J. Thorson

发表

Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly.

Rocco Moretti, Jon S Thorson, P. Dervan, 2008, ACS chemical biology.

'Sweetening' natural products via glycorandomization.

J. Thorson, Byron R. Griffith, J. M. Langenhan, 2005, Current opinion in biotechnology.

Colchicine glycorandomization influences cytotoxicity and mechanism of action.

James A. Watson, F. Hoffmann, J. Thorson, 2006, Journal of the American Chemical Society.

Recombinant E. coli prototype strains for in vivo glycorandomization.

Gavin J. Williams, Jie Yang, J. Thorson, 2011, ACS chemical biology.

Assessing the regioselectivity of OleD-catalyzed glycosylation with a diverse set of acceptors.

A. Hamza, C. Zhan, J. Thorson, 2013, Journal of natural products.

The structural biology of enzymes involved in natural product glycosylation.

G. Phillips, J. Thorson, Shanteri Singh, 2012, Natural product reports.

Structural and functional characterization of CalS11, a TDP-rhamnose 3'-O-methyltransferase involved in calicheamicin biosynthesis.

Greg L. Hura, Kevin N Dyer, G. Phillips, 2013, ACS chemical biology.

Endophytes of Brazilian Medicinal Plants With Activity Against Phytopathogens

J. Thorson, H. Ferreira, J. Rohr, 2021, Frontiers in Microbiology.

Terfestatins B and C, New p-Terphenyl Glycosides Produced by Streptomyces sp. RM-5-8.

J. Hower, J. Thorson, A. Morris, 2015, Organic letters.

Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides.

Jon S Thorson, Jiqing Jiang, Daniel Kahne, 2002, Chemistry & biology.

Structure-based engineering of E. coli galactokinase as a first step toward in vivo glycorandomization.

Jie Yang, J. Thorson, Xun Fu, 2005, Chemistry & biology.

Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses.

J. Thorson, Hung‐wen Liu, Changsheng Zhang, 2006, Angewandte Chemie.

Structure‐Based Enzyme Engineering and Its Impact on In Vitro Glycorandomization

J. Thorson, D. Nikolov, D. Hoffmeister, 2004, Chembiochem : a European journal of chemical biology.

Natural product glycorandomization.

Jie Yang, J. Thorson, D. Hoffmeister, 2004, Bioorganic & medicinal chemistry.

Studies on the substrate specificity of Escherichia coli galactokinase.

Jie Yang, J. Thorson, Jingjing Zhao, 2003, Organic letters.

Biosynthetic and Synthetic Strategies for Assembling Capuramycin-Type Antituberculosis Antibiotics

J. Thorson, Xiaodong Liu, Zhao-yong Yang, 2019, Molecules.

A biosynthetic approach for the incorporation of unnatural amino acids into proteins.

P. Schultz, J. Thorson, V. Cornish, 1998, Methods in molecular biology.

The Biosynthesis of Indolocarbazoles in a Heterologous E. coli Host

J. Thorson, C. Hyun, Jianchun Liao, 2003, Chembiochem : a European journal of chemical biology.

Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation.

G. Phillips, J. Thorson, A. Chang, 2011, Current opinion in biotechnology.

Bioprospecting of Diaporthe terebinthifolii LGMF907 for antimicrobial compounds

J. Thorson, J. Rohr, D. Savi, 2018, Folia Microbiologica.

A comparison of sugar indicators enables a universal high-throughput sugar-1-phosphate nucleotidyltransferase assay.

Rocco Moretti, J. Thorson, 2008, Analytical biochemistry.

CDP-6-deoxy-delta 3,4-glucoseen reductase from Yersinia pseudotuberculosis: enzyme purification and characterization of the cloned gene

J. Thorson, V. Miller, S. Lo, 1994, Journal of bacteriology.

Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia

J. Thorson, N. Muthusamy, M. Leggas, 2021, Leukemia.

Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia

J. Thorson, N. Muthusamy, M. Leggas, 2020 .

Crystal structure of SsfS 6 , the putative C-glycosyltransferase involved in SF 2575 biosynthesis

G. Phillips, J. Thorson, R. Yennamalli, 2014 .

Crystal structure of SsfS6, the putative C‐glycosyltransferase involved in SF2575 biosynthesis

G. Phillips, J. Thorson, R. Yennamalli, 2013, Proteins.

The structure of flavin‐dependent tryptophan 7‐halogenase RebH

G. Phillips, J. Thorson, Yu Huang, 2007, Proteins.

Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate

G. Phillips, A. Joachimiak, J. Thorson, 2016, Structural dynamics.

Venturicidin C, A New 20-Membered Macrolide Produced by Streptomyces sp. TS-2-2

J. Hower, J. Thorson, A. Morris, 2013, The Journal of Antibiotics.

Exploiting the Reversibility of Natural Product Glycosyltransferase-Catalyzed Reactions

J. Thorson, Lingjun Li, Changsheng Zhang, 2006, Science.

Dihydroisocoumarins produced by Diaporthe cf. heveae LGMF1631 inhibiting citrus pathogens

J. Thorson, J. Rohr, D. Savi, 2019, Folia Microbiologica.

Vochysiamides A and B: Two new bioactive carboxamides produced by the new species Diaporthe vochysiae.

J. Thorson, J. Rohr, D. Savi, 2019, Fitoterapia.

Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15.

J. Hower, J. Thorson, A. Morris, 2013, Journal of natural products.

Puromycins B-E, Naturally Occurring Amino-Nucleosides Produced by the Himalayan Isolate Streptomyces sp. PU-14G.

J. Thorson, Muhammad Abbas, K. Shaaban, 2018, Journal of natural products.

OleD Loki as a Catalyst for Hydroxamate Glycosylation

S. Voss, C. Zhan, J. Thorson, 2020, Chembiochem : a European journal of chemical biology.

Enzymatic Synthesis of the Ribosylated Glycyl-Uridine Disaccharide Core of Peptidyl Nucleoside Antibiotics.

J. Thorson, Xiaodong Liu, S. V. Van Lanen, 2018, The Journal of organic chemistry.

OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation

G. Phillips, J. Thorson, K. Shaaban, 2017, Chembiochem : a European journal of chemical biology.

Identification of Neuroprotective Spoxazomicin and Oxachelin Glycosides via Chemoenzymatic Glycosyl-Scanning.

J. Thorson, A. Morris, Manjula Sunkara, 2017, Journal of natural products.

Natural product disaccharide engineering through tandem glycosyltransferase catalysis reversibility and neoglycosylation.

J. Thorson, D. Andes, Maoquan Zhou, 2012, Organic letters.

The impact of enzyme engineering upon natural product glycodiversification.

Gavin J. Williams, J. Thorson, R. Gantt, 2008, Current opinion in chemical biology.

Probing the aglycon promiscuity of an engineered glycosyltransferase.

Gavin J. Williams, J. Thorson, R. Gantt, 2008, Angewandte Chemie.

The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710.

J. Thorson, Qunjie Gao, 2008, FEMS microbiology letters.

Thebiosyntheticgenes encoding for theproductionofthe dynemicin enediyne core inMicromonospora chersina ATCC 53710

J. Thorson, Qunjie Gao, 2008 .

Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia

J. Thorson, N. Muthusamy, M. Leggas, 2020, bioRxiv.

Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.

J. Thorson, M. Leggas, K. Shaaban, 2015, Journal of natural products.

Development of a universal glycosyltransferase assay amenable to high-throughput formats.

J. Thorson, Hyun Soo Lee, H. Lee, 2011, Analytical biochemistry.

Structure, activity, synthesis and biosynthesis of aryl-C-glycosides.

J. Thorson, Byron R. Griffith, Tsion Bililign, 2005, Natural product reports.

Biosynthesis of 3,6-dideoxyhexoses: new mechanistic reflections upon 2,6-dideoxy, 4,6-dideoxy, and amino sugar construction

J. Thorson, Hung‐wen Liu, C. Hutchinson, 1993 .

The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers.

J. Thorson, D. Hoffmeister, A. Bechthold, 2004, Angewandte Chemie.

The crystal structure of AbsH3: A putative flavin adenine dinucleotide‐dependent reductase in the abyssomicin biosynthesis pathway

Mitchell D. Miller, G. Phillips, C. Zhan, 2020, Proteins.

Probing the coenzyme and substrate binding events of CDP-D-glucose 4,6-dehydratase: mechanistic implications.

J. Thorson, H. Liu, X. He, 1996, Biochemistry.

Mechanistic studies of the biosynthesis of 3,6-dideoxyhexoses in Yersinia pseudotuberculosis. Purification and stereochemical analysis of CDP-D-glucose oxidoreductase.

R. N. Russell, J. Thorson, H. Liu, 1992, The Journal of biological chemistry.

Cloning, Sequencing, and Overexpression in Escherichia Coli of the O-d-glucose-l-phosphate Cytidylyltransferase Gene Isolated from Yersinia Pseudotuberculosis

J. Thorson, T. Kelly, H. Liu, 1993 .

Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria.

J. Thorson, H. Liu, 1994, Annual review of microbiology.

Structural Characterization of CalS8, a TDP-α-d-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis*

G. Phillips, A. Joachimiak, M. Endres, 2015, The Journal of Biological Chemistry.

High-throughput colorimetric assays for nucleotide sugar formation and glycosyl transfer.

J. Thorson, R. Gantt, 2012, Methods in enzymology.

Expanding the Pyrimidine Diphosphosugar Repertoire: The Chemoenzymatic Synthesis of Amino- and Acetamidoglucopyranosyl Derivatives.

J. Thorson, J. Biggins, Jiqing Jiang, 2001, Angewandte Chemie.

Selective Detection of Sugar Phosphates by Capillary Electrophoresis/Mass Spectrometry and Its Application to an Engineered E. coli Host

Jie Yang, E. C. Soo, J. Thorson, 2007, Chembiochem : a European journal of chemical biology.

Pyridoxal-5′-Phosphate-Dependent Alkyl Transfer in Nucleoside Antibiotic Biosynthesis

J. Thorson, Xiaodong Liu, S. V. Van Lanen, 2020, Nature Chemical Biology.

A Methodological Comparison: The Advantage of Phosphorimidates in Expanding the Sugar Nucleotide Repertoire.

J. Thorson, Yongxin Zhao, 1998, The Journal of organic chemistry.

The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity

Q. She, J. Thorson, Q. Ye, 2014, Journal of medicinal chemistry.

Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities

M. Shaaban, J. Thorson, A. Abdel-Razek, 2021, Biotechnology reports.

Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.

J. Thorson, Qunjie Gao, Changsheng Zhang, 2006, Chemistry & biology.

The Calicheamicin Gene Cluster and Its Iterative Type I Enediyne PKS

J. Thorson, A. Staffa, C. Farnet, 2002, Science.

The Biosynthesis of Capuramycin-type Antibiotics

J. Thorson, S. Garneau‐Tsodikova, A. Morris, 2015, The Journal of Biological Chemistry.

Loop dynamics of thymidine diphosphate-rhamnose 3′-O-methyltransferase (CalS11), an enzyme in calicheamicin biosynthesis

G. Phillips, J. Thorson, Shanteri Singh, 2016, Structural dynamics.

Antibacterial and Cytotoxic Actinomycins Y6-Y9 and Zp from Streptomyces sp. Strain Gö-GS12.

J. Thorson, Xiaodong Liu, S. V. Van Lanen, 2016, Journal of natural products.

Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes

B. Shen, J. Thorson, Geoff P. Horsman, 2010, Proceedings of the National Academy of Sciences.

Baraphenazines A-G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces.

S. Voss, J. Thorson, S. V. Van Lanen, 2019, Journal of natural products.

Mullinamides A and B, New Cyclopeptides Produced by the Ruth Mullins Coal Mine Fire Isolate Streptomyces sp. RM-27-46

J. Hower, J. Thorson, A. Morris, 2014, The Journal of Antibiotics.

Frenolicins C-G, pyranonaphthoquinones from Streptomyces sp. RM-4-15.

J. Hower, J. Thorson, A. Morris, 2013, Journal of natural products.

Diversifying vancomycin via chemoenzymatic strategies.

J. Thorson, Changsheng Zhang, C. Albermann, 2005, Organic letters.

Antibiotic optimization via in vitro glycorandomization

J. Thorson, Changsheng Zhang, C. Albermann, 2003, Nature Biotechnology.

Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated Streptomyces.

S. Voss, Q. She, J. Hower, 2019, Journal of natural products.

Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects.

Q. She, D. S. St. Clair, J. Thorson, 2019, Cell chemical biology.

The In Vitro Characterization of the Erythronolide Mycarosyltransferase EryBV and Its Utility in Macrolide Diversification

J. Thorson, Lingjun Li, Changsheng Zhang, 2007, Chembiochem : a European journal of chemical biology.

Sugar-pirating as an enabling platform for the synthesis of 4,6-dideoxyhexoses.

J. Thorson, S. V. Van Lanen, L. Ponomareva, 2020, Journal of the American Chemical Society.

A Simple Strategy for Glycosyltransferase‐Catalyzed Aminosugar Nucleotide Synthesis

J. Thorson, A. Morris, Manjula Sunkara, 2014, Chembiochem : a European journal of chemical biology.

The in vitro Characterization of Polyene Glycosyltransferases AmphDI and NysDI

Rocco Moretti, J. Thorson, Changsheng Zhang, 2008, Chembiochem : a European journal of chemical biology.

The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility.

J. Thorson, Changsheng Zhang, C. Albermann, 2006, Journal of the American Chemical Society.

Enzymatic tools for engineering natural product glycosylation.

J. Thorson, Sophie Blanchard, 2006, Current opinion in chemical biology.

Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization.

J. Thorson, D. Nikolov, J. Biggins, 2003, Organic letters.

A General Enzymatic Method for the Synthesis of Natural and “Unnatural” UDP- and TDP-Nucleotide Sugars

J. Thorson, Jiqing Jiang, A. Biggins, 2000 .

Engineering a methymycin/pikromycin-calicheamicin hybrid: Construction of two new macrolides carrying a designed sugar moiety [6]

D. Sherman, J. Thorson, Hung‐wen Liu, 1999 .

Increasing carbohydrate diversity via amine oxidation: aminosugar, hydroxyaminosugar, nitrososugar, and nitrosugar biosynthesis in bacteria.

J. Thorson, Shannon C Timmons, 2008, Current opinion in chemical biology.

Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization.

Gavin J. Williams, J. Thorson, Changsheng Zhang, 2008, Chemistry & biology.

The hedamycin locus implicates a novel aromatic PKS priming mechanism.

J. Thorson, C. Hyun, Jessica S. Williams, 2004, Chemistry & biology.

Using Ambystoma mexicanum (Mexican axolotl) embryos, chemical genetics, and microarray analysis to identify signaling pathways associated with tissue regeneration.

Antony T. Athippozhy, S. Voss, J. Thorson, 2015, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Recent Carbohydrate-Based Chemoselective Ligation Applications

J. Thorson, J. M. Langenhan, 2005 .

Chemoenzymatic synthesis of the Salmonella group E1 core trisaccharide using a recombinant beta-(1-->4)-mannosyltransferase.

J. Thorson, Y. Zhao, 1999, Carbohydrate research.

Neoglycorandomization and chemoenzymatic glycorandomization: two complementary tools for natural product diversification.

J. Thorson, Byron R. Griffith, J. M. Langenhan, 2005, Journal of natural products.

Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis

J. Thorson, Maoquan Zhou, Shanteri Singh, 2013, Proceedings of the National Academy of Sciences.

Cofactor characterization and mechanistic studies of CDP-6-deoxy-delta 3,4-glucoseen reductase: exploration into a novel enzymatic C-O bond cleavage event.

J. Thorson, O. Ploux, S. Lo, 1993, Biochemistry.

Characterization of the first PMP-dependent iron-sulfur-containing enzyme which is essential for the biosynthesis of 3,6-dideoxyhexoses

J. Thorson, Hung‐wen Liu, 1993 .

Application of the Nucleotidylyltransferase Ep toward the Chemoenzymatic Synthesis of dTDP‐Desosamine Analogues

J. Thorson, C. Albermann, Jiqing Jiang, 2003, Chembiochem : a European journal of chemical biology.

Natures Carbohydrate Chemists The Enzymatic Glycosylation of Bioactive Bacterial Metabolites

J. Thorson, J. Biggins, Jiqing Jiang, 2001 .

Analysis of hydrogen bonding strengths in proteins using unnatural amino acids

P. Schultz, J. Thorson, E. Chapman, 1995 .

Characterization of Early Enzymes Involved in TDP‐Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433

J. Thorson, Shanteri Singh, Pauline Peltier-Pain, 2015, Chembiochem : a European journal of chemical biology.

Total synthesis of griseusins and elucidation of the griseusin mechanism of action† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc02289a

S. Voss, Q. She, J. Thorson, 2019, Chemical science.

Self-Resistance during Muraymycin Biosynthesis: a Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order

J. Thorson, J. Rohr, Xiaodong Liu, 2018, Antimicrobial Agents and Chemotherapy.

Terfestatins B and C, New p-Terphenyl Glycosides Produced by Streptomyces sp. RM-5-8.

J. Hower, J. Thorson, A. Morris, 2015, Organic letters.

Characterization of the Calicheamicin Orsellinate C2‐O‐Methyltransferase CalO6

J. Thorson, Shanteri Singh, N. Nandurkar, 2014, Chembiochem : a European journal of chemical biology.

Glycosyloxyamine Neoglycosylation: A Model Study Using Calicheamicin

J. Thorson, Shanteri Singh, Randal D. Goff, 2011, ChemMedChem.

A sweet success for substrate engineering

J. Thorson, Byron R. Griffith, 2006, Nature chemical biology.

On the Origin of Deoxypentoses: Evidence to Support a Glucose Progenitor in the Biosynthesis of Calicheamicin

J. Thorson, Tsion Bililign, J. Ahlert, 2002, Chembiochem : a European journal of chemical biology.

Acceptor Specificity of Salmonella GDP-Man:αlRha1→3αdGal-PP-Und β1→4-Mannosyltransferase: A Simplified Assay Based on Unnatural Acceptors

J. Thorson, A. Biggins, Yongxin Zhao, 1998 .

A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in Streptomyces coelicolor

G. V. van Wezel, J. Thorson, S. E. Nybo, 2022, ACS synthetic biology.

Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics

J. Thorson, S. V. Van Lanen, C. Ducho, 2018, ChemMedChem.

RebG‐ and RebM‐Catalyzed Indolocarbazole Diversification

D. V. Van Vranken, J. Thorson, J. Chisholm, 2006, Chembiochem : a European journal of chemical biology.

Natural product glycosyltransferases: properties and applications.

Gavin J. Williams, J. Thorson, 2009, Advances in enzymology and related areas of molecular biology.

Enediyne Biosynthesis and Self-Resistance: A Progress Report

B. Shen, J. Thorson, Yuan Li, 1999 .

Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution.

Gavin J. Williams, J. Thorson, Changsheng Zhang, 2007, Nature chemical biology.

Influence of Sugar Amine Regiochemistry on Digitoxigenin Neoglycoside Anticancer Activity.

C. Zhan, J. Thorson, Yaxia Yuan, 2015, ACS medicinal chemistry letters.

Using Simple Donors to Drive the Equilibria of Glycosyltransferase-Catalyzed Reactions

J. Thorson, Pauline Peltier-Pain, R. Gantt, 2011, Nature chemical biology.

Coenzyme B6 as a Redox Cofactor: A New Role for an Old Coenzyme?

J. Thorson, Hung‐wen Liu, 1993 .

Molecular basis of 3,6-dideoxyhexose biosynthesis elucidation of CDP-ascarylose biosynthetic genes and their relationship to other 3,6-dideoxyhexose pathways

J. Thorson, Hung‐wen Liu, S. Lo, 1993 .

Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR

M. Shaaban, J. Thorson, M. Frese, 2021, Green chemistry letters and reviews.

Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules.

J. Thorson, Pauline Peltier-Pain, R. Gantt, 2011, Natural product reports.

Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization.

F. Hoffmann, J. Thorson, I. Guzei, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A comprehensive review of glycosylated bacterial natural products.

J. Thorson, K. Shaaban, S. Elshahawi, 2015, Chemical Society reviews.

A divergent enantioselective strategy for the synthesis of griseusins.

Q. She, J. Thorson, Q. Ye, 2015, Angewandte Chemie.

A continuous assay for DNA cleavage: the application of "break lights" to enediynes, iron-dependent agents, and nucleases.

J. Thorson, J. Prudent, J. Biggins, 2000, Proceedings of the National Academy of Sciences of the United States of America.

A diastereoselective oxa-Pictet-Spengler-based strategy for (+)-frenolicin B and epi-(+)-frenolicin B synthesis.

Q. She, J. Thorson, Q. Ye, 2013, Organic letters.

Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues.

J. Thorson, J. Rohr, A. Morris, 2014, Angewandte Chemie.

Mechanistic Studies of the Biosynthesis of 3,6‐Dideoxysugars in Bacteria: Exploration of a Novel C‐O Bond Cleavage Event

Ding-Yah Yang, J. Thorson, Hung‐wen Liu, 1995 .

Enhancing the divergent activities of betulinic acid via neoglycosylation.

J. Thorson, Randal D. Goff, 2009, Organic letters.

Structure and Function of a Dual Reductase-Dehydratase Enzyme System Involved in p-Terphenyl Biosynthesis.

Mitchell D. Miller, G. Phillips, J. Thorson, 2021, ACS chemical biology.

Warfarin Glycosylation Invokes a Switch from Anticoagulant to Anticancer Activity

J. Thorson, Pauline Peltier-Pain, Shannon C Timmons, 2011, ChemMedChem.

Antibacterial Activity of Endophytic Actinomycetes Isolated from the Medicinal Plant Vochysia divergens (Pantanal, Brazil)

J. Thorson, J. Rohr, D. Savi, 2017, Front. Microbiol..

Structural characterization of the mitomycin 7‐O‐methyltransferase

G. Phillips, D. Sherman, J. Thorson, 2011, Proteins.

Structure and Mechanism of the Rebeccamycin Sugar 4′-O-Methyltransferase RebM*

G. Phillips, J. Thorson, Changsheng Zhang, 2008, Journal of Biological Chemistry.

RF-3192C and other polyketides from the marine endophytic Aspergillus niger ASSB4: structure assignment and bioactivity investigation

M. Shaaban, J. Thorson, A. Abdel-Razek, 2020, Medicinal Chemistry Research.

Secondary metabolites produced by Microbacterium sp. LGMB471 with antifungal activity against the phytopathogen Phyllosticta citricarpa

J. Thorson, J. Rohr, D. Savi, 2019, Folia Microbiologica.

Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate Streptomyces sp. RM-14-6.

Matthew S. Tremblay, J. Hower, J. Thorson, 2017, Journal of natural products.

Synthesis and antibacterial activity of doxycycline neoglycosides.

J. Thorson, D. Andes, K. Marchillo, 2013, Journal of natural products.

Structure and Specificity of a Permissive Bacterial C-Prenyltransferase

G. Phillips, J. Thorson, M. Farman, 2016, Nature chemical biology.

Phaeophleospora vochysiae Savi & Glienke sp. nov. Isolated from Vochysia divergens Found in the Pantanal, Brazil, Produces Bioactive Secondary Metabolites

J. Thorson, J. Rohr, D. Savi, 2018, Scientific Reports.

Enhancing the Latent Nucleotide Triphosphate Flexibility of the Glucose-1-phosphate Thymidylyltransferase RmlA*

Rocco Moretti, J. Thorson, 2007, Journal of Biological Chemistry.

Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering

Jon S Thorson, Jiqing Jiang, J. Thorson, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization

P. Jeffrey, J. Thorson, K. Rajashankar, 2001, Nature Structural Biology.

Taxonomic and Metabolomics Profiling of Actinobacteria Strains from Himalayan Collection Sites in Pakistan

S. Voss, J. Thorson, Tao Liu, 2021, Current Microbiology.

Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2.

J. Hower, C. Zhan, J. Thorson, 2017, Journal of natural products.

Mccrearamycins A-D, Geldanamycin-Derived Cyclopentenone Macrolactams from an Eastern Kentucky Abandoned Coal Mine Microbe.

S. Voss, J. Hower, C. Zhan, 2017, Angewandte Chemie.

The native production of the sesquiterpene isopterocarpolone by Streptomyces sp. RM-14-6

J. Hower, J. Thorson, A. Morris, 2014, Natural product research.

Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15.

Lei Fang, J. Hower, C. Zhan, 2014, Organic letters.

Neoglycosylation and neoglycorandomization: Enabling tools for the discovery of novel glycosylated bioactive probes and early stage leads.

Randal D Goff, Jon S Thorson, J. Thorson, 2014, MedChemComm.

Enhancement of cyclopamine via conjugation with nonmetabolic sugars.

J. Thorson, Randal D. Goff, 2012, Organic letters.

Assessment of chemoselective neoglycosylation methods using chlorambucil as a model.

J. Thorson, Randal D. Goff, 2010, Journal of medicinal chemistry.

Model for antibiotic optimization via neoglycosylation: synthesis of liponeoglycopeptides active against VRE.

C. Edmiston, C. Krepel, J. Thorson, 2007, Journal of the American Chemical Society.

Antitumor antibiotics: bleomycin, enediynes, and mitomycin.

B. Shen, M. Hager, J. Thorson, 2005, Chemical reviews.

Structural Basis for the Stereochemical Control of Amine Installation in Nucleotide Sugar Aminotransferases.

Mitchell D. Miller, G. Phillips, J. Thorson, 2015, ACS chemical biology.

A General NMR-Based Strategy for the in Situ Characterization of Sugar-Nucleotide-Dependent Biosynthetic Pathways

J. Thorson, M. Tonelli, Shanteri Singh, 2014, Organic letters.

Characterization of CalE10, the N-oxidase involved in calicheamicin hydroxyaminosugar formation.

H. D. Johnson, J. Thorson, 2008, Journal of the American Chemical Society.

Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research.

J. Thorson, E. Sievers, J S Thorson, 2000, Current pharmaceutical design.

Structure‐Based Enhancement of the First Anomeric Glucokinase

Jie Yang, J. Thorson, Lesley Liu, 2004, Chembiochem : a European journal of chemical biology.

Enzyme-mediated bioorthogonal technologies: catalysts, chemoselective reactions and recent methyltransferase applications.

J. Thorson, Elnaz Jalali, 2021, Current opinion in biotechnology.

Methionine adenosyltransferase engineering to enable bioorthogonal platforms for AdoMet-utilizing enzymes.

Mitchell D. Miller, G. Phillips, J. Thorson, 2020, ACS chemical biology.

AdoMet analog synthesis and utilization: current state of the art.

J. Thorson, Jianjun Zhang, Brooke R. Johnson, 2016, Current opinion in biotechnology.

Natural product diversification using a non-natural cofactor analogue of S-adenosyl-L-methionine.

J. Thorson, Changsheng Zhang, S. Rajski, 2006, Journal of the American Chemical Society.

Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins

J. Thorson, F. Malavasi, J. Prudent, 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

Probing the regiospecificity of enzyme-catalyzed steroid glycosylation.

Chang-Guo Zhan, Adel Hamza, Jon S Thorson, 2012, Organic letters.

A Comprehensive Review of Glycosylated Bacterial Natural Products

J. Thorson, K. Shaaban, S. Elshahawi, 2015 .

Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model

B. Shen, J. Thorson, Qunjie Gao, 2003, Proceedings of the National Academy of Sciences of the United States of America.

A genomics-guided approach for discovering and expressing cryptic metabolic pathways

Brian O. Bachmann, Alfredo Staffa, Wen Liu, 2003, Nature Biotechnology.

Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19

Jing Chen, Liang Tong, Yunhuang Yang, 2014, ACS chemical biology.

Structural insight into the self-sacrifice mechanism of enediyne resistance.

Changsheng Zhang, John L Markley, Jon S Thorson, 2006, ACS chemical biology.

Resistance to Enediyne Antitumor Antibiotics by CalC Self-Sacrifice

J. Thorson, J. Biggins, K. Onwueme, 2003, Science.

Himalaquinones A-G, Angucyclinone-Derived Metabolites Produced by the Himalayan Isolate Streptomyces sp. PU-MM59.

S. Voss, Q. She, J. Thorson, 2021, Journal of natural products.

Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway.

G. Phillips, J. Thorson, A. Chang, 2011, Acta crystallographica. Section D, Biological crystallography.

Structural characterization of CalO2: A putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway

George N Phillips, Jon S Thorson, H. D. Johnson, 2009, Proteins.

Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis.

G. Phillips, J. Thorson, Changsheng Zhang, 2008, Chemistry & biology.

HDAC Regulates Transcription at the Outset of Axolotl Tail Regeneration

S. Voss, J. Thorson, Q. Qiu, 2019, Scientific Reports.

Chemical genetics of regeneration: Contrasting temporal effects of CoCl2 on axolotl tail regeneration

S. Voss, J. Thorson, L. Ponomareva, 2021, Developmental dynamics : an official publication of the American Association of Anatomists.

Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471.

J. Thorson, S. V. Van Lanen, C. Ducho, 2018, Journal of natural products.

Microbispora sp. LGMB259 Endophytic Actinomycete Isolated from Vochysia divergens (Pantanal, Brazil) Producing β-Carbolines and Indoles with Biological Activity

J. Thorson, J. Rohr, D. Savi, 2015, Current Microbiology.

Bioprospecting of Diaporthe terebinthifolii LGMF907 for antimicrobial compounds

J. Thorson, J. Rohr, D. Savi, 2018, Folia Microbiologica.

Enzymatic Cβ-H Functionalization of l-Arg and l-Leu in Nonribosomally Derived Peptidyl Natural Products: A Tale of Two Oxidoreductases.

J. Thorson, S. V. Van Lanen, C. Ducho, 2021, Journal of the American Chemical Society.

Bioprospecting of desert actinobacteria with special emphases on griseoviridin, mitomycin C and a new bacterial metabolite producing Streptomyces sp. PU-KB10–4

J. Thorson, Chenghang Sun, K. Shaaban, 2023, BMC Microbiology.

Creation of the first anomeric D/L-sugar kinase by means of directed evolution.

Jie Yang, J. Thorson, D. Hoffmeister, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution*

G. Phillips, Rocco Moretti, J. Thorson, 2011, The Journal of Biological Chemistry.

Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity

G. Phillips, J. Thorson, A. Chang, 2011, Proceedings of the National Academy of Sciences.

Functionalized Anodic Aluminum Oxide Membrane–Electrode System for Enzyme Immobilization

Jon S. Thorson, J. Thorson, B. Hinds, 2014, ACS nano.

Asymmetric enzymatic glycosylation of mitoxantrone.

J. Thorson, Maoquan Zhou, 2011, Organic letters.

A high-throughput fluorescence-based glycosyltransferase screen and its application in directed evolution

Gavin J. Williams, J. Thorson, 2008, Nature Protocols.

Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2.

J. Thorson, J. Rohr, Guojun Wang, 2015, Angewandte Chemie.

Engineering BioBricks for Deoxysugar Biosynthesis and Generation of New Tetracenomycins

J. Thorson, S. E. Nybo, K. Shaaban, 2023, ACS omega.

Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA

J. Thorson, O. Ploux, S. Lo, 1994, Journal of bacteriology.

Faculty Opinions recommendation of Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks.

J. Thorson, 2002 .

Mithramycin 2'-Oximes with Improved Selectivity, Pharmacokinetics, and Ewing Sarcoma Antitumor Efficacy.

J. Thorson, O. Tsodikov, J. Rohr, 2020, Journal of medicinal chemistry.

Mechanistic Implications of Escherichia coli Galactokinase Structure‐Based Engineering

J. Thorson, D. Hoffmeister, 2004, Chembiochem : a European journal of chemical biology.

Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis

G. Phillips, A. Joachimiak, M. Endres, 2015, Proteins.

A continuous assay for DNA cleavage using molecular break lights.

J. Thorson, J. Prudent, J. Biggins, 2006, Methods in molecular biology.

Mutational Analysis of Backbone Hydrogen Bonds in Staphylococcal Nuclease

P. Schultz, J. Thorson, E. Chapman, 1997 .

Linear Free Energy Analysis of Hydrogen Bonding in Proteins

P. Schultz, J. Thorson, E. C. Murphy, 1995 .

HDAC Regulates Transcription at the Outset of Axolotl Tail Regeneration

S. Voss, J. Thorson, Q. Qiu, 2019, Scientific Reports.

Structural characterization of DynU16, a START/Bet v1-like protein involved in dynemicin biosynthesis

Mitchell D. Miller, G. Phillips, J. Thorson, 2021, Acta crystallographica. Section F, Structural biology communications.

The crystal structure of AbsH3: A putative flavin adenine dinucleotide‐dependent reductase in the abyssomicin biosynthesis pathway

Mitchell D. Miller, G. Phillips, C. Zhan, 2020, Proteins.

Studies of complex enzymic pyridine nucleotide-dependent transformations: structure and cofactor binding correlation in CDP-D-glucose oxidoreductase

J. Thorson, Hung‐wen Liu, E. Oh, 1992 .

Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution*

G. Phillips, Rocco Moretti, J. Thorson, 2011, The Journal of Biological Chemistry.

Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues.

J. Thorson, J. Rohr, A. Morris, 2014, Angewandte Chemie.

Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules.

J. Thorson, Pauline Peltier-Pain, R. Gantt, 2011, Natural product reports.

Influence of Sugar Amine Regiochemistry on Digitoxigenin Neoglycoside Anticancer Activity.

C. Zhan, J. Thorson, Yaxia Yuan, 2015, ACS medicinal chemistry letters.

Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways.

G. Phillips, J. Thorson, Fengbin Wang, 2016, ACS chemical biology.

The Biosynthesis of Capuramycin-type Antibiotics

J. Thorson, S. Garneau‐Tsodikova, A. Morris, 2015, The Journal of Biological Chemistry.

Spore forming Actinobacterial diversity of Cholistan Desert Pakistan: Polyphasic taxonomy, antimicrobial potential and chemical profiling

J. Thorson, Usman Aftab, K. Shaaban, 2019, BMC Microbiology.

Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly.

P. Dervan, A. Ansari, Rocco Moretti, 2008, ACS chemical biology.