H. Mizuguchi

发表

Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter

Takao Hayakawa, Hiroyuki Mizuguchi, Takahito Nakagawa, 2002, Molecular and Cellular Biology.

Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter.

A. Nakagawara, T. Ozaki, Masato Takahashi, 2002, Molecular and cellular biology.

Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems.

Takao Hayakawa, Hiroyuki Mizuguchi, Hideyoshi Harashima, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[Development of non-viral vector based on the quantitative comparison of intracellular trafficking with viral vector].

H. Mizuguchi, H. Harashima, H. Akita, 2006, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Enhancement of phage-mediated gene transfer by nuclear localization signal.

H. Inokuchi, H. Mizuguchi, T. Hayakawa, 2002, Biochemical and biophysical research communications.

Innate immune response induced by gene delivery vectors.

Shinsaku Nakagawa, Hiroyuki Mizuguchi, S. Nakagawa, 2008, International journal of pharmaceutics.

A novel T7 system utilizing mRNA coding for T7 RNA polymerase.

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 2003, Biochemical and biophysical research communications.

Comparison of the efficiency and safety of non-viral vector-mediated gene transfer into a wide range of human cells.

H. Mizuguchi, T. Hayakawa, E. Uchida, 2002, Biological & pharmaceutical bulletin.

Optimization of transcriptional regulatory elements for constructing plasmid vectors.

T. Mayumi, H. Mizuguchi, T. Hayakawa, 2001, Gene.

Nuclear targeting of DNA.

H. Mizuguchi, A. Eguchi, E. Nagoshi, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Long‐term replication of Epstein‐Barr virus‐derived episomal vectors in the rodent cells

H. Mizuguchi, T. Hayakawa, T. Hosono, 2000, FEBS letters.

Target-cell specificity of fusogenic liposomes: membrane fusion-mediated macromolecule delivery into human blood mononuclear cells.

T. Mayumi, H. Mizuguchi, T. Hayakawa, 1999, Biochimica et biophysica acta.

Tumor necrosis factor alpha-mediated tumor regression by the in vivo transfer of genes into the artery that leads to tumors.

Y. Tsutsumi, T. Mayumi, H. Mizuguchi, 1998, Cancer research.

Particle tracking of intracellular trafficking of octaarginine-modified liposomes: a comparative study with adenovirus.

T. Tani, H. Mizuguchi, H. Harashima, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction.

S. Nakagawa, H. Mizuguchi, F. Sakurai, 2011, Biomaterials.

Transduction of adenovirus vectors modified with cell-penetrating peptides

Y. Yoshioka, S. Nakagawa, H. Mizuguchi, 2009, Peptides.

Tat conjugation of adenovirus vector broadens tropism and enhances transduction efficiency.

Y. Yoshioka, S. Nakagawa, H. Mizuguchi, 2008, Life sciences.

Role of H1-calponin in pancreatic AR42J cell differentiation into insulin-producing cells.

S. Fukumoto, H. Mizuguchi, T. Hayakawa, 2003, Diabetes.

Approaches to improving the kinetics of adenovirus-delivered genes and gene products.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2005, Advanced drug delivery reviews.

TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection.

Y. Yoshioka, S. Nakagawa, H. Mizuguchi, 2007, Biochemical and biophysical research communications.

Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA

H. Mizuguchi, F. Sakurai, M. Tachibana, 2016, Molecular therapy. Nucleic acids.

Improving adenovirus vector-mediated RNAi efficiency by lacking the expression of virus-associated RNAs.

H. Mizuguchi, F. Sakurai, K. Katayama, 2013, Virus research.

An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors.

Masahide Takahashi, H. Mizuguchi, Takuya Kato, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Efficient Adenovirus Gene Transfer Methods in Human Colonic Caco-2 Epithelial Cells Using Capric Acid.

H. Mizuguchi, M. Fujii, Yoshiteru Watanabe, 2015, Biological & pharmaceutical bulletin.

Optimal human iPS cell culture method for efficient hepatic differentiation.

H. Mizuguchi, T. Yamashita, F. Sakurai, 2018, Differentiation; research in biological diversity.

Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1.

H. Mizuguchi, T. Hayakawa, T. Taguchi, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Antibody-targeted cell fusion

S. Russell, H. Mizuguchi, T. Hayakawa, 2004, Nature Biotechnology.

Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2016, Biochemical and biophysical research communications.

Detection of circulating tumor cells in cervical cancer using a conditionally replicative adenovirus targeting telomerase‐positive cells

T. Sasagawa, S. Kyo, M. Takakura, 2017, Cancer science.

Fiber-modified adenovirus vectors mediate efficient gene transfer into undifferentiated and adipogenic-differentiated human mesenchymal stem cells.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2005, Biochemical and biophysical research communications.

Cytomedical therapy for IgG1 plasmacytosis in human interleukin-6 transgenic mice using hybridoma cells microencapsulated in alginate-poly(L)lysine-alginate membrane.

O. Ueda, T. Mayumi, H. Mizuguchi, 1997, Biochimica et biophysica acta.

Instructions for use Title Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirusand lipoplex

H. Mizuguchi, H. Harashima, H. Akita, 2017 .

Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2016, Biochemical and biophysical research communications.

Augmentation of the migratory ability of DC-based vaccine into regional lymph nodes by efficient CCR7 gene transduction

S. Nakagawa, T. Mayumi, H. Mizuguchi, 2005, Gene Therapy.

Adenovirus vector-based vaccine for infectious diseases

H. Mizuguchi, F. Sakurai, M. Tachibana, 2021, Drug Metabolism and Pharmacokinetics.

Induction of type I interferon by adenovirus-encoded small RNAs

K. Ishii, S. Akira, H. Mizuguchi, 2010, Proceedings of the National Academy of Sciences.

Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance

K. Harada, H. Mizuguchi, K. Hirata, 2020, PloS one.

Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes

Y. Abe, H. Yagi, H. Mizuguchi, 2022, Cells.

Tumor-specific delivery of biologics by a novel T-cell line HOZOT

T. Fujiwara, H. Mizuguchi, Y. Umeda, 2016, Scientific Reports.

PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 2005, The journal of gene medicine.

Selective Enhancement by Tumor Necrosis Factor‐α of Vascular Permeability of New Blood Vessels Induced with Agarose Hydrogel‐entrapped Meth‐A Fibrosarcoma Cells

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 1996, Japanese journal of cancer research : Gann.

Reduction of Natural Adenovirus Tropism to Mouse Liverby Fiber-Shaft Exchange in Combination with both CAR- andαv Integrin-BindingAblation

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2003, Journal of Virology.

Immunological properties and vaccine efficacy of murine dendritic cells simultaneously expressing melanoma-associated antigen and interleukin-12

S. Nakagawa, T. Mayumi, H. Mizuguchi, 2005, Cancer Gene Therapy.

Two-step differentiation of mast cells from induced pluripotent stem cells.

K. Fukuda, H. Mizuguchi, K. Kawabata, 2013, Stem cells and development.

Adenovirus vector-mediated doxycycline-inducible RNA interference.

S. Nakagawa, T. Mayumi, H. Mizuguchi, 2004, Human gene therapy.

Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine.

H. Mizuguchi, Kazuo Takayama, Sayaka Deguchi, 2020, Biological & pharmaceutical bulletin.

Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin.

K. Yagi, H. Mizuguchi, M. Fujii, 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction.

K. Yagi, H. Mizuguchi, M. Fujii, 2007, Biochemical pharmacology.

Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells

H. Mizuguchi, T. Yamashita, Kazuo Takayama, 2021, Molecular therapy. Methods & clinical development.

Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma

S. Nakagawa, T. Mayumi, H. Mizuguchi, 2005, Cancer Gene Therapy.

A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model.

S. Nakagawa, T. Mayumi, H. Mizuguchi, 2003, Gastroenterology.

Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus

R. Hoffman, T. Fujiwara, H. Mizuguchi, 2017, Cell cycle.

RNA interfering approach for clarifying the PPARγ pathway using lentiviral vector expressing short hairpin RNA

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 2004, FEBS letters.

A TGFβ Signaling Inhibitor, SB431542, Inhibits Reovirus-mediated Lysis of Human Hepatocellular Carcinoma Cells in a TGFβ-independent Manner

H. Mizuguchi, F. Sakurai, I. Ishigami, 2021, AntiCancer Research.

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection

H. Mizuguchi, Yasuhito Tanaka, T. Wakita, 2017, Scientific Reports.

Genetic Vaccines and Therapy

I. Kobayashi, H. Mizuguchi, T. Hayakawa, 2005 .

Systemically Administered Reovirus-Induced Downregulation of Hypoxia Inducible Factor-1α in Subcutaneous Tumors

H. Mizuguchi, F. Sakurai, T. Hotani, 2018, Molecular therapy oncolytics.

A dopamine antagonist, domperidone enhances the replication of an oncolytic adenovirus in human tumour cells.

H. Mizuguchi, F. Sakurai, Kosuke Takayama, 2022, The Journal of general virology.

Optimization of an E1A Gene Expression Cassette in an Oncolytic Adenovirus for Efficient Tumor Cell Killing Activity

H. Mizuguchi, F. Sakurai, Kosuke Takayama, 2021, AntiCancer Research.

Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A

T. Fujiwara, H. Mizuguchi, F. Sakurai, 2020, AntiCancer Research.

Thyroid cancer immuno‐therapy with retroviral and adenoviral vectors expressing granulocyte macrophage colony stimulating factor and interleukin‐12 in a rat model

H. Mizuguchi, T. Hayakawa, K. Nakao, 2003, Clinical endocrinology.

LY341495, an mGluR2/3 Antagonist, Regulates the Immunosuppressive Function of Myeloid-Derived Suppressor Cells and Inhibits Melanoma Tumor Growth.

H. Mizuguchi, F. Sakurai, Y. Ago, 2018, Biological & pharmaceutical bulletin.

Generation of Human iPSC–Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction

K. Harada, H. Yamada, H. Mizuguchi, 2019, Cellular and molecular gastroenterology and hepatology.

Generation of safe and therapeutically effective human induced pluripotent stem cell‐derived hepatocyte‐like cells for regenerative medicine

O. Ohara, K. Sekiguchi, T. Morio, 2017, Hepatology communications.

Reovirus double-stranded RNA genomes and polyI:C induce down-regulation of hypoxia-inducible factor 1α.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2015, Biochemical and biophysical research communications.

Tumor‐targeted fluorescence labeling systems for cancer diagnosis and treatment

Takeshi Imamura, Hisataka Kobayashi, T. Fujiwara, 2022, Cancer science.

A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob

M. Kay, H. Mizuguchi, T. Hayakawa, 2001, Gene Therapy.

Thyrotropin Receptor Injection of Adenovirus Expressing the Hyperthyroidism with Intramuscular A Novel Murine Model of Graves'

H. Mizuguchi, T. Ando, K. Eguchi, 2002 .

Tolloid‐Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling

H. Mizuguchi, Yasuhito Tanaka, Kazuo Takayama, 2020, Hepatology communications.

Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference

H. Mizuguchi, T. Hayakawa, K. Taira, 2005, Gene Therapy.

Adenovirus serotype 35 vector-mediated transduction following direct administration into organs of nonhuman primates

H. Mizuguchi, T. Hayakawa, K. Terao, 2009, Gene Therapy.

Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-gamma activation.

H. Mizuguchi, T. Hayakawa, K. Eguchi, 2007, Biochemical and biophysical research communications.

Different Reactions of Aortic and Venular Endothelial Cell Monolayers to Histamine on Macromolecular Permeability: Role of cAMP, Cytosolic Ca2+ and F-actin

S. Nakagawa, T. Mayumi, K. Ikeda, 1999, Inflammation.

Effect of tumour cell-conditioned medium on endothelial macromolecular permeability and its correlation with collagen.

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 1996, British Journal of Cancer.

Ascorbic acid stimulates barrier function of cultured endothelial cell monolayer

S. Nakagawa, T. Mayumi, H. Mizuguchi, 1995, Journal of cellular physiology.

Role of H 1-Calponin in Pancreatic AR 42 J Cell Differentiation Into Insulin-Producing Cells

S. Fukumoto, H. Mizuguchi, T. Hayakawa, 2003 .

Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

K. Harada, H. Mizuguchi, E. Noguchi, 2014, Proceedings of the National Academy of Sciences.

Fiber-mutant technique can augment gene transduction efficacy and anti-tumor effects against established murine melanoma by cytokine-gene therapy using adenovirus vectors.

S. Nakagawa, T. Mayumi, H. Mizuguchi, 2002, Cancer letters.

Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV

K. Okuda, H. Mizuguchi, T. Hayakawa, 2005, Gene Therapy.

Adenovirus-Mediated MUC1 Gene Transduction into Human Blood-Derived Dendritic Cells

K. Yamaguchi, Y. Akiyama, H. Mizuguchi, 2001, Journal of immunotherapy.

RNA interference of PPARγ using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells

S. Nakagawa, T. Mayumi, H. Mizuguchi, 2005 .

Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells.

A. Ryo, H. Mizuguchi, K. Okuda, 2010, Vaccine.

A targeted adenovirus vector displaying a human fibronectin type III domain-based monobody in a fiber protein.

H. Mizuguchi, F. Sakurai, K. Katayama, 2013, Biomaterials.

Adenovirus Vector–Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity

H. Mizuguchi, Y. Fujio, F. Sakurai, 2020, The Journal of Immunology.

[Development of pegylated adenovirus vector for cancer gene therapy].

Y. Yoshioka, S. Nakagawa, H. Mizuguchi, 2008, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Role of N-Terminal Amino Acids in the Absorption-Enhancing Effects of the C-Terminal Fragment of Clostridium perfringens Enterotoxin

H. Mizuguchi, M. Fujii, Y. Horiguchi, 2005, Journal of Pharmacology and Experimental Therapeutics.

Intramuscular DNA immunization with in vivo electroporation induces antigen-specific cellular and humoral immune responses in both systemic and gut-mucosal compartments.

H. Mizuguchi, F. Sakurai, K. Katayama, 2012, Vaccine.

Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa.

K. Ishii, S. Akira, H. Mizuguchi, 2012, Biochemical and biophysical research communications.

Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector.

S. Nakagawa, H. Mizuguchi, T. Nakanishi, 2011, Biomaterials.

Transduction Properties of an Adenovirus Vector Containing Sequences Complementary to a Liver-Specific microRNA, miR-122a, in the 3'-Untranslated Region of the E4 Gene in Human Hepatocytes from Chimeric Mice with Humanized Liver.

K. Chayama, H. Mizuguchi, F. Sakurai, 2021, Biological & pharmaceutical bulletin.

Adenoviral Expression of Suppressor of Cytokine Signaling-1 Reduces Adenovirus Vector-Induced Innate Immune Responses1

S. Nakagawa, H. Mizuguchi, F. Sakurai, 2008, The Journal of Immunology.

Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure.

H. Mizuguchi, F. Sakurai, K. Kawabata, 2016, Journal of hepatology.

Fiber-Modified Adenovirus Vectors Decrease Liver Toxicity through Reduced IL-6 Production1

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2007, The Journal of Immunology.

Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration.

Y. Yoshioka, Y. Tsutsumi, S. Nakagawa, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Enhancement of survival rate by human iPSC-derived hepatocyte sheet transplantation in acute liver failure mice

H. Mizuguchi, F. Sakurai, K. Kawabata, 2016 .

Cytoplasmic gene expression system enhances the efficiency of cationic liposome-mediated in vivo gene transfer into mouse brain.

T. Kondo, T. Mayumi, H. Mizuguchi, 1997, Biochemical and biophysical research communications.

Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses

H. Mizuguchi, F. Sakurai, K. Katayama, 2011, Pharmaceutics.

Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors.

H. Mizuguchi, N. Okada, K. Yamanishi, 2007, Human gene therapy.

NK cells are migrated and indispensable in the anti-tumor activity induced by CCL27 gene therapy

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 2009, Cancer Immunology, Immunotherapy.

Intratumor administration of fusogenic liposomes containing fragment A of diphtheria toxin suppresses tumor growth.

T. Mayumi, H. Mizuguchi, T. Nakanishi, 1996, Cancer letters.

T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination

K. Ishii, S. Akira, H. Mizuguchi, 2017, Front. Immunol..

The Early Activation of CD8+ T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector

K. Ishii, S. Akira, H. Mizuguchi, 2014, BioMed research international.

Efficient gene transfer into murine pancreatic islets using adenovirus vectors.

H. Mizuguchi, F. Sakurai, K. Kawabata, 2007, Journal of controlled release : official journal of the Controlled Release Society.

A Flow Cytometry-Based Method to Determine the Titer of Adenoviruses Expressing an Extraneous Gene.

H. Mizuguchi, F. Sakurai, Y. Urata, 2018, Biological & pharmaceutical bulletin.

Adenovirus type 5 with modified hexons induces robust transgene‐specific immune responses in mice with pre‐existing immunity against adenovirus type 5

H. Mizuguchi, K. Okuda, D. Klinman, 2009, The journal of gene medicine.

[Differentiation of functional cells from iPS cells by efficient gene transfer].

H. Mizuguchi, K. Kawabata, K. Tashiro, 2010, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Gene delivery into stem cells by modified adenovirus vectors

H. Mizuguchi, F. Sakurai, K. Kawabata, 2007 .

Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice

T. Mayumi, H. Mizuguchi, T. Hayakawa, 2003, Gene Therapy.

Evaluation of Transduction Properties of an Adenovirus Vector in Neonatal Mice

H. Mizuguchi, F. Sakurai, K. Ohashi, 2015, BioMed research international.

Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA

H. Mizuguchi, F. Sakurai, M. Tachibana, 2016, Scientific Reports.

Suppressive effects of sugar-modified cationic liposome/NF-kappaB decoy complexes on adenovirus vector-induced innate immune responses.

S. Kawakami, M. Hashida, H. Mizuguchi, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors.

T. Mayumi, H. Mizuguchi, T. Hayakawa, 2003, Biochimica et biophysica acta.

Efficient Gene Transduction of Dispersed Islet Cells in Culture Using Fiber-Modified Adenoviral Vectors.

T. Okano, H. Mizuguchi, F. Sakurai, 2015, Cell medicine.

Tumor suppressive efficacy through augmentation of tumor-infiltrating immune cells by intratumoral injection of chemokine-expressing adenoviral vector

S. Nakagawa, H. Mizuguchi, T. Fujita, 2006, Cancer Gene Therapy.

Intratracheal Delivery of CX3CL1-Expressing Mesenchymal Stem Cells to Multiple Lung Tumors

H. Mizuguchi, H. Xin, Ruowen Sun, 2009, Molecular medicine.

Engineering of highly immunogenic long-lived DC vaccines by antiapoptotic protein gene transfer to enhance cancer vaccine potency

H. Mizuguchi, T. Yoshikawa, N. Okada, 2008, Gene Therapy.

Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus.

H. Mizuguchi, F. Sakurai, Kazuo Takayama, 2021, Virus research.

An improved method for detection of replication-competent retrovirus in retrovirus vector products.

H. Mizuguchi, T. Hayakawa, E. Uchida, 2004, Biologicals : journal of the International Association of Biological Standardization.

Gene transduction efficiency and maturation status in mouse bone marrow-derived dendritic cells infected with conventional or RGD fiber-mutant adenovirus vectors

H. Mizuguchi, T. Hayakawa, T. Fujita, 2003, Cancer Gene Therapy.

Prevention of Autoantibody-Mediated Graves’-Like Hyperthyroidism in Mice with IL-4, a Th2 Cytokine

H. Mizuguchi, T. Hayakawa, B. Rapoport, 2003, The Journal of Immunology.

A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression.

T. Fujiwara, H. Mizuguchi, F. Uno, 2012, European journal of cancer.

Optimization of adenovirus serotype 35 vectors for efficient transduction in human hematopoietic progenitors: comparison of promoter activities

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2005, Gene Therapy.

Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody.

T. Fujiwara, H. Mizuguchi, S. Kagawa, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

NF-κB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector

H. Mizuguchi, F. Sakurai, M. Tachibana, 2016, Scientific Reports.

Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer

H. Mizuguchi, H. Iwao, E. Sasaki, 2004, Gene Therapy.

Receptor-independent augmentation of adenovirus-mediated gene transfer with chitosan in vitro.

H. Mizuguchi, T. Hayakawa, Toshinori Sato, 2002, Biomaterials.

Tumor Necrosis Factor α‐Gene Therapy for an Established Murine Melanoma Using RGB (Arg‐Gly‐Asp) Fiber‐mutant Adenovirus Vectors

S. Nakagawa, T. Mayumi, H. Mizuguchi, 2002, Japanese journal of cancer research : Gann.

EpCAM‐ and EGFR‐targeted selective gene therapy for biliary cancers using Z33‐fiber‐modified adenovirus

I. Hyodo, H. Mizuguchi, Y. Obata, 2011, International journal of cancer.

Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors

H. Mizuguchi, T. Hayakawa, H. Xin, 2006, European journal of immunology.

Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector.

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 2003, Cancer research.

Development of fiber-substituted adenovirus vectors containing foreign peptides in the adenovirus serotype 35 fiber knob

H. Mizuguchi, K. Yamanishi, F. Sakurai, 2009, Gene Therapy.

Comparison of transgene expression mediated by several Fiber-modified adenovirus vectors in trophoblast cells.

H. Mizuguchi, T. Hayakawa, T. Nakanishi, 2005, Placenta.

A soluble CAR‐SCF fusion protein improves adenoviral vector‐mediated gene transferto c‐Kit‐positive hematopoietic cells

H. Mizuguchi, T. Hayakawa, H. Mizukami, 2003, The journal of gene medicine.

Generation of fiber‐modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob

H. Mizuguchi, T. Hayakawa, N. Utoguchi, 2003, The journal of gene medicine.

Modification of a fiber protein in an adenovirus vector improves in vitro gene transfer efficiency to the mouse microglial cell line

F. Shibasaki, H. Mizuguchi, T. Hayakawa, 2002, Neuroscience Letters.

Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells.

K. Sekiguchi, H. Mizuguchi, F. Sakurai, 2016, Biochemical and biophysical research communications.

Modification of pIX or hexon based on fiberless Ad vectors is not effective for targeted Ad vectors.

S. Nakagawa, H. Mizuguchi, F. Sakurai, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Fiber-modified adenovirus vectors containing the TAT peptide derived from HIV-1 in the fiber knob have efficient gene transfer activity

S. Nakagawa, H. Okamoto, H. Mizuguchi, 2007, Gene Therapy.

Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon

S. Nakagawa, H. Mizuguchi, T. Hayakawa, 2007, Gene Therapy.

Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo.

P. Bosma, H. Mizuguchi, R. O. Oude Elferink, 2009, World journal of gastroenterology.

Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2013, Stem cell reports.

Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells.

H. Mizuguchi, T. Yamashita, F. Sakurai, 2018, Biochemical and biophysical research communications.

On the mechanism of plasmin-induced platelet aggregation. Implications of the dual role of granule ADP.

H. Mizuguchi, T. Hayakawa, A. Ishii‐Watabe, 2000, Biochemical pharmacology.

Adenovirus vectors containing chimeric type 5 and type 35 fiber proteins exhibit altered and expanded tropism and increase the size limit of foreign genes.

H. Mizuguchi, T. Hayakawa, 2002, Gene.

Preparation of glial extracellular matrix: a novel method to analyze glial-endothelial cell interaction.

T. Mayumi, H. Mizuguchi, N. Utoguchi, 1997, Brain research. Brain research protocols.

Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase

H. Mizuguchi, T. Hayakawa, 2002, Cancer Gene Therapy.

Efficient gene transfer into human CD34+ cells by an adenovirus type 35 vector

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2003, Gene Therapy.

Strength evaluation of transcriptional regulatory elements for transgene expression by adenovirus vector.

T. Mayumi, H. Mizuguchi, T. Hayakawa, 2002, Journal of controlled release : official journal of the Controlled Release Society.

Glial extracellular matrix modulates γ-glutamyl transpeptidase activity in cultured bovine brain capillary and bovine aortic endothelial cells

S. Nakagawa, T. Mayumi, H. Mizuguchi, 1994, Brain Research.

Cotransduction of CCL27 gene can improve the efficacy and safety of IL-12 gene therapy for cancer

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 2007, Gene Therapy.

Adenoviral‐encoded antigens are presented efficiently by a subset of dendritic cells expressing high levels of αvβ3 integrins

M. Roth, H. Mizuguchi, A. Harui, 2006 .

Efficient osteoblast differentiation from mouse bone marrow stromal cells with polylysin-modified adenovirus vectors.

H. Mizuguchi, T. Hayakawa, K. Yamanishi, 2009, Biochemical and biophysical research communications.

Ca(2+) spiking activity caused by the activation of store-operated Ca(2+) channels mediates TNF-α release from microglial cells under chronic purinergic stimulation.

T. Yoshioka, H. Mizuguchi, M. Ikeda, 2013, Biochimica et biophysica acta.

Coating with spermine-pullulan polymer enhances adenoviral transduction of mesenchymal stem cells

Y. Tabata, S. Nakagawa, H. Mizuguchi, 2016, International journal of nanomedicine.

Establishment of MDR1-knockout human enteroids for pharmaceutical application.

H. Mizuguchi, T. Yamashita, H. Nakase, 2022, Drug metabolism and pharmacokinetics.

Abstract 706: A novel photodynamic therapy with virus-mediated delivery of photosensitive cytotoxic fluorescent protein KillerRed for human cancers

T. Fujiwara, H. Mizuguchi, H. Tazawa, 2014 .

In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus

S. Kyo, T. Fujiwara, H. Mizuguchi, 2006, Nature Medicine.

Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 (‘Telomelysin-RGD’)

S. Kyo, T. Fujiwara, H. Mizuguchi, 2005, Oncogene.

Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells

K. Harada, H. Mizuguchi, T. Yamashita, 2019, Drug Metabolism and Disposition.

Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice

Yuka Egusa, H. Mizuguchi, F. Sakurai, 2022, PloS one.

Chimeric adenovirus type 5/35 vector encoding SIV gag and HIV env genes affords protective immunity against the simian/human immunodeficiency virus in monkeys.

H. Mizuguchi, N. Yamamoto, K. Xin, 2007, Virology.

Design and synthesis of a Tat-related gene transporter: a tool for carrying the adenovirus vector into cells.

S. Nakagawa, T. Mayumi, H. Mizuguchi, 2006, Bioorganic & medicinal chemistry letters.

Development of recombinant viruses containing microRNA-regulated gene expression system

H. Mizuguchi, F. Sakurai, K. Kawabata, 2009 .

Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1‐Expressing Mesoderm

H. Mizuguchi, K. Kawabata, Tomoko Yamaguchi, 2015, Stem cells translational medicine.

TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector.

K. Ishii, S. Akira, H. Mizuguchi, 2016, International immunology.

Kobe University Repository : Kernel タイトル Tit le Human Herpesvirus-6 U 14 Induces Cell-Cycle Arrest in G 2 / M Phase by Associat ing with a Cellular Protein

H. Mizuguchi, K. Kuroda, Huamin Tang, 2019 .

Human Herpesvirus-6 U14 Induces Cell-Cycle Arrest in G2/M Phase by Associating with a Cellular Protein, EDD

H. Mizuguchi, K. Kuroda, Huamin Tang, 2015, PloS one.

Optimization of antitumor efficacy and safety of in vivo cytokine gene therapy using RGD fiber-mutant adenovirus vector for preexisting murine melanoma.

T. Mayumi, H. Mizuguchi, T. Hayakawa, 2004, Biochimica et biophysica acta.

Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells

H. Mizuguchi, Yoji Sato, A. Matsuyama, 2019, Scientific Reports.

Expression of HIF-1α ODD domain fused canine caspase 3 by EGFR promoter-driven adenovirus vector induces cytotoxicity in canine breast tumor cells under hypoxia

H. Mizuguchi, M. Okamoto, T. Ikeda, 2016, Veterinary Research Communications.

Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer

T. Fujiwara, H. Mizuguchi, F. Sakurai, 2016, Molecular Cancer Therapeutics.

Centrifugation enhances integrin-mediated transduction of dendritic cells by conventional and RGD-modified adenoviral vectors.

M. Roth, H. Mizuguchi, A. Harui, 2006, Journal of immunological methods.

Graves'-Like Hyperthyroidism in Mice with Prevention of Autoantibody-Mediated

H. Mizuguchi, T. Hayakawa, B. Rapoport, 2003 .

Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob.

H. Mizuguchi, F. Sakurai, K. Katayama, 2011, Virus research.

[Characterization of adenovirus serotype 35 vectors using genetically modified animals and non-human primates].

H. Mizuguchi, F. Sakurai, K. Kawabata, 2006, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Label-free assessment of hiPS-derived hepatocytes by Raman microscopy

H. Mizuguchi, K. Fujita, Menglu Li, 2022, BiOS.

Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells

H. Mizuguchi, F. Sakurai, K. Kawabata, 2007, International journal of cancer.

Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models.

Y. Yoshioka, Y. Tsutsumi, S. Nakagawa, 2010, International immunopharmacology.

Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration

H. Mizuguchi, H. Kamada, F. Sakurai, 2018, Scientific Reports.

NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.

Y. Saga, H. Mizuguchi, H. Mizukami, 2013, Cancer research.

Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells.

S. Nakagawa, T. Mayumi, H. Mizuguchi, 2005, Bioorganic & medicinal chemistry letters.

A selective cytotoxic adenovirus vector for concentration of pluripotent stem cells in human pluripotent stem cell-derived neural progenitor cells

H. Mizuguchi, Yoji Sato, A. Matsuyama, 2021, Scientific Reports.

Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome.

K. Yagi, H. Mizuguchi, T. Hayakawa, 2011, Virus research.

[Development of improved adenovirus vectors and transduction into neural cells].

H. Mizuguchi, F. Sakurai, K. Katayama, 2011, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Development of an adenovirus vector lacking the expression of virus-associated RNAs.

H. Mizuguchi, H. Miyoshi, F. Sakurai, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector.

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 2005, Biological & pharmaceutical bulletin.

Downregulation of human CD46 by adenovirus serotype 35 vectors

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2007, Gene Therapy.

Enhanced antitumor effect of combined replicative adenovirus and nonreplicative adenovirus expressing interleukin-12 in an immunocompetent mouse model

H. Mizuguchi, T. Hayakawa, K. Nakao, 2003, Gene Therapy.

Targeted Delivery of CX3CL1 to Multiple Lung Tumors by Mesenchymal Stem Cells

H. Mizuguchi, T. Hayakawa, H. Xin, 2007, Stem cells.

Characterization of in vitro and in vivo gene transfer properties of adenovirus serotype 35 vector.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Enhanced expression of the β4-galactosyltransferase 2 gene impairs mammalian tumor growth

K. Kato, H. Mizuguchi, M. Tagawa, 2014, Cancer Gene Therapy.

Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction.

Takao Hayakawa, Hiroyuki Mizuguchi, H. Mizuguchi, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction.

Takao Hayakawa, Hiroyuki Mizuguchi, H. Mizuguchi, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox Gene HEX

Hidenori Akutsu, Takao Hayakawa, Akihiro Umezawa, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Novel polyvalent live vaccine against varicella–zoster and mumps virus infections

H. Mizuguchi, K. Yamanishi, K. Kawabata, 2013, Microbiology and immunology.

miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers

N. Sakamoto, H. Mizuguchi, T. Imaizumi, 2019, Virology Journal.

Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection.

Yoshiharu Matsuura, Hiroyuki Mizuguchi, Masuo Kondoh, 2011, Biochemical and biophysical research communications.

Combination of two fiber-mutant adenovirus vectors, one encoding the chemokine FKN and another encoding cytokine interleukin 12, elicits notably enhanced anti-tumor responses

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 2008, Cancer Immunology, Immunotherapy.

miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy.

K. Yagi, H. Mizuguchi, F. Sakurai, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy.

K. Yagi, H. Mizuguchi, F. Sakurai, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2

H. Mizuguchi, F. Sakurai, M. Tachibana, 2017, Journal of Virology.

Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

H. Mizuguchi, F. Sakurai, K. Katayama, 2014, Molecular therapy. Methods & clinical development.

Generation of Tetrafluoroethylene–Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies

F. Yamashita, Y. Torisawa, H. Mizuguchi, 2021, ACS omega.

Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes.

K. Maeda, H. Kusuhara, F. Yamashita, 2021, ACS biomaterials science & engineering.

A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2

H. Mizuguchi, F. Sakurai, K. Kawabata, 2017, Scientific Reports.

MicroRNA-regulated transgene expression systems for gene therapy and virotherapy.

H. Mizuguchi, F. Sakurai, K. Katayama, 2011, Frontiers in bioscience.

Optimization of a microRNA expression vector for function analysis of microRNA.

N. Seki, H. Mizuguchi, F. Sakurai, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Characteristics of adenovirus-mediated tetracycline-controllable expression system.

H. Mizuguchi, T. Hayakawa, 2001, Biochimica et biophysica acta.

Vanadate enhances leptin-induced activation of JAK/STAT pathway in CHO cells.

H. Mizuguchi, T. Hayakawa, K. Eguchi, 2003, Biochemical and biophysical research communications.

Enhanced Cancer Immunotherapy Using STAT3-Depleted Dendritic Cells with High Th1-Inducing Ability and Resistance to Cancer Cell-Derived Inhibitory Factors

K. Takeda, H. Mizuguchi, M. Miyagishi, 2011, The Journal of Immunology.

Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cells

T. Hibi, H. Mizuguchi, T. Kanai, 2012, Gastric Cancer.

Generation of Brain Microvascular Endothelial-Like Cells from Human Induced Pluripotent Stem Cells by Co-Culture with C6 Glioma Cells

H. Mizuguchi, K. Kawabata, Tomoko Yamaguchi, 2015, PloS one.

Neonatal Gene Therapy for Hemophilia B by a Novel Adenovirus Vector Showing Reduced Leaky Expression of Viral Genes

H. Mizuguchi, F. Sakurai, K. Ohashi, 2017, Molecular therapy. Methods & clinical development.

Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening.

H. Mizuguchi, Kazuo Takayama, 2017, Drug metabolism and pharmacokinetics.

Efficient adenovirus vector‐mediated PPAR gamma gene transfer into mouse embryoid bodies promotes adipocyte differentiation

H. Mizuguchi, K. Yamanishi, F. Sakurai, 2008, The journal of gene medicine.

Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells

H. Mizuguchi, F. Sakurai, M. Tachibana, 2017, Stem Cell Reviews and Reports.

Nanaomycin A treatment promotes hepatoblast differentiation from human iPS cells

H. Mizuguchi, F. Sakurai, Kazuo Takayama, 2018 .

Efficient Adipocyte and Osteoblast Differentiation from Mouse Induced Pluripotent Stem Cells by Adenoviral Transduction

H. Mizuguchi, T. Hayakawa, K. Yamanishi, 2009, Stem cells.

A Novel Murine Model of Graves’ Hyperthyroidism with Intramuscular Injection of Adenovirus Expressing the Thyrotropin Receptor

Masami Niwa, Takao Ando, Takao Hayakawa, 2002, The Journal of Immunology.

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

H. Mizuguchi, F. Sakurai, Kazuo Takayama, 2017, Scientific Reports.

Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells

K. Harada, H. Mizuguchi, E. Noguchi, 2017, Scientific Reports.

Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells

Ryuji Kato, H. Mizuguchi, H. Nikawa, 2016, Stem cells and development.

Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine

H. Mizuguchi, F. Sakurai, K. Kawabata, 2015, Scientific Reports.

Endodermal and Hepatic Differentiation from Human Embryonic StemCells and Human Induced Pluripotent Stem Cells

H. Mizuguchi, K. Kawabata, Kazuo Takayama, 2012 .

Simultaneous imaging of initiator/effector caspase activity and mitochondrial membrane potential during cell death in living HeLa cells.

H. Mizuguchi, T. Hayakawa, Tetsu Kobayashi, 2004, Biochimica et biophysica acta.

Improved gene transfer into bladder cancer cells using adenovirus vector containing RGD motif.

K. Hamada, H. Mizuguchi, A. Gotoh, 2012, Anticancer research.

Efficient generation of adenovirus vectors carrying the Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated proteins (Cas)12a system by suppressing Cas12a expression in packaging cells.

H. Mizuguchi, F. Sakurai, E. Sakai, 2019, Journal of biotechnology.

Generation of the Adenovirus Vector-Mediated CRISPR/Cpf1 System and the Application for Primary Human Hepatocytes Prepared from Humanized Mice with Chimeric Liver.

H. Mizuguchi, F. Sakurai, E. Sakai, 2018, Biological & pharmaceutical bulletin.

Efficient and Directive Generation of Two Distinct Endoderm Lineages from Human ESCs and iPSCs by Differentiation Stage-Specific SOX17 Transduction

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2011, PloS one.

Upregulation of RECK gene expression by small double-stranded RNA targeting the promoter region

H. Mizuguchi, F. Sakurai, M. Tachibana, 2014, Cancer Gene Therapy.

Characteristics of transcription-regulatory elements for gene expression from plasmid vectors in human trophoblast cell lines.

H. Mizuguchi, T. Nakanishi, M. Fujii, 2006, Placenta.

Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production

H. Mizuguchi, O. Kaminuma, F. Sakurai, 2019, International immunology.

Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells

H. Mizuguchi, M. Tagawa, M. Kawabata, 2011, Cancer Gene Therapy.

Comparison of human biopsy-derived and human iPS cell-derived intestinal organoids established from a single individual.

H. Mizuguchi, T. Yamashita, H. Nakase, 2022, Drug metabolism and pharmacokinetics.

Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research

K. Harada, H. Mizuguchi, T. Yamashita, 2021, Molecular therapy. Methods & clinical development.

Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies

K. Harada, H. Mizuguchi, F. Sakurai, 2018, Stem cell reports.

Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG.

N. Seki, M. Ohira, A. Nakagawara, 2002, Cancer research.

in a Mouse Mammary Epithelial Cell Line NMuMG by Using cDNA Microarray DEK and Proto-oncogene Cyclin B 1-regulated Genes that Include ING 1 Identification of the p 33 Updated

N. Seki, M. Ohira, A. Nakagawara, 2002 .

Adenoviral Vector Construction II

H. Mizuguchi, M. Hemmi, 2016 .

5 – Adenoviral Vector Construction II: Bacterial Systems

H. Mizuguchi, M. Hemmi, 2016 .

Rapid construction of small interfering RNA-expressing adenoviral vectors on the basis of direct cloning of short hairpin RNA-coding DNAs.

Takao Hayakawa, Hiroyuki Mizuguchi, H. Mizuguchi, 2006, Human gene therapy.

Detection of replication-competent adenoviruses spiked into recombinant adenovirus vector products by infectivity PCR.

H. Mizuguchi, T. Hayakawa, E. Uchida, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice

M. Okabe, H. Mizuguchi, T. Hayakawa, 2006, Gene Therapy.

CAR- or αv integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice

H. Mizuguchi, T. Hayakawa, E. Uchida, 2002, Gene Therapy.

The tet‐off system is more effective than the tet‐on system for regulating transgene expression in a single adenovirus vector

H. Mizuguchi, T. Hayakawa, 2002, The journal of gene medicine.

Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB

N. Kato, T. Fujiwara, H. Mizuguchi, 2017, Molecular therapy oncolytics.

Correlation between adenovirus-neutralizing antibody titer and adenovirus vector-mediated transduction efficiency following intratumoral injection.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2012, Anticancer research.

Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates.

H. Mizuguchi, T. Hayakawa, K. Terao, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

The short consensus repeats 1 and 2, not the cytoplasmic domain, of human CD46 are crucial for infection of subgroup B adenovirus serotype 35.

H. Mizuguchi, T. Hayakawa, N. Okada, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, alphav integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2006, Human gene therapy.

A simple method for constructing E1- and E1/E4-deleted recombinant adenoviral vectors.

M. Kay, H. Mizuguchi, H Mizuguchi, 1999, Human gene therapy.

Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method.

M. Kay, H. Mizuguchi, 1998, Human gene therapy.

IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector.

H. Mizuguchi, T. Hayakawa, E. Uchida, 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

Isolation and expansion of human pluripotent stem cell‐derived hepatic progenitor cells by growth factor defined serum‐free culture conditions

H. Mizuguchi, M. Furue, M. Suga, 2017, Experimental cell research.

Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells

K. Matsumoto, T. Nakamura, H. Mizuguchi, 2007, Cancer Gene Therapy.

Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transduction.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2012, Stem cell research.

Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells

H. Mizuguchi, Yoji Sato, A. Matsuyama, 2019, Scientific Reports.

Proteolytic Disassembly of Viral Outer Capsid Proteins Is Crucial for Reovirus-Mediated Type-I Interferon Induction in Both Reovirus-Susceptible and Reovirus-Refractory Tumor Cells

H. Mizuguchi, F. Sakurai, M. Tachibana, 2015, BioMed research international.

Adenovirus vector-mediated gene transfer into stem cells.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2006, Molecular pharmaceutics.

Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Targeted adenovirus vectors.

H. Mizuguchi, T. Hayakawa, 2004, Human gene therapy.

Sensitive detection of viable circulating tumor cells using a novel conditionally telomerase-selective replicating adenovirus in non-small cell lung cancer patients

Kenji Suzuki, H. Mizuguchi, Kazuhisa Takahashi, 2017, Oncotarget.

Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer

T. Fujiwara, H. Mizuguchi, F. Teraishi, 2020, Molecular therapy oncolytics.

The infectivity of progeny adenovirus in the presence of neutralizing antibody

H. Mizuguchi, F. Sakurai, M. Fujii, 2021, The Journal of general virology.

Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants.

S. Nakagawa, H. Mizuguchi, T. Fujita, 2008, Virology.

Interaction of penton base Arg-Gly-Asp motifs with integrins is crucial for adenovirus serotype 35 vector transduction in human hematopoietic cells

H. Mizuguchi, T. Hayakawa, T. Fujita, 2007, Gene Therapy.

Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system

H. Mizuguchi, Takashi Yamamoto, F. Sakurai, 2017, Nucleic acids research.

Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis.

Y. Tsutsumi, K. Yagi, H. Mizuguchi, 2008, Biochemical pharmacology.

Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin.

K. Yagi, H. Mizuguchi, M. Fujii, 2007, Biochemical pharmacology.

Efficient gene delivery into dendritic cells by fiber-mutant adenovirus vectors.

T. Mayumi, H. Mizuguchi, T. Hayakawa, 2001, Biochemical and biophysical research communications.

Regulated gene expression from adenovirus vectors: a systematic comparison of various inducible systems.

T. Mayumi, H. Mizuguchi, T. Hayakawa, 2003, Gene.

Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis

Y. Yoshioka, H. Mizuguchi, N. Okada, 2009, Gene Therapy.

Approaches for generating recombinant adenovirus vectors.

M. Kay, H. Mizuguchi, T. Hayakawa, 2001, Advanced drug delivery reviews.

Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration

H. Mizuguchi, H. Kamada, F. Sakurai, 2018, Scientific Reports.

Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner

K. Ishii, S. Akira, H. Mizuguchi, 2018, The Journal of Immunology.

In Vivo Biological Purging for Lymph Node Metastasis of Human Colorectal Cancer by Telomerase-Specific Oncolytic Virotherapy

S. Kyo, T. Fujiwara, H. Mizuguchi, 2010, Annals of surgery.

A Novel Strategy for the Enhancement of Drug Absorption Using a Claudin Modulator

H. Mizuguchi, T. Hayakawa, M. Fujii, 2005, Molecular Pharmacology.

Tumor-conditioned medium increases macromolecular permeability of endothelial cell monolayer.

Y. Tsutsumi, T. Mayumi, H. Mizuguchi, 1995, Cancer letters.

Transduction Properties of Adenovirus Serotype 35 Vectors After Intravenous Administration Into Nonhuman Primates.

Takao Hayakawa, Hiroaki Shibata, Hiroyuki Mizuguchi, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology

K. Harada, H. Mizuguchi, T. Okamoto, 2021, Hepatology communications.

Efficient antigen gene transduction using Arg-Gly-Asp fiber-mutant adenovirus vectors can potentiate antitumor vaccine efficacy and maturation of murine dendritic cells.

T. Mayumi, H. Mizuguchi, T. Hayakawa, 2001, Cancer research.

Downregulation of CD46 during muscle differentiation: implications for gene transfer to human skeletal muscle using group B adenoviruses.

P. Holland, H. Mizuguchi, V. Srivastava, 2008, Human gene therapy.

Enhanced Safety Profiles of the Telomerase-Specific Replication- Competent Adenovirus by Incorporation of Normal Cell-Specific microRNA-Targeted Sequences

T. Fujiwara, H. Mizuguchi, T. Hayakawa, 2011, Clinical Cancer Research.

A fiber modified adenovirus vector that targets to the EphrinA2 receptor reveals enhanced gene transfer to ex vivo pancreatic cancer.

D. Gouma, P. Bosma, K. Kuhlmann, 2009, International journal of oncology.

Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism

H. Mizuguchi, D. Okuzaki, F. Sakurai, 2022, Biochemistry and biophysics reports.

Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions.

T. Mayumi, H. Mizuguchi, T. Hayakawa, 2003, Human gene therapy.

Anti-tumor activity of chemokine is affected by both kinds of tumors and the activation state of the host's immune system: implications for chemokine-based cancer immunotherapy.

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 2004, Biochemical and biophysical research communications.

Tumor Necrosis Factor Â«-mediatedTumor Regression by the in Vivo Transfer of Genes into the Artery That Leads to Tumors1

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 2006 .

Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex

Hiroyuki Mizuguchi, Hideyoshi Harashima, Hidetaka Akita, 2007, Nucleic acids research.

Targeting the replication of adenovirus to p53-defective thyroid carcinoma with a p53-regulated Cre/loxP system

H. Mizuguchi, T. Hayakawa, H. Namba, 2001, Cancer Gene Therapy.

Review Targeted Adenovirus Vectors

H. Mizuguchi, T. Hayakawa, 2004 .

Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus

T. Fujiwara, H. Mizuguchi, F. Sakurai, 2016, Molecular therapy. Methods & clinical development.

Efficient gene delivery in human and rodent mast cells using adenovirus vectors.

H. Mizuguchi, F. Sakurai, K. Kawabata, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Efficient gene transfer into differentiated human trophoblast cells with adenovirus vector containing RGD motif in the fiber protein.

H. Mizuguchi, T. Nakanishi, M. Fujii, 2006, Biological & pharmaceutical bulletin.

Efficient regulation of gene expression using self-contained fiber-modified adenovirus vectors containing the tet-off system.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Improvement of Adenovirus Vectors for Gene Transfer

H. Mizuguchi, T. Hayakawa, 2002 .

Efficient gene transfer by fiber-mutant adenoviral vectors containing RGD peptide.

H. Mizuguchi, T. Hayakawa, E. Uchida, 2001, Biochimica et biophysica acta.

Improving gene transfer in human renal carcinoma cells: Utilization of adenovirus vectors containing chimeric type 5 and type 35 fiber proteins.

K. Hamada, H. Mizuguchi, A. Gotoh, 2010, Experimental and therapeutic medicine.

Improved gene transfer into renal carcinoma cells using adenovirus vector containing RGD motif.

K. Hamada, H. Mizuguchi, A. Gotoh, 2009, Anticancer research.

Oncolytic adenovirus serotype 35 mediated tumor growth suppression via efficient activation and tumor infiltration of natural killer cells

H. Mizuguchi, F. Sakurai, R. Ono, 2022, bioRxiv.

Immunogenic Comparison of Chimeric Adenovirus 5/35 Vector Carrying Optimized Human Immunodeficiency Virus Clade C Genes and Various Promoters

H. Mizuguchi, K. Okuda, M. Shimada, 2012, PloS one.

Fusion of sendai virus with liposome depends on only F protein, but not HN protein.

Y. Tsutsumi, T. Mayumi, H. Mizuguchi, 1999, Virus research.

Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors.

K. Yagi, H. Mizuguchi, H. Nishimori, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Designed recombinant adenovirus type 5 vector induced envelope‐specific CD8+ cytotoxic T lymphocytes and cross‐reactive neutralizing antibodies against human immunodeficiency virus type 1

H. Mizuguchi, K. Xin, K. Okuda, 2009, The journal of gene medicine.

Adenovirus vectors composed of subgroup B adenoviruses.

H. Mizuguchi, F. Sakurai, K. Kawabata, 2007, Current gene therapy.

Further reduction in adenovirus vector-mediated liver transduction without largely affecting transgene expression in target organ by exploiting microrna-mediated regulation and the Cre-loxP recombination system.

H. Mizuguchi, F. Sakurai, K. Katayama, 2012, Molecular pharmaceutics.

Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV.

H. Mizuguchi, K. Xin, K. Okuda, 2007, Vaccine.

Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines

Takeshi Tomonaga, Kenji Ishimoto, Hiroyuki Mizuguchi, 2016, Scientific Reports.

Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4.

H. Mizuguchi, F. Sakurai, T. Yokoi, 2014, Drug metabolism and pharmacokinetics.

Adenovirus vector-mediated assay system for hepatitis C virus replication

N. Sakamoto, K. Yagi, H. Mizuguchi, 2011, Nucleic acids research.

Quantitative analysis of the leaky expression of adenovirus genes in cells transduced with a replication-incompetent adenovirus vector.

H. Mizuguchi, F. Sakurai, K. Katayama, 2011, Molecular pharmaceutics.

Vector-Induced Innate Immune Responses Cytokine Signaling-1 Reduces Adenovirus Adenoviral Expression of Suppressor of

H. Mizuguchi, F. Sakurai, K. Kawabata, 2010 .

Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4.

H. Mizuguchi, M. Fujii, Y. Horiguchi, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Telomerase-Specific Virotheranostics for Human Head and Neck Cancer

S. Kyo, T. Fujiwara, H. Mizuguchi, 2009, Clinical Cancer Research.

A simple biological imaging system for detecting viable human circulating tumor cells.

S. Kyo, T. Fujiwara, H. Mizuguchi, 2009, The Journal of clinical investigation.

In Vivo Gene Expression Profile of Human Intestinal Epithelial Cells: From the Viewpoint of Drug Metabolism and Pharmacokinetics

H. Mizuguchi, T. Yamashita, D. Hirayama, 2020, Drug Metabolism and Disposition.

Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2012, Journal of hepatology.

The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets.

Takao Hayakawa, Hiroyuki Mizuguchi, H. Mizuguchi, 2012, Biomaterials.

Preparation of a Claudin-Targeting Molecule Using a C-Terminal Fragment of Clostridium perfringens Enterotoxin

H. Mizuguchi, M. Fujii, Y. Horiguchi, 2006, Journal of Pharmacology and Experimental Therapeutics.

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.

Takao Hayakawa, Hiroyuki Mizuguchi, K. Kanda, 2013, Biomaterials.

Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors.

K. Yagi, H. Mizuguchi, F. Sakurai, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.

K. Sekiguchi, H. Mizuguchi, F. Sakurai, 2018, Biomaterials.

miR-27b antagonizes BMP signaling in early differentiation of human induced pluripotent stem cells

H. Mizuguchi, F. Sakurai, E. Sakai, 2021, Scientific Reports.

Generation of Hepatocytes from Human ES/iPS Cells for Regenerative Medicine

H. Mizuguchi, T. Yamashita, Kazuo Takayama, 2021 .

HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin

H. Mizuguchi, F. Sakurai, K. Katayama, 2014, PloS one.

Hepatic Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by Two- and Three-Dimensional Culture Systems In Vitro

H. Mizuguchi, Maiko Higuchi, 2014 .

Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2017, Biological & pharmaceutical bulletin.

Photoactivatable oncolytic adenovirus for optogenetic cancer therapy

J. Ohta, K. Sasagawa, T. Tokuda, 2020, Cell Death & Disease.

A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X.

S. Nakagawa, H. Mizuguchi, F. Sakurai, 2012, Biomaterials.

Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy.

H. Mizuguchi, Kazuo Takayama, 2018, ACS chemical biology.

ETV2-TET1/TET2 Complexes Induce Endothelial Cell-Specific Robo4 Expression via Promoter Demethylation

W. Aird, H. Mizuguchi, Y. Okada, 2018, Scientific Reports.

Occludin as a functional marker of vascular endothelial cells on tube‐forming activity

H. Mizuguchi, Teruhide Yamaguchi, Y. Kikuchi, 2017, Journal of cellular physiology.

Efficient hepatic differentiation from human iPS cells by gene transfer.

H. Mizuguchi, K. Kawabata, Mitsuru Inamura, 2012, Methods in molecular biology.

CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision

T. Okano, H. Mizuguchi, T. Hayakawa, 2014, Development.

Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation.

H. Mizuguchi, S. Takaki, F. Sakurai, 2012, Stem cells and development.

Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2010, Cellular reprogramming.

Adenovirus Vector With ADP Gene Induces Cytopathic Effects in HEK293 Cells Without Significant Elevation of Virus Titers

H. Mizuguchi, F. Sakurai, Fumitaka Nishimae, 2022, AntiCancer Research.

ZFAND3 Overexpression in the Mouse Liver Improves Glucose Tolerance and Hepatic Insulin Resistance.

H. Mizuguchi, F. Sakurai, T. Nishinaka, 2021, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35

H. Mizuguchi, F. Sakurai, Kosuke Takayama, 2021, Molecular therapy oncolytics.

A MicroRNA Derived from Adenovirus Virus-Associated RNAII Promotes Virus Infection via Posttranscriptional Gene Silencing

H. Mizuguchi, F. Sakurai, M. Tachibana, 2018, Journal of Virology.

Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis

H. Mizuguchi, F. Sakurai, T. Nishinaka, 2017, Biochemistry and biophysics reports.

Identification of Adenovirus-Derived Cell-Penetrating Peptide.

H. Mizuguchi, F. Sakurai, M. Fujii, 2017, Biological & pharmaceutical bulletin.

Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xLMutant Gene

H. Mizuguchi, Yasuhito Tanaka, F. Sakurai, 2015, Cell transplantation.

Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells.

Y. Yoshioka, S. Nakagawa, H. Mizuguchi, 2014, Biochemical and biophysical research communications.

Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy.

Y. Yoshioka, S. Nakagawa, H. Mizuguchi, 2012, Biomacromolecules.

Title : Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation Running title : The role of Lnk in hematopoietic differentiation

H. Mizuguchi, S. Takaki, F. Sakurai, 2012 .

Adenovirus serotype 35 vector-induced innate immune responses in dendritic cells derived from wild-type and human CD46-transgenic mice: Comparison with a fiber-substituted Ad vector containing fiber proteins of Ad serotype 35.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer.

Y. Yoshioka, S. Nakagawa, H. Mizuguchi, 2010, Biological & pharmaceutical bulletin.

Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration.

Y. Yoshioka, S. Nakagawa, H. Mizuguchi, 2010, Biological & pharmaceutical bulletin.

Comparison of gene expression efficiency and innate immune response induced by Ad vector and lipoplex.

S. Nakagawa, H. Mizuguchi, F. Sakurai, 2007, Journal of controlled release : official journal of the Controlled Release Society.

A single intratumoral injection of a fiber-mutant adenoviral vector encoding interleukin 12 induces remarkable anti-tumor and anti-metastatic activity in mice with Meth-A fibrosarcoma.

Y. Tsutsumi, S. Nakagawa, T. Mayumi, 2005, Biochemical and biophysical research communications.

Efficient gene transfer into human trophoblast cells with adenovirus vector containing chimeric type 5 and 35 fiber protein.

H. Mizuguchi, T. Hayakawa, M. Fujii, 2004, Biological & pharmaceutical bulletin.

Neutralizing antibody evasion ability of adenovirus vector induced by the bioconjugation of methoxypolyethylene glycol succinimidyl propionate (MPEG-SPA).

Takao Hayakawa, Yasuo Tsutsumi, Tadanori Mayumi, 2004, Biological & pharmaceutical bulletin.

Quantitative Analysis of Virus-associated RNAI Expression following Transduction with a Replication-incompetent Adenovirus Vector In Vitro and In Vivo

H. Mizuguchi, F. Sakurai, M. Tachibana, 2014 .

Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy.

Y. Yoshioka, S. Nakagawa, H. Mizuguchi, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Cancer Cell-Derived Inhibitory Factors Th1-Inducing Ability and Resistance to STAT3-Depleted Dendritic Cells with High Enhanced Cancer Immunotherapy Using

K. Takeda, H. Mizuguchi, M. Miyagishi, 2011 .

DRUG DISCOVERY AND GENOMIC TECHNOLOGIES Benchmark In Vitro Ligation-Based Cloning of Foreign DNAs into the E 3 and E 1 Deletion Regions for Generation of Recombinant Adenovirus Vectors

M. Kay, H. Mizuguchi, T. Hayakawa, 2005 .

In vitro ligation-based cloning of foreign DNAs into the E3 and E1 deletion regions for generation of recombinant adenovirus vectors.

M. Kay, H. Mizuguchi, T. Hayakawa, 2001, BioTechniques.

FGF signal is not required for hepatoblast differentiation of human iPS cells

H. Mizuguchi, F. Sakurai, Kazuo Takayama, 2019, Scientific Reports.

[Basic study for next-generation gene therapy products].

H. Mizuguchi, 2003, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells.

N. Sakamoto, H. Mizuguchi, T. Wakita, 2017, Virus research.

Impact of convective flow on the cellular uptake and transfection activity of lipoplex and adenovirus.

T. Fujiwara, K. Furukawa, T. Ushida, 2006, Biological & pharmaceutical bulletin.

A comparison of drug transport through cultured monolayers of bovine brain capillary and bovine aortic endothelial cells.

T. Mayumi, H. Mizuguchi, S. Nakagawa, 1994, Biological & pharmaceutical bulletin.

RNA interference of PPARgamma using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells.

S. Nakagawa, T. Mayumi, H. Mizuguchi, 2005, Gene.

Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies.

H. Mizuguchi, T. Yamashita, M. Harada‐Shiba, 2019, Biological & pharmaceutical bulletin.

A doxycycline-inducible CYP3A4-Caco-2 cell line as a model for evaluating safety of aflatoxin B1 in the human intestine.

H. Mizuguchi, M. Okuda, M. Kondoh, 2022, Toxicology letters.

Pre-treatment of oncolytic reovirus improves tumor accumulation and intratumoral distribution of PEG-liposomes.

H. Mizuguchi, F. Sakurai, A. Kasai, 2023, Journal of controlled release : official journal of the Controlled Release Society.

Activity levels of cathepsins B and L in tumor cells are a biomarker for efficacy of reovirus-mediated tumor cell killing

H. Mizuguchi, F. Sakurai, M. Tachibana, 2015, Cancer Gene Therapy.

A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy

S. Kyo, T. Fujiwara, H. Mizuguchi, 2010, Oncogene.

Clinical features of squamous cell lung cancer with anaplastic lymphoma kinase (ALK)-rearrangement: a retrospective analysis and review

H. Mizuguchi, Kazuhisa Takahashi, F. Sakurai, 2018, Oncotarget.

Targeted Photodynamic Virotherapy Armed with a Genetically Encoded Photosensitizer

T. Fujiwara, H. Mizuguchi, S. Kagawa, 2015, Molecular Cancer Therapeutics.

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

H. Mizuguchi, F. Sakurai, Kazuo Takayama, 2017, Scientific Reports.

Comparison of culture media for human intestinal organoids from the viewpoint of pharmacokinetic studies.

H. Mizuguchi, T. Yamashita, H. Nakase, 2021, Biochemical and biophysical research communications.

Development of a 3D Cell Culture System Using Amphiphilic Polydepsipeptides and Its Application to Hepatic Differentiation

H. Mizuguchi, Hayato Matsui, Masaki Kanai, 2021, ACS Applied Bio Materials.

A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2

H. Mizuguchi, F. Sakurai, K. Kawabata, 2017, Scientific Reports.

Cationic liposome-mediated delivery of reovirus enhances the tumor cell-killing efficiencies of reovirus in reovirus-resistant tumor cells.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2017, International journal of pharmaceutics.

Oncolytic reovirus-mediated killing of mouse cancer-associated fibroblasts.

H. Mizuguchi, F. Sakurai, I. Ishigami, 2021, International journal of pharmaceutics.

Plasma elevation of vascular endothelial growth factor leads to the reduction of mouse hematopoietic and mesenchymal stem/progenitor cells in the bone marrow.

H. Mizuguchi, K. Kawabata, Tomoko Yamaguchi, 2014, Stem Cells and Development.

Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan

H. Mizuguchi, K. Ozawa, K. Mitani, 2020, Human gene therapy.

miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers

N. Sakamoto, H. Mizuguchi, T. Imaizumi, 2019, Virology Journal.

Development of a method of passaging and freezing human iPS cell-derived hepatocytes to improve their functions

H. Mizuguchi, Seiji Mitani, Jumpei Inui, 2023, PloS one.

Effect of therapeutic immunization using Ad5/35 and MVA vectors on SIV infection of rhesus monkeys undergoing antiretroviral therapy

H. Mizuguchi, K. Okuda, D. Klinman, 2009, Gene Therapy.

Gene delivery systems using the Sendai virus.

T. Mayumi, H. Mizuguchi, T. Hayakawa, 1999, Molecular membrane biology.

A novel nonviral vector based on vesicular stomatitis virus.

T. Mayumi, H. Mizuguchi, T. Nakanishi, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Biliary epithelial cell differentiation of bipotent human liver-derived organoids by 2D and 3D culture

H. Mizuguchi, Yukiko Ueyama-Toba, Yanran Tong, 2023, Biochemistry and biophysics reports.

miR-27b targets MAIP1 to mediate lipid accumulation in cultured human and mouse hepatic cells

H. Mizuguchi, F. Sakurai, Eiko Sakai, 2023, Communications biology.

Regional Transcriptomics and Proteomics of Pharmacokinetics-Related Genes in Human Intestine.

H. Mizuguchi, T. Yamashita, D. Hirayama, 2023, Molecular pharmaceutics.

Application of fusogenic liposomes containing fragment A of diphtheria toxin to cancer therapy.

T. Mayumi, H. Mizuguchi, T. Nakanishi, 1996, British Journal of Cancer.

Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system

H. Mizuguchi, Kazuo Takayama, Moe Ichikawa, 2021, Scientific Reports.

Adenovirus targeting for gene therapy of pancreatic cancer

P. Bosma, H. Mizuguchi, R. Elferink, 2011 .

Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus

H. Mizuguchi, F. Sakurai, Fumitaka Nishimae, 2022, Scientific reports.

Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a.

N. Sakamoto, K. Yagi, H. Mizuguchi, 2012, Virus research.

Human iPS Cell–based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B

H. Suemizu, H. Mizuguchi, F. Sakurai, 2018, Cell transplantation.

H. Mizuguchi, F. Sakurai, K. Katayama, 2012, Molecular pharmaceutics.

Label-Free Evaluation of Maturation and Hepatotoxicity of Human iPSC-Derived Hepatocytes Using Hyperspectral Raman Imaging.

H. Mizuguchi, Y. Kumamoto, K. Fujita, 2023, Analytical chemistry.

Two-step differentiation of mast cells from induced pluripotent stem cells.

K. Fukuda, H. Mizuguchi, K. Kawabata, 2013, Stem cells and development.

Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa.

K. Ishii, S. Akira, H. Mizuguchi, 2012, Biochemical and biophysical research communications.

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.

K. Kanda, H. Mizuguchi, T. Hayakawa, 2013, Biomaterials.

Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation

H. Mizuguchi, Jumpei Inui, Akira Watanabe, 2023, Molecular Therapy: Methods & Clinical Development.

FGF signal is not required for hepatoblast differentiation of human iPS cells

H. Mizuguchi, F. Sakurai, Kazuo Takayama, 2019, Scientific Reports.

Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a.

N. Sakamoto, K. Yagi, H. Mizuguchi, 2012, Virus research.

Identification of Adenovirus-Derived Cell-Penetrating Peptide.

H. Mizuguchi, F. Sakurai, M. Fujii, 2017, Biological & pharmaceutical bulletin.

Gamma-delta T Cells may Function as Carrier Vehicles in Adenovirus Vector-based Gene Therapy

H. Mizuguchi, T. Aoi, M. Naoe, 2013 .

Efficient gene transfer into mammalian cells using fusogenic liposome.

T. Mayumi, H. Mizuguchi, M. Nakanishi, 1996, Biochemical and biophysical research communications.

Establishment of MDR1-knockout human induced pluripotent stem cell line.

H. Mizuguchi, Kazuo Takayama, Ryosuke Negoro, 2020, Drug metabolism and pharmacokinetics.

Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies

H. Mizuguchi, T. Yamashita, K. Hirata, 2019, Molecular therapy. Methods & clinical development.

Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2016, Biochemical and biophysical research communications.

Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants.

S. Nakagawa, H. Mizuguchi, T. Fujita, 2008, Virology.

Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy.

Y. Yoshioka, S. Nakagawa, H. Mizuguchi, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection.

N. Sakamoto, K. Yagi, H. Mizuguchi, 2011, Biochemical and biophysical research communications.

Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome.

K. Yagi, H. Mizuguchi, T. Hayakawa, 2011, Virus research.

Treatment of Human Pancreatic Cancers Following Local and Systemic Administration of Oncolytic Adenovirus Serotype 35

H. Mizuguchi, F. Sakurai, Kosuke Takayama, 2023, AntiCancer Research.

Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1α

H. Mizuguchi, F. Sakurai, T. Hotani, 2023, Inflammation.

Oncolytic adenovirus serotype 35 mediated tumor growth suppression via efficient activation and tumor infiltration of natural killer cells

H. Mizuguchi, F. Sakurai, R. Ono, 2023, bioRxiv.