A. Hounslow

发表

Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1

Timothy D. Craggs, Ian A. Bennet, L. Finger, 2018, Nucleic acids research.

Detection of salt bridges to lysines in solution in barnase.

A. Hounslow, M. Williamson, Joe Ford, 2013, Chemical communications.

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF 3 - rather than by phosphoranes

N. J. Baxter, A. Hounslow, J. Waltho, 2010, Proceedings of the National Academy of Sciences.

Transition state analogue structures of human phosphoglycerate kinase establish the importance of charge balance in catalysis.

Matthew W Bowler, N. J. Baxter, A. Hounslow, 2010, Journal of the American Chemical Society.

Reprogramming of Escherichia coli K-12 Metabolism during the Initial Phase of Transition from an Anaerobic to a Micro-Aerobic Environment

G. Sanguinetti, A. Hounslow, M. Williamson, 2011, PloS one.

EPA decoration is essential for virulence

A. Hounslow, M. Williamson, P. Serror, 2018 .

Near attack conformers dominate β-phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate

C. E. Webster, N. J. Baxter, A. Hounslow, 2012, Proceedings of the National Academy of Sciences.

Evidence supporting a cis-enediol-based mechanism for Pyrococcus furiosus phosphoglucose isomerase.

Stan J. J. Brouns, Jasper Akerboom, D. Rice, 2006, Journal of molecular biology.

Cystatin forms a tetramer through structural rearrangement of domain-swapped dimers prior to amyloidogenesis.

M. J. Conroy, A. Hounslow, J. Waltho, 2004, Journal of molecular biology.

Two site recognition of Staphylococcus aureus peptidoglycan by lysostaphin SH3b

A. Hounslow, M. Williamson, E. Jagielska, 2019, Nature Chemical Biology.

Structure and Dynamics of Coxsackievirus B4 2A Proteinase, an Enyzme Involved in the Etiology of Heart Disease

N. J. Baxter, A. Hounslow, J. Waltho, 2006, Journal of Virology.

Loss of the first β-strand of human prion protein generates an aggregation-competent partially “open” form

J. Collinge, D. Sangar, M. Batchelor, 2022, bioRxiv.

Prioritization of charge over geometry in transition state analogues of a dual specificity protein kinase.

N. J. Baxter, A. Hounslow, J. Waltho, 2011, Journal of the American Chemical Society.

Enzymatic production of β-glucose 1,6-bisphosphate through manipulation of catalytic magnesium coordination

C. R. Trevitt, N. J. Baxter, A. Hounslow, 2020, Green Chemistry.

Structural and functional analysis of RNA and TAP binding to SF 2 / ASF

Stuart A. Wilson, L. Lian, A. Hounslow, 2007 .

Correlations between nuclear magnetic resonance spectra and crystal structure. III. A13C nuclear magnetic resonance study in the solid state of bis(xanthato) complexes of mercury(II); The crystal and molecular structure of bis(n-propyl-dithiocarbonato)mercury(II)

E. Tiekink, A. Hounslow, 1991 .

Nuclear magnetic resonance study of solvent exchange on hexakis(N,N-dimethylacetamide)cobalt(II), hexakis(N,N-diethylformamide)cobalt(II), and their nickel(II) analogs. Effect of solvent molecular size on lability

A. Hounslow, S. Lincoln, A. Boffa, 1986 .

Slow solvent exchange on five coordinate (N,N-dimethylformamide)2,2′, 2″-tri(N,N-dimethylamino)-triethylaminezinc(II), [Zn(Me6tren)dmf]2+

A. Hounslow, S. Lincoln, J. Coates, 1983 .

The inclusion of diflunisal by γ-cyclodextrin and permethylatedβ-cyclodextrin. A UV-visible and19F nuclear magnetic resonance spectroscopic study

A. Hounslow, S. Lincoln, J. Coates, 1988 .

The inclusion of diflunisal by α- and β-cyclodextrins. A 19F Nuclear magnetic resonance and spectrophotometric study

B. Doddridge, A. Hounslow, S. Lincoln, 1987 .

Sodium ion exchange on the 1,4,7,10,13,16-hexaoxaoctadecanesodium(I) cation ([Na.18C6]+) in several solvents. A sodium-23 nuclear magnetic resonance study

A. Hounslow, S. Lincoln, Alex White, 1987 .

Kinetic and equilibrium studies of the sodium(I) cryptates [Na.C211]+ and [Na.C21C5]+, and the sodium(I) diaza crown ether complex [Na.C21]+ in non-aqueous solution

A. Hounslow, S. Lincoln, A. Abou-Hamdan, 1988 .

Correlations between nuclear magnetic resonance spectra and crystal structures. A carbon-13 nuclear magnetic resonance study in the solid state of the Group 15 xanthates [A(S2COR)3](A = AsIII, SbIII, or BiIII; R = Me, Et, or Pri)

E. Tiekink, A. Hounslow, S. Lincoln, 1989 .

Correlations between nuclear magnetic resonance spectra and crystal structure: II. The observation of 199Hg13C scalaar coupling in the solid state for some methylmercury derivatives.

E. Tiekink, A. Hounslow, S. Lincoln, 1988 .

Use of solid and gel state 13C NMR spectroscopy for differentiation between agarophytes and carrageenophytes

A. Hounslow, M. Tate, E. Gordon-Mills, 1990, Hydrobiologia.

The effects of disulfide bonds on the denatured state of barnase

C. J. Bond, A. Fersht, V. Daggett, 2000, Protein science : a publication of the Protein Society.

Water in methacrylates—III. a cppemas 13c-nmr study of the effect of water on group motion in poly(2-hydroxyethyl methacrylate) copolymer networks

A. Hounslow, P. Allen, D.R.G. Williams, 1992 .

The radical polymerization of dimethacrylate monomers—the use of NMR spectrometry to follow the development of network structure

A. Hounslow, G. Simon, P. Allen, 1989 .

Structure of a Wbl protein and implications for NO sensing by M. tuberculosis

A. Hounslow, M. Williamson, Jason C. Crack, 2017, Nature Communications.

Ferrous Iron Binding Key to Mms6 Magnetite Biomineralisation: A Mechanistic Study to Understand Magnetite Formation Using pH Titration and NMR Spectroscopy

Sarah S. Staniland, J. P. Bramble, A. Rawlings, 2016, Chemistry.

Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones

N. J. Baxter, A. Hounslow, J. Waltho, 2001, Nature Structural Biology.

Molecular Mechanism for the Hofmeister Effect Derived from NMR and DSC Measurements on Barnase

Robert J. Falconer, N. J. Baxter, A. Hounslow, 2016, ACS omega.

Obligate heterodimerization of the archaeal Alba2 protein with Alba1 provides a mechanism for control of DNA packaging.

M. F. White, G. Taylor, M. J. Conroy, 2005, Structure.

Allomorphy as a mechanism of post-translational control of enzyme activity

C. R. Trevitt, N. J. Baxter, A. Hounslow, 2020, Nature Communications.

When simple sequence comparison fails: the cryptic case of the shared domains of the bacterial replication initiation proteins DnaB and DnaD

A. Grossman, A. Hounslow, W. Smits, 2010, Nucleic acids research.

Multi-omic based production strain improvement (MOBpsi) for bio-manufacturing of toxic chemicals.

G. H. Thomas, K. Lilley, V. Springthorpe, 2022, Metabolic engineering.

Molecular basis for bacterial peptidoglycan recognition by LysM domains

S. Foster, S. Lacroix-Desmazes, J. Dimitrov, 2014, Nature Communications.

Structural effects of the highly protective V127 polymorphism on human prion protein

J. Collinge, G. Jackson, D. Sangar, 2020, Communications Biology.

Catalysis by Glomerella cingulata cutinase requires conformational cycling between the active and inactive states of its catalytic triad.

D. Rice, A. Moir, A. Hounslow, 2009, Journal of molecular biology.

High-affinity tamoxifen analogues retain extensive positional disorder when bound to calmodulin

C. R. Trevitt, A. Hounslow, J. Waltho, 2021, Magnetic Resonance.

High-affinity tamoxifen analogues retain extensive positional disorder when bound to calmodulin

C. Hunter, C. R. Trevitt, A. Hounslow, 2021, Magnetic resonance.

Determinants of the endosomal localization of sorting nexin 1.

A. Hounslow, J. Waltho, G. Gill, 2005, Molecular biology of the cell.

Solution structure of the helicase-interaction domain of the primase DnaG: a model for helicase activation.

A. Hounslow, J. Waltho, Karl Syson, 2005, Structure.

Why the Energy Landscape of Barnase Is Hierarchical

N. J. Baxter, A. Hounslow, M. Williamson, 2018, Front. Mol. Biosci..

The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.

A. Hounslow, M. Williamson, A. Ong, 2016, Journal of the American Society of Nephrology : JASN.

An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition

N. J. Baxter, A. Hounslow, J. Waltho, 2022, ACS catalysis.

Three‐dimensional domain swapping in the folded and molten‐globule states of cystatins, an amyloid‐forming structural superfamily

M. J. Conroy, A. Hounslow, J. Waltho, 2001, The EMBO journal.

Carbon-13 and cadmium-113 nuclear magnetic resonance evidence for a novel transannular oscillation of cadmium(II) in the pendant arm macrocyclic complex [1,4,8,11-tetrakis(2-hydroxyethyl)-1,4,8,11-tetraazacyclotetradecane]cadmium(II)

A. Hounslow, R. Keough, S. Lincoln, 1990 .

A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies.

D. Kirschner, A. Hounslow, J. Waltho, 2014, Journal of molecular biology.

Structural tightening and interdomain communication in the catalytic cycle of phosphoglycerate kinase.

M. Reed, A. Hounslow, J. Waltho, 2010, Journal of molecular biology.

Charge-balanced metal fluoride complexes for protein kinase A with adenosine diphosphate and substrate peptide SP20.

N. J. Baxter, A. Hounslow, J. Waltho, 2012, Angewandte Chemie.

Effects of domain dissection on the folding and stability of the 43 kDa protein PGK probed by NMR.

M. Reed, A. Clarke, A. Hounslow, 2003, Journal of molecular biology.

Proton nuclear magnetic resonance study of N,N-diethylformamide exchange on (N,N-diethylformamide)2,2′2″-tris(dimethylamino)triethylamine)cobalt(II) and its copper(II) analogue

B. Doddridge, A. Hounslow, S. Lincoln, 1985 .

Proton nuclear magnetic resonance study of N,N-dimethylformamide exchange on (N,N-dimethylformamide)(2,2",2""-tris(dimethylamino)triethylamine)manganese(II) and its cobalt(II) and copper(II) analogs

B. Doddridge, A. Hounslow, S. Lincoln, 1984 .

Solvent exchange and anation on five-coordinate (N,N-dimethylformamide)(2,2',2″-tris(dimethylamino)triethylamine)copper(II)

B. Doddridge, A. Hounslow, S. Lincoln, 1983 .

SOLVENT EXCHANGE AND ANATION ON FIVE-COORDINATE (N,N-DIMETHYLFORMAMIDE)(2,2′,2“-TRIS(DIMETHYLAMINO)TRIETHYLAMINE)COPPER(II)

B. Doddridge, A. Hounslow, S. Lincoln, 1984 .

PROTON NUCLEAR MAGNETIC RESONANCE STUDY OF N,N-DIMETHYLFORMAMIDE EXCHANGE ON (N,N-DIMETHYLFORMAMIDE)(2,2′,2′′-TRIS(DIMETHYLAMINO)TRIETHYLAMINE)MANGANESE(II) AND ITS COBALT(II) AND COPPER(II) ANALOGS

B. Doddridge, A. Hounslow, S. Lincoln, 1984 .

The denatured state under native conditions: a non-native-like collapsed state of N-PGK.

M. Reed, A. Clarke, A. Hounslow, 2006, Journal of molecular biology.

Disulfide mutants of barnase. II: Changes in structure and local stability identified by hydrogen exchange.

A. Fersht, J. Clarke, A. Hounslow, 1995, Journal of molecular biology.

A Trojan horse transition state analogue generated by MgF3− formation in an enzyme active site

F. Hollfelder, N. J. Baxter, A. Hounslow, 2006, Proceedings of the National Academy of Sciences.

Structure of a Wbl protein and implications for NO sensing by M. tuberculosis

A. Hounslow, M. Williamson, Jason C. Crack, 2017, Nature Communications.

Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system

A. Hounslow, M. Williamson, P. Serror, 2019, PLoS pathogens.

Local breathing and global unfolding in hydrogen exchange of barnase and its relationship to protein folding pathways.

A. Fersht, M. Bycroft, J. Clarke, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Relationship between equilibrium amide proton exchange behavior and the folding pathway of barnase.

A. Fersht, J. Clarke, A. Hounslow, 1995, Biochemistry.

1H, 15N and 13C backbone resonance assignments of the P146A variant of β-phosphoglucomutase from Lactococcus lactis in its substrate-free form

N. J. Baxter, A. Hounslow, J. Waltho, 2019, Biomolecular NMR Assignments.

Improved methodology for protein NMR structure calculation using hydrogen bond restraints and ANSURR validation: the SH2 domain of SH2B1

A. Hounslow, M. Williamson, N. Fowler, 2022, bioRxiv.

31P NMR Spectroscopy Demonstrates Large Amounts of Phosphohistidine in Mammalian Cells

Mehul V. Makwana, A. Hounslow, M. Williamson, 2020, bioRxiv.

Determination of the microscopic equilibrium dissociation constants for risedronate and its analogues reveals two distinct roles for the nitrogen atom in nitrogen-containing bisphosphonate drugs.

A. Hounslow, G. Blackburn, D. Rejman, 2008, Journal of medicinal chemistry.

Mapping local structural perturbations in the native state of stefin B (cystatin B) under amyloid forming conditions

A. Hounslow, J. Waltho, M. Cliff, 2012, Front. Mol. Neurosci..

Exclusion of the native alpha-helix from the amyloid fibrils of a mixed alpha/beta protein.

A. Hounslow, J. Waltho, V. Turk, 2008, Journal of molecular biology.

Loss of residues 119 – 136, including the first β-strand of human prion protein, generates an aggregation-competent partially “open” form

J. Collinge, D. Sangar, M. Batchelor, 2023, Journal of Molecular Biology.

Structural effects of the highly protective V127 polymorphism on human prion protein

J. Collinge, G. Jackson, D. Sangar, 2020, Communications Biology.

Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.

F. Hollfelder, D. Wemmer, N. J. Baxter, 2008, Journal of the American Chemical Society.

When simple sequence comparison fails: the cryptic case of the shared domains of the bacterial replication initiation proteins DnaB and DnaD

A. Grossman, A. Hounslow, W. Smits, 2010, Nucleic Acids Research.

Structural and functional analysis of RNA and TAP binding to SF2/ASF

L. Lian, A. Hounslow, Aura Tintaru, 2007, EMBO reports.

Backbone assignment and secondary structure of the PLAT domain of human polycystin-1

A. Hounslow, M. Williamson, A. Ong, 2015, Biomolecular NMR assignments.

Backbone assignment and secondary structure of the PLAT domain of human polycystin-1

A. Hounslow, M. Williamson, A. Ong, 2015, Biomolecular NMR Assignments.

van der Waals Contact between Nucleophile and Transferring Phosphorus Is Insufficient To Achieve Enzyme Transition-State Architecture

L. A. Johnson, C. R. Trevitt, N. J. Baxter, 2018, ACS Catalysis.

Transition state analogue structures of human phosphoglycerate kinase establish the importance of charge balance in catalysis.

N. J. Baxter, A. Hounslow, J. Waltho, 2010, Journal of the American Chemical Society.

MgF(3)(-) and alpha-galactose 1-phosphate in the active site of beta-phosphoglucomutase form a transition state analogue of phosphoryl transfer.

N. J. Baxter, A. Hounslow, J. Waltho, 2009, Journal of the American Chemical Society.

Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.

F. Hollfelder, N. J. Baxter, A. Hounslow, 2008, Journal of the American Chemical Society.