I. Imoto

发表

RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest

C. Tanikawa, Y. Nakamura, J. Inazawa, 2007, Oncogene.

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

M. Kanai, Y. Kamatani, Y. Okada, 2020, Nature Genetics.

Large scale genome-wide association study in a Japanese population identified 45 novel susceptibility loci for 22 diseases

M. Kanai, Y. Kamatani, Y. Okada, 2019, bioRxiv.

Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer.

J. Inazawa, I. Imoto, K. Omura, 2008, Cancer research.

Early manifestations of BPAN in a pediatric patient

I. Imoto, N. Okamoto, Tae Ikeda, 2014, American journal of medical genetics. Part A.

Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy

Y. Miki, J. Inazawa, Y. Eishi, 2008, The British journal of surgery.

Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines.

E Soeda, J. Inazawa, E. Soeda, 2000, Biochemical and biophysical research communications.

Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas

J. Inazawa, I. Imoto, M. Kitagawa, 2007, Oncogene.

Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification.

F. Hosoda, J. Inazawa, M. Ohki, 2005, Cancer research.

PPM1D is a potential target for 17q gain in neuroblastoma.

Akira Nakagawara, J. Inazawa, A. Nakagawara, 2003, Cancer research.

Novel targets for the 18p11.3 amplification frequently observed in esophageal squamous cell carcinomas.

J. Inazawa, I. Imoto, M. Imamura, 2002, Carcinogenesis.

miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma.

Shinji Tanaka, J. Inazawa, I. Imoto, 2010, Carcinogenesis.

SNP array screening of cryptic genomic imbalances in 450 Japanese subjects with intellectual disability and multiple congenital anomalies previously negative for large rearrangements

J. Inazawa, S. Saitoh, A. Hata, 2016, Journal of Human Genetics.

Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma

Kazuya Kondo, Kiyoshi Masuda, A. Tangoku, 2016, Oncotarget.

Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue.

J. Inazawa, H. Tsuda, I. Imoto, 2008, International journal of oral and maxillofacial surgery.

Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas.

J. Inazawa, H. Tsuda, I. Imoto, 2005, Cancer letters.

Genetic or epigenetic silencing of low density lipoprotein receptor‐related protein 1B expression in oral squamous cell carcinoma

J. Inazawa, I. Imoto, T. Nakagawa, 2006, Cancer science.

TP63 mutation mapping information in TP63 mutation-associated syndromes

I. Imoto, Y. Harazono, T. Yoda, 2022, Advances in Oral and Maxillofacial Surgery.

The expression and clinical significance of connective tissue growth factor in advanced head and neck squamous cell cancer

A. Shiotani, H. Tsuda, I. Imoto, 2014, Human Cell.

Conservation of the TGFβ/Labial Homeobox Signaling Loop in Endoderm-Derived Cells between Drosophila and Mammals

I. Imoto, G. Lomberk, R. Urrutia, 2010, Pancreatology.

Functionally confirmed compound heterozygous ADAM17 missense loss-of-function variants cause neonatal inflammatory skin and bowel disease 1

K. Horiuchi, K. Masuda, I. Imoto, 2021, Scientific Reports.

Heterozygous deletion at 14q22.1–q22.3 including the BMP4 gene in a patient with psychomotor retardation, congenital corneal opacity and feet polysyndactyly

J. Inazawa, A. Hata, I. Imoto, 2008, American journal of medical genetics. Part A.

Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels

I. Imoto, A. Tajima, Takehiro Sato, 2020, Journal of Human Genetics.

Lysosomal-Associated Protein Multispanning Transmembrane 5 Gene (LAPTM5) Is Associated with Spontaneous Regression of Neuroblastomas

S. Ichinose, J. Inazawa, I. Imoto, 2009, PloS one.

No association between the COMT Val158Met polymorphism and the long‐term clinical response in obsessive–compulsive disorder in the Japanese population

S. Nakaaki, I. Imoto, M. Kinoshita, 2015, Human psychopharmacology.

SKI and MEL1 Cooperate to Inhibit Transforming Growth Factor-β Signal in Gastric Cancer Cells*

J. Inazawa, K. Miyazono, M. Matsuoka, 2009, Journal of Biological Chemistry.

SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing

S. Ichinose, J. Inazawa, J. Kudoh, 2011, EMBO molecular medicine.

Construction of a combinatorial pipeline using two somatic variant calling methods for whole exome sequence data of gastric cancer.

K. Masuda, I. Imoto, D. Ichikawa, 2017, The journal of medical investigation : JMI.

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

I. Imoto, H. Sakaue, Y. Higashikuni, 2016, Science Advances.

Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous‐cell carcinoma

J. Inazawa, H. Tsuda, I. Imoto, 2008, Cancer science.

Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma

J. Inazawa, K. Tanaka, T. Kawano, 2007, Oncogene.

ACTN4 gene amplification and actinin‐4 protein overexpression drive tumour development and histological progression in a high‐grade subset of ovarian clear‐cell adenocarcinomas

Tesshi Yamada, J. Inazawa, H. Tsuda, 2012, Histopathology.

Abstract 2080: miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma

J. Inazawa, I. Imoto, S. Arii, 2010 .

HuR Regulates Alternative Splicing of the TRA2β Gene in Human Colon Cancer Cells under Oxidative Stress

K. Masuda, K. Nishida, K. Rokutan, 2014, Molecular and Cellular Biology.

Genome-first approach diagnosed Cabezas syndrome via novel CUL4B mutation detection

K. Masuda, I. Imoto, N. Okamoto, 2017, Human Genome Variation.

Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation

J. Inazawa, Y. Goto, I. Imoto, 2010, Journal of Human Genetics.

Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma.

I. Imoto, Y. Dobashi, J. Itakura, 2009, Anticancer research.

Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas.

I. Imoto, Y. Dobashi, H. Matsubara, 2011, Human pathology.

Identification of a novel fusion gene in a pre‐B acute lymphoblastic leukemia with t(1;19)(q23;p13)

J. Inazawa, I. Imoto, Y. Kaneko, 2004, Cancer science.

Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E–Deficient Mice

I. Imoto, T. Wakatsuki, K. Kusunose, 2018, Circulation.

Frequent Silencing of Low Density Lipoprotein Receptor-Related Protein 1B (LRP1B) Expression by Genetic and Epigenetic Mechanisms in Esophageal Squamous Cell Carcinoma

K. Chin, J. Gray, S. Hirohashi, 2004, Cancer Research.

DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung

S. Hirohashi, F. Hosoda, J. Inazawa, 2010, Oncogene.

Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma.

J. Inazawa, H. Tsuda, I. Imoto, 2009, Carcinogenesis.

Multiplex PCR/liquid chromatography assay for screening of subtelomeric rearrangements.

J. Inazawa, R. Kosaki, K. Kosaki, 2007, Genetic testing.

Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells

J. Inazawa, Y. Mizutani, T. Miki, 2007, Cancer science.

Genomic loss and epigenetic silencing of very-low-density lipoprotein receptor involved in gastric carcinogenesis

S. Hirohashi, J. Inazawa, H. Tsuda, 2006, Oncogene.

Identification of target genes within an amplicon at 14q12‐q13 in esophageal squamous cell carcinoma

Y. Nakamura, J. Inazawa, I. Imoto, 2001, Genes, chromosomes & cancer.

Copy number alterations in urothelial carcinomas: their clinicopathological significance and correlation with DNA methylation alterations

F. Hosoda, T. Shibata, J. Inazawa, 2010, Carcinogenesis.

Functions of Breast Cancer Predisposition Genes: Implications for Clinical Management

H. Iwata, I. Imoto, A. Yoshimura, 2022, International journal of molecular sciences.

Tomoyuki TagiTakeshi MatsuiShojiro KikuchiSachi Hoshi • Toshiya OchiaiYukihito KokubaYoko Kinoshita-IdaFumie Kisumi-Hayashi • Koji MorimotoToshio ImaiIssei ImotoJohji InazawaEigo Otsuji

I. Imoto, Koji Morimoto, Shojiro Kikuchi, 2010 .

APOB codon 4311 polymorphism is associated with hepatitis C virus infection through altered lipid metabolism

T. Takayama, I. Imoto, H. Honda, 2018, BMC Gastroenterology.

Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16.

J. Inazawa, I. Imoto, H. Moritake, 2005, Cancer genetics and cytogenetics.

New insights into the genetic contribution of ALDH2 rs671 in pancreatic carcinogenesis: Evaluation by mediation analysis

K. Matsuo, Hidemi Ito, I. Imoto, 2022, Cancer science.

Replication Study and Meta-Analysis of Human Nonobstructive Azoospermia in Japanese Populations1

I. Imoto, I. Inoue, A. Tajima, 2013, Biology of reproduction.

Running title: Replication study of NOA

I. Imoto, A. Tajima, T. Iwamoto, 2013 .

NF-κB Inducing Kinase, a Central Signaling Component of the Non-Canonical Pathway of NF-κB, Contributes to Ovarian Cancer Progression

J. Inazawa, I. Imoto, T. Kiyono, 2014, PloS one.

Esophageal squamous cell carcinoma developed 11 years after allogeneic bone marrow transplantation for acute lymphatic leukemia.

J. Inazawa, Y. Tokairin, T. Kawano, 2013, Japanese journal of clinical oncology.

Definition of a 1-Mb homozygous deletion at 9q32-q33 in a human bladder-cancer cell line

M. Emi, I. Imoto, T. Habuchi, 2001, Journal of Human Genetics.

Prevalence of Pathogenic Germline BRCA1/2 Variants and Their Association with Clinical Characteristics in Patients with Epithelial Ovarian Cancer in a Rural Area of Japan

I. Imoto, M. Nishimura, A. Abe, 2022, Genes.

Calcium Signaling Pathway Is Associated with the Long-Term Clinical Response to Selective Serotonin Reuptake Inhibitors (SSRI) and SSRI with Antipsychotics in Patients with Obsessive-Compulsive Disorder

I. Imoto, T. Ohmori, A. Tajima, 2016, PloS one.

Actin Cytoskeletal Reorganization Function of JRAB/MICAL-L2 Is Fine-tuned by Intramolecular Interaction between First LIM Zinc Finger and C-terminal Coiled-coil Domains

K. Mizuguchi, I. Imoto, Y. Tsuchiya, 2019, Scientific Reports.

Alteration in Copy Numbers of Genes as a Mechanism for Acquired Drug Resistance

J. Inazawa, A. Tomida, T. Tsuruo, 2004, Cancer Research.

A homozygous mutation of VWA3B causes cerebellar ataxia with intellectual disability

I. Imoto, T. Kawarai, A. Orlacchio, 2015, Journal of Neurology, Neurosurgery & Psychiatry.

Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer

K. Masuda, I. Imoto, D. Ichikawa, 2019, Gastric Cancer.

Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis

J. Inazawa, I. Imoto, J. Mimura, 2001, Journal of Human Genetics.

Cell culture in esophageal squamous cell carcinoma and the association with molecular markers.

J. Inazawa, I. Imoto, M. Imamura, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

The Xq22 inversion breakpoint interrupted a novel Ras-like GTPase gene in a patient with Duchenne muscular dystrophy and profound mental retardation.

K. Yamakawa, Masahiro Ito, Yusuke Nakamura, 2002, American journal of human genetics.

Genome-Wide Association Study to Identify a New Susceptibility Locus for Central Serous Chorioretinopathy in the Japanese Population.

K. Matsuo, I. Imoto, M. Nakatochi, 2018, Investigative ophthalmology & visual science.

22q13 microduplication in two patients with common clinical manifestations: A recognizable syndrome?

J. Inazawa, I. Imoto, N. Okamoto, 2007, American journal of medical genetics. Part A.

Detection of 1p36 deletion by clinical exome-first diagnostic approach

K. Masuda, I. Imoto, S. Kagami, 2016, Human Genome Variation.

Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II–Induced Atherosclerosis

T. Akasaka, K. Masuda, I. Imoto, 2019, Journal of the American Heart Association.

Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.

J. Inazawa, Y. Iwasaki, T. Masuda, 2008, Blood.

Overexpressed NF- (cid:1) B–inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells

J. Inazawa, Y. Iwasaki, T. Masuda, 2008 .

A novel frameshift mutation of CHD7 in a Japanese patient with CHARGE syndrome

K. Masuda, I. Imoto, S. Kagami, 2016, Human Genome Variation.

The first Japanese patient with mandibular hypoplasia, deafness, progeroid features and lipodystrophy diagnosed via POLD1 mutation detection

K. Masuda, I. Imoto, I. Yokota, 2017, Human Genome Variation.

Molecular cloning of t(2;7)(p24.3;p14.2), a novel chromosomal translocation in myelodysplastic syndrome-derived acute myeloid leukemia

J. Inazawa, M. Sanada, I. Imoto, 2009, Journal of Human Genetics.

JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes

T. Yano, S. Kurisu, I. Imoto, 2021, Communications Biology.

Amendment history : Erratum ( August 2006 ) Early G 2 / M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations

J. Inazawa, M. Nagasawa, S. Mizutani, 2018 .

Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations.

J. Inazawa, M. Nagasawa, S. Mizutani, 2005, The Journal of clinical investigation.

A unique TBX5 microdeletion with microinsertion detected in patient with Holt–Oram syndrome

H. Kurahashi, K. Masuda, I. Imoto, 2015, American journal of medical genetics. Part A.

Moderate-Risk Genes for Hereditary Ovarian Cancers Involved in the Homologous Recombination Repair Pathway

I. Imoto, A. Ueki, H. Kanao, 2022, International journal of molecular sciences.

Frequent silencing of RASSF1A by DNA methylation in thymic neuroendocrine tumours.

A. Tangoku, K. Masuda, K. Kondo, 2017, Lung cancer.

Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.

Y. Nakamura, S. Sugano, J. Inazawa, 2000, Cancer research.

Deletion at chromosome 10p11.23-p12.1 defines characteristic phenotypes with marked midface retrusion

J. Inazawa, A. Hata, R. Kosaki, 2012, Journal of Human Genetics.

An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies

I. Imoto, A. Tajima, T. Iwamoto, 2017, Human reproduction open.

A replication study of a candidate locus for follicle-stimulating hormone levels and association analysis for semen quality traits in Japanese men

I. Imoto, A. Tajima, T. Iwamoto, 2016, Journal of Human Genetics.

The cryptic Y-autosome translocation in the small Indian mongoose, Herpestes auropunctatus, revealed by molecular cytogenetic approaches

I. Imoto, A. Kuroiwa, Katsushi Nakata, 2016, Chromosoma.

Fetal Megalencephaly with Cortical Dysplasia at 18 Gestational Weeks Related to Paternal UPD Mosaicism with PTEN Mutation

A. Shiozaki, S. Saito, I. Imoto, 2021, Genes.

Translocation (1;22)(p36;q11.2) with concurrent del(22)(q11.2) resulted in homozygous deletion of SNF5/INI1 in a newly established cell line derived from extrarenal rhabdoid tumor

J. Inazawa, I. Imoto, H. Hosoi, 2004, Journal of Human Genetics.

A novel missense mutation of COL5A2 in a patient with Ehlers–Danlos syndrome

K. Masuda, I. Imoto, S. Kagami, 2016, Human Genome Variation.

The CASK gene harbored in a deletion detected by array‐CGH as a potential candidate for a gene causative of X‐linked dominant mental retardation

O. Migita, J. Inazawa, A. Hata, 2008, American journal of medical genetics. Part A.

Simultaneous Detection of Both Single Nucleotide Variations and Copy Number Alterations by Next-Generation Sequencing in Gorlin Syndrome

J. Inazawa, K. Masuda, I. Imoto, 2015, PloS one.

An association study of four candidate loci for human male fertility traits with male infertility.

I. Imoto, A. Tajima, T. Iwamoto, 2015, Human reproduction.

Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis

J. Inazawa, H. Tsuda, S. Okabe, 2005, Laboratory Investigation.

The cryptic Y-autosome translocation in the small Indian mongoose, Herpestes auropunctatus, revealed by molecular cytogenetic approaches

I. Imoto, A. Kuroiwa, Katsushi Nakata, 2016, Chromosoma.

A novel COL11A1 mutation affecting splicing in a patient with Stickler syndrome

K. Masuda, I. Imoto, N. Okamoto, 2015, Human Genome Variation.

Novel PAX9 Mutations Cause Non-syndromic Tooth Agenesis

K. Masuda, I. Imoto, S. Horiuchi, 2014, Journal of dental research.

Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer.

S. Hirohashi, J. Inazawa, T. Kasamatsu, 2008, Cancer research.

YAP is a candidate oncogene for esophageal squamous cell carcinoma.

J. Inazawa, T. Kawano, H. Tsuda, 2011, Carcinogenesis.

miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer.

J. Inazawa, I. Imoto, D. Aoki, 2011, Cancer research.

Screening of DNA copy‐number aberrations in gastric cancer cell lines by array‐based comparative genomic hybridization

Hidetaka Mochizuki, Hitoshi Tsuda, J. Inazawa, 2005, Cancer science.

Deep intronic GPR143 mutation in a Japanese family with ocular albinism

K. Masuda, I. Imoto, N. Okamoto, 2015, Scientific Reports.

TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.

J. Inazawa, I. Imoto, T. Iizasa, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

A Novel Amplicon at 9p23‐24 in Squamous Cell Carcinoma of the Esophagus That Lies Proximal to GASC1 and Harbors NFIB

M. Oka, J. Inazawa, I. Imoto, 2001, Japanese journal of cancer research : Gann.

Hypomethylation of Long Interspersed Nuclear Element-1 (LINE-1) is Associated with Poor Prognosis via Activation of c-MET in Hepatocellular Carcinoma

T. Utsunomiya, I. Imoto, Y. Morine, 2014, Annals of Surgical Oncology.

PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma

J. Inazawa, H. Tsuda, I. Imoto, 2006, Cancer science.

PIK 3 CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma

J. Inazawa, H. Tsuda, I. Imoto, 2006 .

Differentially Regulated Genes as Putative Targets of Amplifications at 20q in Ovarian Cancers

J. Inazawa, M. Emi, I. Imoto, 2002, Japanese journal of cancer research : Gann.

De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity

I. Imoto, M. Kinoshita, T. Ohmori, 2017, Scientific Reports.

Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia

R. Hashimoto, I. Imoto, M. Kikuchi, 2017, International journal of molecular sciences.

Monitoring the HER2 copy number status in circulating tumor DNA by droplet digital PCR in patients with gastric cancer

K. Masuda, I. Imoto, D. Ichikawa, 2016, Gastric Cancer.

DGCR6 at the proximal part of the DiGeorge critical region is involved in conotruncal heart defects

M. Eguchi, I. Imoto, M. Eguchi-Ishimae, 2015, Human Genome Variation.

DNA Methylation Signatures of Peripheral Leukocytes in Schizophrenia

I. Imoto, H. Kubo, Shin-ya Watanabe, 2013, NeuroMolecular Medicine.

Initiation of recombination suppression and PAR formation during the early stages of neo-sex chromosome differentiation in the Okinawa spiny rat, Tokudaia muenninki

Y. Kuroki, I. Imoto, A. Kuroiwa, 2015, BMC Evolutionary Biology.

NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis

K. Masuda, K. Nishida, K. Rokutan, 2013, International journal of molecular sciences.

Aberrant DNA Methylation of Blood in Schizophrenia by Adjusting for Estimated Cellular Proportions

K. Ohi, R. Hashimoto, M. Takeda, 2014, NeuroMolecular Medicine.

Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer

F. Hosoda, J. Inazawa, Y. Arai, 2014, Oncogene.

Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development

K. Masuda, I. Imoto, S. Oyadomari, 2016, Scientific Reports.

Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer.

Yusuke Nakamura, S. Hirohashi, F. Hosoda, 2009, Carcinogenesis.

microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer

T. Nagao, I. Imoto, Y. Abiko, 2016, Oncotarget.

Title Sex differences of leukocytes DNA methylation adjusted for estimatedcellular proportions

R. Hashimoto, I. Imoto, H. Yamamori, 2017 .

Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions

I. Imoto, H. Yamamori, Masatoshi Inoshita, 2015, Biology of Sex Differences.

Unfavorable prognostic factors associated with high frequency of microsatellite instability and comparative genomic hybridization analysis in endometrial cancer.

J. Inazawa, I. Imoto, D. Aoki, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Comparative genomic hybridization (CGH)‐arrays pave the way for identification of novel cancer‐related genes

J. Inazawa, I. Imoto, Issei Imoto, 2004, Cancer science.

Ancestral Y-linked genes were maintained by translocation to the X and Y chromosomes fused to an autosomal pair in the Okinawa spiny rat Tokudaia muenninki

Y. Kuroki, I. Imoto, A. Kuroiwa, 2016, Chromosome Research.

Array‐based comparative genomic hybridization analysis of high‐grade neuroendocrine tumors of the lung

S. Hirohashi, F. Hosoda, T. Shibata, 2005, Cancer science.

Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.

S. Hirohashi, T. Shibata, J. Inazawa, 2005, Human molecular genetics.

Genetic Classification of Lung Adenocarcinoma Based on Array-Based Comparative Genomic Hybridization Analysis: Its Association with Clinicopathologic Features

S. Hirohashi, F. Hosoda, T. Shibata, 2005, Clinical Cancer Research.

TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas

Masakazu Ueda, J. Inazawa, M. Emi, 2002, Hepatology.

Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma.

J. Inazawa, T. Kawano, H. Kawachi, 2010, Carcinogenesis.

PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation

J. Inazawa, N. Kamata, I. Imoto, 2007, Oncogene.

Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.

S. Hirohashi, J. Inazawa, T. Kasamatsu, 2007, Cancer research.

Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers.

S. Hirohashi, F. Hosoda, T. Shibata, 2006, Cancer research.

Cancers Small-Cell Lung − by Epigenetic Mechanism in Non PCDH 20 Frequent Silencing of the Candidate Tumor Suppressor

S. Hirohashi, F. Hosoda, T. Shibata, 2006 .

Advances in Brief Frequent Silencing of Low Density Lipoprotein Receptor-Related Protein 1 B ( LRP 1 B ) Expression by Genetic and Epigenetic Mechanisms in Esophageal Squamous Cell Carcinoma

K. Chin, J. Gray, S. Hirohashi, 2004 .

Physical map and haplotype analysis of 16q-linked autosomal dominant cerebellar ataxia (ADCA) type III in Japan

I. Kanazawa, J. Inazawa, I. Imoto, 2003, Journal of Human Genetics.

Clinical application of array-based comparative genomic hybridization by two-stage screening for 536 patients with mental retardation and multiple congenital anomalies

Y. Fukushima, J. Inazawa, S. Saitoh, 2011, Journal of Human Genetics.

Identification of ZASC1 encoding a Krüppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas.

J. Inazawa, I. Imoto, M. Imamura, 2003, Cancer research.

Nonrandom Chromosomal Imbalances in Esophageal Squamous Cell Carcinoma Cell Lines: Possible Involvement of the ATF3 and CENPF Genes in the 1q32 Amplicon

Yusuke Nakamura, Yutaka Shimada, Masayuki Imamura, 2000, Japanese journal of cancer research : Gann.

Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome.

S. Hirohashi, F. Hosoda, T. Shibata, 2005, Journal of hepatology.

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

Hiromi Nakamura, S. Kōzuma, Y. Taketani, 2009, The EMBO journal.

Expression and Gene Amplification of Actinin-4 in Invasive Ductal Carcinoma of the Pancreas

S. Hirohashi, J. Inazawa, H. Tsuda, 2008, Clinical Cancer Research.

Genome‐wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage

S. Hirohashi, F. Hosoda, T. Shibata, 2010, Cancer science.

Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome

S. Hirohashi, F. Hosoda, T. Shibata, 2008, Carcinogenesis.

A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity

J. Inazawa, M. Emi, I. Imoto, 2007, Oncogene.

Genotype-stratified GWAS meta-analysis reveals novel loci associated with alcohol consumption

T. Kawaguchi, Hidemi Ito, F. Matsuda, 2021, medRxiv.

Genomic copy‐number alterations of MYC and FHIT genes are associated with survival in esophageal squamous‐cell carcinoma

J. Inazawa, T. Kawano, Y. Eishi, 2012, Cancer science.

Promoter analysis and chromosomal mapping of human EBAG9 gene.

S. Inoue, J. Inazawa, M. Emi, 2000, Biochemical and biophysical research communications.

CD44 is a potential target of amplification within the 11p13 amplicon detected in gastric cancer cell lines

J. Inazawa, I. Imoto, K. Yanagihara, 2000, Genes, chromosomes & cancer.

Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas.

J. Inazawa, H. Tsuda, M. Ohki, 2001, Cancer research.

Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma.

J. Inazawa, M. Taniwaki, S. Shimizu, 2004, The American journal of pathology.

Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets.

J. Inazawa, I. Imoto, D. Aoki, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Overexpression of NF-κB inducing kinase underlies constitutive NF-κB activation in lung cancer cells.

J. Inazawa, A. Hasegawa, I. Imoto, 2010, Lung cancer.

Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers

Phillipe Loher, Megumi Shigematsu, Isidore Rigoutsos, 2015, Proceedings of the National Academy of Sciences.

Genome‐wide association study identifies gastric cancer susceptibility loci at 12q24.11‐12 and 20q11.21

Y. Kamatani, Yusuke Nakamura, C. Tanikawa, 2018, Cancer science.

SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus.

N. Nomura, J. Inazawa, I. Imoto, 2001, Biochemical and biophysical research communications.

Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance

Hitoshi Tsuda, Masashi Takano, Tesshi Yamada, 2009, Modern Pathology.

Novel targets for the 18 p 11 . 3 amplification frequently observed in esophageal squamous cell carcinomas

J. Inazawa, I. Imoto, M. Imamura, 2001 .

Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy.

Masahiko Miura, Hitoshi Tsuda, Setsuo Hirohashi, 2002, Cancer research.

Expression of cIAP 1 , a Target for 11 q 22 Amplification , Correlates with Resistance of Cervical Cancers to Radiotherapy 1

S. Hirohashi, J. Inazawa, H. Tsuda, 2002 .

Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes

J. Inazawa, M. Nagasawa, S. Mizutani, 2008, Cancer science.

Prevalence of pathogenic germline variants detected by multigene sequencing in unselected Japanese patients with ovarian cancer

H. Tsuda, K. Masuda, I. Imoto, 2017, Oncotarget.

Identification of SMURF1 as a possible target for 7q21.3‐22.1 amplification detected in a pancreatic cancer cell line by in‐house array‐based comparative genomic hybridization

S. Hirohashi, T. Shibata, J. Inazawa, 2008, Cancer science.

IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A

A. Tanigami, J. Inazawa, S. Kuroda, 2001, Journal of Human Genetics.

Case of non‐mosaic trisomy 20 in amniotic fluid cultures without anomalies in the fetus: Cytogenetic discrepancy between amniocytes and fetal blood

I. Imoto, M. Irahara, S. Nakayama, 2015, The journal of obstetrics and gynaecology research.

BCL2L2 is a probable target for novel 14q11.2 amplification detected in a non‐small cell lung cancer cell line

J. Inazawa, H. Tsuda, I. Imoto, 2007, Cancer science.

Overexpressed Skp2 within 5p amplification detected by array‐based comparative genomic hybridization is associated with poor prognosis of glioblastomas

T. Yoshimine, J. Inazawa, H. Tsuda, 2005, Cancer science.

GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines

J. Inazawa, Y. Matsuo, I. Imoto, 2003, Journal of Human Genetics.

Association of 17 q 21-q 24 Gain in Ovarian Clear Cell Adenocarcinomas with Poor Prognosis and Identification of PPM 1 D and APPBP 2 as Likely Amplification Targets 1

J. Inazawa, I. Imoto, D. Aoki, 2003 .

MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas

Yutaka Shimada, Masayuki Imamura, Masakazu Ueda, 2002, Journal of Human Genetics.

Genetic Clustering of Clear Cell Renal Cell Carcinoma Based on Array-Comparative Genomic Hybridization: Its Association with DNA Methylation Alteration and Patient Outcome

S. Hirohashi, F. Hosoda, T. Shibata, 2008, Clinical Cancer Research.

Non-incidental coamplification of Myc and ERBB2, and Myc and EGFR, in gastric adenocarcinomas

J. Inazawa, H. Fujii, I. Imoto, 2007, Modern Pathology.

Krüppel‐like factor 12 plays a significant role in poorly differentiated gastric cancer progression

Misao Ohki, Kengo Takeuchi, Yasuhito Arai, 2009, International journal of cancer.

Dermokine as a novel biomarker for early-stage colorectal cancer

J. Inazawa, I. Imoto, E. Otsuji, 2010, Journal of Gastroenterology.

Tokuda Akihiro Tomida Shinya Toyokuni Hitoshi Tsuda Shoichiro Tsugane Tatsuhiko Tsunoda Heiichiro Udono Koji Ueda Yoshimasa Uehara Hiroo Ueno Kazuo Umezawa Toshikazu Ushijima Toshihiko Wakabayashi Kenji Wakai Tetsuro Watabe

H. Aburatani, S. Hirota, Y. Kaneda, 2016 .

Identification of PAK4 as a putative target gene for amplification within 19q13.12‐q13.2 in oral squamous‐cell carcinoma

J. Inazawa, H. Tsuda, I. Imoto, 2009, Cancer science.

Stabilization of phenotypic plasticity through mesenchymal-specific DNA hypermethylation in cancer cells

J. Inazawa, I. Imoto, T. Amagasa, 2012, Oncogene.

SIX1 promotes epithelial–mesenchymal transition in colorectal cancer through ZEB1 activation

J. Inazawa, H. Tsuda, I. Imoto, 2012, Oncogene.

A 590 kb deletion caused by non‐allelic homologous recombination between two LINE‐1 elements in a patient with mesomelia‐synostosis syndrome

K. Masuda, I. Imoto, T. Naruto, 2017, American journal of medical genetics. Part A.

The incidence of hypoplasia of the corpus callosum in patients with dup (X)(q28) involving MECP2 is associated with the location of distal breakpoints

J. Inazawa, Y. Goto, I. Imoto, 2012, American journal of medical genetics. Part A.

Concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation

J. Inazawa, Y. Goto, I. Imoto, 2011, Journal of Human Genetics.

Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis

J. Inazawa, Y. Goto, I. Imoto, 2010, Journal of Human Genetics.

A case with concurrent duplication, triplication, and uniparental isodisomy at 1q42.12-qter supporting microhomology-mediated break-induced replication model for replicative rearrangements

H. Kurahashi, K. Masuda, I. Imoto, 2017, Molecular Cytogenetics.

The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase

T. Noda, J. Inazawa, M. Yanagida, 2006, The Journal of cell biology.

Association between germline pathogenic variants and breast cancer risk in Japanese women: The HERPACC study

K. Matsuo, Hidemi Ito, I. Imoto, 2022, Cancer science.

Assay of serum E2 concentration in postmenopausal breast cancer patients using a high-sensitivity RIA method is generally useful.

A. Tangoku, I. Imoto, M. Sasa, 2016, The journal of medical investigation : JMI.

Genome‐wide array‐based comparative genomic hybridization analysis of pancreatic adenocarcinoma: Identification of genetic indicators that predict patient outcome

S. Hirohashi, F. Hosoda, T. Shibata, 2007, Cancer science.

Fortuitous detection of a submicroscopic deletion at 1q25 in a girl with Cornelia‐de Lange syndrome carrying t(5;13)(p13.1;q12.1) by array‐based comparative genomic hybridization

J. Inazawa, S. Mizutani, I. Imoto, 2007, American journal of medical genetics. Part A.

Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla

K. Masuda, F. Hirota, M. Matsumoto, 2015, The Journal of Immunology.

Six years’ accomplishment of the Initiative on Rare and Undiagnosed Diseases: nationwide project in Japan to discover causes, mechanisms, and cures

Y. Fukushima, T. Morio, H. Kurahashi, 2022, Journal of Human Genetics.

POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17

J. Inazawa, S. Iida, R. Ueda, 2008, Oncogene.

Establishment and characterization of a new malignant peritoneal mesothelioma cell line, KOG-1, from the ascitic fluid of a patient with pemetrexed chemotherapy resistance

I. Imoto, D. Aoki, A. Hirasawa, 2019, Human Cell.

Meta-analyses of Blood Homocysteine Levels for Gender and Genetic Association Studies of the MTHFR C677T Polymorphism in Schizophrenia

K. Ohi, R. Hashimoto, M. Takeda, 2014, Schizophrenia bulletin.

Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions

R. Hashimoto, I. Imoto, H. Yamamori, 2015, Biology of Sex Differences.

Clinical and molecular cytogenetic characterization of two patients with non‐mutational aberrations of the FMR2 gene

J. Inazawa, S. Mizutani, I. Imoto, 2007, American journal of medical genetics. Part A.

Prognostic significance of GAD1 overexpression in patients with resected lung adenocarcinoma

A. Tangoku, K. Masuda, K. Kondo, 2019, Cancer medicine.

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

M. Kanai, Y. Kamatani, Y. Okada, 2020, Nature Genetics.

Clinical utility of circulating cell-free Epstein–Barr virus DNA in patients with gastric cancer

K. Masuda, I. Imoto, D. Ichikawa, 2017, Oncotarget.

Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma

K. Masuda, I. Imoto, D. Ichikawa, 2016, Oncotarget.

An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli.

Tsonwin Hai, J. Inazawa, I. Imoto, 2002, Nucleic acids research.

The c-Jun NH2-terminal kinase3 (JNK3) gene: genomic structure, chromosomal assignment, and loss of expression in brain tumors

Akira Teramoto, Hiroshi Takahashi, J. Inazawa, 2001, Journal of Human Genetics.

A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genomic hybridization.

S. Inoue, J. Inazawa, I. Imoto, 2001, Gynecologic oncology.

A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells

Kenji Mizuguchi, Yi-An Chen, Masato Komatsu, 2017, Nature Communications.

The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer.

J. Inazawa, I. Imoto, K. Omura, 2011, Cancer research.

Title Gene amplification of ERBB 2 and EGFR in adenocarcinoma in situ andintramucosal adenocarcinoma of Barrett ' s esophagus

I. Imoto, Y. Zen, Y. Dobashi, 2017 .

Gene amplification of ERBB2 and EGFR in adenocarcinoma in situ and intramucosal adenocarcinoma of Barrett's esophagus

I. Imoto, Y. Zen, Y. Dobashi, 2010, Pathology international.

Specific molecular signatures of non-tumor liver tissue may predict a risk of hepatocarcinogenesis

T. Utsunomiya, I. Imoto, Y. Morine, 2014, Cancer science.

Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma.

J. Inazawa, I. Imoto, S. Arii, 2012, Clinical cancer research : an official journal of the American Association for Cancer Research.

Genome‐wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma

S. Hirohashi, F. Hosoda, T. Shibata, 2009, International journal of cancer.

A rare male patient with classic Rett syndrome caused by MeCP2_e1 mutation

K. Masuda, I. Imoto, S. Kagami, 2018, American journal of medical genetics. Part A.

Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia

I. Imoto, M. Kinoshita, T. Ohmori, 2013, Epigenetics.

Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines

J. Inazawa, I. Imoto, A. Hirasawa, 2004, Oncogene.

Junctional Rab13‐binding protein (JRAB) regulates cell spreading via filamins

I. Imoto, T. Kitamura, K. Honda, 2013, Genes to cells : devoted to molecular & cellular mechanisms.

Novel CLCN7 compound heterozygous mutations in intermediate autosomal recessive osteopetrosis

T. Komori, K. Masuda, I. Imoto, 2017, Human Genome Variation.

An 8-cM interstitial deletion on 4q21-q22 in DNA from an infant with hepatoblastoma overlaps with a commonly deleted region in adult liver cancers.

J. Inazawa, M. Emi, I. Imoto, 2001, American journal of medical genetics.

Association analysis of SNPs with CT image-based phenotype of emphysema progression in heavy smokers

Noboru Niki, Yoshiki Kawata, Yasutaka Nakano, 2020, Medical Imaging.

Cumulative effect of the plasma total homocysteine-related genetic variants on schizophrenia risk

I. Imoto, Shin-ya Watanabe, M. Kinoshita, 2016, Psychiatry Research.

Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.

S. Hirohashi, F. Hosoda, T. Shibata, 2007, Gastroenterology.

Comparison of the efficacy and safety of 10-mg empagliflozin every day versus every other day in Japanese patients with Type 2 Diabetes Mellitus: a pilot trial.

I. Imoto, K. Tani, R. Tabata, 2017, The journal of medical investigation : JMI.

Attitudes toward and current status of disclosure of secondary findings from next-generation sequencing: a nation-wide survey of clinical genetics professionals in Japan

I. Imoto, F. Nomura, A. Hirasawa, 2020, Journal of Human Genetics.

HECT-type Ubiquitin Ligase ITCH Targets Lysosomal-associated Protein Multispanning Transmembrane 5 (LAPTM5) and Prevents LAPTM5-mediated Cell Death*

J. Inazawa, I. Imoto, K. Kozaki, 2011, The Journal of Biological Chemistry.

A significant causal association between C-reactive protein levels and schizophrenia

M. Ikeda, R. Hashimoto, I. Imoto, 2016, Scientific Reports.

MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway

T. Tokino, M. Idogawa, I. Imoto, 2023, BMC Cancer.

Detection of cryptic chromosome aberrations in a patient with a balanced t(1;9)(p34.2;p24) by array‐based comparative genomic hybridization

J. Inazawa, S. Mizutani, I. Imoto, 2005, American journal of medical genetics. Part A.

B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma/polyp (SSA/P) and cancer in SSA/P

T. Takayama, T. Fujimori, I. Imoto, 2014, British Journal of Cancer.

Attitudes of clinical geneticists and certified genetic counselors to genome editing and its clinical applications: A nation-wide questionnaire survey in Japan

I. Imoto, F. Nomura, K. Kurosawa, 2019, Journal of Human Genetics.

Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis

I. Imoto, M. Kinoshita, T. Ohmori, 2015, BMC Medical Genetics.

An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies

I. Imoto, A. Tajima, T. Iwamoto, 2017, Human reproduction open.

Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Y. Kamatani, Y. Okada, T. Kawaguchi, 2020, Nature Communications.

Genome-wide association meta-analysis identifies novel GP2 gene risk variants for pancreatic cancer in the Japanese population

Y. Kamatani, Y. Okada, T. Kawaguchi, 2018, bioRxiv.

Retraction: A significant causal association between C-reactive protein levels and schizophrenia

Tetsuro Ohmori, Hidenaga Yamamori, Ryota Hashimoto, 2018, Scientific Reports.

Construction of a high-density and high-resolution human chromosome X array for comparative genomic hybridization analysis

J. Inazawa, R. Kosaki, S. Mizutani, 2007, Journal of Human Genetics.

Genome-wide association study identifies ERBB4 on 2q34 as a novel locus associated with sperm motility in Japanese men

I. Imoto, A. Tajima, Takehiro Sato, 2018, Journal of Medical Genetics.

Lack of replication of four candidate SNPs implicated in human male fertility traits: a large-scale population-based study.

I. Imoto, A. Tajima, T. Iwamoto, 2015, Human reproduction.

KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression

A. Tangoku, K. Masuda, I. Imoto, 2017, Oncotarget.

Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis

K. Matsuo, Hidemi Ito, I. Imoto, 2020, Cancer Research.

HER2 amplification detected in the circulating DNA of patients with gastric cancer: a retrospective pilot study

K. Masuda, I. Imoto, D. Ichikawa, 2015, Gastric Cancer.

Overexpression of SMYD2 contributes to malignant outcome in gastric cancer

J. Inazawa, H. Tsuda, I. Imoto, 2014, British Journal of Cancer.

Miyuki Kanematsu

A. Tangoku, I. Imoto, M. Sasa, 2016 .

Thirty percent of ductal carcinoma in situ of the breast in Japan is extremely low-grade ER(+)/HER2(-) type without comedo necrosis.

A. Tangoku, I. Imoto, M. Sasa, 2016, The journal of medical investigation : JMI.

Blood diagnostic biomarkers for major depressive disorder using multiplex DNA methylation profiles: discovery and validation

I. Imoto, Shin-ya Watanabe, M. Kinoshita, 2015, Epigenetics.

Genome-Wide DNA Methylation Profiles in Renal Tumors of Various Histological Subtypes and Non-Tumorous Renal Tissues

S. Hirohashi, F. Hosoda, T. Shibata, 2011, Pathobiology.

Diagnosis and Prognostication of Ductal Adenocarcinomas of the Pancreas Based on Genome-Wide DNA Methylation Profiling by Bacterial Artificial Chromosome Array-Based Methylated CpG Island Amplification

F. Hosoda, T. Shibata, J. Inazawa, 2010, Journal of biomedicine & biotechnology.

ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation

S. Hirohashi, F. Hosoda, J. Inazawa, 2005, Oncogene.

Identification and characterization of human PKNOX2, a novel homeobox-containing gene.

J. Inazawa, I. Imoto, I Imoto, 2001, Biochemical and biophysical research communications.

A Personal Breast Cancer Risk Stratification Model Using Common Variants and Environmental Risk Factors in Japanese Females

K. Matsuo, Hidemi Ito, S. Tsugane, 2021, Cancers.

A case with concurrent duplication, triplication, and uniparental isodisomy at 1q42.12-qter supporting microhomology-mediated break-induced replication model for replicative rearrangements

H. Kurahashi, K. Masuda, I. Imoto, 2017, Molecular Cytogenetics.

The C-terminal region including the MH6 domain of Msx1 regulates skeletal development.

I. Imoto, S. Oyadomari, S. N. Mitsui, 2020, Biochemical and biophysical research communications.

A novel COL11A1 missense mutation in siblings with non-ocular Stickler syndrome

T. Morio, K. Masuda, I. Imoto, 2016, Human Genome Variation.

Genetic analysis of multifocal superficial urothelial cancers by array-based comparative genomic hybridisation

J. Inazawa, G. Tsujimoto, H. Nishiyama, 2007, British Journal of Cancer.

Outcomes of 6 years of activities by the Tokushima Medical Association’s Steering Committee for Diabetes Prevention to prevent type 2 diabetes in the general population of Tokushima Prefecture

M. Matsuhisa, I. Imoto, A. Shirakami, 2013, Diabetology International.

Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer

T. Shibata, J. Inazawa, T. Kinoshita, 2019, BMC Cancer.

A 16q22.2-q23.1 deletion identified in a male infant with West syndrome

I. Imoto, S. Kagami, K. Mori, 2019, Brain and Development.

Clinical heterogeneity of α‐synuclein gene duplication in Parkinson's disease

A. Singleton, M. Farrer, J. Inazawa, 2006 .

Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer.

Y. Kamatani, K. Matsuda, A. Spurdle, 2023, The New England journal of medicine.

Novel intragenic duplications and mutations of CASK in patients with mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH)

J. Inazawa, A. Hata, I. Imoto, 2011, Human Genetics.

ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array‐based comparative genomic hybridization

J. Inazawa, H. Tsuda, I. Imoto, 2008, Cancer science.

Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.

A. Singleton, M. Farrer, J. Inazawa, 2006, Annals of neurology.

Next-generation sequencing for the diagnosis of patients with congenital multiple anomalies and / or intellectual disabilities.

I. Imoto, S. Kagami, M. Urushihara, 2020, The journal of medical investigation : JMI.

Manifestation of recessive combined D‐2‐, L‐2‐hydroxyglutaric aciduria in combination with 22q11.2 deletion syndrome

M. Eguchi, K. Masuda, I. Imoto, 2018, American journal of medical genetics. Part A.

Verifying nomenclature of DNA variants in submitted manuscripts: Guidance for journals

G. Barsh, L. Gong, H. Rehm, 2020, Human mutation.

Skp2 overexpression is a p27Kip1‐independent predictor of poor prognosis in patients with biliary tract cancers

J. Inazawa, I. Imoto, S. Arii, 2004, Cancer science.

predictor of poor prognosis in patients with biliary tract cancers

J. Inazawa, I. Imoto, S. Arii, 2004 .

Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels

I. Imoto, A. Tajima, Takehiro Sato, 2020, Journal of Human Genetics.

Early Results of Omitting Completion Axillary Lymph Node Dissection in Sentinel Lymph Node Metastasis-Positive Breast Cancer Patients

I. Imoto, M. Sasa, Takahiro Yoshida, 2013 .

Aberrant DNA Methylation of Blood in Schizophrenia by Adjusting for Estimated Cellular Proportions

K. Ohi, R. Hashimoto, M. Takeda, 2014, NeuroMolecular Medicine.

Impact of annual body mass index gain on obesity development in Japanese 6‐year‐old non‐obese children

I. Imoto, Y. Nakahori, M. Sei, 2013, Pediatrics international : official journal of the Japan Pediatric Society.

Molecular diagnosis of an infant with TSC2/PKD1 contiguous gene syndrome

I. Imoto, S. Kagami, M. Urushihara, 2020, Human Genome Variation.

Detection of novel fusion genes by next-generation sequencing-based targeted RNA sequencing analysis in adenoid cystic carcinoma of head and neck.

I. Imoto, Y. Harazono, H. Harada, 2021, Oral surgery, oral medicine, oral pathology and oral radiology.

Three patients with Schaaf–Yang syndrome exhibiting arthrogryposis and endocrinological abnormalities

N. Matsumoto, I. Imoto, S. Ida, 2018, American journal of medical genetics. Part A.

The Association of Elastin Gene Variants with Two Angiographic Subtypes of Polypoidal Choroidal Vasculopathy

I. Imoto, S. Honda, A. Miki, 2013, PloS one.

Genomic structure and mapping of human orphan receptor LXR alpha: upregulation of LXRa mRNA during monocyte to macrophage differentiation.

H. Aburatani, T. Nakajima, J. Inazawa, 2000, Journal of atherosclerosis and thrombosis.

Partial tandem duplication of GRIA3 in a male with mental retardation

J. Inazawa, I. Imoto, Zhengping Jia, 2007, American journal of medical genetics. Part A.

Targeted exome sequencing and chromosomal microarray for the molecular diagnosis of nevoid basal cell carcinoma syndrome.

M. Tohyama, Y. Kubo, I. Imoto, 2017, Journal of dermatological science.

Novel compound heterozygous CDH23 variants in a patient with Usher syndrome type I

K. Masuda, I. Imoto, Y. Makita, 2019, Human Genome Variation.

Primary microcephaly caused by novel compound heterozygous mutations in ASPM

K. Masuda, I. Imoto, N. Okamoto, 2018, Human Genome Variation.

Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer

T. Shibata, J. Inazawa, T. Kinoshita, 2019, BMC Cancer.

A novel PTCH1 mutation in a patient with Gorlin syndrome

T. Komori, I. Imoto, T. Naruto, 2014, Human Genome Variation.

Meta-analysis of association studies between DISC1 missense variants and schizophrenia in the Japanese population

K. Ohi, M. Takeda, I. Imoto, 2012, Schizophrenia Research.

The expression and clinical significance of connective tissue growth factor in advanced head and neck squamous cell cancer

A. Shiotani, H. Tsuda, I. Imoto, 2014, Human Cell.

Molecular and Cellular Pathobiology the Tumor Suppressive Microrna Mir-218 Targets the Mtor Component Rictor and Inhibits Akt Phosphorylation in Oral Cancer

J. Inazawa, I. Imoto, K. Omura, 2022 .

BCL 2 L 2 is a probable target for novel 14 q 11 . 2 amplification detected in a non-small cell lung cancer cell line

J. Inazawa, H. Tsuda, I. Imoto, 2007 .

A FRMD7 variant in a Japanese family causes congenital nystagmus

T. Komori, I. Imoto, T. Naruto, 2015, Human Genome Variation.

Squamous Cell Carcinoma Genetic and Epigenetic Mechanisms in Esophageal ) Expression by Receptor-Related Protein 1 B ( LRP 1 B Low Density Lipoprotein Frequent Silencing of Updated

K. Chin, J. Gray, S. Hirohashi, 2004 .

Molecular cloning, tissue expression, and chromosomal assignment of a novel gene encoding a subunit of the human signal-recognition particle

J. Inazawa, M. Emi, T. Yokota, 2001, Journal of Human Genetics.

The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer.

I. Imoto, K. Kozaki, Mayuko Furuta, 2011, Cancer research.

Overexpressed NF- (cid:1) B–inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells

J. Inazawa, Y. Iwasaki, T. Masuda, 2008 .

Genome‐wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage

S. Hirohashi, F. Hosoda, T. Shibata, 2010, Cancer science.

Ancestral Y-linked genes were maintained by translocation to the X and Y chromosomes fused to an autosomal pair in the Okinawa spiny rat Tokudaia muenninki

Y. Kuroki, I. Imoto, A. Kuroiwa, 2016, Chromosome Research.

ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array‐based comparative genomic hybridization

J. Inazawa, H. Tsuda, I. Imoto, 2008, Cancer Science.

Impact of annual body mass index gain on obesity development in Japanese 6‐year‐old non‐obese children

I. Imoto, Y. Nakahori, M. Sei, 2013, Pediatrics international : official journal of the Japan Pediatric Society.

Genome-Wide DNA Methylation Profiles in Renal Tumors of Various Histological Subtypes and Non-Tumorous Renal Tissues

S. Hirohashi, F. Hosoda, T. Shibata, 2011, Pathobiology.

DNA Methylation Signatures of Peripheral Leukocytes in Schizophrenia

I. Imoto, H. Kubo, Shin-ya Watanabe, 2012, NeuroMolecular Medicine.

Conformational plasticity of JRAB/MICAL-L2 provides “law and order” in collective cell migration

Kenji Mizuguchi, Hideo Yokota, Masaomi Nishimura, 2016, Molecular biology of the cell.

Exome-first approach identified a novel gloss deletion associated with Lowe syndrome

I. Imoto, S. Kagami, T. Naruto, 2016, Human Genome Variation.

De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity

I. Imoto, M. Kinoshita, T. Ohmori, 2017, Scientific Reports.