G. Swarup

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Direct Transcriptional Activation of Human Caspase-1 by Tumor Suppressor p53*

Sanjeev Gupta, V. Radha, Y. Furukawa, 2001, The Journal of Biological Chemistry.

Inhibition of anchorage-independent cell growth, adhesion, and cyclin D1 gene expression by a dominant negative mutant of a tyrosine phosphatase.

G. Swarup, S. Mitra, 2001, Experimental cell research.

Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate.

G. Swarup, D. Garbers, S. Cohen, 1982, Biochemical and biophysical research communications.

Autophagy receptor optineurin promotes autophagosome formation by potentiating LC3-II production and phagophore maturation

G. Swarup, Megha Bansal, S. Moharir, 2018, Communicative & integrative biology.

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

V. Radha, G. Swarup, D. Balasubramanian, 2010, BMC Cell Biology.

Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

G. Swarup, Megha Bansal, A. Nagabhushana, 2011, PloS one.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Reaction of brain hexokinase with a substrate-like reagent. Alkylation of a single thiol at the active site.

G. Swarup, U. W. Kenkare, 1980, Biochemistry.

CASP1 (caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase))

Radha, G. Swarup, Y. Kumar, 2011 .

Two Splice Variants of a Tyrosine Phosphatase Differ in Substrate Specificity, DNA Binding, and Subcellular Location*

V. Radha, G. Swarup, S. Nambirajan, 1996, The Journal of Biological Chemistry.

Functional analysis of optineurin and some of its disease‐associated mutants

G. Swarup, D. Balasubramanian, Megha Bansal, 2015, IUBMB life.

IRF-1-binding site in the first intron mediates interferon-γ-induced optineurin promoter activation.

G. Swarup, C. Sudhakar, Vipul Vaibhava, 2013, Biochemical and biophysical research communications.

Nuclear Matrix: Methods of Preparation

V. Radha, G. Swarup, 2001 .

A nuclear protein tyrosine phosphatase activates p53 and induces caspase‐1‐dependent apoptosis

Sanjeev Gupta, V. Radha, G. Swarup, 2002, FEBS letters.

PTP-S2, a nuclear tyrosine phosphatase, is phosphorylated and excluded from condensed chromosomes during mitosis

V. Radha, G. Swarup, S. Nambirajan, 2000, Journal of Biosciences.

Optineurin, a multifunctional protein involved in glaucoma, amyotrophic lateral sclerosis and antiviral signalling

G. Swarup, A. Nagabhushana, 2010, Journal of Biosciences.

Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

G. Swarup, A. Kumari, A. Nagabhushana, 2012, Journal of Cell Science.

Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi

G. Swarup, Vijay R. Gupta, Madhavi Muppirala, 2011, Biology of the cell.

Tyrosine phosphorylation of a SNARE protein, syntaxin 17: implications for membrane trafficking in the early secretory pathway.

G. Swarup, Vijay R. Gupta, Madhavi Muppirala, 2012, Biochimica et biophysica acta.

Regulation of cellular and molecular functions by protein phosphorylation

G. Swarup, 1998 .

Optineurin promotes aggregation of mutant huntingtin and mutant ataxin-3, and reduces cytotoxicity of aggregates

G. Swarup, S. Moharir, Akhouri Kishore Raghawan, 2020 .

Induction of p53 dependent apoptosis upon overexpression of a nuclear protein tyrosine phosphatase

V. Radha, G. Swarup, C. Sudhakar, 1999, FEBS letters.

NLRC4 (NLR Family, CARD domain containing 4)

V. Radha, G. Swarup, Y. Kumar, 2011 .

Molecular cloning and expresion of a protein‐tyrosine phosphatase showing homology with transcription factors Fos and Jun

V. Radha, G. Swarup, V. Rema, 1991, FEBS letters.

Optineurin mediates delivery of membrane from transferrin receptor-positive endosomes to autophagosomes

G. Swarup, Kapil Sirohi, Megha Bansal, 2022, bioRxiv.

Identification of a splice variant of optineurin which is defective in autophagy and phosphorylation.

G. Swarup, Megha Bansal, S. Moharir, 2018, Biochimica et biophysica acta. Molecular cell research.

Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein

G. Swarup, Kapil Sirohi, Megha Bansal, 2017, The Journal of Biological Chemistry.

Focus on molecules: optineurin.

G. Swarup, D. Balasubramanian, M. Chalasani, 2008, Experimental eye research.

Phosphotyrosyl-protein phosphatase of TCRC-2 cells.

G. Swarup, D. Garbers, S. Cohen, 1982, The Journal of biological chemistry.

Alternative splicing generates four different forms of a non-transmembrane protein tyrosine phosphatase mRNA.

G. Swarup, R. Reddy, 1995, DNA and cell biology.

Physical and Functional Interaction between Hck Tyrosine Kinase and Guanine Nucleotide Exchange Factor C3G Results in Apoptosis, Which Is Independent of C3G Catalytic Domain*

V. Radha, G. Swarup, C. Sudhakar, 2003, Journal of Biological Chemistry.

Induction of cytochrome c release and apoptosis by Hck-SH3 domain-mediated signalling requires caspase-3

V. Radha, G. Swarup, C. Sudhakar, 2002, Apoptosis.

Sp1‐like sequences mediate human caspase‐3 promoter activation by p73 and cisplatin

G. Swarup, N. Jain, C. Sudhakar, 2008, The FEBS journal.

The Nobel Prize for understanding autophagy, a cellular mechanism of waste disposal that keeps us healthy

G. Swarup, Megha Bansal, 2016, Journal of Biosciences.

A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death*

V. Radha, G. Swarup, Y. Kumar, 2016, The Journal of Biological Chemistry.

A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants.

V. Radha, G. Swarup, Vijay R. Gupta, 2007, Investigative ophthalmology & visual science.

Interaction with Sug 1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death

V. Radha, G. Swarup, Y. Kumar, 2010 .

Stimulation of rhodopsin phosphorylation by guanine nucleotides in rod outer segments.

G. Swarup, D. Garbers, 1983, Biochemistry.

Protein phosphatase 2A inhibitors, phoslactomycins. Effects on the cytoskeleton in NIH/3T3 cells.

M. Inagaki, G. Swarup, G. Marriott, 1999, Journal of biochemistry.

BMC Molecular Biology BioMed Central Research article Regulation of p73 by Hck through kinase-dependent and

V. Radha, G. Swarup, P. Paliwal, 2007 .

Association of Lyn tyrosine kinase with the nuclear matrix and cell-cycle-dependent changes in matrix-associated tyrosine kinase activity.

V. Radha, G. Swarup, S. Nambirajan, 1996, European journal of biochemistry.

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

V. Radha, G. Swarup, A. Kumari, 2013, Autophagy.

Selective dephosphorylation of proteins containing phosphotyrosine by alkaline phosphatases.

G. Swarup, D. Garbers, S. Cohen, 1981, The Journal of biological chemistry.

Binding of a protein-tyrosine phosphatase to DNA through its carboxy-terminal noncatalytic domain.

V. Radha, G. Swarup, S. Kamatkar, 1993, Biochemistry.

Tyrosine-specific protein kinases of normal tissues.

G. Swarup, D. Garbers, J. Dasgupta, 1984, Advances in enzyme regulation.

Phosphoprotein phosphatase activity of sea urchin spermatozoa.

G. Swarup, D. Garbers, 1982, Biology of reproduction.

Tyrosine protein kinase activity of rat spleen and other tissues.

G. Swarup, D. Garbers, J. Dasgupta, 1983, The Journal of biological chemistry.

Activation of a cellular tyrosine‐specific protein kinase by phosphorylation

G. Swarup, G. Subrahmanyam, 1985, FEBS letters.

661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively

V. Radha, G. Swarup, Kapil Sirohi, 2017, Scientific Reports.

Optineurin and Its Mutants: Molecules Associated with Some Forms of Glaucoma

G. Swarup, D. Balasubramanian, M. Chalasani, 2009, Ophthalmic Research.

Functional Defects Caused by Glaucoma – Associated Mutations in Optineurin

G. Swarup, A. Nagabhushana, Vipul Vaibhava, 2013 .

A nuclear protein tyrosine phosphatase induces shortening of G1 phase and increase in c-Myc protein level.

V. Radha, G. Swarup, P. Manogaran, 2001, Experimental cell research.

HSC70 as a sensor of low temperature: role in cold‐triggered autoinflammatory disorders

V. Radha, G. Swarup, Akhouri Kishore Raghawan, 2021, The FEBS journal.

Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice

G. Swarup, S. Moharir, 2021, bioRxiv.

C3G is required for c-Abl-induced filopodia and its overexpression promotes filopodia formation.

V. Radha, G. Swarup, N. Rangaraj, 2007, Experimental cell research.

Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.

V. Radha, G. Swarup, Y. Kumar, 2010, The Biochemical journal.

HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4

V. Radha, G. Swarup, Akhouri Kishore Raghawan, 2019, Proceedings of the National Academy of Sciences.

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

V. Radha, G. Swarup, A. Kumari, 2015, PloS one.

E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy

V. Radha, G. Swarup, A. Kumari, 2014, PloS one.

NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB

G. Swarup, N. Jain, A. Nagabhushana, 2009, PloS one.

Tumor necrosis factor‐α‐induced caspase‐1 gene expression

G. Swarup, N. Jain, C. Sudhakar, 2007 .

Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis

V. Radha, G. Swarup, S. Thalappilly, 2006, The FEBS journal.

Role of p73 in Regulating Human Caspase-1 Gene Transcription Induced by Interferon-γ and Cisplatin*

Sanjeev Gupta, V. Radha, G. Swarup, 2005, Journal of Biological Chemistry.

Identification of a novel splice variant of C3G which shows tissue-specific expression.

G. Swarup, R. Singh, Shivakrupa, 1999, DNA and cell biology.

Downregulation of phospho‐tyrosine phosphatases in a macrophage tumor

G. Swarup, A. Khar, T. Sridhar, 1993, FEBS letters.

Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton

V. Radha, G. Swarup, A. Rajanna, 2004, BMC Cell Biology.

Emerging role of tyrosine phosphatase, TCPTP, in the organelles of the early secretory pathway.

G. Swarup, Vijay R. Gupta, Madhavi Muppirala, 2013, Biochimica et biophysica acta.

A cataract-causing connexin 50 mutant is mislocalized to the ER due to loss of the fourth transmembrane domain and cytoplasmic domain

G. Swarup, C. Kannabiran, Madhavi Latha Somaraju Chalasani, 2012, FEBS open bio.

Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER

G. Swarup, Vijay R. Gupta, Vijay Gupta, 2006, Journal of Cell Science.

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin

G. Swarup, Zuberwasim Sayyad, 2018, Front. Immunol..

Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

T. Kundu, Sanjeev Gupta, V. Radha, 2005, Oncogene.

Defects in autophagy caused by glaucoma-associated mutations in optineurin.

G. Swarup, Kapil Sirohi, 2016, Experimental eye research.

Purification and characterization of a protein-phosphotyrosine phosphatase from rat spleen which dephosphorylates and inactivates a tyrosine-specific protein kinase.

G. Swarup, G. Subrahmanyam, 1989, The Journal of biological chemistry.

Enhanced expression of a chromatin associated protein tyrosine phosphatase during G0 to S transition

G. Swarup, S. Nambirajan, A. Reddy, 1995, Journal of Biosciences.

Subcellular localization of a protein-tyrosine phosphatase: evidence for association with chromatin.

V. Radha, G. Swarup, S. Nambirajan, 1994, Biochemical Journal.

Stabilization of a protein-tyrosine phosphatase mRNA upon mitogenic stimulation of T-lymphocytes.

V. Radha, G. Swarup, G. V. Rajendrakumar, 1993, Biochimica et biophysica acta.

Protein-tyrosine phosphatases as regulators of protein kinase activity

V. Radha, G. Swarup, 1992 .

Overexpression of a nuclear protein tyrosine phosphatase increases cell proliferation

V. Radha, G. Swarup, S. Nambirajan, 1997, FEBS letters.

NUCLEAR PROTEIN TYROSINE PHOSPHATASES AND CONTROL OF CELL PROLIFERATION

V. Radha, G. Swarup, 1997 .

A glaucoma‐ and ALS‐associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress

G. Swarup, Priyanka Tare, Zuberwasim Sayyad, 2021, The FEBS journal.

Tyrosine-Protein Phosphatase Non-Receptor Type 2

G. Swarup, Madhavi Muppirala, Vijay Gupta, 2020, Definitions.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Transferrin-induced signaling through transferrin receptor and AKT kinase mediates formation of Rab8- and MICAL-L1-positive tubules involved in receptor recycling

G. Swarup, N. Rangaraj, S. Moharir, 2023, bioRxiv.

Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants.

G. Swarup, Kapil Sirohi, S. Moharir, 2023, Progress in molecular biology and translational science.

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

A glaucoma‐associated OPTN polymorphism, M98K sensitizes retinal cells to endoplasmic reticulum stress and tumour necrosis factor α

G. Swarup, N. Jain, D. Bhattacharjee, 2023, The FEBS journal.

Optineurin modulates ER stress-induced signaling pathways and cell death.

G. Swarup, S. Moharir, T. R. Raghunand, 2020, Biochemical and biophysical research communications.

Cold-induced loss of interaction with HSC70 triggers inflammasome activity of familial cold autoinflammatory syndrome-causing mutants of NLRP3

G. Swarup, Akhouri Kishore Raghawan, Rajashree Ramaswamy, 2022, bioRxiv.

Human primary retinal cells as an in-vitro model for investigating defective signalling caused by OPTN mutants associated with glaucoma

V. Radha, G. Swarup, M. Naik, 2021, Neurochemistry International.

Modulation of phosphorylation and dephosphorylation of keratin and other polypeptides by estradiol‐17β in rat vaginal epithelium

G. Swarup, A. G. Reddy, P. Gupta, 1990, FEBS Letters.

Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton

V. Radha, G. Swarup, A. Rajanna, 2004, BMC Cell Biology.

Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

G. Swarup, A. Kumari, A. Nagabhushana, 2012, Journal of Cell Science.

Tyrosine protein kinase activity in normal rat tissues: brain.

G. Swarup, D. Garbers, J. Dasgupta, 1984, Advances in cyclic nucleotide and protein phosphorylation research.