C. Okafor

发表

Ligand modulation of allosteric networks in an ancestral steroid receptor

E. Ortlund, C. Okafor, 2018, bioRxiv.

Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.

Megan F. Cole, Megan F Cole, Eric A Gaucher, 2018, Structure.

Ligand-Induced Allosteric Effects Governing SR Signaling

E. Ortlund, C. Okafor, J. K. Colucci, 2019, Nuclear Receptor Research.

Ribosomal small subunit domains radiate from a central core

C. Okafor, N. Hud, A. Petrov, 2016, Scientific Reports.

Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design

D. Moore, E. Ortlund, C. Okafor, 2019, bioRxiv.

Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors.

E. Ortlund, C. Okafor, D. Hercules, 2019, Structure.

Two enhancer binding proteins activate σ54-dependent transcription of a quorum regulatory RNA in a bacterial symbiont

C. Okafor, K. R. Guckes, Mark J. Mandel, 2022, bioRxiv.

Structure and assembly of the diiron cofactor in the heme-oxygenase-like domain of the N-nitrosourea-producing enzyme SznF

J. Bollinger, C. Okafor, A. K. Boal, 2020, bioRxiv.

Ancestral sequence reconstruction for evolutionary characterization of proteins.

C. Okafor, Namita Dube, Sabab H. Khan, 2021, Trends in biochemical sciences.

Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis

C. Okafor, A. K. Boal, K. Davis, 2022, eLife.

Allosteric regulation of Thioesterase Superfamily Member 1 by free fatty acids and lysophosphatidylcholine

E. Ortlund, C. Okafor, Puneet Juneja, 2020, bioRxiv.

Structural analysis of the glucocorticoid receptor ligand-binding domain in complex with triamcinolone acetonide and a fragment of the atypical coregulator, SHP

E. Ortlund, C. Okafor, J. K. Colucci, 2017 .

Ligand-induced shifts in conformational ensembles that predict transcriptional activation

C. Okafor, G. Anand, S. Koehler, 2022, bioRxiv.

Identification of Antimalarial Compounds that Inhibit Apicomplexan AP2 Proteins in the Human Malaria Parasite Plasmodium falciparum

M. Llinás, F. Gamo, Erandi K. De Silva, 2022, bioRxiv.

Bile acids and the gut microbiota: metabolic interactions and impacts on disease

C. Okafor, A. Patterson, J. Bisanz, 2022, Nature Reviews Microbiology.

Ligand-induced shifts in conformational ensembles that describe transcriptional activation

C. Okafor, G. Anand, S. Koehler, 2022, eLife.

Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine

E. Ortlund, C. Okafor, Puneet Juneja, 2020, Proceedings of the National Academy of Sciences.

Interactions governing transcriptional activity of nuclear receptors.

C. Okafor, S. H. Khan, 2022, Biochemical Society transactions.

Nonenzymatic Ligation of DNA with a Reversible Step and a Final Linkage that Can Be Used in PCR

C. Okafor, N. Hud, L. Williams, 2012, Chembiochem : a European journal of chemical biology.

Folding and Catalysis Near Life’s Origin: Support for Fe 2+ as a Dominant Divalent Cation

C. Okafor, N. Hud, J. Bowman, 2018 .

Iron mediates catalysis of nucleic acid processing enzymes: support for Fe(II) as a cofactor before the great oxidation event

C. Okafor, N. Hud, J. Bowman, 2017, Nucleic acids research.

Metallobiochemistry of RNA: Mg(II) and Fe(II) in divalent binding sites

C. Okafor, 2015 .

RNA-magnesium-protein interactions in large ribosomal subunit.

Chad R Bernier, S. Harvey, C. Okafor, 2012, The journal of physical chemistry. B.

Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design

D. Moore, E. Ortlund, C. Okafor, 2019, bioRxiv.

The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor

E. Ortlund, C. Okafor, F. Frank, 2018, Scientific Reports.

RNA with iron(II) as a cofactor catalyses electron transfer.

I. Chou, S. Harvey, C. Okafor, 2013, Nature chemistry.

Identification of an Evolutionarily Conserved Allosteric Network in Steroid Receptors

C. Okafor, Namita Dube, S. H. Khan, 2023, J. Chem. Inf. Model..

Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner

Jace W. Jones, S. Heyward, P. Swaan, 2017, Molecular Pharmacology.

Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists*♦

P. Griffin, E. Ortlund, C. Okafor, 2016, The Journal of Biological Chemistry.

Crystal Structures of LRH-1 with Synthetic Agonists Reveal a Novel Mechanism of Receptor Activation

P. Griffin, E. Ortlund, C. Okafor, 2016 .

The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells

E. Ortlund, C. Okafor, H. Qadota, 2020, Nature Communications.

Identification of Antimalarial Compounds that Inhibit Apicomplexan AP2 Proteins

M. Llinás, F. Gamo, Erandi K. De Silva, 2022, bioRxiv.

A phospholipid mimetic targeting LRH-1 ameliorates colitis.

R. Houtman, D. Moore, E. Ortlund, 2022, Cell chemical biology.

The nuclear receptor LRH‐1 discriminates between ligands using distinct allosteric signaling circuits

E. Ortlund, C. Okafor, S. Mays, 2023, bioRxiv.

Tapping into a phospholipid-LRH-1 axis yields a powerful anti-inflammatory agent with in vivo activity against colitis

R. Houtman, D. Moore, E. Ortlund, 2020, bioRxiv.

A novel phospholipid mimetic targeting LRH-1 ameliorates colitis

R. Houtman, D. Moore, E. Ortlund, 2020 .

Structure and Dynamics of the Liver Receptor Homolog 1–PGC1α Complex

P. Griffin, E. Ortlund, C. Okafor, 2017, Molecular Pharmacology.

Molecular mechanism regulating transcriptional control of the hig toxin-antitoxin locus of antibiotic-resistance plasmid Rts1 from Proteus vulgaris

C. Dunham, C. Okafor, Dongxue Wang, 2021, bioRxiv.