C. Romier

发表

The NF-YB/NF-YC Structure Gives Insight into DNA Binding and Transcription Regulation by CCAAT Factor NF-Y*

Christophe Romier, Dino Moras, Roberto Mantovani, 2003, The Journal of Biological Chemistry.

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.

W. Sippl, C. Romier, M. Jung, 2016, Journal of medicinal chemistry.

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

W. Sippl, S. Kannan, C. Romier, 2018, Molecules.

Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines.

H. Gohlke, C. Romier, F. Hansen, 2017, Journal of medicinal chemistry.

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.

H. Gohlke, C. Romier, F. Hansen, 2017, Journal of medicinal chemistry.

Assembly of protein complexes by coexpression in prokaryotic and eukaryotic hosts: an overview.

Christophe Romier, Anastassis Perrakis, C. Romier, 2008, Methods in molecular biology.

Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study.

R. Owens, Y. Peleg, K. Büssow, 2011, Journal of structural biology.

Crystal structure of tRNA‐guanine transglycosylase: RNA modification by base exchange.

D. Suck, C. Romier, K. Reuter, 1996, The EMBO journal.

Structural Basis of Base Exchange by tRNA-Guanine Transglycosylases

D. Suck, C. Romier, R. Ficner, 1998 .

Slight sequence variations of a common fold explain the substrate specificities of tRNA‐guanine transglycosylases from the three kingdoms

D. Suck, C. Romier, J. Meyer, 1997, FEBS letters.

Functional Analysis of the TFIID-specific Yeast TAF4 (yTAFII48) Reveals an Unexpected Organization of Its Histone-fold Domain*

C. Romier, S. Sanders, P. A. Weil, 2002, The Journal of Biological Chemistry.

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2).

A. Mai, C. Romier, M. Jung, 2019, Journal of medicinal chemistry.

Dissecting the interaction network of multiprotein complexes by pairwise coexpression of subunits in E. coli.

D. Moras, C. Romier, S. Fribourg, 2001, Journal of molecular biology.

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Tobias Rumpf, W. Sippl, C. Romier, 2014, Journal of molecular biology.

Hydroxamates of para-aminobenzoic acid as selective inhibitors of HDAC8.

C. Romier, M. Jung, U. Kulandaivelu, 2014, Bioorganic chemistry.

Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni.

C. Romier, R. Pierce, M. Marek, 2016, Methods in molecular biology.

Isophthalic Acid‐Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni

W. Sippl, C. Romier, F. Hansen, 2017, Archiv der Pharmazie.

Baculovirus VP1054 Is an Acquired Cellular PURα, a Nucleic Acid-Binding Protein Specific for GGN Repeats

C. Romier, M. V. van Oers, O. Merten, 2013, Journal of Virology.

Specific conformational dynamics of the ATPase head domains and DNA exit gate mediate the Cohesin ATPase cycle

C. Romier, E. Watrin, K. Brillet, 2022, bioRxiv.

The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination

L. Drouard, C. Romier, Efil Bayam, 2021, Nucleic acids research.

Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2.

W. Sippl, C. Romier, S. Goldenberg, 2021, Cell reports.

Purification, crystallization, and preliminary X‐ray diffraction studies of tRNA‐guanine transglycosylase from Zymomonas mobilis

D. Suck, C. Romier, K. Reuter, 1996, Proteins.

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2).

A. Mai, C. Romier, M. Jung, 2019, Journal of medicinal chemistry.

Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

W. Sippl, C. Romier, M. Jung, 2022, International journal of molecular sciences.

Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase reveal aspartate 102 as the active site nucleophile.

D. Suck, C. Romier, K. Reuter, 1996, Biochemistry.

Strategies for bacterial expression of protein-peptide complexes: application to solubilization of papillomavirus E6.

Y. Nominé, G. Travé, K. Zanier, 2011, Protein expression and purification.

One-Atom-Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity.

W. Sippl, C. Romier, M. Schutkowski, 2019, Biochemistry.

Sequence and structure requirements for specific recognition of HIV-1 TAR and DIS RNA by the HIV-1 Vif protein

P. Dumas, Y. Nominé, C. Romier, 2012, RNA biology.

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 (HDAC6) Inhibitors

Dina, W. Sippl, C. Romier, 2019 .

Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni

J. Keiser, C. Romier, M. Jung, 2022, ChemMedChem.

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies.

Christophe Romier, Tamar Unger, Joel L Sussman, 2006, Acta crystallographica. Section D, Biological crystallography.

Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1.

W. Sippl, C. Romier, S. Günther, 2020, European journal of medicinal chemistry.

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.

O. Witt, W. Sippl, C. Romier, 2016, Journal of medicinal chemistry.

Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides.

W. Sippl, C. Romier, M. Jung, 2017, Organic & biomolecular chemistry.

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement

Aubry K. Miller, Raphael R. Steimbach, W. Sippl, 2022, Chembiochem : a European journal of chemical biology.

Recognition of single‐stranded DNA by nuclease P1: High resolution crystal structures of complexes with substrate analogs

D. Suck, R. Dominguez, C. Romier, 1998, Proteins.

Structural Biology of Epigenetic Targets

C. Romier, J. Wurtz, J. Renaud, 2009 .

The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control.

T. Ceska, D. Suck, G. Stier, 1997, Structure.

Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors.

W. Sippl, C. Romier, D. Robaa, 2015, Journal of molecular graphics & modelling.

Sequence-Specific Transcription Factor NF-Y Displays Histone-like DNA Binding and H2B-like Ubiquitination

M. Nardini, M. Bolognesi, N. Gnesutta, 2013, Cell.

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity.

O. Witt, W. Sippl, C. Romier, 2017, Journal of medicinal chemistry.

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation

Christophe Romier, Irwin Davidson, Benoit Ballester, 2014, eLife.

The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26

F. Winston, C. Romier, J. Cavarelli, 2010, The EMBO journal.

Noncanonical Tandem SH2 Enables Interaction of Elongation Factor Spt6 with RNA Polymerase II*

F. Winston, C. Romier, J. Cavarelli, 2010, The Journal of Biological Chemistry.

TFIID TAF 6-TAF 9 Complex Formation Involves the HEAT Repeat-containing C-terminal Domain of TAF 6 and Is Modulated by TAF 5 Protein *

D. Moras, L. Tora, C. Romier, 2012 .

The TFIID Components Human TAFII140 andDrosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger

M. Brand, L. Tora, C. Romier, 2001, Molecular and Cellular Biology.

Expression in Escherichia coli: becoming faster and more complex.

R. Vincentelli, C. Romier, 2013, Current opinion in structural biology.

Deciphering correct strategies for multiprotein complex assembly by co-expression: application to complexes as large as the histone octamer.

C. Romier, S. Fribourg, Michael Koch, 2011, Journal of structural biology.

ANP32E is a histone chaperone that removes H2A.Z from chromatin

T. Mak, C. Romier, S. Dimitrov, 2014, Nature.

Zinc-finger UBPs: regulators of deubiquitylation.

L. Tora, C. Romier, J. Bonnet, 2008, Trends in biochemical sciences.

Crystallization and preliminary crystallographic analysis of eukaryotic transcription and mRNA export factor Iws1 from Encephalitozoon cuniculi.

C. Romier, J. Cavarelli, Michael Koch, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

The structure of an Iws 1 / Spt 6 complex reveals an interaction domain conserved in TFIIS , Elongin A and Med 26 Marie -

F. Winston, C. Romier, J. Cavarelli, 2010 .

Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.

W. Sippl, C. Romier, G. Oliveira, 2015, Future medicinal chemistry.

Schistosome sirtuins as drug targets.

W. Sippl, C. Romier, J. Schultz, 2015, Future medicinal chemistry.

Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni

Adriana S. A. Pereira, C. Romier, Letícia Anderson, 2017, PLoS neglected tropical diseases.

The histone fold is a key structural motif of transcription factor TFIID.

C. Romier, I. Davidson, S. Werten, 2001, Trends in biochemical sciences.

Human TAFII28 and TAFII18 Interact through a Histone Fold Encoded by Atypical Evolutionary Conserved Motifs Also Found in the SPT3 Family

D. Moras, C. Birck, C. Romier, 1998, Cell.

Functional and structural analysis of the subunits of human transcription factor TFIID.

D. Moras, C. Birck, C. Romier, 1998, Cold Spring Harbor symposia on quantitative biology.

Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.

Christophe Romier, Simone Brogi, Lucia Altucci, 2018, European journal of medicinal chemistry.

NF-Y Recruitment of TFIID, Multiple Interactions with Histone Fold TAFIIs*

D. Moras, L. Tora, R. Mantovani, 2002, The Journal of Biological Chemistry.

HDAC8: a multifaceted target for therapeutic interventions.

O. Witt, W. Sippl, C. Romier, 2015, Trends in pharmacological sciences.

Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.

W. Sippl, C. Romier, D. Christianson, 2022, European journal of medicinal chemistry.

Identification of HDAC10 Inhibitors that Modulate Autophagy-Related Proteins in Transformed Cells

W. Sippl, C. Romier, D. Christianson, 2022 .

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

W. Sippl, S. Kannan, C. Romier, 2013, PLoS pathogens.

Molecular basis and specificity of H2A.Z–H2B recognition and deposition by the histone chaperone YL1

C. Romier, S. Dimitrov, A. Hamiche, 2016, Nature Structural &Molecular Biology.

Structure‐Based Design, Synthesis, and Biological Evaluation of Triazole‐Based smHDAC8 Inhibitors

W. Sippl, C. Romier, M. Jung, 2019, ChemMedChem.

Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties.

W. Sippl, C. Romier, M. Schutkowski, 2022, Journal of medicinal chemistry.

Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity

W. Sippl, C. Romier, M. Schutkowski, 2021, International journal of molecular sciences.

Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly

Christophe Romier, Christiane Branlant, Bruno Charpentier, 2013, Nucleic acids research.

DNA Binding by Sgf11 Protein Affects Histone H2B Deubiquitination by Spt-Ada-Gcn5-Acetyltransferase (SAGA)*

C. Romier, B. Kieffer, J. Bonnet, 2014, The Journal of Biological Chemistry.

The Human SPT20-Containing SAGA Complex Plays a Direct Role in the Regulation of Endoplasmic Reticulum Stress-Induced Genes

Jiahuai Han, H. Stunnenberg, L. Tora, 2008, Molecular and Cellular Biology.

Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation

C. Romier, L. Negroni, I. Davidson, 2019, Nature Communications.

CHD4 regulates PADI1 and PADI3 expression linking pyruvate kinase M2 citrullination to glycolysis and proliferation

C. Romier, L. Negroni, I. Davidson, 2019, bioRxiv.

Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.

Takayoshi Suzuki, W. Sippl, C. Romier, 2018, Journal of medicinal chemistry.

Robots, pipelines, polyproteins: Enabling multiprotein expression in prokaryotic and eukaryotic cells

T. Richmond, C. Romier, C. Schaffitzel, 2011, Journal of Structural Biology.

Automated unrestricted multigene recombineering for multiprotein complex production

T. Richmond, M. Steinmetz, C. Romier, 2009, Nature Methods.

Discovery of Inhibitors of Schistosoma mansoni HDAC8 by Combining Homology Modeling, Virtual Screening, and in Vitro Validation

Christophe Romier, Wolfgang Sippl, Jelena Melesina, 2014, J. Chem. Inf. Model..

Histone Folds Mediate Selective Heterodimerization of Yeast TAFII25 with TFIID Components yTAFII47 and yTAFII65 and with SAGA Component ySPT7

L. Tora, C. Romier, I. Davidson, 2001, Molecular and Cellular Biology.

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.

W. Sippl, C. Romier, D. Christianson, 2019, Journal of medicinal chemistry.

Characterization and production of protein complexes by co-expression in Escherichia coli.

C. Romier, U. Schlattner, I. Berger, 2015, Methods in molecular biology.

Crystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assembly.

D. Moras, C. Birck, C. Romier, 2007, Journal of molecular biology.

The structural plasticity of SCA7 domains defines their differential nucleosome‐binding properties

L. Tora, C. Romier, B. Kieffer, 2010, EMBO reports.

Structural Biology of Epigenetic Targets: Exploiting Complexity

C. Romier, M. Marek, T. B. Shaik, 2019, Epigenetic Drug Discovery.

The Human TFIID Components TAFII135 and TAFII20 and the Yeast SAGA Components ADA1 and TAFII68 Heterodimerize to Form Histone-Like Pairs

D. Moras, C. Romier, O. Poch, 2000, Molecular and Cellular Biology.

Binding Free Energy (BFE) Calculations and Quantitative Structure–Activity Relationship (QSAR) Analysis of Schistosoma mansoni Histone Deacetylase 8 (smHDAC8) Inhibitors

W. Sippl, C. Romier, Ehab Ghazy, 2021, Molecules.

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

A. Ganesan, W. Sippl, C. Romier, 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

Synergistic Transcriptional Activation by TATA-Binding Protein and hTAFII28 Requires Specific Amino Acids of the hTAFII28 Histone Fold

D. Moras, C. Birck, C. Romier, 1999, Molecular and Cellular Biology.

TFIID TAF6-TAF9 Complex Formation Involves the HEAT Repeat-containing C-terminal Domain of TAF6 and Is Modulated by TAF5 Protein*

D. Moras, L. Tora, C. Romier, 2012, The Journal of Biological Chemistry.

Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis

W. Sippl, C. Romier, M. Jung, 2018, ChemMedChem.

Crystal Structure of a Subcomplex of Human Transcription Factor TFIID Formed by TATA Binding Protein-associated Factors hTAF4 (hTAFII135) and hTAF12 (hTAFII20)*

D. Moras, C. Romier, A. Mitschler, 2002, The Journal of Biological Chemistry.

Complex Reconstitution and Characterization by Combining Co-expression Techniques in Escherichia coli with High-Throughput.

Renaud Vincentelli, Christophe Romier, R. Vincentelli, 2016, Advances in experimental medicine and biology.

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.

O. Witt, W. Sippl, C. Romier, 2016, Journal of Medicinal Chemistry.

Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides.

W. Sippl, C. Romier, D. Robaa, 2017, Organic & biomolecular chemistry.

Fluorescence-Based Screening Assays for the NAD+-Dependent Histone Deacetylase smSirt2 from Schistosoma mansoni

W. Sippl, C. Romier, J. Schultz, 2015, Journal of biomolecular screening.

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity.

O. Witt, W. Sippl, C. Romier, 2017, Journal of medicinal chemistry.

Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD+-Dependent Lysine Deacylase Sirtuin 2.

W. Sippl, C. Romier, D. Robaa, 2024, Journal of medicinal chemistry.

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Tobias Rumpf, W. Sippl, C. Romier, 2014, Journal of molecular biology.

The Cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains

C. Romier, E. Watrin, Marie-Laure Diebold-Durand, 2024, bioRxiv.