Lindy Astl

Data-driven computational analysis of allosteric proteins by exploring protein dynamics, residue coevolution and residue interaction networks.

Gennady M Verkhivker, Lindy Astl, 2019, Biochimica et biophysica acta. General subjects.

Establishing Computational Approaches Towards Identifying Malarial Allosteric Modulators: A Case Study of Plasmodium falciparum Hsp70s

Gennady M Verkhivker, Lindy Astl, Arnold Amusengeri, 2019, International journal of molecular sciences.

Dissecting Molecular Principles of the Hsp90 Chaperone Regulation by Allosteric Modulators Using a Hierarchical Simulation Approach and Network Modeling of Allosteric Interactions: Conformational Selection Dictates Diversity of Protein Responses and Ligand-Specific Functional Mechanisms.

Gennady M Verkhivker, Lindy Astl, Gabrielle Stetz, 2020, Journal of chemical theory and computation.

Exploring Mechanisms of Communication Switching in the Hsp90-Cdc37 Regulatory Complexes with Client Kinases through Allosteric Coupling of Phosphorylation Sites: Perturbation-based Modeling and Hierarchical Community Analysis of Residue Interaction Networks.

Gennady M Verkhivker, Lindy Astl, Gabrielle Stetz, 2020, Journal of chemical theory and computation.

Allosteric Mechanism of the Hsp90 Chaperone Interactions with Cochaperones and Client Proteins by Modulating Communication Spines of Coupled Regulatory Switches: Integrative Atomistic Modeling of Hsp90 Signaling in Dynamic Interaction Networks

Gabrielle Stetz, Gennady M Verkhivker, Lindy Astl, 2020, J. Chem. Inf. Model..

Interrogating Regulatory Mechanisms in Signaling Proteins by Allosteric Inhibitors and Activators: A Dynamic View Through the Lens of Residue Interaction Networks.

Gennady M Verkhivker, Lindy Astl, Amanda Tse, 2019, Advances in experimental medicine and biology.

Dynamic View of Allosteric Regulation in the Hsp70 Chaperones by J-Domain Cochaperone and Post-Translational Modifications: Computational Analysis of Hsp70 Mechanisms by Exploring Conformational Landscapes and Residue Interaction Networks

Gennady M Verkhivker, Lindy Astl, Lindy Astl, 2020, J. Chem. Inf. Model..

Atomistic Modeling of the ABL Kinase Regulation by Allosteric Modulators Using Structural Perturbation Analysis and Community-Based Network Reconstruction of Allosteric Communications.

Gennady M Verkhivker, Lindy Astl, 2019, Journal of chemical theory and computation.