M. Alexis

发表

Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes.

H. Stunnenberg, P. Moulos, Kees-Jan Françoijs, 2011, Genome research.

The estrogen receptor and polyphenols: molecular simulation studies of their interactions, a review

M. Alexis, G. Lambrinidis, A. Skaltsounis, 2006 .

Quantitative Fluorescence Cytometric Measurement of Estrogen and Progesterone Receptors: Correlation with the Hormone Binding Assay

M. Alexis, J. Yotis, A. Gritzapis, 2003, Breast Cancer Research and Treatment.

Biological and computational evaluation of resveratrol inhibitors against Alzheimer’s disease

B. R. Steele, Elizabeth Hamelink, B. Steele, 2016, Journal of enzyme inhibition and medicinal chemistry.

Erymildbraedin A and B, two novel cytotoxic dimethylpyrano-isoflavones from the stem bark of Erythrina mildbraedii: evaluation of their activity toward endocrine cancer cells

M. Alexis, X. Alexi, A. Skaltsounis, 2010, Journal of enzyme inhibition and medicinal chemistry.

Cytotoxic effects of 2-arylbenzofuran phytoestrogens on human cancer cells: Modulation by adrenal and gonadal steroids

M. Alexis, X. Alexi, A. Skaltsounis, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Differential estrogen receptor subtype modulators: Assessment of estrogen receptor subtype-binding selectivity and transcription-regulating properties of new cycloalkyl pyrazoles

M. Alexis, X. Alexi, G. Lambrinidis, 2009, The Journal of Steroid Biochemistry and Molecular Biology.

Estrogenic activity of isoflavonoids from Onobrychis ebenoides.

M. Alexis, X. Alexi, G. Lambrinidis, 2006, Planta medica.

Estrogen receptor alpha and beta in uterine fibroids: a basis for altered estrogen responsiveness.

M. Alexis, S. Vlahopoulos, P. Bakas, 2008, Fertility and sterility.

Estrogen receptor a and b in uterine fibroids : a basis for altered estrogen responsiveness

M. Alexis, S. Vlahopoulos, P. Bakas, 2022 .

Heat-induced degradation of overexpressed glucocorticoid receptor Separate protective roles of hsp90 and hsp70

M. Alexis, D. Mitsiou, D. Siriani, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Pronounced enhancement of glucocorticoid-induced gene expression following severe heat shock of heat-conditioned cells hints to intricate cell survival tactics

L. Baki, A. Georgakopoulos, M. Alexis, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Maintenance of glucocorticoid receptor function following severe heat-shock of heat-conditioned cells

A. Georgakopoulos, M. Alexis, D. Mitsiou, 2003, Molecular and Cellular Endocrinology.

Overexpressed glucocorticoid receptor negatively regulates gene expression under conditions that favour accumulation of non-hormone-binding forms of the receptor

M. Alexis, D. Mitsiou, D. Siriani, 2003, The Journal of Steroid Biochemistry and Molecular Biology.

The brominated flame retardants TBECH and DPTE alter prostate growth, histology and gene expression patterns in the mouse.

M. Alexis, D. Mitsiou, Ceyhun Bereketoglu, 2021, Reproductive toxicology.

The efficiency of nuclear processing of the tyrosine aminotransferase mRNA transcript increases after partial hepatectomy.

L. Baki, M. Alexis, 1994, European journal of biochemistry.

Temporary loss of glucocorticoid receptor‐mediated regulation of gene expression in heat‐shocked cells

M. Alexis, D. Mitsiou, Dimitra J. Mitsiou, 1995, FEBS letters.

Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity.

M. Alexis, X. Alexi, M. Koufaki, 2010, European journal of medicinal chemistry.

Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835]

V. Apostolopoulos, M. Alexis, M. Plebanski, 2006, Breast Cancer Research.

9,11-Secosterols with antiproliferative activity from the gorgonian Eunicella cavolini.

M. Alexis, X. Alexi, E. Ioannou, 2009, Bioorganic & medicinal chemistry.

5α,8α-Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: Isolation and evaluation of their antiproliferative activity

M. Alexis, X. Alexi, E. Ioannou, 2009, Steroids.

Chroman/catechol hybrids: synthesis and evaluation of their activity against oxidative stress induced cellular damage.

M. Alexis, M. Koufaki, D. Galaris, 2006, Journal of medicinal chemistry.

Discovery of New non-steroidal selective glucocorticoid receptor agonists

M. Alexis, D. Mitsiou, C. Potamitis, 2019, The Journal of Steroid Biochemistry and Molecular Biology.

Design, synthesis, and biological evaluation of new raloxifene analogues of improved antagonist activity and endometrial safety.

M. Alexis, D. Mitsiou, G. Lambrinidis, 2020, Bioorganic chemistry.

Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity.

N. Avlonitis, M. Alexis, X. Alexi, 2009, Journal of medicinal chemistry.

Natural and Nature-Derived Products Targeting Human Coronaviruses

M. Alexis, A. Skaltsounis, E. Tramontano, 2021, Molecules.

Activation and changes in the sedimentation properties of rat liver glucocorticoid receptor.

M. Alexis, C. Sekeris, R. Djordević-Marković, 1983, Journal of steroid biochemistry.

Glucocorticoid receptors in developing rat brain and liver.

M. Alexis, E. Kitraki, F. Stylianopoulou, 1984, Journal of steroid biochemistry.

Isoxazole substituted chromans against oxidative stress-induced neuronal damage.

M. Alexis, X. Alexi, M. Koufaki, 2011, Bioorganic & medicinal chemistry.

Activation of Hormone and Growth Factor Receptors

M. Alexis, C. Sekeris, 1990 .

New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription.

B. R. Steele, C. Screttas, M. Alexis, 2011, Bioorganic & medicinal chemistry.

Engineered chimeric enzymes as tools for drug discovery: generating reliable bacterial screens for the detection, discovery, and assessment of estrogen receptor modulators.

Georgios Skretas, B. R. Steele, David W Wood, 2007, Journal of the American Chemical Society.

Pregnanes with antiproliferative activity from the gorgonian Eunicella cavolini

M. Alexis, X. Alexi, E. Ioannou, 2008 .

Design and synthesis of 1,2-dithiolane derivatives and evaluation of their neuroprotective activity.

M. Alexis, M. Koufaki, Faidra Nikoloudaki, 2007, Bioorganic & medicinal chemistry letters.

Biological evaluation of isoflavonoids from Genista halacsyi using estrogen-target cells: Activities of glucosides compared to aglycones

M. Alexis, D. Mitsiou, X. Alexi, 2019, PloS one.

Ester and carbamate ester derivatives of Biochanin A: synthesis and in vitro evaluation of estrogenic and antiproliferative activities.

M. Alexis, X. Alexi, H. Pratsinis, 2012, Bioorganic & medicinal chemistry.

Comparison of thermal effects of stilbenoid analogs in lipid bilayers using differential scanning calorimetry and molecular dynamics: correlation of thermal effects and topographical position with antioxidant activity

B. R. Steele, M. Alexis, X. Alexi, 2011, European Biophysics Journal.

A new class of phytoestrogens; evaluation of the estrogenic activity of deoxybenzoins.

M. Alexis, D. Mitsiou, G. Lambrinidis, 2004, Chemistry & biology.

Interaction of skeletal myosin light chains with calcium ions.

M. Alexis, W. Gratzer, 1978, Biochemistry.

Ontogeny of the glucocorticoid receptor in the rat brain.

M. Alexis, E. Kitraki, F. Stylianopoulou, 1990, Advances in experimental medicine and biology.

Subunit composition of the untransformed glucocorticoid receptor in the cytosol and in the cell.

M. Alexis, D. Mitsiou, I. Mavridou, 1992, European journal of biochemistry.

Estrogenic activity of isoflavonoids from the stem bark of the tropical tree Amphimas pterocarpoides, a source of traditional medicines

J. Mbanya, J. Tchoumtchoua, M. Alexis, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

Microarray analysis of the differential transformation mediated by Kirsten and Harvey Ras oncogenes in a human colorectal adenocarcinoma cell line

M. Alexis, Michael L. Roberts, A. Pintzas, 2006, International journal of cancer.

Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: the quantitative and temporal interrogation of chemically induced cell death at the protein level.

Eugenia G. Giannopoulou, Dyan N. Ankrett, P. Townsend, 2013, Journal of proteome research.

Glucocorticoid receptor structure as probed by endogenous proteases.

L. Baki, M. Alexis, C. Sekeris, 1988, Journal of steroid biochemistry.

Phosphorylation and the binding of calcium and magnesium to skeletal myosin.

E. Kardami, M. Alexis, W. Gratzer, 1980, European journal of biochemistry.

A novel quantitative flow cytometric method for measuring glucocorticoid receptor (GR) in cell lines: correlation with the biochemical determination of GR.

M. Alexis, S. Perez, A. Gritzapis, 2007, Journal of immunological methods.

Insights into ectopic estrogen receptor expression, nucleocytoplasmic distribution and interaction with chromatin obtained with new antibodies to estrogen receptors α and β

Christos C. Petrou, M. Alexis, D. Mitsiou, 2011, Steroids.

Mechanisms of the Action of Zoledronic Acid on Human MG-63 Osteosarcoma Cells

M. Alexis, M. Koutsilieris, M. Manoussakis, 2008, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Glucocorticoid receptor gene expression in the embryonic rat brain.

M. Alexis, E. Kitraki, F. Stylianopoulou, 1996, Neuroendocrinology.

Design and synthesis of novel neuroprotective 1,2-dithiolane/chroman hybrids.

M. Alexis, X. Alexi, M. Koufaki, 2009, Bioorganic & medicinal chemistry.

Ebenfurans IV-VIII from Onobrychis ebenoides: evidence that C-prenylation is the key determinant of the cytotoxicity of 3-formyl-2-arylbenzofurans.

M. Alexis, X. Alexi, A. Skaltsounis, 2008, Journal of natural products.

Synthesis of a second generation chroman/catechol hybrids and evaluation of their activity in protecting neuronal cells from oxidative stress-induced cell death.

M. Alexis, X. Alexi, M. Koufaki, 2010, Bioorganic & medicinal chemistry.

Peltogynoids and 2-Phenoxychromones from Peltophorum pterocarpum and Evaluation of Their Estrogenic Activity

L. Marcourt, M. Alexis, A. Skaltsounis, 2013, Planta Medica.

Isoflavonoid Profiling and Estrogen-Like Activity of Four Genista Species from the Greek Flora

M. Alexis, N. Fokialakis, M. Makropoulou, 2020, Molecules.

Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response in rats.

M. Alexis, D. Mitsiou, Emily Panagiotidou, 2014, The Journal of endocrinology.

Phytochemical study and biological evaluation of chemical constituents of Platanus orientalis and Platanus × acerifolia buds.

J. Tchoumtchoua, M. Alexis, D. Mitsiou, 2016, Phytochemistry.

High affinity 17α-substituted estradiol derivatives: Synthesis and evaluation of estrogen receptor agonist activity

M. Alexis, S. Haroutounian, K. Kasiotis, 2006, Steroids.

ERβ1 Sensitizes and ERβ2 Desensitizes ERα-Positive Breast Cancer Cells to the Inhibitory Effects of Tamoxifen, Fulvestrant and Their Combination with All-Trans Retinoic Acid

A. Chatziioannou, M. Alexis, D. Mitsiou, 2023, International journal of molecular sciences.

Glucocorticoids: new insights into their molecular mechanisms

M. Alexis, 1987 .

Glucocorticoid regulation of glycerolphosphate dehydrogenase expression in the developing rat brain

M. Alexis, E. Kitraki, F. Stylianopoulou, 1995, Neurochemical Research.

Isoflavonoids from Erythrina poeppigiana: evaluation of their binding affinity for the estrogen receptor.

M. Alexis, A. Skaltsounis, D. Njamen, 2009, Journal of natural products.

Insights into ectopic estrogen receptor expression, nucleocytoplasmic distribution and interaction with chromatin obtained with new antibodies to estrogen receptors α and β

Christos C. Petrou, M. Alexis, D. Mitsiou, 2011, Steroids.

The distribution and properties of the glucocorticoid receptor from rat brain and pituitary.

M. Alexis, E. Kitraki, F. Stylianopoulou, 1983, The Journal of biological chemistry.