transcriptional regulation of the lysozyme gene in airway gland serous cells

Jian-Dong Li, H. Kai, K. Takeuchi, 1996, Journal of cellular biochemistry.

Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi

Jian-Dong Li, H. Kai, Haidong Xu, 2015, Proceedings of the National Academy of Sciences.

Role of Ca 2 (cid:1) /Calmodulin–Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy

A. Wojtovich, C. Yan, J. Beavo, 2009 .

Panel 2- recent advance in otitis media bioinformatics.

A. Kurabi, Kensei Komatsu, Jian-Dong Li, 2019, International journal of pediatric otorhinolaryngology.

RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke.

I. Rahman, Jian-Dong Li, P. Sime, 2009, American journal of respiratory cell and molecular biology.

Co-immunization with virus-like particle and DNA vaccines induces protection against respiratory syncytial virus infection and bronchiolitis.

Jian-Dong Li, Yu-Jin Jung, Young‐Tae Lee, 2014, Antiviral research.

In Vitro Interaction of Pseudomonas aeruginosa with Human Middle Ear Epithelial Cells

X. Liu, Jian-Dong Li, D. Yan, 2014, PloS one.

Receptor Interacting Protein-2 acts as negative regulator for nontypeable Haemophilus influenzae-induced mucin MUC5AC expression

Kensei Komatsu, Jian-Dong Li, S. Matsuyama, 2017 .

TGF‐β induces p65 acetylation to enhance bacteria‐induced NF‐κB activation

Lin-Feng Chen, Tomoaki Koga, Jian-Dong Li, 2007 .

Vinpocetine Suppresses Streptococcus pneumoniae–Induced Inflammation via Inhibition of ERK1 by CYLD

Kensei Komatsu, Jian-Dong Li, Ji-Yun Lee, 2020, The Journal of Immunology.

A structure-activity relationship of non-peptide macrocyclic histone deacetylase inhibitors and their anti-proliferative and anti-inflammatory activities.

M. Mrksich, Jian-Dong Li, Sandra C. Mwakwari, 2015, Bioorganic & medicinal chemistry.

Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD

Tomoaki Koga, Kensei Komatsu, Jian-Dong Li, 2013, Nature Communications.

The Tumor Suppressor Cylindromatosis (CYLD) Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7*

Jian-Dong Li, H. Kai, H. Jono, 2005, Journal of Biological Chemistry.

Vinpocetine Inhibits Streptococcus pneumoniae–Induced Upregulation of Mucin MUC5AC Expression via Induction of MKP-1 Phosphatase in the Pathogenesis of Otitis Media

Kensei Komatsu, Jian-Dong Li, Haidong Xu, 2015, The Journal of Immunology.

Critical role of type 1 plasminogen activator inhibitor (PAI-1) in early host defense against nontypeable Haemophilus influenzae (NTHi) infection.

Jian-Dong Li, J. Lim, C. Woo, 2011, Biochemical and biophysical research communications.

CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia

Jian-Dong Li, J. Lim, U. Ha, 2008, Cellular microbiology.

Myeloid Elf-1-like Factor, an ETS Transcription Factor, Up-regulates Lysozyme Transcription in Epithelial Cells through Interaction with Promyelocytic Leukemia Protein*

M. Nakao, M. Suico, T. Shuto, 2004, Journal of Biological Chemistry.

Role of innate immunity in the pathogenesis of otitis media.

X. Liu, K. Mathee, Jian-Dong Li, 2014, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Clinical significance of CYLD downregulation in breast cancer

Aiko Sueta, Jian-Dong Li, H. Jono, 2014, Breast Cancer Research and Treatment.

EVI1 Acts as an Inducible Negative-Feedback Regulator of NF-κB by Inhibiting p65 Acetylation

Jian-Dong Li, J. Lim, Haidong Xu, 2012, The Journal of Immunology.

Metformin ameliorates the severity of experimental Alport syndrome

M. Suico, T. Shuto, Jian-Dong Li, 2021, Scientific Reports.

Extracellular Signal-Regulated Kinase 5 SUMOylation Antagonizes Shear Stress–Induced Antiinflammatory Response and Endothelial Nitric Oxide Synthase Expression in Endothelial Cells

Jian-Dong Li, J. Lim, Chen Yan, 2008, Circulation research.

Early-Life Microbiota Exposure Restricts Myeloid-Derived Suppressor Cell–Driven Colonic Tumorigenesis

T. Denning, Jian-Dong Li, Y. Naito, 2019, Cancer Immunology Research.

Tumor Suppressor CYLD Acts as a Negative Regulator for Non-Typeable Haemophilus influenza-Induced Inflammation in the Middle Ear and Lung of Mice

P. Bourne, Tomoaki Koga, Jian-Dong Li, 2007, PloS one.