C. Pérez

发表

Identification of new allosteric sites and modulators of AChE through computational and experimental tools

T. Blundell, Carlos Roca, C. Requena, 2018, Journal of enzyme inhibition and medicinal chemistry.

From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease.

I. Carvalho, E. Sakamoto-Hojo, Carlos Roca, 2017, European journal of medicinal chemistry.

Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.

C. Pérez, Manuela G. López, M. Villarroya, 2010, Journal of medicinal chemistry.

Guanidinium-based derivatives: searching for new kinase inhibitors.

C. Pérez, D. Zisterer, D. K. Nevin, 2014, European journal of medicinal chemistry.

New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.

E. Laurini, S. Pricl, C. Pérez, 2016, Future medicinal chemistry.

Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities.

C. Pérez, Ana Martínez, N. Campillo, 2011, Journal of medicinal chemistry.

First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease.

C. Pérez, Ana Martínez, M. Alonso, 2002, Journal of medicinal chemistry.

Recent strategies in the development of new human cytomegalovirus inhibitors

C. Pérez, Ana Martínez, C. Gil, 2001, Medicinal research reviews.

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

K. Kuča, C. Pérez, Ana Martínez, 2018, Journal of enzyme inhibition and medicinal chemistry.

Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.

C. Pérez, B. Bartolomé, B. Hernández-Ledesma, 2006, Journal of medicinal chemistry.

Indazolylketones as new multitarget cannabinoid drugs.

M. L. de Ceballos, Carlos Roca, C. Pérez, 2019, European journal of medicinal chemistry.

Supercritical fluid extraction of grape seeds: extract chemical composition, antioxidant activity and inhibition of nitrite production in LPS-stimulated Raw 264.7 cells.

C. Pérez, G. P. Blanch, G. Flores, 2015, Food & function.

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.

E. Laurini, S. Pricl, C. Pérez, 2018, European journal of medicinal chemistry.

Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease.

Peterson de Andrade, I. Carvalho, C. Pérez, 2019, Bioorganic & medicinal chemistry.

Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3

V. Sebastián-Pérez, C. Pérez, Ana Martínez, 2018, Journal of enzyme inhibition and medicinal chemistry.

Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.

A. Cuadrado, F. Gago, C. Pérez, 2020, European journal of medicinal chemistry.

Pyrazino[2,3-c]-1,2,6-thiadiazine 2,2-dioxides. Synthesis of SO2 analogues of folic acid antagonists

C. Pérez, I. Alkorta, P. Goya, 1991 .

Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases.

C. Pérez, Manuela G. López, M. Villarroya, 2014, European journal of medicinal chemistry.

Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.

C. Pérez, Manuela G. López, M. Villarroya, 2010, European journal of medicinal chemistry.

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

E. Laurini, S. Pricl, C. Pérez, 2019, Journal of enzyme inhibition and medicinal chemistry.

Methyl jasmonate treatment of strawberry fruits enhances antioxidant activity and the inhibition of nitrite production in LPS-stimulated Raw 264.7 cells

C. Pérez, G. P. Blanch, G. Flores, 2013 .

Synthesis of New N‐(4‐Pyridyl)‐1‐aminopyrazoles and Their Muscarinic and Adrenergic Properties

C. Pérez, A. Badía, Ana Martínez, 2000, Archiv der Pharmazie.

Benzothiadiazine Dioxide Human Cytomegalovirus Inhibitors: Synthesis and Antiviral Evaluation of Main Heterocycle Modified Derivatives

C. Pérez, Ana Martínez, A. M. Bruno, 2003, Antiviral chemistry & chemotherapy.

Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools.

F. J. Luque, J. Gelpí, C. Pérez, 2009, Bioorganic & medicinal chemistry.

Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress.

C. Pérez, J. Souza, D. Perez, 2012, European journal of medicinal chemistry.

Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin-Pinoline Hybrids.

C. Pérez, M. de la Fuente Revenga, M. Yáñez, 2015, ACS chemical neuroscience.

Multitarget drugs as potential therapeutic agents for alzheimer’s disease. A new family of 5-substituted indazole derivatives as cholinergic and BACE1 inhibitors

C. Pérez, N. Campillo, Á. Martín-Requero, 2022, Journal of enzyme inhibition and medicinal chemistry.

Non-ATP competitive glycogen synthase kinase 3beta (GSK-3beta) inhibitors: study of structural requirements for thiadiazolidinone derivatives.

C. Pérez, S. Bräse, Ana Martínez, 2008, Bioorganic & medicinal chemistry.

Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds.

F. J. Luque, P. Dans, C. Pérez, 2011, Journal of medicinal chemistry.

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

C. Pérez, Ana Martínez, N. Campillo, 2012, Journal of medicinal chemistry.

Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching.

C. Pérez, Ana Martínez, D. Perez, 2003, Journal of medicinal chemistry.

Naphthoquinone as a New Chemical Scaffold for Leishmanicidal Inhibitors of Leishmania GSK-3

V. Sebastián-Pérez, C. Pérez, N. Campillo, 2022, Biomedicines.

Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors

M. Loza, J. Brea, F. Feixas, 2022, Journal of medicinal chemistry.

Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice.

M. Loza, J. Brea, M. Cadavid, 2012, ACS chemical neuroscience.

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

F. J. Luque, H. Ke, J. Gelpí, 2009, ChemMedChem.

Activation of the Cannabinoid Type 2 Receptor by a Novel Indazole Derivative Normalizes the Survival Pattern of Lymphoblasts from Patients with Late-Onset Alzheimer’s Disease

C. Pérez, N. Campillo, E. Carro, 2018, CNS Drugs.

Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.

C. Pérez, Manuela G. López, M. Villarroya, 2009, Journal of medicinal chemistry.

Tacrine–Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties

C. Pérez, N. Campillo, Manuela G. López, 2009, ChemMedChem.

Targeting Cannabinoid Receptor Activation and BACE-1 Activity Counteracts TgAPP Mice Memory Impairment and Alzheimer’s Disease Lymphoblast Alterations

C. Pérez, N. Campillo, C. Alquezar, 2020, Molecular Neurobiology.

From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3).

Carlos Roca, C. Pérez, Ana Martínez, 2019, Organic & biomolecular chemistry.

Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors.

I. Carvalho, Carlos Roca, V. Sebastián-Pérez, 2018, European journal of medicinal chemistry.

Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.

C. Pérez, Ignacio Moraleda, I. Iriepa, 2012, European journal of medicinal chemistry.

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model.

M. A. Moro, Cristina Val, M. Loza, 2012, European journal of medicinal chemistry.

New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.

C. Pérez, M. Rodríguez-Franco, D. Viña, 2016, European journal of medicinal chemistry.

New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.

Jörg Rademann, C. Pérez, J. Rademann, 2012, Journal of medicinal chemistry.

Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry.

C. Pérez, R. León, Manuela G. López, 2012, ACS chemical neuroscience.

N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.

C. Pérez, R. León, Manuela G. López, 2011, European journal of medicinal chemistry.

New cannabinoid receptor antagonists as pharmacological tool.

C. Pérez, N. Campillo, J. A. Páez, 2020, Bioorganic & medicinal chemistry.

Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease.

M. García-Arencibia, C. Pérez, N. Campillo, 2014, European journal of medicinal chemistry.

1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation.

C. Pérez, Ana Martínez, W. V. van Otterlo, 2019, Bioorganic & medicinal chemistry letters.

2-Oxaadamant-1-yl ureas as soluble epoxide hydrolase inhibitors: in vivo evaluation in a murine model of acute pancreatitis.

M. Loza, J. Brea, J. Oyarzábal, 2020, Journal of medicinal chemistry.

In vitro biological activity of Salvia fruticosa Mill. infusion against amyloid β-peptide-induced toxicity and inhibition of GSK-3β, CK-1δ, and BACE-1 enzymes relevant to Alzheimer's disease

C. Pérez, M. Yerer, Fatih Göger, 2021, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.

Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3β, β-secretase, and casein kinase 1δ

C. Pérez, Ana Martínez, Loreto Martínez-González, 2019, Industrial Crops and Products.

A Triazolotriazine‐Based Dual GSK‐3β/CK‐1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition

A. Cavalli, Maicol Bissaro, S. Moro, 2019, ChemMedChem.

Differentiation of U‐937 promonocytic cells with mitomycin C or cis‐diamminedichloroplatinum II

C. Pérez, A. Ballester, P. Aller, 1996, International journal of cancer.

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro.

C. Pérez, Irene Bolea, Abdelouahid Samadi, 2013, Current Alzheimer research.

Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.

P. Agostinho, C. Pérez, Ignacio Moraleda, 2013, ACS chemical neuroscience.

Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades

C. Pérez, R. León, Manuela G. López, 2022, Journal of medicinal chemistry.

Anthocyanins constituents, antioxidant and anti-Inflammatory activity of strawberries. Comparison with other berry fruits

C. Pérez, G. P. Blanch, G. Flores, 2014 .

Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase.

C. Pérez, Ana Martínez, M. I. Fernández-Bachiller, 2005, Bioorganic & medicinal chemistry.

Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors.

M. Bartolini, M. Bolognesi, G. Zuccheri, 2018, Journal of medicinal chemistry.

Anti-HIV-1 Activity of Benzothiadiazine Dioxide

E. De Clercq, C. Pannecouque, C. Pérez, 2001, Antiviral chemistry & chemotherapy.

Benzothiadiazine dioxides (BTD) derivatives as non-nucleoside human cytomegalovirus (HCMV) inhibitors. study of structural requirements for biological activity.

C. Pérez, Ana Martínez, C. Gil, 2003, Bioorganic & medicinal chemistry.

Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson’s Disease

F. Belluti, A. Bisi, S. Gobbi, 2020, ACS chemical neuroscience.

Nonnucleoside human cytomegalovirus inhibitors: synthesis and antiviral evaluation of (chlorophenylmethyl)benzothiadiazine dioxide derivatives.

E. De Clercq, C. Pérez, J. Balzarini, 2000, Journal of medicinal chemistry.

SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors.

F. J. Luque, J. Gelpí, C. Pérez, 2005, Journal of medicinal chemistry.

Optical control of muscular nicotinic channels with azocuroniums, photoswitchable azobenzenes bearing two N-methyl-N-carbocyclic quaternary ammonium groups.

C. Pérez, M. de la Fuente Revenga, C. Villalba-Galea, 2020, European journal of medicinal chemistry.

From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein‐Templated Synthesis

C. Pérez, Ana Martínez, V. Palomo, 2021, Angewandte Chemie.

Improved linkage design for the discovery of multitarget ligands as powerful drugs for Alzheimer’s disease

C. Pérez, Ana Martínez, V. Palomo, 2019 .

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases.

L. Rubin, N. Rodriguez-Muela, Carlos Roca, 2017, Journal of medicinal chemistry.

Caffeine attenuates the action of amsacrine and etoposide in U‐937 cells by mechanisms which involve inhibition of RNA synthesis

C. Pérez, N. Vilaboa, P. Aller, 1994, International journal of cancer.

Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3β.

M. Davies, C. Pérez, Ana Martínez, 2021, Journal of medicinal chemistry.

3-(Benzyloxy)-1-(5-[18F]fluoropentyl)-5-nitro-1H-indazole: a PET radiotracer to measure acetylcholinesterase in brain.

H. Engler, C. Pérez, D. Perez, 2017, Future medicinal chemistry.

Lipase-catalysed synthesis of new acetylcholinesterase inhibitors: N-benzylpiperidine aminoacid derivatives.

C. Pérez, S. Conde, A. Castro, 2000, Bioorganic & medicinal chemistry.

From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis

M. Loza, J. Brea, F. Feixas, 2021, Journal of medicinal chemistry.

Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.

E. Uriarte, P. Oliveira, C. Pérez, 2018, European journal of medicinal chemistry.

Benzothiadiazine dioxide dibenzyl derivatives as potent human cytomegalovirus inhibitors: synthesis and comparative molecular field analysis.

M. I. Abasolo, C. Pérez, A. M. Bruno, 2000, Journal of medicinal chemistry.

Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects

M. Loza, J. Brea, M. Cadavid, 2017, Molecules.

Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease

C. Pérez, Ana Martínez, C. Gil, 2011, PloS one.

Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis.

Nicole F. Liachko, B. Kraemer, C. Pérez, 2020, European journal of medicinal chemistry.

Protein Kinase CK-1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis

Nicole F. Liachko, B. Kraemer, C. Pérez, 2014, Journal of medicinal chemistry.

Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease.

C. Pérez, V. Palomo, D. Perez, 2013, ACS chemical neuroscience.

Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets.

V. Andrisano, C. Pérez, D. Perez, 2016, Fitoterapia.

Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.

C. Pérez, R. León, Manuela G. López, 2017, European journal of medicinal chemistry.

Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease.

C. Pérez, M. de la Fuente Revenga, Ignacio Moraleda, 2013, European journal of medicinal chemistry.

Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.

C. Pérez, Ignacio Moraleda, I. Iriepa, 2012, European journal of medicinal chemistry.

Novel indolic AMPK modulators induce vasodilatation through activation of the AMPK–eNOS–NO pathway

C. Pérez, C. Estarellas, J. Cumella, 2022, Scientific Reports.

New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.

C. Pérez, Manuela G. López, M. Villarroya, 2014, Journal of medicinal chemistry.

Targeting Cannabinoid Receptor Activation and BACE-1 Activity Counteracts TgAPP Mice Memory Impairment and Alzheimer’s Disease Lymphoblast Alterations

C. Pérez, N. Campillo, Á. Martín-Requero, 2020, Molecular Neurobiology.

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds.

Cristina Val, M. Loza, J. Brea, 2012, Journal of medicinal chemistry.

Multitarget cannabinoids as novel strategy for Alzheimer disease.

C. Pérez, N. Campillo, J. A. Páez, 2013, Current Alzheimer research.

Neuroprotective Effect of IND1316, an Indole-Based AMPK Activator, in Animal Models of Huntington Disease.

C. Pérez, R. Vázquez-Manrique, J. Cumella, 2021, ACS chemical neuroscience.

Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.

Arantxa Encinas, Nuria E. Campillo, Carmen Gil, 2008, Bioorganic & medicinal chemistry.

Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.

C. Pérez, Manuela G. López, M. Villarroya, 2010, Journal of medicinal chemistry.

New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.

C. Pérez, J. Rademann, M. I. Fernández-Bachiller, 2012, Journal of medicinal chemistry.