G. Perini

发表

Michael R. Green, Rossella Tupler, R. Tupler, 2001, Nature.

Role of p75 Neurotrophin Receptor in the Neurotoxicity by β-amyloid Peptides and Synergistic Effect of Inflammatory Cytokines

G. Perini, U. Armato, V. Della-Bianca, 2002, The Journal of experimental medicine.

The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer

M. Severgnini, M. Rocchi, S. Purgato, 2017, Genetics.

Fine mapping of a replication origin of human DNA.

L. Zentilin, M. Giacca, S. Riva, 1994, Proceedings of the National Academy of Sciences of the United States of America.

In vivo transcriptional regulation of N-Myc target genes is controlled by E-box methylation.

Antonio Porro, G. Perini, G. Della Valle, 2005, Proceedings of the National Academy of Sciences of the United States of America.

In vivo functional dissection of human inner kinetochore protein CENP-C.

W. Earnshaw, G. Perini, S. Trazzi, 2002, Journal of structural biology.

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.

H. Pickett, P. Gunaratne, S. Purgato, 2016, Cancer research.

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

Leming Shi, J. Vandesompele, M. Fischer, 2019, Nature Communications.

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

F. Giorgi, G. Perini, D. Mercatelli, 2020, Genes.

Repurposing a psychoactive drug for children with cancer: p27Kip1-dependent inhibition of metastatic neuroblastomas by Prozac

S. Purgato, V. de Laurenzi, G. Perini, 2020, Oncogenesis.

MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma

M. Fischer, A. Oberthuer, B. Brors, 2015, Oncotarget.

SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability

A. Biankin, C. Scarlett, G. Perini, 2011, PLoS genetics.

Nitric oxide control of MYCN expression and multi drug resistance genes in tumours of neural origin.

A. Contestabile, G. Perini, F. Cambuli, 2010, Current pharmaceutical design.

Nitric Oxide Protects Neuroblastoma Cells from Apoptosis Induced by Serum Deprivation through cAMP-response Element-binding Protein (CREB) Activation*

A. Contestabile, R. Bartesaghi, G. Perini, 2002, The Journal of Biological Chemistry.

Off–label long acting injectable antipsychotics in real–world clinical practice: a cross-sectional analysis of prescriptive patterns from the STAR Network DEPOT study

M. Ruggeri, M. Piccinelli, G. Serafini, 2022, BMC Psychiatry.

MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma

Pavel Sumazin, C. Coarfa, Zihua Zeng, 2022, Nature Communications.

Epigenetic origin of evolutionary novel centromeres

E. Eichler, John Huddleston, M. Malig, 2017, Scientific Reports.

The gene for a novel human lamin maps at a highly transcribed locus of chromosome 19 which replicates at the onset of S-phase

L. Zentilin, M. Giacca, S. Riva, 1992, Molecular and cellular biology.

Centromere sliding on a mammalian chromosome

K. Sullivan, M. Rocchi, S. Purgato, 2014, Chromosoma.

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma

S. Agarwal, K. Rajapakshe, C. Coarfa, 2018, Oncotarget.

Searching for replication origins in mammalian DNA.

L. Zentilin, M. Giacca, G. Biamonti, 1993, Gene.

SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma.

G. Perini, D. Newell, L. Evans, 2015, Cancer letters.

Neurotrophin p75 Receptor Is Involved in Neuronal Damage by Prion Peptide-(106–126)*

G. Perini, U. Armato, V. Della-Bianca, 2001, The Journal of Biological Chemistry.

The Amyloid Precursor Protein (APP) Triplicated Gene Impairs Neuronal Precursor Differentiation and Neurite Development through Two Different Domains in the Ts65Dn Mouse Model for Down Syndrome*

R. Bartesaghi, G. Perini, E. Ciani, 2013, The Journal of Biological Chemistry.

PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis

Dachuan Huang, C. Ong, A. Jeyasekharan, 2020, Nature Communications.

Gfi-1 inhibits proliferation and colony formation of p210BCR/ABL-expressing cells via transcriptional repression of STAT 5 and Mcl-1

B. Calabretta, M. Lidonnici, A. R. Soliera, 2012, Leukemia.

The absence of dystrophin brain isoform expression in healthy human heart ventricles explains the pathogenesis of 5' X-linked dilated cardiomyopathy

F. Muntoni, C. Rapezzi, A. Ferlini, 2012, BMC Medical Genetics.

Physical Interaction between MYCN Oncogene and Polycomb Repressive Complex 2 (PRC2) in Neuroblastoma

G. Perini, A. Sala, D. Corvetta, 2013, The Journal of Biological Chemistry.

Letting the breaks off MYCN

P. Ekert, G. Perini, G. Milazzo, 2016, Cell Death and Differentiation.

Ring chromosomes, breakpoint clusters, and neocentromeres in sarcomas

Christopher W. Whelan, M. Rocchi, S. Purgato, 2015, Genes, chromosomes & cancer.

Transcriptional and epigenetic analyses of the DMD locus reveal novel cis‑acting DNA elements that govern muscle dystrophin expression.

M. Falzarano, H. Osman, A. Ferlini, 2017, Biochimica et biophysica acta. Gene regulatory mechanisms.

Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects

F. Stossi, B. Katzenellenbogen, A. Biankin, 2010, Oncogene.

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.

R. Bartesaghi, G. Perini, F. Hansen, 2016, Human molecular genetics.

Restoration of the molecular clock is tumor suppressive in neuroblastoma

Pavel Sumazin, G. Perini, Mahmoud A. Mohammad, 2021, Nature Communications.

Expression of doxorubicin-daunorubicin resistance genes in different anthracycline-producing mutants of Streptomyces peucetius

G. Biamonti, G. Perini, F. Torti, 1992, Journal of bacteriology.

The Hepatitis B pX Protein Promotes Dimerization and DNA Binding of Cellular Basic Region/Leucine Zipper Proteins by Targeting the Conserved Basic Region*

G. Perini, E. Oetjen, M. Green, 1999, The Journal of Biological Chemistry.

A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma

R. Stallings, F. Speleman, J. Vandesompele, 2021, Cancers.

The DMD Locus Harbours Multiple Long Non-Coding RNAs Which Orchestrate and Control Transcription of Muscle Dystrophin mRNA Isoforms

M. Falzarano, A. Ferlini, G. Perini, 2012, PloS one.

Non-Coding RNAs in Muscle Dystrophies

A. Ferlini, G. Perini, D. Erriquez, 2013, International journal of molecular sciences.

Association between imatinib transporters and metabolizing enzymes genotype and response in newly diagnosed chronic myeloid leukemia patients receiving imatinib therapy

J. Radich, M. Baccarani, M. Thornquist, 2013, Haematologica.

CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains.

W. Earnshaw, I. Raška, G. Perini, 2002, Journal of cell science.

Deep learning for MYC binding site recognition

G. Perini, R. Fioresi, P. Demurtas, 2022, bioRxiv.

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.

R. C. Poulos, J. W. Wong, C. Arrowsmith, 2015, Cancer research.

Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis

G. Perini, G. Della Valle, M. Haber, 2007, Proceedings of the National Academy of Sciences.

A human DNA replication origin: localization and transcriptional characterization

L. Zentilin, M. Giacca, S. Riva, 2006, Chromosoma.

Targeting Oncogenic Transcriptional Networks in Neuroblastoma: From N-Myc to Epigenetic Drugs

G. Perini, R. Ciaccio, G. Milazzo, 2021, International journal of molecular sciences.

which replicates at the onset of S-phase. highly transcribed locus of chromosome 19 The gene for a novel human lamin maps at a

L. Zentilin, M. Giacca, G. D. Valle, 2013 .

JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma

R. C. Poulos, J. W. Wong, M. Fischer, 2019, Nature Communications.

Single-Cell Gene Network Analysis and Transcriptional Landscape of MYCN-Amplified Neuroblastoma Cell Lines

F. Giorgi, G. Perini, P. Sanna, 2021, Biomolecules.

The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription.

R. C. Poulos, C. Scarlett, J. Wong, 2017, Cancer research.

MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4

G. Perini, Bing Liu, W. London, 2016, Oncotarget.

N-Myc regulates expression of the detoxifying enzyme glutathione transferase GSTP1, a marker of poor outcome in neuroblastoma.

A. Oberthuer, G. Perini, J. Fletcher, 2012, Cancer research.

Mutations in the 5' UTR of ANKRD26, the ankirin repeat domain 26 gene, cause an autosomal-dominant form of inherited thrombocytopenia, THC2.

P. Noris, S. Perrotta, T. Pippucci, 2011, American journal of human genetics.

Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression.

J. Mattick, M. Dinger, A. Fox, 2014, Journal of the National Cancer Institute.

IKAROS Deletions Dictate a Unique Gene Expression Signature in Patients with Adult B-Cell Acute Lymphoblastic Leukemia

R. Foà, M. Baccarani, S. Chiaretti, 2012, PloS one.

Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance.

R. Foà, M. Baccarani, S. Chiaretti, 2008, Blood.

Presence of transcription signals in two putative DNA replication origins of human cells.

C. Tribioli, M. Giacca, S. Riva, 1988, Biochimica et biophysica acta.

CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells

R. Bartesaghi, G. Perini, E. Ciani, 2012, Biochimica et biophysica acta.

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.

R. Bartesaghi, G. Perini, E. Ciani, 2011, Human molecular genetics.

MYCN-mediated transcriptional repression in neuroblastoma: the other side of the coin

G. Perini, E. Valli, S. Gherardi, 2013, Front. Oncol..

Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax

G. Perini, S. Wagner, M. Green, 1995, Nature.

A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.

G. Perini, M. Eilers, G. Della Valle, 2011, Cancer research.

Molecular and Cellular Pathobiology A SP 1 / MIZ 1 / MYCN Repression Complex Recruits HDAC 1 at the TRKA and p 75 NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF

G. D. Valle, G. Perini, M. Eilers, 2011 .

Direct and Coordinate Regulation of ATP-binding Cassette Transporter Genes by Myc Factors Generates Specific Transcription Signatures That Significantly Affect the Chemoresistance Phenotype of Cancer Cells*

M. Schwab, G. Perini, G. Della Valle, 2010, The Journal of Biological Chemistry.

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

M. Fischer, A. Oberthuer, S. Purgato, 2019, Science Translational Medicine.

Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface.

M. Fischer, A. Oberthuer, M. Parker, 2019, Cancer research.

Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma

G. Perini, S. Amente, L. Lania, 2015, Oncotarget.

c-MYC Oncoprotein Dictates Transcriptional Profiles of ATP-Binding Cassette Transporter Genes in Chronic Myelogenous Leukemia CD34+ Hematopoietic Progenitor Cells

M. Baccarani, G. Martinelli, G. Perini, 2011, Molecular Cancer Research.

Cancer Genes and Genomics c-MYC Oncoprotein Dictates Transcriptional Profiles of ATP-Binding Cassette Transporter Genes in Chronic Myelogenous Leukemia CD 34 þ Hematopoietic Progenitor Cells

M. Baccarani, G. Martinelli, G. Perini, 2011 .

ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux

M. Schwab, A. Sartorelli, G. Perini, 2011, Journal of the National Cancer Institute.

The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells

A. Giangrande, G. Martinelli, G. Perini, 2016, Oncotarget.

Functional cooperation between TrkA and p75(NTR) accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities.

G. Perini, J. Herbert, S. Trazzi, 2007, Experimental cell research.

A repeated element in the human lamin B2 gene covers most of an intron and reiterates the exon/intron junction.

S. Riva, G. Biamonti, G. Perini, 1997, Gene.

A critical appraisal of tools available for monitoring epigenetic changes in clinical samples from patients with myeloid malignancies

C. Plass, K. Grønbæk, S. Lehmann, 2012, Haematologica.

CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming

Rosa A. Uribe, Pavel Sumazin, C. Coarfa, 2021, Advanced science.

p53 is a direct transcriptional target of MYCN in neuroblastoma.

Nunzio Iraci, J. Lunec, G. Perini, 2010, Cancer research.

MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma.

S. Purgato, G. Perini, M. Haber, 2018, Biochimica et biophysica acta. Gene regulatory mechanisms.

MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells

G. Perini, G. Capranico, G. Milazzo, 2023, International journal of molecular sciences.

PRDM12 in Health and Diseases

A. Casamassimi, G. Perini, M. Rienzo, 2021, International journal of molecular sciences.

The C-Terminal Domain of CENP-C Displays Multiple and Critical Functions for Mammalian Centromere Formation

G. D. Valle, A. Musacchio, G. Perini, 2009, PloS one.

Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients

I. Laurenzana, G. Martinelli, G. Perini, 2016, Oncotarget.

Myc proteins in cell biology and pathology.

G. Perini, B. Majello, 2015, Biochimica et biophysica acta.

HTLV-I Tax

Michael R. Green, G. Perini, Michael R. Green, 1996 .

Centromere sliding on a mammalian chromosome

K. Sullivan, M. Rocchi, S. Purgato, 2014, Chromosoma.

A new BCR-ABL1 Drosophila model as a powerful tool to elucidate the pathogenesis and progression of chronic myeloid leukemia

A. Giangrande, G. Perini, D. Cilloni, 2018, Haematologica.

Single-Cell Sequencing Identifies Master Regulators Affected by Panobinostat in Neuroblastoma Cells