M. Thompson

发表

Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1

Timothy D. Craggs, Ian A. Bennet, L. Finger, 2018, Nucleic acids research.

Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29.

M. Thompson, J. Avigan, D. Steinberg, 1960, The Journal of biological chemistry.

Regioselective synthesis of 3-aminoimidazo[1,2-a]-pyrimidines under continuous flow conditions.

H. Adams, M. Thompson, Kai Guo, 2014, The Journal of organic chemistry.

Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability

J. Tainer, S. Mirkin, S. Hamdan, 2017, Nature Communications.

Improved 2,4‐Diarylthiazole‐Based Antiprion Agents: Switching the Sense of the Amide Group at C5 Leads to an Increase in Potency

M. Thompson, G. Greenwood, Beining Chen, 2010, ChemMedChem.

An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer.

Lucinda V. Jackson, P. Lockey, D. Norman, 2015, Journal of medicinal chemistry.

Synthesis and Evaluation of 1‐Amino‐6‐halo‐β‐carbolines as Antimalarial and Antiprion Agents

M. P. Jackson, M. Thompson, Beining Chen, 2012, ChemMedChem.

2,4-diarylthiazole antiprion compounds as a novel structural class of antimalarial leads.

M. Thompson, Beining Chen, I. Coldham, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis, and structure-activity relationship of indole-3-glyoxylamide libraries possessing highly potent activity in a cell line model of prion disease.

M. Thompson, Vinciane Borsenberger, Beining Chen, 2009, Journal of medicinal chemistry.

Methylene analogues of adenosine 5′‐tetraphosphate

M. Thompson, E. Darżynkiewicz, J. Kowalska, 2006 .

Methylene analogues of adenosine 5'-tetraphosphate. Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases.

M. Thompson, E. Darżynkiewicz, J. Kowalska, 2006, The FEBS journal.

Mechanistic studies leading to a new procedure for rapid, microwave assisted generation of pyridine-3,5-dicarbonitrile libraries

M. Thompson, Kai Guo, R. Mutter, 2007 .

Ugi reactions with ammonia offer rapid access to a wide range of 5-aminothiazole and oxazole derivatives.

M. Thompson, Beining Chen, 2009, The Journal of organic chemistry.

Versatile assembly of 5-aminothiazoles based on the Ugi four-component coupling

M. Thompson, Beining Chen, 2008 .

Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity.

M. P. Jackson, J. Gever, H. Roehl, 2011, European journal of medicinal chemistry.

ATP analogues with modified phosphate chains and their selectivity for rat P2X2 and P2X2/3 receptors

R. North, M. Thompson, G. Blackburn, 2003, British journal of pharmacology.

Synthesis of 5-aminothiazoles as building blocks for library synthesis

M. Thompson, Beining Chen, W. Heal, 2006 .

Regioselective, Solvent-FreeSynthesis of 3-Aminoimidazo[1,2-a]pyrimidines UnderMicrowave Irradiation Promoted by Zeolite HY

M. Thompson, Beining Chen, Jenny M. Hurst, 2008 .

Synthesis and evaluation of a focused library of pyridine dicarbonitriles against prion disease.

M. Thompson, S. Pratt, Kai Guo, 2008, European journal of medicinal chemistry.

4-Phosphopyrazol-2-yl alanine: a non-hydrolysable analogue of phosphohistidine.

M. Thompson, R. Muimo, R. Jackson, 2015, Chemical communications.

Exploring catalyst and solvent effects in the multicomponent synthesis of pyridine-3,5-dicarbonitriles.

M. Thompson, Kai Guo, Beining Chen, 2009, The Journal of organic chemistry.

Sugar conjugates of fulvestrant (ICI 182,780): efficient general procedures for glycosylation of the fulvestrant core

M. Thompson, G. Blackburn, W. B. Bowler, 2004 .

Homochiral synthesis of an aza analogue of S-adenosyl-L-methionine (AdoMet) and its binding to the E. coli methionine repressor protein (MetJ)

S. Phillips, M. Thompson, G. Blackburn, 1996 .

Library synthesis and screening: 2,4-diphenylthiazoles and 2,4-diphenyloxazoles as potential novel prion disease therapeutics.

M. Thompson, R. Mutter, Beining Chen, 2007, Journal of medicinal chemistry.

Synthesis of Two Stable Nitrogen Analogues of S-Adenosyl-l-methionine

M. Thompson, G. Blackburn, A. Mekhalfia, 1999 .

DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction*

Timothy D. Craggs, Ian A. Bennet, L. Finger, 2016, The Journal of Biological Chemistry.

Catalytic Roles for Carbon-Oxygen Hydrogen Bonding in SET Domain Lysine Methyltransferases*

M. Thompson, R. Trievel, G. Blackburn, 2006, Journal of Biological Chemistry.

A conserved loop–wedge motif moderates reaction site search and recognition by FEN1

M. Thompson, J. Grasby, Barbara Ciani, 2018, Nucleic acids research.

Cellular Active N-Hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site

J. Debreczeni, J. Nissink, L. Finger, 2016, Nature chemical biology.

Structure–Activity Relationship Refinement and Further Assessment of Indole‐3‐glyoxylamides as a Lead Series against Prion Disease

M. Thompson, A. Meijer, S. Ferrara, 2011, ChemMedChem.

Design and Synthesis of New Compounds for Hepatobiliary Imaging

M. Thompson, G. Benness, C. Evill, 1982 .

Synthesis of brassino steroids: new plant-growth-promoting steroids

J. Flippen-Anderson, W. Lusby, M. Thompson, 1979 .

Two-Phase Nitration of Phenols. Part 3. The Nitration of Anisole.

M. Thompson, P. Zeegers, 1992 .